PMC:7461420 / 37875-38068 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T201","span":{"begin":135,"end":143},"obj":"Body_part"}],"attributes":[{"id":"A201","pred":"fma_id","subj":"T201","obj":"http://purl.org/sig/ont/fma/fma82751"}],"text":"In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T440","span":{"begin":12,"end":13},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T441","span":{"begin":48,"end":49},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T442","span":{"begin":154,"end":155},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T340","span":{"begin":55,"end":64},"obj":"Chemical"},{"id":"T341","span":{"begin":135,"end":143},"obj":"Chemical"}],"attributes":[{"id":"A340","pred":"chebi_id","subj":"T340","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A341","pred":"chebi_id","subj":"T341","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"}],"text":"In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1164","span":{"begin":135,"end":143},"obj":"Chemical"}],"attributes":[{"id":"A1164","pred":"tao:has_database_id","subj":"1164","obj":"MESH:D003545"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner."}

{"project":"LitCovid-sentences","denotations":[{"id":"T351","span":{"begin":0,"end":193},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner."}