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PMC:7461420 / 35552-81452 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T195 487-495 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T196 507-510 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T197 519-527 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T198 806-814 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T199 1128-1136 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T200 1186-1195 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T201 2458-2466 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T202 2781-2791 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T203 3571-3578 Body_part denotes leucine http://purl.org/sig/ont/fma/fma82757
T204 4682-4686 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T205 4955-4961 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T206 5455-5459 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T207 5597-5605 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T208 5929-5936 Body_part denotes leucine http://purl.org/sig/ont/fma/fma82757
T209 6009-6022 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T210 6139-6145 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T211 6360-6364 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T212 7510-7516 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T213 8891-8899 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T214 8956-8964 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T215 9180-9188 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T216 9502-9506 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T217 9583-9589 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T218 9647-9653 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T219 9950-9958 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T220 10021-10028 Body_part denotes leucine http://purl.org/sig/ont/fma/fma82757
T221 10471-10477 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T222 10542-10547 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T223 10891-10904 Body_part denotes cell‐membrane http://purl.org/sig/ont/fma/fma63841
T224 10891-10895 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T225 11266-11271 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T226 12118-12127 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T227 14605-14609 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T228 15078-15086 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T229 15256-15264 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T230 15536-15544 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T231 15972-15976 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T232 17646-17651 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T233 17730-17735 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T234 17890-17894 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T235 18548-18554 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T236 18664-18670 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T237 18708-18714 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T238 18715-18723 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T239 18959-18965 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T240 19056-19062 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T241 19290-19296 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T242 19297-19304 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T243 19933-19938 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T244 20103-20120 Body_part denotes cellular membrane http://purl.org/sig/ont/fma/fma63841
T245 20147-20151 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T246 20241-20247 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T247 20248-20255 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T248 20347-20351 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T249 20971-20979 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T250 22084-22090 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T251 22094-22102 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T252 22687-22695 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T253 22941-22949 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T254 22950-22960 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T255 23659-23665 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T256 23974-23982 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T257 24026-24033 Body_part denotes leucine http://purl.org/sig/ont/fma/fma82757
T258 24500-24508 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T259 25411-25415 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T260 26969-26972 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T261 27176-27179 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T262 27377-27380 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T263 27403-27406 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T264 27777-27781 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T265 28862-28866 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T266 29302-29307 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T267 32942-32953 Body_part denotes pyrimidines http://purl.org/sig/ont/fma/fma82773
T268 33444-33454 Body_part denotes pyrimidine http://purl.org/sig/ont/fma/fma82773
T269 34637-34642 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T270 38789-38793 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T271 38868-38877 Body_part denotes serotonin http://purl.org/sig/ont/fma/fma67245
T272 40583-40591 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T273 40784-40788 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T274 40911-40919 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T275 42125-42130 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T276 42585-42589 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T277 42875-42880 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T278 43300-43304 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T279 43509-43513 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T280 43781-43785 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T281 45808-45816 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T23 5455-5459 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T24 20147-20151 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T25 20347-20351 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T200 644-653 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T201 829-833 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 1362-1366 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T203 1381-1390 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T204 2029-2038 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T205 2698-2702 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T206 2815-2819 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T207 2886-2890 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T208 2933-2937 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 2943-2976 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T210 3157-3161 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 3404-3441 Disease denotes porcine transmissible gastroenteritis http://purl.obolibrary.org/obo/MONDO_0025420
T212 3426-3441 Disease denotes gastroenteritis http://purl.obolibrary.org/obo/MONDO_0002269
T213 3621-3625 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T214 3884-3888 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 3955-3959 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T216 5292-5296 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 5386-5390 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T218 5396-5429 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T219 7090-7094 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T220 7403-7413 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T221 7414-7424 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T222 7476-7480 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 7535-7539 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T224 7677-7681 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T225 7716-7720 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T226 7797-7801 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 7843-7847 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T228 7903-7907 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T229 7953-7961 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T230 8056-8060 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T231 8129-8133 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T232 8365-8373 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T233 10244-10248 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T234 10371-10375 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T235 10561-10565 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 10659-10663 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T237 10669-10702 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T238 10940-10944 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T239 11071-11075 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T240 11397-11401 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T241 12603-12607 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T242 14223-14227 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T243 14489-14518 Disease denotes feline infectious peritonitis http://purl.obolibrary.org/obo/MONDO_0025491
T244 14496-14506 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T245 14507-14518 Disease denotes peritonitis http://purl.obolibrary.org/obo/MONDO_0004522
T246 15176-15180 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T247 15414-15418 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T248 15730-15734 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 16100-16104 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T250 16433-16437 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T251 16504-16508 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T252 16514-16547 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T253 17044-17048 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T254 17157-17161 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T255 17195-17199 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T256 17205-17238 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T257 17317-17321 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T258 17621-17625 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T259 17937-17941 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 17957-17961 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T261 18095-18099 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 18208-18212 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T263 18280-18284 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T264 18352-18356 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T265 18757-18761 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T266 18800-18804 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T267 18810-18843 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T268 19421-19425 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T269 19672-19676 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T270 19731-19735 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T271 19844-19848 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T272 19901-19905 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T273 21615-21619 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T274 21653-21657 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T275 21663-21696 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T276 22416-22420 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T277 22519-22523 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 23366-23370 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T279 24305-24309 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T280 24785-24789 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T281 24823-24827 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T282 24833-24866 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T283 25304-25308 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T284 25552-25556 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T285 25688-25692 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T286 26197-26201 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T287 26779-26783 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T288 26802-26806 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T289 26812-26845 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T290 26929-26933 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T291 27028-27032 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T292 27153-27157 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T293 27337-27341 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T294 27414-27430 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T295 27459-27463 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T296 27469-27502 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T297 27661-27665 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T298 27934-27938 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T299 27983-27987 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T300 27993-28026 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T301 28302-28306 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T302 28602-28606 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T303 29042-29046 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T304 29091-29095 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T305 29101-29134 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T306 29655-29659 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T307 29874-29878 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T308 29923-29927 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T309 29933-29966 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T310 30095-30099 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T311 30215-30219 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T312 30344-30348 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T313 30911-30915 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T314 30966-30970 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T315 31058-31062 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T316 31528-31532 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T317 31819-31823 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T318 32213-32216 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T319 32288-32292 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T320 32957-32961 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T321 33006-33010 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T322 33016-33049 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T323 33131-33135 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T324 33470-33474 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T325 33583-33586 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T326 33707-33711 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T327 33914-33918 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T328 33963-33967 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T329 33973-34006 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T330 34066-34070 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T331 34285-34289 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T332 34446-34450 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T333 34609-34613 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 34721-34725 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T335 