
PMC:7461420 / 41285-41606
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"At first, the P1‐lactam ring was identified as a more specific moiety for the S1‐site, forming multiple hydrogen‐bond interactions with the enzyme as can be seen in the crystal structure (36); P2‐leucine showed a fourfold increased inhibitory activity when compared to the P2‐phenylalanine or ‐4‐fluorophenylalanine (37).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T208","span":{"begin":196,"end":203},"obj":"Body_part"},{"id":"T209","span":{"begin":276,"end":289},"obj":"Body_part"}],"attributes":[{"id":"A208","pred":"fma_id","subj":"T208","obj":"http://purl.org/sig/ont/fma/fma82757"},{"id":"A209","pred":"fma_id","subj":"T209","obj":"http://purl.org/sig/ont/fma/fma82754"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T495","span":{"begin":14,"end":16},"obj":"http://purl.obolibrary.org/obo/CLO_0008285"},{"id":"T496","span":{"begin":47,"end":48},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T497","span":{"begin":78,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T498","span":{"begin":188,"end":190},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T499","span":{"begin":193,"end":195},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T500","span":{"begin":211,"end":212},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T501","span":{"begin":243,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T502","span":{"begin":273,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"}],"attributes":[{"subj":"T495","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T496","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T497","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T498","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T499","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T500","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T501","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T502","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T412","span":{"begin":14,"end":16},"obj":"Chemical"},{"id":"T413","span":{"begin":17,"end":28},"obj":"Chemical"},{"id":"T414","span":{"begin":17,"end":23},"obj":"Chemical"},{"id":"T415","span":{"begin":104,"end":112},"obj":"Chemical"},{"id":"T416","span":{"begin":193,"end":195},"obj":"Chemical"},{"id":"T417","span":{"begin":196,"end":203},"obj":"Chemical"},{"id":"T418","span":{"begin":273,"end":275},"obj":"Chemical"},{"id":"T419","span":{"begin":276,"end":289},"obj":"Chemical"}],"attributes":[{"id":"A412","pred":"chebi_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/CHEBI_60949"},{"id":"A413","pred":"chebi_id","subj":"T413","obj":"http://purl.obolibrary.org/obo/CHEBI_77730"},{"id":"A414","pred":"chebi_id","subj":"T414","obj":"http://purl.obolibrary.org/obo/CHEBI_24995"},{"id":"A415","pred":"chebi_id","subj":"T415","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A416","pred":"chebi_id","subj":"T416","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A417","pred":"chebi_id","subj":"T417","obj":"http://purl.obolibrary.org/obo/CHEBI_25017"},{"id":"A418","pred":"chebi_id","subj":"T418","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A419","pred":"chebi_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/CHEBI_28044"},{"id":"A420","pred":"chebi_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/CHEBI_58095"},{"subj":"T412","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T413","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T414","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T415","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T416","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T417","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T418","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1256","span":{"begin":14,"end":23},"obj":"Chemical"},{"id":"1257","span":{"begin":104,"end":112},"obj":"Chemical"},{"id":"1258","span":{"begin":196,"end":203},"obj":"Chemical"},{"id":"1259","span":{"begin":273,"end":289},"obj":"Chemical"},{"id":"1260","span":{"begin":293,"end":315},"obj":"Chemical"}],"attributes":[{"id":"A1257","pred":"tao:has_database_id","subj":"1257","obj":"MESH:D006859"},{"id":"A1258","pred":"tao:has_database_id","subj":"1258","obj":"MESH:D007930"},{"id":"A1260","pred":"tao:has_database_id","subj":"1260","obj":"MESH:D010135"},{"subj":"1256","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1257","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1258","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1259","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1260","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T379","span":{"begin":0,"end":321},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T379","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecd8","default":true},{"id":"LitCovid-PD-CLO","color":"#ecbe93"},{"id":"LitCovid-PD-CHEBI","color":"#a493ec"},{"id":"LitCovid-PubTator","color":"#9bec93"},{"id":"LitCovid-sentences","color":"#ec93b5"}]}]}}