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PMC:7461420 / 53454-54276 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T235 646-652 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T236 762-768 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T237 806-812 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T238 813-821 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T259 35-39 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 55-59 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T261 193-197 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 306-310 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T263 378-382 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T264 450-454 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T676 128-133 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T677 191-192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T678 399-400 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T679 471-472 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T680 592-594 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T681 646-652 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T682 762-768 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T683 806-812 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T7603 179-187 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T40736 204-218 Chemical denotes Mpro inhibitor http://purl.obolibrary.org/obo/CHEBI_147285
T97159 209-218 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T77172 592-594 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T56473 598-603 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T64629 618-626 Chemical denotes pyridone http://purl.obolibrary.org/obo/CHEBI_38183
T15402 736-745 Chemical denotes Boc group http://purl.obolibrary.org/obo/CHEBI_48502
T58006 740-745 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T93511 813-821 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1625 204-208 Gene denotes Mpro Gene:8673700
1626 461-465 Gene denotes Mpro Gene:8673700
1627 389-393 Gene denotes Mpro Gene:8673700
1628 317-321 Gene denotes Mpro Gene:8673700
1629 66-70 Gene denotes Mpro Gene:8673700
1630 46-50 Gene denotes Mpro Gene:8673700
1631 35-43 Species denotes SARS‐CoV Tax:694009
1632 55-65 Species denotes SARS‐CoV‐2 Tax:2697049
1633 193-203 Species denotes SARS‐CoV‐2 Tax:2697049
1634 306-316 Species denotes SARS‐CoV‐2 Tax:2697049
1635 378-386 Species denotes SARS‐CoV Tax:694009
1636 450-460 Species denotes SARS‐CoV‐2 Tax:2697049
1637 592-594 Chemical denotes P2 MESH:C020845
1638 598-603 Chemical denotes amide MESH:D000577
1639 618-626 Chemical denotes pyridone MESH:D011728

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T473 0-142 Sentence denotes Due to the high similarity between SARS‐CoV‐1 Mpro and SARS‐CoV‐2 Mpro authors speculated that 64 was likely to inhibit the new virus as well.
T474 143-249 Sentence denotes Zhang et al. recently reported this molecule as a SARS‐CoV‐2 Mpro inhibitor with an IC50 value of 0.18 µM.
T475 250-423 Sentence denotes They first resolved the unliganded crystal structure of SARS‐CoV‐2 Mpro (Figure 20), 157 which is largely identical to that of SARS‐CoV‐1 Mpro with a 96% sequence identity.
T476 424-565 Sentence denotes Compound 64 was docked to SARS‐CoV‐2 Mpro, and a series of structural modifications were performed to improve its pharmacokinetic properties.
T477 566-822 Sentence denotes Specifically, masking the P2‐P3 amide bond with the pyridone ring could improve plasma half‐life; and exchanging the lipophilic cinnamoyl residue for the less lipophilic Boc group, could increase plasma solubility and reduce its binding to plasma proteins.