34806-34810 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 34816-34849 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T337 35324-35328 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T338 35460-35464 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T339 35509-35513 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T340 35596-35600 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T341 35606-35639 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T342 36285-36289 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T343 36786-36790 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T344 36831-36835 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T345 36841-36874 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T346 36954-36958 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T347 37612-37616 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T348 37708-37712 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T349 37849-37853 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T350 38165-38169 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T351 38222-38226 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T352 38232-38265 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T353 38463-38467 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T354 38563-38566 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T355 38662-38666 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T356 38800-38804 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T357 38992-38996 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T358 39076-39080 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T359 39141-39145 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T360 39230-39233 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T361 39953-39957 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T362 40324-40334 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T363 41227-41231 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T364 41355-41358 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T365 41450-41454 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T366 42173-42177 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T367 42261-42265 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T368 42271-42304 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T369 42802-42806 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T370 43763-43767 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T371 43882-43885 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T372 43964-43968 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T373 44155-44159 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T374 44219-44223 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T375 44448-44452 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T376 44458-44491 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T377 44576-44580 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T378 44809-44813 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T379 44890-44894 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T380 45012-45016 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T381 45092-45096 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T382 45306-45310 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T383 45478-45482 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T384 45587-45591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T385 45717-45721 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T422 16-17 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T423 160-165 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T424 398-400 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T425 792-793 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T426 909-912 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T427 1069-1075 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T428 1086-1087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T429 1230-1237 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T430 1270-1271 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T431 1425-1432 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T432 1543-1548 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T433 1550-1558 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptides
T434 1757-1765 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T435 1807-1815 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T436 1872-1880 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T437 2015-2016 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T438 2043-2044 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T439 2136-2143 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T440 2335-2336 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T441 2371-2372 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T442 2477-2478 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T443 2517-2524 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptide
T444 2562-2563 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T445 2612-2620 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T446 2667-2674 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T447 2781-2799 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residue
T448 2781-2799 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residue
T449 2812-2813 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T450 2859-2860 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T451 3088-3089 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T452 3189-3190 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T453 3191-3199 http://purl.obolibrary.org/obo/PR_000018263 denotes peptidic
T454 3214-3217 http://purl.obolibrary.org/obo/CLO_0037067 denotes Val
T455 3377-3378 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T456 3469-3470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T457 3502-3504 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T458 3544-3546 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T459 3568-3570 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T460 3610-3612 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T461 3610-3612 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T462 3678-3679 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T463 3708-3713 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T464 3940-3946 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T465 4078-4079 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T466 4125-4133 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T467 4173-4175 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T468 4191-4193 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T469 4217-4218 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T470 4248-4256 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T471 4291-4293 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T472 4327-4328 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T473 4384-4385 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T474 4435-4443 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T475 4476-4478 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T476 4538-4540 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T477 4682-4686 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T478 4700-4702 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T479 4722-4725 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T480 4825-4831 http://purl.obolibrary.org/obo/CLO_0001751 denotes and 33
T481 4948-4950 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T482 5039-5041 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T483 5076-5084 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T484 5184-5186 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T485 5218-5220 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T486 5238-5246 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T487 5273-5275 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T488 5288-5290 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T489 5348-5349 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T490 5487-5488 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T491 5499-5506 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T492 5523-5524 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T493 5626-5627 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T494 5714-5716 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T495 5747-5749 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T496 5780-5781 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T497 5811-5813 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T498 5921-5923 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T499 5926-5928 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T500 5944-5945 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T501 5976-5984 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T502 6006-6008 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T503 6055-6056 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T504 6108-6109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T505 6180-6182 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T506 6204-6205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T507 6246-6254 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T508 6282-6284 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T509 6330-6338 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T510 6360-6364 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T511 6436-6437 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T512 6499-6506 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T513 6609-6611 http://purl.obolibrary.org/obo/CLO_0002105 denotes C2
T514 6609-6611 http://purl.obolibrary.org/obo/CLO_0051742 denotes C2
T515 6644-6645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T516 6747-6755 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T517 6846-6854 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T518 6979-6987 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T519 7009-7017 http://purl.obolibrary.org/obo/PR_000018263 denotes peptidic
T520 7028-7029 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T521 7159-7160 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T522 7338-7341 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T523 7372-7380 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T524 7387-7393 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T525 7425-7430 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T526 7828-7834 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T527 7888-7894 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T528 7962-7967 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T529 7994-7996 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T530 8007-8010 http://purl.obolibrary.org/obo/CLO_0007437 denotes M−1
T531 8007-8010 http://purl.obolibrary.org/obo/CLO_0007448 denotes M−1
T532 8007-8010 http://purl.obolibrary.org/obo/CLO_0007449 denotes M−1
T533 8007-8010 http://purl.obolibrary.org/obo/CLO_0050175 denotes M−1
T534 8007-8010 http://purl.obolibrary.org/obo/CLO_0052399 denotes M−1
T535 8011-8014 http://purl.obolibrary.org/obo/CLO_0050050 denotes s−1
T536 8021-8028 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptide
T537 8079-8080 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T538 8298-8299 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T539 8374-8379 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T540 8406-8407 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T541 8464-8465 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T542 8525-8526 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T543 8544-8545 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T544 8784-8785 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T545 8812-8813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T546 9352-9353 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T547 9502-9506 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T548 9522-9532 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T549 9583-9589 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T550 9647-9653 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T551 9657-9676 http://purl.obolibrary.org/obo/NCBITaxon_314147 denotes rodents and rabbits
T552 9919-9920 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T553 9921-9928 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T554 9934-9935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T555 10018-10020 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T556 10075-10076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T557 10145-10153 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T558 10177-10184 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T559 10194-10196 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T560 10227-10235 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T561 10313-10323 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T562 10454-10459 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T563 10465-10470 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T564 10471-10477 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T565 10542-10547 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T566 10606-10613 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T567 10760-10767 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T568 10891-10895 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T569 10896-10904 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T570 11054-11062 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T571 11159-11167 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T572 11229-11234 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T573 11266-11271 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T574 11317-11325 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T575 11340-11345 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T576 11385-11386 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T577 11449-11456 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T578 11493-11494 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T579 11516-11519 http://purl.obolibrary.org/obo/CLO_0037067 denotes Val
T580 11535-11538 http://purl.obolibrary.org/obo/CLO_0002421 denotes CHO
T581 11535-11538 http://purl.obolibrary.org/obo/CLO_0052479 denotes CHO
T582 11535-11538 http://purl.obolibrary.org/obo/CLO_0052480 denotes CHO
T583 11535-11538 http://purl.obolibrary.org/obo/CLO_0052483 denotes CHO
T584 11535-11538 http://purl.obolibrary.org/obo/CLO_0052484 denotes CHO
T585 11535-11538 http://purl.obolibrary.org/obo/CLO_0052485 denotes CHO
T586 11565-11573 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T587 11635-11637 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T588 11671-11673 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T589 11762-11764 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T590 11767-11769 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T591 11776-11778 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T592 11930-11938 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T593 12041-12047 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T594 12058-12060 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T595 12093-12094 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T596 12166-12168 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T597 12208-12210 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T598 12208-12210 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T599 12255-12256 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T600 12346-12347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T601 12364-12371 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T602 12394-12395 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T603 12437-12439 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T604 12471-12479 http://purl.obolibrary.org/obo/PR_000018263 denotes peptidic
