PMC:7461420 / 48667-49101 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T615","span":{"begin":78,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T616","span":{"begin":78,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T617","span":{"begin":110,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T618","span":{"begin":132,"end":133},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T619","span":{"begin":161,"end":162},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T620","span":{"begin":241,"end":243},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T621","span":{"begin":264,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T622","span":{"begin":318,"end":326},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T623","span":{"begin":394,"end":396},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T624","span":{"begin":394,"end":396},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T625","span":{"begin":425,"end":433},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"This group further extended their study to find inhibitors that interact with S2 to S4 subsites. Taking 49 as a lead, they designed a new compound, by combining a nonprime substituent at the decahydroisoquinoline moiety, as shown in example 52. 149 The resulting 52 showed more than twofold increased Mpro inhibitory activity compared to 49. This indicates that the additional interactions at S2–S4 sites enhance inhibitory activity."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T559","span":{"begin":5,"end":10},"obj":"Chemical"},{"id":"T560","span":{"begin":48,"end":58},"obj":"Chemical"},{"id":"T561","span":{"begin":78,"end":80},"obj":"Chemical"},{"id":"T562","span":{"begin":84,"end":86},"obj":"Chemical"},{"id":"T563","span":{"begin":394,"end":396},"obj":"Chemical"},{"id":"T564","span":{"begin":397,"end":399},"obj":"Chemical"}],"attributes":[{"id":"A559","pred":"chebi_id","subj":"T559","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A560","pred":"chebi_id","subj":"T560","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A561","pred":"chebi_id","subj":"T561","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A562","pred":"chebi_id","subj":"T562","obj":"http://purl.obolibrary.org/obo/CHEBI_29401"},{"id":"A563","pred":"chebi_id","subj":"T563","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A564","pred":"chebi_id","subj":"T564","obj":"http://purl.obolibrary.org/obo/CHEBI_29401"}],"text":"This group further extended their study to find inhibitors that interact with S2 to S4 subsites. Taking 49 as a lead, they designed a new compound, by combining a nonprime substituent at the decahydroisoquinoline moiety, as shown in example 52. 149 The resulting 52 showed more than twofold increased Mpro inhibitory activity compared to 49. This indicates that the additional interactions at S2–S4 sites enhance inhibitory activity."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1466","span":{"begin":302,"end":306},"obj":"Gene"},{"id":"1467","span":{"begin":191,"end":212},"obj":"Chemical"}],"attributes":[{"id":"A1466","pred":"tao:has_database_id","subj":"1466","obj":"Gene:8673700"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"This group further extended their study to find inhibitors that interact with S2 to S4 subsites. Taking 49 as a lead, they designed a new compound, by combining a nonprime substituent at the decahydroisoquinoline moiety, as shown in example 52. 149 The resulting 52 showed more than twofold increased Mpro inhibitory activity compared to 49. This indicates that the additional interactions at S2–S4 sites enhance inhibitory activity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T437","span":{"begin":97,"end":244},"obj":"Sentence"},{"id":"T438","span":{"begin":245,"end":342},"obj":"Sentence"},{"id":"T439","span":{"begin":343,"end":434},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This group further extended their study to find inhibitors that interact with S2 to S4 subsites. Taking 49 as a lead, they designed a new compound, by combining a nonprime substituent at the decahydroisoquinoline moiety, as shown in example 52. 149 The resulting 52 showed more than twofold increased Mpro inhibitory activity compared to 49. This indicates that the additional interactions at S2–S4 sites enhance inhibitory activity."}