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PMC:7461420 / 36294-37458 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T198 64-72 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T199 386-394 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T200 444-453 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T201 87-91 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 620-624 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T203 639-648 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T425 50-51 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T426 167-170 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T427 327-333 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T428 344-345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T429 488-495 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T430 528-529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T431 683-690 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T432 801-806 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T433 808-816 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptides
T434 1015-1023 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T435 1065-1073 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T436 1130-1138 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T319 64-72 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T320 154-156 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T321 386-394 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T322 407-418 Chemical denotes nucleophile http://purl.obolibrary.org/obo/CHEBI_59740
T323 444-453 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T324 473-477 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T325 478-482 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T326 488-495 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T327 509-518 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T328 558-560 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T329 694-713 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T331 703-713 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T332 751-755 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T333 818-833 Chemical denotes peptidomimetics http://purl.obolibrary.org/obo/CHEBI_63175
T334 850-859 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T335 978-987 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T55 426-437 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1126 37-41 Gene denotes Mpro Gene:8673700
1127 33-36 Species denotes CoV Tax:11118
1138 42-46 Gene denotes Mpro Gene:8673700
1139 322-326 Gene denotes Mpro Gene:8673700
1140 98-102 Gene denotes Mpro Gene:8673700
1141 87-95 Species denotes SARS‐CoV Tax:694009
1142 318-321 Species denotes CoV Tax:11118
1143 64-81 Gene denotes cysteine protease Gene:1508
1144 362-368 Chemical denotes Cys145
1145 369-374 Chemical denotes His41
1146 386-394 Chemical denotes cysteine MESH:D003545
1147 444-453 Chemical denotes histidine MESH:D006639
1150 1011-1014 Species denotes CoV Tax:11118
1151 635-648 Disease denotes CoV infection MESH:D018352

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T335 0-41 Sentence denotes 3.1.1 Structure and function of CoV Mpro
T336 42-82 Sentence denotes Mpro is a homodimeric cysteine protease.
T337 83-129 Sentence denotes The SARS‐CoV‐1 Mpro consists of three domains:
T338 130-308 Sentence denotes I (residues 8–101), and II (residues 102–184), which are β‐barrel domains that shape the chymotrypsin‐like structure, while domain III (residues 201–306) is made up by α‐helices.
T339 309-483 Sentence denotes 124 The CoV Mpro active site uses a catalytic dyad (Cys145‐His41), in which cysteine acts as the nucleophile in the proteolysis while histidine behaves as general acid‐base.
T340 484-561 Sentence denotes The peptide substrate or inhibitor binds in a cleft between domains I and II.
T341 562-565 Sentence denotes 125
T342 566-714 Sentence denotes As far as the development of new therapeutics against SARS‐ and MERS‐CoV infection is concerned, efforts have mainly focused on protease inhibitors.
T343 715-807 Sentence denotes These enzymes are highly attractive drug targets because they are so essential to the virus.
T344 808-947 Sentence denotes Peptides, peptidomimetics, and even small molecules can inhibit them, which leads to markedly reduced viral transmission and pathogenicity.
T345 948-1139 Sentence denotes Although most of the reported molecules display only weak anti‐CoV activity, several of studies elucidated structure–activity relationships that can be used to further improve their activity.
T346 1140-1164 Sentence denotes 100 , 126 , 127 , 128