T605 12506-12507 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T606 12588-12594 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T607 12638-12641 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T608 12708-12710 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T609 12768-12770 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T610 12768-12770 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T611 12790-12792 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T612 12823-12825 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T613 12962-12968 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T614 12986-12993 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptide
T615 13193-13195 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T616 13193-13195 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T617 13225-13226 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T618 13247-13248 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T619 13276-13277 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T620 13356-13358 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T621 13379-13381 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T622 13433-13441 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T623 13509-13511 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T624 13509-13511 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T625 13540-13548 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T626 13669-13671 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T627 13669-13671 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T628 13696-13698 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T629 13912-13914 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T630 13973-13979 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T631 14152-14156 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T632 14188-14189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T633 14263-14267 http://purl.obolibrary.org/obo/CLO_0001736 denotes a P3
T634 14426-14427 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 14519-14524 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T636 14577-14585 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T637 14605-14609 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T638 15149-15153 http://purl.obolibrary.org/obo/NCBITaxon_314295 denotes APEs
T639 15347-15350 http://purl.obolibrary.org/obo/CLO_0007437 denotes M−1
T640 15347-15350 http://purl.obolibrary.org/obo/CLO_0007448 denotes M−1
T641 15347-15350 http://purl.obolibrary.org/obo/CLO_0007449 denotes M−1
T642 15347-15350 http://purl.obolibrary.org/obo/CLO_0050175 denotes M−1
T643 15347-15350 http://purl.obolibrary.org/obo/CLO_0052399 denotes M−1
T644 15351-15354 http://purl.obolibrary.org/obo/CLO_0050050 denotes s−1
T645 15397-15405 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T646 15508-15509 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T647 15644-15652 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T648 15775-15777 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T649 15795-15804 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T650 15821-15829 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T651 15942-15950 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T652 15972-15976 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T653 16123-16124 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T654 16248-16249 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T655 16259-16260 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T656 16284-16290 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T657 16414-16416 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T658 16698-16703 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5439 17264-17265 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T660 17421-17429 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T661 17437-17439 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T662 17451-17452 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T663 17480-17482 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T664 17495-17497 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T665 17559-17561 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T666 17641-17645 http://purl.obolibrary.org/obo/CLO_0009989 denotes Huh7
T667 17646-17651 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T668 17685-17693 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T669 17725-17729 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T670 17725-17729 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T671 17730-17735 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T672 17750-17758 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T673 17837-17845 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T674 17854-17855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T675 17890-17900 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T676 18030-18035 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T677 18093-18094 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T678 18301-18302 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T679 18373-18374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T680 18494-18496 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T681 18548-18554 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T682 18664-18670 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T683 18708-18714 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T684 18940-18944 http://purl.obolibrary.org/obo/CLO_0001577 denotes a ~3
T685 18959-18965 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T686 19019-19021 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T687 19056-19062 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T688 19074-19077 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T689 19096-19097 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T690 19204-19205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T691 19226-19228 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T692 19284-19289 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T693 19290-19296 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T694 19389-19390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T695 19404-19412 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T696 19518-19519 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T697 19558-19560 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T698 19595-19603 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T699 19921-19926 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T700 19927-19938 http://purl.obolibrary.org/obo/CLO_0051840 denotes Calu3 cells
T701 19927-19938 http://purl.obolibrary.org/obo/CLO_0051841 denotes Calu3 cells
T702 19927-19938 http://purl.obolibrary.org/obo/CLO_0051842 denotes Calu3 cells
T703 19927-19938 http://purl.obolibrary.org/obo/CLO_0051843 denotes Calu3 cells
T704 19927-19938 http://purl.obolibrary.org/obo/CLO_0051844 denotes Calu3 cells
T705 19927-19932 http://purl.obolibrary.org/obo/CLO_0002192 denotes Calu3
T706 19991-19994 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4–5
T707 20060-20061 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T708 20112-20120 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T709 20241-20247 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T710 20347-20351 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T711 20347-20351 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T712 20526-20527 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T713 20819-20820 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T714 20879-20880 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T715 21025-21027 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T716 21068-21070 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T717 21112-21113 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T718 21230-21231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T719 21254-21256 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T720 21290-21292 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T721 21290-21292 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T722 21309-21311 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T723 21565-21573 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T724 21832-21833 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T725 21881-21882 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T726 21933-21934 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T727 22068-22074 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T728 22139-22141 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T729 22151-22153 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T730 22155-22162 http://purl.obolibrary.org/obo/PR_000018263 denotes Peptide
T731 22305-22306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T732 22343-22350 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T733 22373-22374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T734 22453-22455 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T735 22489-22490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T736 22504-22507 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T737 22577-22585 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T738 22631-22632 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T739 22703-22709 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T740 22765-22766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T741 22767-22769 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T742 22781-22783 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T743 22806-22807 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T744 22840-22848 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T745 22950-22969 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T746 22950-22969 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T747 23092-23094 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T748 23125-23127 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T749 23189-23190 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T750 23230-23231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T751 23288-23290 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T752 23299-23301 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T753 23327-23336 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T754 23382-23383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T755 23424-23426 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T756 23491-23497 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T757 23552-23553 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T758 23684-23686 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T759 23705-23706 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T760 23847-23855 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T761 23960-23961 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T762 24023-24025 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T763 24038-24040 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T764 24322-24325 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T765 24746-24747 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T766 24774-24775 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T767 24955-24956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T768 25014-25017 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T769 25043-25050 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T770 25072-25074 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T771 25078-25080 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T772 25112-25120 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T773 25218-25221 http://purl.obolibrary.org/obo/CLO_0001003 denotes 163
T774 25245-25246 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T775 25374-25382 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T776 25395-25399 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T777 25395-25399 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T778 25404-25415 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco‐2 cell
T779 25494-25495 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T780 25513-25520 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T781 25790-25791 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T782 26083-26084 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T783 26135-26136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T784 26524-26525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T785 26560-26566 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T786 26628-26630 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T787 26692-26700 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T788 26729-26736 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T789 27026-27027 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T790 27408-27413 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T791 27431-27436 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T792 27738-27746 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T793 27765-27781 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity in cell
T794 27892-27894 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T795 27917-27923 http://purl.obolibrary.org/obo/CLO_0001658 denotes Active
T796 28044-28045 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T797 28125-28126 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T798 28137-28143 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T799 28290-28298 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T800 28346-28354 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T801 28448-28450 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T802 28559-28560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T803 28595-28597 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T804 28756-28764 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T805 28862-28866 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T806 28994-28996 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T807 29302-29307 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T808 29393-29394 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T809 29515-29516 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T810 29628-29631 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T811 29716-29718 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T812 29788-29789 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T813 30296-30302 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T814 30951-30957 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T815 31085-31093 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T816 31342-31348 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T817 31679-31682 http://purl.obolibrary.org/obo/CLO_0001178 denotes 243
T818 31679-31682 http://purl.obolibrary.org/obo/CLO_0052433 denotes 243
