PMC:7461420 / 55181-55990
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T243 | 304-309 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T244 | 474-491 | Body_part | denotes | cellular membrane | http://purl.org/sig/ont/fma/fma63841 |
| T245 | 518-522 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T246 | 612-618 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T247 | 619-626 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T248 | 718-722 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T24 | 518-522 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T25 | 718-722 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T269 | 43-47 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T270 | 102-106 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T271 | 215-219 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T272 | 272-276 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T699 | 292-297 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T700 | 298-309 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu3 cells |
| T701 | 298-309 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu3 cells |
| T702 | 298-309 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu3 cells |
| T703 | 298-309 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu3 cells |
| T704 | 298-309 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu3 cells |
| T705 | 298-303 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu3 |
| T706 | 362-365 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 4–5 |
| T707 | 431-432 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T708 | 483-491 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T709 | 612-618 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T710 | 718-722 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T711 | 718-722 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T26920 | 387-390 | Chemical | denotes | Boc | http://purl.obolibrary.org/obo/CHEBI_48502 |
| T18812 | 451-456 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T15971 | 553-562 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T72808 | 619-626 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T61 | 314-345 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibited the viral replication |
| T62 | 328-345 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T63 | 328-345 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T64 | 723-730 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1671 | 147-151 | Gene | denotes | Mpro | Gene:8673700 |
| 1672 | 113-117 | Gene | denotes | Mpro | Gene:8673700 |
| 1673 | 54-58 | Gene | denotes | Mpro | Gene:8673700 |
| 1674 | 43-53 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 1675 | 102-110 | Species | denotes | SARS‐CoV | Tax:694009 |
| 1676 | 138-146 | Species | denotes | MERS‐CoV | Tax:1335626 |
| 1677 | 215-223 | Species | denotes | SARS‐CoV | Tax:694009 |
| 1678 | 292-297 | Species | denotes | human | Tax:9606 |
| 1679 | 766-770 | Species | denotes | mice | Tax:10090 |
| 1680 | 272-291 | Disease | denotes | SARS‐CoV‐2 infected | MESH:C000657245 |
| 1681 | 298-303 | CellLine | denotes | Calu3 | CVCL:0609 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T484 | 0-83 | Sentence | denotes | Compound 67 (Figure 19) inhibited purified SARS‐CoV‐2 Mpro with an IC50 of 0.67 µM. |
| T485 | 84-189 | Sentence | denotes | It also inhibited SARS‐CoV‐1 Mpro (IC50, 0.90 µM) and MERS‐CoV Mpro (IC50, 0.58 µM) with similar potency. |
| T486 | 190-268 | Sentence | denotes | It was effective against SARS‐CoV‐1 replication with an EC50 value of 1.75 µM. |
| T487 | 269-504 | Sentence | denotes | In SARS‐CoV‐2 infected human Calu3 cells, it inhibited the viral replication with an EC50 of 4–5 µM, when in fact the Boc‐unprotected 68 was inactive, suggesting a bulky hydrophobic group is necessary for cellular membrane penetration. |
| T488 | 505-662 | Sentence | denotes | On the other hand, increasing hydrophobicity of molecules should be pondered carefully, as it can increase plasma protein binding as it was described for 64. |
| T489 | 663-809 | Sentence | denotes | The pharmacokinetic properties of 67 revealed striking lung tropism and was suitable for inhalation in mice without any perceived adverse effects. |