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PMC:7461420 / 38656-39463 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T203 467-474 Body_part denotes leucine http://purl.org/sig/ont/fma/fma82757

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T210 53-57 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 300-337 Disease denotes porcine transmissible gastroenteritis http://purl.obolibrary.org/obo/MONDO_0025420
T212 322-337 Disease denotes gastroenteritis http://purl.obolibrary.org/obo/MONDO_0002269
T213 517-521 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T214 780-784 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T452 85-86 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T453 87-95 http://purl.obolibrary.org/obo/PR_000018263 denotes peptidic
T454 110-113 http://purl.obolibrary.org/obo/CLO_0037067 denotes Val
T455 273-274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T456 365-366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T457 398-400 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T458 440-442 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T459 464-466 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T460 506-508 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T461 506-508 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T462 574-575 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T463 604-609 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T356 96-105 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T357 106-109 Chemical denotes Cbz http://purl.obolibrary.org/obo/CHEBI_51097
T358 110-113 Chemical denotes Val http://purl.obolibrary.org/obo/CHEBI_16414|http://purl.obolibrary.org/obo/CHEBI_30015
T360 114-117 Chemical denotes Asn http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347
T363 118-121 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T365 122-125 Chemical denotes Thr http://purl.obolibrary.org/obo/CHEBI_16857|http://purl.obolibrary.org/obo/CHEBI_30013
T367 126-129 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T370 130-133 Chemical denotes Gln http://purl.obolibrary.org/obo/CHEBI_30011
T371 147-153 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T372 194-200 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T373 398-400 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T374 401-404 Chemical denotes Gln http://purl.obolibrary.org/obo/CHEBI_30011
T375 464-466 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T376 467-474 Chemical denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T377 506-508 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T378 576-590 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T379 591-600 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T380 656-665 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T381 720-729 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T382 791-806 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T383 796-806 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1200 791-795 Gene denotes Mpro Gene:8673700
1201 64-68 Gene denotes Mpro Gene:8673700
1202 699-703 Gene denotes Mpro Gene:8673700
1203 528-532 Gene denotes Mpro Gene:8673700
1204 349-353 Gene denotes Mpro Gene:8673700
1205 53-61 Species denotes SARS‐CoV Tax:694009
1206 343-347 Species denotes TGEV Tax:11149
1207 517-525 Species denotes SARS‐CoV Tax:694009
1208 604-622 Species denotes human rhinovirus 3 Tax:44130
1209 694-698 Species denotes TGEV Tax:11149
1210 780-788 Species denotes SARS‐CoV Tax:694009
1211 308-321 Species denotes transmissible Tax:11149
1212 106-153 Chemical denotes Cbz‐Val‐Asn‐Ser‐Thr‐Leu‐Gln‐chloromethyl ketone
1213 181-200 Chemical denotes chloromethyl ketone
1214 398-400 Chemical denotes P1 MESH:C480041
1215 401-404 Chemical denotes Gln MESH:D005973
1216 467-474 Chemical denotes leucine MESH:D007930
1217 548-559 Chemical denotes rupintrivir MESH:C118874
1218 565-571 Chemical denotes AG7088 MESH:C118874
1219 322-341 Disease denotes gastroenteritis CoV MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T358 0-257 Sentence denotes The disclosure of the first crystal structure of the SARS‐CoV‐1 Mpro in complex with a peptidic inhibitor Cbz‐Val‐Asn‐Ser‐Thr‐Leu‐Gln‐chloromethyl ketone (also known as hexapeptide chloromethyl ketone; 28) 125 provided clues for the substrate‐based design.
T359 258-533 Sentence denotes Although it is a substrate analog for the porcine transmissible gastroenteritis CoV (TGEV) Mpro, it offers a structural explanation for the P1‐Gln entering into the specific subsite S1 pocket and decreased P2‐leucine specificity in the hydrophobic S2 site of SARS‐CoV‐1 Mpro.
T360 534-704 Sentence denotes Additionally, rupintrivir (29; AG7088), a peptidomimetic inhibitor of human rhinovirus 3C protease is oriented similar to inhibitor 28 in the binding pocket of TGEV Mpro.
T361 705-807 Sentence denotes 129 These two molecules became prototype compounds for the development of SARS‐CoV‐1 Mpro inhibitors.