T819 31748-31756 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T820 31846-31854 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T821 31934-31940 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T822 32017-32018 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T823 32075-32083 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T824 32368-32371 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T825 32396-32399 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T826 32528-32536 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T827 32647-32649 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T828 32712-32720 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T829 32834-32836 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T830 33266-33276 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T831 33296-33299 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T832 33326-33334 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T833 33433-33434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T834 33502-33505 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T835 33517-33520 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T836 33579-33582 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T837 33616-33619 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T838 33616-33619 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T839 33616-33619 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T840 33616-33619 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T841 33616-33619 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T842 33616-33619 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T843 33616-33619 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T844 34269-34271 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T845 34465-34466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T846 34505-34506 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T847 34569-34577 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T848 34629-34642 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T849 34761-34763 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T850 34943-34951 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T851 34978-34980 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T852 35075-35083 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T853 35134-35136 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T854 35358-35359 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T855 35458-35459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T856 35664-35672 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T857 35734-35742 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T858 35847-35849 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T859 35906-35908 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T860 35909-35911 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T861 35951-35952 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T862 35984-35985 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T863 36036-36039 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T864 36244-36253 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T865 36391-36392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T866 36548-36549 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T867 36769-36777 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T868 36906-36907 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T869 37049-37055 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T870 37260-37268 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T871 37395-37396 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T872 37596-37597 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T873 37798-37799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T874 37957-37958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T875 38004-38006 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T876 38148-38150 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T877 38395-38398 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T878 38450-38451 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T879 38673-38681 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T880 38704-38706 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T881 38784-38793 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero cell
T882 38868-38877 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin
T883 38913-38915 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T884 38920-38921 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T885 38975-38983 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T886 39052-39057 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T887 39087-39095 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T888 39166-39168 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T889 39411-39413 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T890 39422-39424 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T891 39425-39427 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T892 39658-39666 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T893 39902-39903 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T894 39998-40006 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T895 40059-40061 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T896 40071-40074 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T897 40117-40120 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T898 40121-40122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T899 40172-40175 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T900 40264-40265 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T901 40784-40788 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T902 40909-40910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T903 40937-40943 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T904 40958-40959 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T905 41029-41030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T906 41058-41059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T907 41329-41331 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T908 41362-41363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T909 41459-41463 http://purl.obolibrary.org/obo/CLO_0001757 denotes 1 at
T910 41464-41465 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T911 41571-41572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T912 41953-41961 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T913 41998-41999 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T914 42035-42036 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T915 42108-42116 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T916 42120-42124 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T917 42120-42124 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T918 42125-42130 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T919 42169-42171 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T920 42492-42495 http://purl.obolibrary.org/obo/CLO_0001003 denotes 163
T921 42541-42544 http://purl.obolibrary.org/obo/CLO_0001003 denotes 163
T922 42585-42589 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T923 42607-42610 http://purl.obolibrary.org/obo/CLO_0001003 denotes 163
T924 42645-42655 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T925 42790-42798 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T926 42843-42851 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T927 42870-42874 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T928 42870-42874 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T929 42875-42880 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T930 42929-42930 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T931 43060-43061 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T932 43274-43282 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T933 43300-43304 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T934 43380-43388 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T935 43433-43441 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T936 43509-43513 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T937 43556-43558 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T938 43590-43600 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T939 43721-43729 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T940 43772-43785 http://purl.obolibrary.org/obo/CLO_0001757 denotes 1 in the cell
T941 43889-43890 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T942 43957-43958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T943 44202-44203 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T944 44266-44271 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T945 44624-44625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T946 44857-44858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T947 44888-44889 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T948 45364-45367 http://purl.obolibrary.org/obo/CLO_0001180 denotes 203
T949 45418-45426 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T950 45456-45457 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T951 45628-45629 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T952 45690-45692 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T953 45715-45716 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T954 45796-45802 http://purl.obolibrary.org/obo/CLO_0001658 denotes active

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T315 487-495 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T316 519-527 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T317 725-740 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T318 730-740 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T319 806-814 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T320 896-898 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T321 1128-1136 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T322 1149-1160 Chemical denotes nucleophile http://purl.obolibrary.org/obo/CHEBI_59740
T323 1186-1195 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T324 1215-1219 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T325 1220-1224 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T326 1230-1237 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T327 1251-1260 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T328 1300-1302 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T329 1436-1455 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T331 1445-1455 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T332 1493-1497 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T333 1560-1575 Chemical denotes peptidomimetics http://purl.obolibrary.org/obo/CHEBI_63175
T334 1592-1601 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T335 1720-1729 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T336 1933-1948 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T337 1938-1948 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T338 1970-1975 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T339 2251-2261 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T340 2378-2387 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T341 2458-2466 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T342 2517-2524 Chemical denotes Peptide http://purl.obolibrary.org/obo/CHEBI_16670
T343 2525-2535 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T344 2573-2578 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T345 2602-2607 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T346 2612-2620 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T347 2667-2674 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T348 2781-2799 Chemical denotes amino acid residue http://purl.obolibrary.org/obo/CHEBI_33708
T349 2781-2791 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T350 2781-2786 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T351 2787-2791 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T352 2895-2910 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T353 2900-2910 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T354 3076-3084 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T355 3098-3103 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T356 3200-3209 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T357 3210-3213 Chemical denotes Cbz http://purl.obolibrary.org/obo/CHEBI_51097
T358 3214-3217 Chemical denotes Val http://purl.obolibrary.org/obo/CHEBI_16414|http://purl.obolibrary.org/obo/CHEBI_30015
T360 3218-3221 Chemical denotes Asn http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347
T363 3222-3225 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T365 3226-3229 Chemical denotes Thr http://purl.obolibrary.org/obo/CHEBI_16857|http://purl.obolibrary.org/obo/CHEBI_30013
T367 3230-3233 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T370 3234-3237 Chemical denotes Gln http://purl.obolibrary.org/obo/CHEBI_30011
T371 3251-3257 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T372 3298-3304 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T373 3502-3504 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T374 3505-3508 Chemical denotes Gln http://purl.obolibrary.org/obo/CHEBI_30011
T375 3568-3570 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T376 3571-3578 Chemical denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T377 3610-3612 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T378 3680-3694 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T379 3695-3704 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T380 3760-3769 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T381 3824-3833 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T382 3895-3910 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T383 3900-3910 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T384 4003-4012 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T385 4191-4193 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T386 4194-4200 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T387 4219-4225 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T388 4291-4293 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T389 4329-4341 Chemical denotes phenyl group http://purl.obolibrary.org/obo/CHEBI_30396
T390 4336-4341 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T391 4418-4427 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T392 4476-4478 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T393 4494-4499 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T394 4538-4540 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T395 4541-4547 Chemical denotes benzyl http://purl.obolibrary.org/obo/CHEBI_22744
T396 4887-4892 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T397 4914-4922 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T398 4948-4950 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T399 4951-4954 Chemical denotes Boc http://purl.obolibrary.org/obo/CHEBI_48502
T400 4955-4961 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T401 4987-4995 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T402 5157-5171 Chemical denotes isobutyl group http://purl.obolibrary.org/obo/CHEBI_30356
T403 5166-5171 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T404 5200-5205 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T405 5301-5316 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T406 5306-5316 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T407 5336-5344 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T408 5358-5363 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T409 5499-5506 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T410 5507-5517 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T411 5609-5618 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T412 5747-5749 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T413 5750-5761 Chemical denotes lactam ring http://purl.obolibrary.org/obo/CHEBI_77730
T414 5750-5756 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T415 5837-5845 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T416 5926-5928 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T417 5929-5936 Chemical denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T418 6006-6008 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T419 6009-6022 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044|http://purl.obolibrary.org/obo/CHEBI_58095
