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PMC:7461420 / 47864-48526 JSONTXT

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LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T241 291-295 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T600 34-35 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T601 52-59 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T602 82-83 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T603 125-127 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T604 159-167 http://purl.obolibrary.org/obo/PR_000018263 denotes peptidic
T605 194-195 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T606 276-282 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T607 326-329 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T608 396-398 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T609 456-458 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T610 456-458 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T611 478-480 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T612 511-513 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T613 650-656 http://purl.obolibrary.org/obo/CLO_0001658 denotes active

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T544 18-23 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T545 52-59 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T546 60-70 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T547 125-127 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T548 128-138 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T549 182-192 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T550 396-398 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T551 456-458 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T552 478-480 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T553 481-490 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T555 622-627 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1453 354-358 Gene denotes Mpro Gene:8673700
1454 300-304 Gene denotes Mpro Gene:8673700
1455 291-299 Species denotes SARS‐CoV Tax:694009
1456 84-105 Chemical denotes decahydroisoquinoline
1457 396-420 Chemical denotes P2‐decahydroisoquinoline
1458 481-490 Chemical denotes imidazole MESH:C029899
1459 628-632 Disease denotes fits MESH:D012640

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T431 0-193 Sentence denotes The same research group disclosed a novel series of peptide inhibitors containing a decahydroisoquinoline moiety in place of P2‐cyclohexyl of 46 to reduce the peptidic nature of the inhibitors.
T432 194-240 Sentence denotes A few examples (47–51) are shown in Figure 16.
T433 241-325 Sentence denotes Among them, 49 was moderately more active against SARS‐CoV Mpro when compared to 46.
T434 326-522 Sentence denotes 148 The X‐ray structure of Mpro in complex with 49 revealed that the P2‐decahydroisoquinoline moiety was fittingly placed in the S2‐subsite, while the P1‐imidazole moiety occupied the S1‐subsite.
T435 523-662 Sentence denotes With these key residues located appropriately in their respective pockets, the terminal functional group fits tightly into the active site.