PMC:7461420 / 44920-45323 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"Although the above‐described inhibitors with 1,4‐Michael acceptors (e.g., α,β‐vinyl ethyl ester, –CH═CH–C(O)–OEt) showed enzymatic or cell‐based in‐vitro activities, they can be cleaved to their carboxylic acids by plasma esterases; for instance, AG7088 (29) was inactive in the plasma of rodents and rabbits. 144 , 145 Therefore, scientists explored different reactive groups that are stable in vivo.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T216","span":{"begin":134,"end":138},"obj":"Body_part"},{"id":"T217","span":{"begin":215,"end":221},"obj":"Body_part"},{"id":"T218","span":{"begin":279,"end":285},"obj":"Body_part"}],"attributes":[{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma62970"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T547","span":{"begin":134,"end":138},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T548","span":{"begin":154,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T549","span":{"begin":215,"end":221},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T550","span":{"begin":279,"end":285},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T551","span":{"begin":289,"end":308},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_314147"}],"attributes":[{"subj":"T547","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T548","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T549","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T550","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T551","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T473","span":{"begin":29,"end":39},"obj":"Chemical"},{"id":"T474","span":{"begin":78,"end":83},"obj":"Chemical"},{"id":"T475","span":{"begin":84,"end":95},"obj":"Chemical"},{"id":"T476","span":{"begin":84,"end":89},"obj":"Chemical"},{"id":"T478","span":{"begin":90,"end":95},"obj":"Chemical"},{"id":"T479","span":{"begin":195,"end":211},"obj":"Chemical"},{"id":"T480","span":{"begin":206,"end":211},"obj":"Chemical"}],"attributes":[{"id":"A473","pred":"chebi_id","subj":"T473","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A474","pred":"chebi_id","subj":"T474","obj":"http://purl.obolibrary.org/obo/CHEBI_37603"},{"id":"A475","pred":"chebi_id","subj":"T475","obj":"http://purl.obolibrary.org/obo/CHEBI_23990"},{"id":"A476","pred":"chebi_id","subj":"T476","obj":"http://purl.obolibrary.org/obo/CHEBI_37807"},{"id":"A477","pred":"chebi_id","subj":"T476","obj":"http://purl.obolibrary.org/obo/CHEBI_62801"},{"id":"A478","pred":"chebi_id","subj":"T478","obj":"http://purl.obolibrary.org/obo/CHEBI_35701"},{"id":"A479","pred":"chebi_id","subj":"T479","obj":"http://purl.obolibrary.org/obo/CHEBI_33575"},{"id":"A480","pred":"chebi_id","subj":"T480","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T473","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T474","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T475","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T476","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T478","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T479","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T480","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1355","span":{"begin":289,"end":308},"obj":"Species"},{"id":"1356","span":{"begin":45,"end":56},"obj":"Chemical"},{"id":"1357","span":{"begin":195,"end":211},"obj":"Chemical"},{"id":"1358","span":{"begin":247,"end":253},"obj":"Chemical"},{"id":"1359","span":{"begin":98,"end":105},"obj":"Disease"}],"attributes":[{"id":"A1355","pred":"tao:has_database_id","subj":"1355","obj":"Tax:314147"},{"id":"A1357","pred":"tao:has_database_id","subj":"1357","obj":"MESH:D002264"},{"id":"A1358","pred":"tao:has_database_id","subj":"1358","obj":"MESH:C118874"},{"id":"A1359","pred":"tao:has_database_id","subj":"1359","obj":"MESH:C537418"},{"subj":"1355","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1356","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1357","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1358","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1359","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T408","span":{"begin":0,"end":309},"obj":"Sentence"},{"id":"T409","span":{"begin":310,"end":403},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T408","pred":"source","obj":"LitCovid-sentences"},{"subj":"T409","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#b4ec93","default":true},{"id":"LitCovid-PD-CLO","color":"#ec93ce"},{"id":"LitCovid-PD-CHEBI","color":"#93e8ec"},{"id":"LitCovid-PubTator","color":"#ecd693"},{"id":"LitCovid-sentences","color":"#bb93ec"}]}]}}