T421 6073-6078 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T422 6139-6145 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T423 6180-6182 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T424 6206-6221 Chemical denotes benzyloxy group http://purl.obolibrary.org/obo/CHEBI_48508
T425 6216-6221 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T426 6320-6329 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T427 6405-6414 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T428 6446-6454 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T429 6499-6506 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T430 6507-6517 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T431 6574-6578 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T432 6609-6611 Chemical denotes C2 http://purl.obolibrary.org/obo/CHEBI_30083
T433 6622-6632 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T434 6646-6649 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T436 6650-6653 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T438 6681-6686 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T439 6701-6711 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T440 6836-6845 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T441 6918-6931 Chemical denotes dimethylamine http://purl.obolibrary.org/obo/CHEBI_17170|http://purl.obolibrary.org/obo/CHEBI_58040
T443 6939-6945 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T444 7018-7022 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T445 7038-7046 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T446 7176-7185 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T447 7362-7371 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T448 7808-7823 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T449 7813-7823 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T450 8021-8028 Chemical denotes Peptide http://purl.obolibrary.org/obo/CHEBI_16670
T451 8230-8233 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T454 8325-8327 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T455 8444-8453 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T456 8762-8772 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T457 8794-8802 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T458 8803-8808 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T459 8891-8907 Chemical denotes cysteine residue http://purl.obolibrary.org/obo/CHEBI_32460
T460 8891-8899 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T461 8956-8972 Chemical denotes cysteine residue http://purl.obolibrary.org/obo/CHEBI_32460
T462 8956-8964 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T463 9023-9031 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T464 9032-9037 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T465 9162-9171 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T466 9180-9196 Chemical denotes cysteine residue http://purl.obolibrary.org/obo/CHEBI_32460
T467 9180-9188 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T468 9222-9232 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T469 9246-9254 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T470 9255-9260 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T471 9340-9348 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T472 9362-9367 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T473 9397-9407 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T474 9446-9451 Chemical denotes vinyl http://purl.obolibrary.org/obo/CHEBI_37603
T475 9452-9463 Chemical denotes ethyl ester http://purl.obolibrary.org/obo/CHEBI_23990
T476 9452-9457 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T478 9458-9463 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T479 9563-9579 Chemical denotes carboxylic acids http://purl.obolibrary.org/obo/CHEBI_33575
T480 9574-9579 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T481 9811-9819 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T482 9826-9835 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T483 9921-9928 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T484 9950-9958 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T485 9968-9973 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T486 9981-9992 Chemical denotes an aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T487 10018-10020 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T488 10021-10028 Chemical denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T489 10077-10087 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T490 10097-10111 Chemical denotes aldehyde group http://purl.obolibrary.org/obo/CHEBI_42485
T491 10097-10105 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T492 10106-10111 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T493 10177-10184 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T494 10185-10193 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T495 10303-10312 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T496 10585-10600 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T497 10590-10600 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T498 10606-10613 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T499 10614-10622 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T500 10760-10767 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T501 10768-10776 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T502 10777-10787 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T503 10921-10936 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T504 10926-10936 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T505 11149-11158 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T506 11307-11316 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T507 11408-11423 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T508 11413-11423 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T509 11449-11456 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T510 11495-11507 Chemical denotes pentapeptide http://purl.obolibrary.org/obo/CHEBI_48545
T511 11509-11511 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T513 11512-11515 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T515 11516-11519 Chemical denotes Val http://purl.obolibrary.org/obo/CHEBI_16414|http://purl.obolibrary.org/obo/CHEBI_30015
T517 11520-11523 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T520 11614-11623 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T521 11635-11637 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T522 11638-11647 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T524 11762-11764 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T525 11767-11769 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T526 11776-11778 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T527 11842-11851 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T528 11890-11899 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T529 12058-12060 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T530 12061-12070 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T532 12071-12084 Chemical denotes nitrogen atom http://purl.obolibrary.org/obo/CHEBI_25555|http://purl.obolibrary.org/obo/CHEBI_29351
T534 12080-12084 Chemical denotes atom http://purl.obolibrary.org/obo/CHEBI_33250
T535 12095-12103 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T536 12118-12127 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T537 12138-12147 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T539 12148-12156 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T540 12166-12168 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T541 12169-12179 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T542 12208-12210 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T543 12269-12278 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T544 12330-12335 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T545 12364-12371 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T546 12372-12382 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T547 12437-12439 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T548 12440-12450 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T549 12494-12504 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T550 12708-12710 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T551 12768-12770 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T552 12790-12792 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T553 12793-12802 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T555 12934-12939 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T556 12986-12993 Chemical denotes Peptide http://purl.obolibrary.org/obo/CHEBI_16670
T557 12994-13004 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T558 13016-13026 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T559 13120-13125 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T560 13163-13173 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T561 13193-13195 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T562 13199-13201 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T563 13509-13511 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T564 13512-13514 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T565 13585-13590 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T566 13669-13671 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T567 13696-13698 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T568 13822-13830 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T569 13912-13914 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T570 13915-13924 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T572 13940-13948 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T573 13960-13965 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T574 14006-14011 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T27514 14234-14249 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T82575 14239-14249 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T95892 14268-14278 Chemical denotes piperidine http://purl.obolibrary.org/obo/CHEBI_18049|http://purl.obolibrary.org/obo/CHEBI_589779
T26260 14312-14322 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5217 14356-14364 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T51366 14365-14374 Chemical denotes bisulfite http://purl.obolibrary.org/obo/CHEBI_17137
T39371 14428-14446 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T4181 14437-14446 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T24510 14567-14576 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T26289 14697-14707 Chemical denotes piperidine http://purl.obolibrary.org/obo/CHEBI_18049|http://purl.obolibrary.org/obo/CHEBI_589779
T4261 14768-14770 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T7439 14775-14777 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T16 14830-14838 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T2957 14840-14848 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T41973 14849-14858 Chemical denotes bisulfite http://purl.obolibrary.org/obo/CHEBI_17137
T28623 14871-14878 Chemical denotes epoxide http://purl.obolibrary.org/obo/CHEBI_32955
T56252 14887-14892 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T17852 14957-14966 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T34518 14986-14996 Chemical denotes piperidine http://purl.obolibrary.org/obo/CHEBI_18049|http://purl.obolibrary.org/obo/CHEBI_589779
T78419 15034-15036 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T18768 15139-15147 Chemical denotes epoxides http://purl.obolibrary.org/obo/CHEBI_32955
T82413 15187-15202 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T80325 15192-15202 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T76046 15253-15255 Chemical denotes CD http://purl.obolibrary.org/obo/CHEBI_8673
T31193 15256-15264 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T36285 15293-15300 Chemical denotes epoxide http://purl.obolibrary.org/obo/CHEBI_32955
T21892 15536-15544 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T33497 15547-15551 Chemical denotes atom http://purl.obolibrary.org/obo/CHEBI_33250
T11527 15560-15567 Chemical denotes epoxide http://purl.obolibrary.org/obo/CHEBI_32955
T73113 15616-15623 Chemical denotes epoxide http://purl.obolibrary.org/obo/CHEBI_32955
T71965 15715-15729 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T35724 15741-15756 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T19702 15746-15756 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T43475 15912-15917 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T3504 15932-15941 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T21346 16203-16212 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T52951 16229-16237 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T20290 16444-16459 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T46510 16449-16459 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T87241 16468-16474 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T49684 16578-16588 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T75940 16651-16667 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T48 16784-16789 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T77441 16824-16832 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T50 16883-16888 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T52 16889-16895 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T41687 16942-16950 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T54 16951-16957 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T91863 16962-16971 Chemical denotes aldehydes http://purl.obolibrary.org/obo/CHEBI_17478
T56 16990-16998 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T21097 17004-17012 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T61862 17053-17067 Chemical denotes Mpro inhibitor http://purl.obolibrary.org/obo/CHEBI_147285
T94981 17058-17067 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T52612 17136-17146 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T45586 17437-17439 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T62151 17480-17482 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T56998 17483-17489 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T20063 17495-17497 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T27961 17498-17508 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T86938 17559-17561 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T75961 17562-17573 Chemical denotes cyclopentyl http://purl.obolibrary.org/obo/CHEBI_52880
T61372 17675-17684 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T896 17740-17749 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T87883 17827-17836 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T7603 18081-18089 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T40736 18106-18120 Chemical denotes Mpro inhibitor http://purl.obolibrary.org/obo/CHEBI_147285
T97159 18111-18120 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T77172 18494-18496 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T56473 18500-18505 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T64629 18520-18528 Chemical denotes pyridone http://purl.obolibrary.org/obo/CHEBI_38183
T15402 18638-18647 Chemical denotes Boc group http://purl.obolibrary.org/obo/CHEBI_48502
T58006 18642-18647 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T93511 18715-18723 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T65337 19297-19304 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T67050 19520-19537 Chemical denotes cyclopropyl group http://purl.obolibrary.org/obo/CHEBI_30364
