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PMC:7461420 / 52803-53453 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T232 395-400 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T233 479-484 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T234 639-643 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T257 66-70 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T258 370-374 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T5439 13-14 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T660 170-178 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T661 186-188 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T662 200-201 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T663 229-231 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T664 244-246 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T665 308-310 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T666 390-394 http://purl.obolibrary.org/obo/CLO_0009989 denotes Huh7
T667 395-400 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T668 434-442 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T669 474-478 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T670 474-478 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T671 479-484 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T672 499-507 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T673 586-594 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T674 603-604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T675 639-649 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T45586 186-188 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T62151 229-231 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T56998 232-238 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T20063 244-246 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T27961 247-257 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T86938 308-310 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T75961 311-322 Chemical denotes cyclopentyl http://purl.obolibrary.org/obo/CHEBI_52880
T61372 424-433 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T896 489-498 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T87883 576-585 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1603 381-385 Gene denotes Mpro Gene:8673700
1604 66-74 Species denotes SARS‐CoV Tax:694009
1605 78-87 Species denotes HCoV‐NL63 Tax:277944
1606 93-107 Species denotes coxsackievirus Tax:12066
1607 370-378 Species denotes SARS‐CoV Tax:694009
1608 308-322 Chemical denotes P2‐cyclopentyl
1609 390-394 CellLine denotes Huh7 CVCL:0336

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T470 197-386 Sentence denotes As a result, the replacement of P2‐phenyl with P2‐cyclohexyl (64) was found to be the best substitution, while P2‐cyclopentyl (65) showed similar potency against the enzyme SARS‐CoV‐1 Mpro.
T471 387-546 Sentence denotes In Huh7 cells, 64 also showed strong antiviral activity with an EC50 of 400 pM, but in Vero cells the antiviral activity of 64 was drastically reduced to 5 µM.
T472 547-650 Sentence denotes This compound also exhibited antiviral activity against a range of enteroviruses in various cell lines.