T89827 19532-19537 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T1382 19558-19560 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T4101 19561-19571 Chemical denotes cyclohexyl http://purl.obolibrary.org/obo/CHEBI_52552
T93196 19585-19594 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T26920 20016-20019 Chemical denotes Boc http://purl.obolibrary.org/obo/CHEBI_48502
T18812 20080-20085 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T15971 20182-20191 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T72808 20248-20255 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45343 20607-20616 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93415 20716-20718 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T52365 20791-20800 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T9616 20852-20857 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T14214 20858-20864 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T69815 20908-20914 Chemical denotes amides http://purl.obolibrary.org/obo/CHEBI_32988
T98 20971-20979 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T99 21025-21027 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T1465 21028-21034 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T49981 21088-21094 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T46088 21095-21103 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T71910 21152-21158 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T13154 21208-21216 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T5593 21217-21223 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T19001 21254-21256 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T90582 21257-21268 Chemical denotes cyclopropyl http://purl.obolibrary.org/obo/CHEBI_30364
T32008 21290-21292 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T30690 21309-21311 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T77042 21312-21320 Chemical denotes pyridone http://purl.obolibrary.org/obo/CHEBI_38183
T17126 21398-21407 Chemical denotes Boc group http://purl.obolibrary.org/obo/CHEBI_48502
T6537 21402-21407 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T7038 21441-21443 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T76426 21522-21531 Chemical denotes Boc group http://purl.obolibrary.org/obo/CHEBI_48502
T65557 21526-21531 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T649 21802-21808 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T33650 21846-21852 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T37304 21960-21969 Chemical denotes hemiketal http://purl.obolibrary.org/obo/CHEBI_59772
T45902 22016-22019 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T36506 22026-22029 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T42212 22030-22032 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T45833 22084-22090 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T24832 22094-22102 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T10610 22155-22162 Chemical denotes Peptide http://purl.obolibrary.org/obo/CHEBI_16670
T27374 22163-22173 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T130 22199-22205 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T49997 22343-22350 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T132 22351-22361 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T3406 22375-22390 Chemical denotes trifluoromethyl http://purl.obolibrary.org/obo/CHEBI_50127
T60315 22391-22397 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T59718 22687-22695 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T18276 22767-22769 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T137 22770-22776 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T80163 22781-22783 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T28014 22785-22793 Chemical denotes thiazole http://purl.obolibrary.org/obo/CHEBI_43732|http://purl.obolibrary.org/obo/CHEBI_48901
T13260 22950-22960 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T23846 22950-22955 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T21836 22956-22960 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T66042 23002-23015 Chemical denotes nitrogen atom http://purl.obolibrary.org/obo/CHEBI_25555|http://purl.obolibrary.org/obo/CHEBI_29351
T7803 23011-23015 Chemical denotes atom http://purl.obolibrary.org/obo/CHEBI_33250
T34611 23023-23031 Chemical denotes thiazole http://purl.obolibrary.org/obo/CHEBI_43732|http://purl.obolibrary.org/obo/CHEBI_48901
T29375 23092-23094 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T28695 23095-23101 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T92289 23191-23201 Chemical denotes tripeptide http://purl.obolibrary.org/obo/CHEBI_47923
T52382 23213-23226 Chemical denotes benzothiazole http://purl.obolibrary.org/obo/CHEBI_45993
T54961 23240-23245 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T54093 23279-23284 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T50478 23288-23290 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T91497 23446-23459 Chemical denotes benzothiazole http://purl.obolibrary.org/obo/CHEBI_45993
T52567 23460-23465 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T58318 23536-23541 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T37981 23564-23574 Chemical denotes dipeptides http://purl.obolibrary.org/obo/CHEBI_46761
T97726 23630-23634 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92052 23659-23665 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T38814 23673-23683 Chemical denotes tripeptide http://purl.obolibrary.org/obo/CHEBI_47923
T9588 23911-23916 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T164 23917-23925 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T165 23938-23944 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T22453 23945-23951 Chemical denotes glycyl http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_46740
T7278 24023-24025 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T6255 24026-24033 Chemical denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T170 24038-24040 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T171 24154-24160 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T78384 24163-24177 Chemical denotes carbonyl group http://purl.obolibrary.org/obo/CHEBI_23019
T55500 24172-24177 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T91926 24227-24237 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T7771 24392-24398 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T81173 24399-24404 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T92675 24405-24413 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T52035 24422-24436 Chemical denotes carbonyl group http://purl.obolibrary.org/obo/CHEBI_23019
T73981 24431-24436 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T182 24617-24631 Chemical denotes carbonyl group http://purl.obolibrary.org/obo/CHEBI_23019
T30382 24626-24631 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73351 24671-24677 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T70252 24683-24693 Chemical denotes benzofuran http://purl.obolibrary.org/obo/CHEBI_36790
T18292 24967-24982 Chemical denotes trifluoromethyl http://purl.obolibrary.org/obo/CHEBI_50127
T41093 24983-24990 Chemical denotes ketones http://purl.obolibrary.org/obo/CHEBI_17087
T98772 25043-25050 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T41746 25072-25074 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T191 25078-25080 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T192 25257-25267 Chemical denotes dipeptides http://purl.obolibrary.org/obo/CHEBI_46761
T81044 25294-25300 Chemical denotes ketone http://purl.obolibrary.org/obo/CHEBI_17087
T194 25315-25330 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T2879 25320-25330 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T43478 25513-25520 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T40437 25601-25611 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T68978 25817-25826 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T42650 25887-25895 Chemical denotes dimethyl http://purl.obolibrary.org/obo/CHEBI_33601|http://purl.obolibrary.org/obo/CHEBI_42266
T90668 25896-25901 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T13186 25909-25915 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T89789 25926-25934 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T69586 25969-25975 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T73849 26115-26126 Chemical denotes tripeptides http://purl.obolibrary.org/obo/CHEBI_47923
T93299 26161-26166 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T37065 26208-26223 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T61902 26213-26223 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T209 26362-26367 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T48448 26426-26434 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T62153 26447-26461 Chemical denotes carbonyl group http://purl.obolibrary.org/obo/CHEBI_23019
T63490 26456-26461 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T40231 26546-26549 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T216 26550-26552 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T7763 26628-26630 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T45344 26631-26637 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T96378 26647-26658 Chemical denotes nitro group http://purl.obolibrary.org/obo/CHEBI_29785
T18132 26653-26658 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T44225 26729-26736 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T18237 26764-26775 Chemical denotes tripeptides http://purl.obolibrary.org/obo/CHEBI_47923
T40825 26790-26800 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T20685 26940-26955 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T65888 26945-26955 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T90232 26983-26993 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T34371 27049-27058 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T22085 27243-27249 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T12666 27250-27255 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T27348 27348-27363 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T35234 27353-27363 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T95534 27391-27401 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T2987 27529-27537 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T67003 27538-27548 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T41984 27571-27577 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T15863 27647-27657 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T76768 27755-27764 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T59369 27892-27894 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T57087 27924-27930 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T1438 27945-27960 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T85249 27950-27960 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T33732 28082-28095 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T245 28096-28101 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T79350 28156-28162 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T5859 28174-28183 Chemical denotes thiophene http://purl.obolibrary.org/obo/CHEBI_30856
T72146 28185-28190 Chemical denotes furan http://purl.obolibrary.org/obo/CHEBI_35559
T52453 28196-28202 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T96213 28336-28345 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T97418 28448-28450 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T89322 28524-28530 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T24837 28613-28628 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T66246 28618-28628 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T32608 28746-28755 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T94953 28910-28918 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T6907 29019-29025 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T89170 29053-29068 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T17573 29058-29068 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T64398 29163-29169 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T16685 29186-29190 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T97378 29368-29374 Chemical denotes thiols http://purl.obolibrary.org/obo/CHEBI_29256
T11735 29379-29391 Chemical denotes nucleophiles http://purl.obolibrary.org/obo/CHEBI_59740
T77735 29476-29486 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T49664 29517-29522 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T1032 29526-29535 Chemical denotes methylene http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728
T11556 29536-29543 Chemical denotes ketones http://purl.obolibrary.org/obo/CHEBI_17087
T88640 29583-29592 Chemical denotes methylene http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728
T70579 29593-29600 Chemical denotes ketones http://purl.obolibrary.org/obo/CHEBI_17087
T67480 29610-29619 Chemical denotes pyridinyl http://purl.obolibrary.org/obo/CHEBI_51635
T79188 29620-29626 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T68953 29666-29681 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T12741 29671-29681 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T14743 29716-29718 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T94708 29753-29763 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T95032 29843-29847 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T75474 29852-29858 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T285 29885-29900 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T81531 29890-29900 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5212 30045-30059 Chemical denotes etacrynic acid http://purl.obolibrary.org/obo/CHEBI_4876
T80310 30055-30059 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T60378 30068-30073 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T24346 30082-30087 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T26076 30106-30121 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T62302 30111-30121 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T97944 30160-30171 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T99256 30262-30276 Chemical denotes etacrynic acid http://purl.obolibrary.org/obo/CHEBI_4876
T77207 30272-30276 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T49733 30277-30282 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T50928 30414-30420 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T49983 30528-30536 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T25028 30601-30606 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T9229 30607-30612 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T64536 30633-30647 Chemical denotes carbonyl group http://purl.obolibrary.org/obo/CHEBI_23019
T83383 30642-30647 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57959 30728-30734 Chemical denotes sulfur http://purl.obolibrary.org/obo/CHEBI_26833
T11376 30748-30754 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T88990 31248-31254 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T308 31316-31325 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T76303 31376-31384 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T73811 31399-31405 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T84389 31435-31437 Chemical denotes NH http://purl.obolibrary.org/obo/CHEBI_29339|http://purl.obolibrary.org/obo/CHEBI_73424
T93906 31791-31802 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T3495 31993-32004 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T34567 32042-32054 Chemical denotes sulfonamides http://purl.obolibrary.org/obo/CHEBI_35358
T8963 32237-32247 Chemical denotes pyrazolone http://purl.obolibrary.org/obo/CHEBI_83328
T52199 32252-32260 Chemical denotes pyrazole http://purl.obolibrary.org/obo/CHEBI_14973|http://purl.obolibrary.org/obo/CHEBI_17241
T97302 32299-32314 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T83876 32304-32314 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5399 32426-32436 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T15320 32611-32622 Chemical denotes benzylidene http://purl.obolibrary.org/obo/CHEBI_29857
T78951 32636-32646 Chemical denotes pyrazolone http://purl.obolibrary.org/obo/CHEBI_83328
T73608 32665-32673 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T55153 32807-32813 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T36598 32866-32877 Chemical denotes benzylidene http://purl.obolibrary.org/obo/CHEBI_29857
T28060 32892-32894 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T330 32942-32953 Chemical denotes pyrimidines http://purl.obolibrary.org/obo/CHEBI_39447
T14027 32968-32983 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T68110 32973-32983 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T46132 33085-33090 Chemical denotes furan http://purl.obolibrary.org/obo/CHEBI_35559
T10057 33100-33110 Chemical denotes pyrazolone http://purl.obolibrary.org/obo/CHEBI_83328
T72340 33160-33175 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T95181 33165-33175 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T23116 33444-33454 Chemical denotes pyrimidine http://purl.obolibrary.org/obo/CHEBI_16898
T19786 33481-33496 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T97108 33486-33496 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T42754 33648-33657 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T30698 33834-33844 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T73037 33889-33898 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T42876 33925-33940 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T47808 33930-33940 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T38592 34177-34191 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T67139 34192-34202 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T80936 34266-34268 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T81382 34559-34568 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T52596 34742-34744 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T56133 34765-34767 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T56319 34978-34980 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T49271 35019-35028 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T32879 35134-35136 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T49388 35168-35178 Chemical denotes pyridazine http://purl.obolibrary.org/obo/CHEBI_30954
T17367 35189-35197 Chemical denotes pyrazine http://purl.obolibrary.org/obo/CHEBI_30953
T91954 35272-35277 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T60925 35360-35373 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T359 35520-35535 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T8758 35525-35535 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T361 35551-35564 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T362 35680-35693 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T82901 35768-35773 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T364 35781-35787 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T44892 35794-35802 Chemical denotes triazole http://purl.obolibrary.org/obo/CHEBI_38597
T366 35895-35904 Chemical denotes acetamide http://purl.obolibrary.org/obo/CHEBI_27856
T73169 35906-35908 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T368 35909-35911 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T369 35933-35942 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T40652 35953-35962 Chemical denotes thiophene http://purl.obolibrary.org/obo/CHEBI_30856
T33623 35997-36003 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T20512 36004-36009 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T75590 36126-36136 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T56130 36296-36311 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T18706 36301-36311 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T1326 36402-36412 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T64169 36498-36511 Chemical denotes amentoflavone http://purl.obolibrary.org/obo/CHEBI_2631
T59925 36572-36581 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T37429 36719-36726 Chemical denotes Flavone http://purl.obolibrary.org/obo/CHEBI_42491
T50088 36731-36740 Chemical denotes terpenoid http://purl.obolibrary.org/obo/CHEBI_26873
T70109 36918-36928 Chemical denotes terpenoids http://purl.obolibrary.org/obo/CHEBI_26873
T15757 37005-37015 Chemical denotes ferruginol http://purl.obolibrary.org/obo/CHEBI_78274
T36758 37094-37101 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T94996 37110-37123 Chemical denotes triterpenoids http://purl.obolibrary.org/obo/CHEBI_36615
T73008 37124-37133 Chemical denotes celastrol http://purl.obolibrary.org/obo/CHEBI_63959
T79894 37186-37194 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T67952 37365-37372 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T30069 37381-37386 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88567 37491-37501 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18606 37551-37559 Chemical denotes abietane http://purl.obolibrary.org/obo/CHEBI_35673
T56627 37565-37577 Chemical denotes diterpenoids http://purl.obolibrary.org/obo/CHEBI_23849
T52241 37647-37661 Chemical denotes betulinic acid http://purl.obolibrary.org/obo/CHEBI_3087
T39477 37657-37661 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T42875 37778-37788 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T79585 37820-37822 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T63566 37867-37877 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T7874 37879-37886 Chemical denotes sulfone http://purl.obolibrary.org/obo/CHEBI_35850
T71562 38176-38191 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T25413 38181-38191 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35111 38474-38489 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T69746 38479-38489 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T12655 38538-38540 Chemical denotes VS http://purl.obolibrary.org/obo/CHEBI_75021
T45180 38568-38570 Chemical denotes VS http://purl.obolibrary.org/obo/CHEBI_75021
T92281 38608-38617 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T42633 38642-38651 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T57933 38868-38877 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546
T63607 38878-38888 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T67742 38889-38899 Chemical denotes cinanserin http://purl.obolibrary.org/obo/CHEBI_145999
T60928 38932-38941 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T76939 39184-39194 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T70812 39284-39289 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T94747 39290-39300 Chemical denotes disulfiram http://purl.obolibrary.org/obo/CHEBI_4659
T26685 39338-39345 Chemical denotes ebselen http://purl.obolibrary.org/obo/CHEBI_77543
T67085 39422-39424 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T96011 39425-39427 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T78112 39456-39463 Chemical denotes ebselen http://purl.obolibrary.org/obo/CHEBI_77543
T14009 39495-39505 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T420 39733-39740 Chemical denotes ebselen http://purl.obolibrary.org/obo/CHEBI_77543
T40554 39745-39754 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66228 39794-39803 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T35779 40276-40284 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T82062 40360-40370 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T21071 40583-40591 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T24059 40762-40772 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T54555 40877-40891 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T42980 40877-40886 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T18720 40887-40891 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6945 40911-40919 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T3561 41031-41042 Chemical denotes nucleophile http://purl.obolibrary.org/obo/CHEBI_59740
T22358 41068-41072 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T29111 41073-41077 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T41910 41153-41156 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T437 41157-41159 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T21797 41244-41254 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T17235 41268-41279 Chemical denotes naphthalene http://purl.obolibrary.org/obo/CHEBI_16482
T55336 41294-41308 Chemical denotes lead compounds http://purl.obolibrary.org/obo/CHEBI_33585
T442 41606-41615 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T41674 41648-41663 Chemical denotes racemic mixture http://purl.obolibrary.org/obo/CHEBI_60911
T43552 41656-41663 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T96618 41857-41863 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T72348 41870-41882 Chemical denotes amino groups http://purl.obolibrary.org/obo/CHEBI_51142
T21234 41870-41875 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T15943 41897-41903 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T58369 42098-42107 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T22446 42190-42200 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T452 42210-42221 Chemical denotes naphthalene http://purl.obolibrary.org/obo/CHEBI_16482
T453 42393-42398 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T59470 42399-42401 Chemical denotes NH http://purl.obolibrary.org/obo/CHEBI_29339|http://purl.obolibrary.org/obo/CHEBI_73424
T85501 42444-42453 Chemical denotes benzamide http://purl.obolibrary.org/obo/CHEBI_28179
T21639 42596-42605 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T23665 42672-42677 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T51563 42833-42842 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T1863 43034-43046 Chemical denotes methyl group http://purl.obolibrary.org/obo/CHEBI_32875
T25019 43034-43040 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_29309
T26688 43041-43046 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T68003 43140-43146 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T37926 43147-43157 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T24619 43620-43626 Chemical denotes fluoro http://purl.obolibrary.org/obo/CHEBI_42645
T84377 43639-43648 Chemical denotes benzamide http://purl.obolibrary.org/obo/CHEBI_28179
T85927 43917-43926 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T90186 44031-44040 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3146 44384-44394 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T97002 44532-44542 Chemical denotes thiopurine http://purl.obolibrary.org/obo/CHEBI_35666
T30860 44593-44603 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T25638 44664-44682 Chemical denotes thiocarbonyl group http://purl.obolibrary.org/obo/CHEBI_30256
T11104 44677-44682 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T92852 44750-44767 Chemical denotes anticancer agents http://purl.obolibrary.org/obo/CHEBI_35610
T477 44907-44916 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T95879 44965-44970 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T71817 44986-45002 Chemical denotes diarylheptanoids http://purl.obolibrary.org/obo/CHEBI_78802
T31826 45079-45088 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66600 45156-45164 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T28022 45233-45242 Chemical denotes flavonoid http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T44605 45430-45441 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T3152 45666-45676 Chemical denotes Disulfiram http://purl.obolibrary.org/obo/CHEBI_4659
T19310 45734-45743 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T78735 45808-45816 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T50 217-234 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T51 217-234 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T52 239-252 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T53 501-505 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T54 623-639 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T55 1168-1179 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T56 2125-2134 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T57 9125-9134 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T58 11216-11225 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T59 12301-12310 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T60 15495-15504 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T61 19943-19974 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibited the viral replication
T62 19957-19974 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T63 19957-19974 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T64 20352-20359 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T65 22618-22627 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T66 39691-39712 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T67 39699-39712 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T68 40481-40498 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T69 40481-40498 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T70 40662-40679 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T71 40662-40679 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T72 40724-40740 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitinating
T73 40829-40851 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T74 40836-40851 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T75 44295-44325 http://purl.obolibrary.org/obo/GO_0004843 denotes ubiquitin C‐terminal hydrolase

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 7414-7424 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T18 14507-14518 Phenotype denotes peritonitis http://purl.obolibrary.org/obo/HP_0002586
T19 27414-27430 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1114 81-85 Gene denotes Mpro Gene:8673700
1115 428-432 Gene denotes nsp4 Gene:400668
1116 443-447 Gene denotes Mpro Gene:8673700
1117 668-672 Gene denotes Mpro Gene:8673700
1118 610-614 Gene denotes Mpro Gene:8673700
1119 369-373 Gene denotes Mpro Gene:8673700
1120 501-505 Gene denotes RdRP Gene:43740578
1121 644-653 Disease denotes infection MESH:D007239
1123 725-729 Gene denotes Mpro Gene:8673700
1126 779-783 Gene denotes Mpro Gene:8673700
1127 775-778 Species denotes CoV Tax:11118
1138 784-788 Gene denotes Mpro Gene:8673700
1139 1064-1068 Gene denotes Mpro Gene:8673700
1140 840-844 Gene denotes Mpro Gene:8673700
1141 829-837 Species denotes SARS‐CoV Tax:694009
1142 1060-1063 Species denotes CoV Tax:11118
1143 806-823 Gene denotes cysteine protease Gene:1508
1144 1104-1110 Chemical denotes Cys145
1145 1111-1116 Chemical denotes His41
1146 1128-1136 Chemical denotes cysteine MESH:D003545
1147 1186-1195 Chemical denotes histidine MESH:D006639
1150 1753-1756 Species denotes CoV Tax:11118
1151 1377-1390 Disease denotes CoV infection MESH:D018352
1153 1933-1937 Gene denotes Mpro Gene:8673700
1160 2709-2713 Gene denotes Mpro Gene:8673700
1161 2269-2273 Gene denotes Mpro Gene:8673700
1162 2265-2268 Species denotes CoV Tax:11118
1163 2698-2706 Species denotes SARS‐CoV Tax:694009
1164 2458-2466 Chemical denotes cysteine MESH:D003545
1165 2017-2038 Disease denotes coronavirus infection MESH:D018352
1173 2912-2916 Gene denotes Mpro Gene:8673700
1174 2895-2899 Gene denotes Mpro Gene:8673700
1175 2826-2830 Gene denotes Mpro Gene:8673700
1176 2815-2823 Species denotes SARS‐CoV Tax:694009
1177 2886-2894 Species denotes SARS‐CoV Tax:694009
1178 2933-2941 Species denotes SARS‐CoV Tax:694009
1179 2943-2988 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
1200 3895-3899 Gene denotes Mpro Gene:8673700
1201 3168-3172 Gene denotes Mpro Gene:8673700
1202 3803-3807 Gene denotes Mpro Gene:8673700
1203 3632-3636 Gene denotes Mpro Gene:8673700
1204 3453-3457 Gene denotes Mpro Gene:8673700
1205 3157-3165 Species denotes SARS‐CoV Tax:694009
1206 3447-3451 Species denotes TGEV Tax:11149
1207 3621-3629 Species denotes SARS‐CoV Tax:694009
1208 3708-3726 Species denotes human rhinovirus 3 Tax:44130
1209 3798-3802 Species denotes TGEV Tax:11149
1210 3884-3892 Species denotes SARS‐CoV Tax:694009
1211 3412-3425 Species denotes transmissible Tax:11149
1212 3210-3257 Chemical denotes Cbz‐Val‐Asn‐Ser‐Thr‐Leu‐Gln‐chloromethyl ketone
1213 3285-3304 Chemical denotes chloromethyl ketone
1214 3502-3504 Chemical denotes P1 MESH:C480041
1215 3505-3508 Chemical denotes Gln MESH:D005973
1216 3571-3578 Chemical denotes leucine MESH:D007930
1217 3652-3663 Chemical denotes rupintrivir MESH:C118874
1218 3669-3675 Chemical denotes AG7088 MESH:C118874
1219 3426-3445 Disease denotes gastroenteritis CoV MESH:C000657245
1229 4858-4862 Gene denotes Mpro Gene:8673700
1230 3966-3970 Gene denotes Mpro Gene:8673700
1231 3955-3963 Species denotes SARS‐CoV Tax:694009
1232 4849-4857 Species denotes MERS‐CoV Tax:1335626
1233 4191-4200 Chemical denotes P1‐lactam
1234 4955-4961 Chemical denotes serine MESH:D012694
1235 4987-4995 Chemical denotes hydrogen MESH:D006859
1236 5190-5199 Chemical denotes isoprenyl
1237 4739-4751 Disease denotes cytotoxicity MESH:D064420
1242 5301-5305 Gene denotes Mpro Gene:8673700
1243 5365-5369 Gene denotes Mpro Gene:8673700
1244 5292-5300 Species denotes SARS‐CoV Tax:694009
1245 5386-5394 Species denotes SARS‐CoV Tax:694009
1255 6347-6356 Species denotes HCoV‐229E Tax:11137
1256 5747-5756 Chemical denotes P1‐lactam
1257 5837-5845 Chemical denotes hydrogen MESH:D006859
1258 5929-5936 Chemical denotes leucine MESH:D007930
1259 6006-6022 Chemical denotes P2‐phenylalanine
1260 6026-6048 Chemical denotes ‐4‐fluorophenylalanine MESH:D010135
1261 6117-6119 Chemical denotes P3
1262 6136-6145 Chemical denotes P3‐valine
1263 6180-6198 Chemical denotes P4‐methylisoxazole
1266 6646-6686 Chemical denotes Phe‐Phe‐dipeptidic α,β‐unsaturated ester
1267 6916-6931 Chemical denotes 4‐dimethylamine
1277 7303-7307 Gene denotes Mpro Gene:8673700
1278 7241-7245 Gene denotes Mpro Gene:8673700
1279 7090-7098 Species denotes SARS‐CoV Tax:694009
1280 7218-7222 Species denotes CoVs Tax:11118
1281 7232-7240 Species denotes MERS‐CoV Tax:1335626
1282 7267-7276 Species denotes HCoV‐229E Tax:11137
1283 7278-7287 Species denotes HCoV‐NL63 Tax:277944
1284 7293-7302 Species denotes HCoV‐HKU1 Tax:290028
1285 7403-7430 Species denotes infectious bronchitis virus Tax:11120
1307 7808-7812 Gene denotes Mpro Gene:8673700
1308 7968-7972 Gene denotes Mpro Gene:8673700
1309 8140-8144 Gene denotes Mpro Gene:8673700
1310 8007-8008 Gene denotes M Gene:43740571
1311 8067-8071 Gene denotes Mpro Gene:8673700
1312 7914-7918 Gene denotes Mpro Gene:8673700
1313 7854-7858 Gene denotes Mpro Gene:8673700
1314 7476-7486 Species denotes SARS‐CoV‐2 Tax:2697049
1315 7535-7543 Species denotes SARS‐CoV Tax:694009
1316 7677-7687 Species denotes SARS‐CoV‐2 Tax:2697049
1317 7716-7724 Species denotes SARS‐CoV Tax:694009
1318 7797-7805 Species denotes SARS‐CoV Tax:694009
1319 7843-7853 Species denotes SARS‐CoV‐2 Tax:2697049
1320 7903-7913 Species denotes SARS‐CoV‐2 Tax:2697049
1321 7936-7940 Species denotes kobs Tax:59530
1322 7953-7967 Species denotes COVID‐19 virus Tax:2697049
1323 8056-8064 Species denotes SARS‐CoV Tax:694009
1324 8129-8139 Species denotes SARS‐CoV‐2 Tax:2697049
1325 8180-8183 Species denotes CoV Tax:11118
1326 8021-8031 Chemical denotes Peptide N3
1327 8230-8237 Chemical denotes Cys‐His
1333 8380-8384 Gene denotes Mpro Gene:8673700
1334 8510-8514 Gene denotes Mpro Gene:8673700
1335 8675-8679 Gene denotes Mpro Gene:8673700
1336 8439-8443 Gene denotes Mpro Gene:8673700
1337 8365-8379 Species denotes COVID‐19 virus Tax:2697049
1343 8891-8899 Chemical denotes cysteine MESH:D003545
1344 8956-8964 Chemical denotes cysteine MESH:D003545
1345 9074-9085 Chemical denotes α‐carbanion
1346 9091-9094 Chemical denotes His MESH:D006639
1347 9180-9188 Chemical denotes cysteine MESH:D003545
1349 9340-9348 Chemical denotes aldehyde MESH:D000447
1355 9657-9676 Species denotes rodents and rabbits Tax:314147
1356 9413-9424 Chemical denotes 1,4‐Michael
1357 9563-9579 Chemical denotes carboxylic acids MESH:D002264
1358 9615-9621 Chemical denotes AG7088 MESH:C118874
1359 9466-9473 Disease denotes CH═CH–C MESH:C537418
1373 10269-10273 Gene denotes Mpro Gene:8673700
1374 10244-10252 Species denotes SARS‐CoV Tax:694009
1375 10259-10268 Species denotes HCoV‐229E Tax:11137
1376 10371-10379 Species denotes SARS‐CoV Tax:694009
1377 10410-10419 Species denotes HCoV‐229E Tax:11137
1378 10449-10452 Species denotes rat Tax:10116
1379 10454-10459 Species denotes mouse Tax:10090
1380 10465-10470 Species denotes human Tax:9606
1381 9950-9958 Chemical denotes cysteine MESH:D003545
1382 9984-9992 Chemical denotes aldehyde MESH:D000447
1383 10021-10028 Chemical denotes leucine MESH:D007930
1384 10097-10105 Chemical denotes aldehyde MESH:D000447
1385 10185-10193 Chemical denotes aldehyde MESH:D000447
1392 10638-10642 Gene denotes Mpro Gene:8673700
1393 10585-10589 Gene denotes Mpro Gene:8673700
1394 10561-10569 Species denotes SARS‐CoV Tax:694009
1395 10576-10584 Species denotes MERS‐CoV Tax:1335626
1396 10659-10667 Species denotes SARS‐CoV Tax:694009
1397 10614-10622 Chemical denotes aldehyde MESH:D000447
1410 10921-10925 Gene denotes Mpro Gene:8673700
1411 11082-11086 Gene denotes Mpro Gene:8673700
1412 11115-11119 Gene denotes Mpro Gene:8673700
1413 10940-10948 Species denotes SARS‐CoV Tax:694009
1414 10955-10963 Species denotes MERS‐CoV Tax:1335626
1415 11071-11079 Species denotes SARS‐CoV Tax:694009
1416 11106-11114 Species denotes MERS‐CoV Tax:1335626
1417 11340-11345 Species denotes human Tax:9606
1418 11355-11359 Species denotes CoVs Tax:11118
1419 10760-10776 Chemical denotes peptide‐aldehyde
1420 10973-10985 Disease denotes cytotoxicity MESH:D064420
1421 11253-11265 Disease denotes CoV‐infected MESH:D018352
1434 11408-11412 Gene denotes Mpro Gene:8673700
1435 11549-11553 Gene denotes Mpro Gene:8673700
1436 11837-11841 Gene denotes Mpro Gene:8673700
1437 11979-11983 Gene denotes Mpro Gene:8673700
1438 11397-11405 Species denotes SARS‐CoV Tax:694009
1439 11589-11592 Species denotes SAR Tax:2698737
1440 11635-11647 Chemical denotes P1‐imidazole
1441 12071-12079 Chemical denotes nitrogen MESH:D009584
1442 12095-12103 Chemical denotes hydrogen MESH:D006859
1443 12118-12127 Chemical denotes histidine MESH:D006639
1444 12148-12156 Chemical denotes nitrogen MESH:D009584
1445 11516-11538 Disease denotes Val‐Leu‐N(CH3)2Gln‐CHO MESH:C536108
1453 12666-12670 Gene denotes Mpro Gene:8673700
1454 12612-12616 Gene denotes Mpro Gene:8673700
1455 12603-12611 Species denotes SARS‐CoV Tax:694009
1456 12396-12417 Chemical denotes decahydroisoquinoline
1457 12708-12732 Chemical denotes P2‐decahydroisoquinoline
1458 12793-12802 Chemical denotes imidazole MESH:C029899
1459 12940-12944 Disease denotes fits MESH:D012640
1462 13016-13026 Chemical denotes cyclohexyl
1463 13031-13052 Chemical denotes decahydroisoquinoline
1466 13417-13421 Gene denotes Mpro Gene:8673700
1467 13306-13327 Chemical denotes decahydroisoquinoline
1472 13615-13635 Chemical denotes octahydroisochromene
1473 13836-13864 Chemical denotes (1S,3S)‐octahydroisochromene
1474 13912-13924 Chemical denotes P1‐imidazole
1475 13940-13948 Chemical denotes aldehyde MESH:D000447
1487 14234-14238 Gene denotes Mpro Gene:8673700
1488 14210-14218 Species denotes MERS‐CoV Tax:1335626
1489 14223-14231 Species denotes SARS‐CoV Tax:694009
1490 14472-14476 Species denotes CoVs Tax:11118
1491 14489-14524 Species denotes feline infectious peritonitis virus Tax:11135
1492 14526-14530 Species denotes FIPV Tax:11135
1493 14593-14601 Species denotes MERS‐CoV Tax:1335626
1494 14667-14670 Species denotes SAR Tax:2698737
1495 14265-14278 Chemical denotes P3‐piperidine
1496 14345-14374 Chemical denotes dipeptidic‐aldehyde bisulfite
1497 14697-14707 Chemical denotes piperidine MESH:C032727
1501 14830-14838 Chemical denotes aldehyde MESH:D000447
1502 14840-14858 Chemical denotes aldehyde bisulfite
1503 14871-14878 Chemical denotes epoxide MESH:D004852
1509 14925-14933 Species denotes MERS‐CoV Tax:1335626
1510 14986-14996 Chemical denotes piperidine MESH:C032727
1511 15100-15106 Chemical denotes Gln192
1512 15108-15114 Chemical denotes Gln167
1513 15120-15126 Chemical denotes Glu169
1525 15187-15191 Gene denotes Mpro Gene:8673700
1526 15457-15461 Gene denotes Mpro Gene:8673700
1527 15423-15427 Gene denotes Mpro Gene:8673700
1528 15149-15153 Species denotes APEs Tax:4456
1529 15176-15184 Species denotes SARS‐CoV Tax:694009
1530 15414-15422 Species denotes SARS‐CoV Tax:694009
1531 15128-15147 Chemical denotes Azapeptide epoxides
1532 15293-15300 Chemical denotes epoxide MESH:D004852
1533 15536-15546 Chemical denotes cysteine‐S
1534 15560-15567 Chemical denotes epoxide MESH:D004852
1535 15601-15623 Chemical denotes S,S‐configured epoxide
1544 15741-15745 Gene denotes Mpro Gene:8673700
1545 15842-15846 Gene denotes Mpro Gene:8673700
1546 16111-16115 Gene denotes Mpro Gene:8673700
1547 15730-15740 Species denotes SARS‐CoV‐2 Tax:2697049
1548 16100-16110 Species denotes SARS‐CoV‐2 Tax:2697049
1549 16229-16237 Chemical denotes aldehyde MESH:D000447
1550 16296-16302 Chemical denotes Cys145
1551 16341-16353 Disease denotes Cytotoxicity MESH:D064420
1557 16483-16487 Gene denotes Mpro Gene:8673700
1558 16444-16448 Gene denotes Mpro Gene:8673700
1559 16433-16443 Species denotes SARS‐CoV‐2 Tax:2697049
1560 16504-16512 Species denotes SARS‐CoV Tax:694009
1561 16465-16474 Chemical denotes P3‐indole
1563 16568-16577 Chemical denotes Ketoamide
1575 16712-16716 Species denotes CoVs Tax:11118
1576 17044-17052 Species denotes SARS‐CoV Tax:694009
1577 17053-17057 Gene denotes Mpro Gene:8673700
1578 16609-16632 Chemical denotes dipeptidic α‐ketoamides
1579 16764-16775 Chemical denotes α‐ketoamide
1580 16824-16832 Chemical denotes hydrogen MESH:D006859
1581 16883-16888 Chemical denotes amide MESH:D000577
1582 16889-16895 Chemical denotes oxygen MESH:D010100
1583 16951-16957 Chemical denotes esters MESH:D004952
1584 16962-16971 Chemical denotes aldehydes MESH:D000447
1585 16990-16998 Chemical denotes hydrogen MESH:D006859
1591 17168-17172 Gene denotes Mpro Gene:8673700
1592 17174-17178 Gene denotes Mpro Gene:8673700
1593 17157-17167 Species denotes SARS‐CoV‐2 Tax:2697049
1594 17195-17203 Species denotes SARS‐CoV Tax:694009
1595 17126-17135 Chemical denotes Ketoamide
1603 17632-17636 Gene denotes Mpro Gene:8673700
1604 17317-17325 Species denotes SARS‐CoV Tax:694009
1605 17329-17338 Species denotes HCoV‐NL63 Tax:277944
1606 17344-17358 Species denotes coxsackievirus Tax:12066
1607 17621-17629 Species denotes SARS‐CoV Tax:694009
1608 17559-17573 Chemical denotes P2‐cyclopentyl
1609 17641-17645 CellLine denotes Huh7 CVCL:0336
1625 18106-18110 Gene denotes Mpro Gene:8673700
1626 18363-18367 Gene denotes Mpro Gene:8673700
1627 18291-18295 Gene denotes Mpro Gene:8673700
1628 18219-18223 Gene denotes Mpro Gene:8673700
1629 17968-17972 Gene denotes Mpro Gene:8673700
1630 17948-17952 Gene denotes Mpro Gene:8673700
1631 17937-17945 Species denotes SARS‐CoV Tax:694009
1632 17957-17967 Species denotes SARS‐CoV‐2 Tax:2697049
1633 18095-18105 Species denotes SARS‐CoV‐2 Tax:2697049
1634 18208-18218 Species denotes SARS‐CoV‐2 Tax:2697049
1635 18280-18288 Species denotes SARS‐CoV Tax:694009
1636 18352-18362 Species denotes SARS‐CoV‐2 Tax:2697049
1637 18494-18496 Chemical denotes P2 MESH:C020845
1638 18500-18505 Chemical denotes amide MESH:D000577
1639 18520-18528 Chemical denotes pyridone MESH:D011728
1645 18779-18783 Gene denotes Mpro Gene:8673700
1646 18768-18772 Gene denotes Mpro Gene:8673700
1647 18757-18767 Species denotes SARS‐CoV‐2 Tax:2697049
1648 18800-18808 Species denotes SARS‐CoV Tax:694009
1649 18810-18855 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
1655 19432-19436 Gene denotes Mpro Gene:8673700
1656 18979-18983 Species denotes mice Tax:10090
1657 19284-19289 Species denotes mouse Tax:10090
1658 19421-19431 Species denotes SARS‐CoV‐2 Tax:2697049
1659 19612-19627 Species denotes β‐coronaviruses Tax:694002
1671 19776-19780 Gene denotes Mpro Gene:8673700
1672 19742-19746 Gene denotes Mpro Gene:8673700
1673 19683-19687 Gene denotes Mpro Gene:8673700
1674 19672-19682 Species denotes SARS‐CoV‐2 Tax:2697049
1675 19731-19739 Species denotes SARS‐CoV Tax:694009
1676 19767-19775 Species denotes MERS‐CoV Tax:1335626
1677 19844-19852 Species denotes SARS‐CoV Tax:694009
1678 19921-19926 Species denotes human Tax:9606
1679 20395-20399 Species denotes mice Tax:10090
1680 19901-19920 Disease denotes SARS‐CoV‐2 infected MESH:C000657245
1681 19927-19932 CellLine denotes Calu3 CVCL:0609
1703 20971-20988 Gene denotes cysteine protease Gene:1508
1704 20724-20733 Chemical denotes thioketal
1705 20770-20776 Chemical denotes Cys145
1706 20833-20838 Chemical denotes His41
1707 20852-20857 Chemical denotes amide MESH:D000577
1708 20858-20864 Chemical denotes oxygen MESH:D010100
1709 20908-20914 Chemical denotes amides MESH:D000577
1710 20918-20924 Chemical denotes Gly143
1711 20926-20932 Chemical denotes Cys145
1712 20947-20953 Chemical denotes Ser144
1713 21028-21034 Chemical denotes lactam MESH:D007769
1714 21088-21094 Chemical denotes lactam MESH:D007769
1715 21095-21103 Chemical denotes nitrogen MESH:D009584
1716 21152-21158 Chemical denotes oxygen MESH:D010100
1717 21166-21172 Chemical denotes Phe140
1718 21196-21202 Chemical denotes Glu166
1719 21217-21223 Chemical denotes oxygen MESH:D010100
1720 21242-21248 Chemical denotes His163
1721 21306-21320 Chemical denotes P3‐P2 pyridone
1722 21476-21482 Chemical denotes Pro168
1723 21276-21280 Disease denotes fits MESH:D012640
1729 21626-21630 Gene denotes Mpro Gene:8673700
1730 21632-21636 Gene denotes Mpro Gene:8673700
1731 21615-21625 Species denotes SARS‐CoV‐2 Tax:2697049
1732 21653-21661 Species denotes SARS‐CoV Tax:694009
1733 21663-21708 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
1735 21802-21808 Chemical denotes ketone MESH:D007659
1741 21846-21852 Chemical denotes ketone MESH:D007659
1742 22016-22022 Chemical denotes Ser‐OH
1743 22026-22029 Chemical denotes Cys MESH:D003545
1744 22084-22090 Chemical denotes serine MESH:D012694
1745 21973-21986 Disease denotes hemithioketal
1747 22199-22205 Chemical denotes ketone MESH:D007659
1764 22895-22899 Gene denotes Mpro Gene:8673700
1765 22530-22534 Gene denotes Mpro Gene:8673700
1766 22427-22431 Gene denotes Mpro Gene:8673700
1767 22416-22424 Species denotes SARS‐CoV Tax:694009
1768 22519-22527 Species denotes SARS‐CoV Tax:694009
1769 22375-22397 Chemical denotes trifluoromethyl ketone
1770 22687-22695 Chemical denotes cysteine MESH:D003545
1771 22767-22770 Chemical denotes P1‐ MESH:C480041
1772 22770-22776 Chemical denotes lactam MESH:D007769
1773 22781-22793 Chemical denotes P1'‐thiazole
1774 22970-22976 Chemical denotes Cys143
1775 22978-22984 Chemical denotes Ser144
1776 22990-22996 Chemical denotes Cys145
1777 23002-23010 Chemical denotes nitrogen MESH:D009584
1778 23023-23031 Chemical denotes thiazole MESH:D013844
1779 23092-23101 Chemical denotes P1‐lactam
1800 23993-23997 Gene denotes Mpro Gene:8673700
1801 24316-24320 Gene denotes Mpro Gene:8673700
1802 23358-23362 Gene denotes Mpro Gene:8673700
1803 23366-23374 Species denotes SARS‐CoV Tax:694009
1804 24305-24313 Species denotes SARS‐CoV Tax:694009
1805 23191-23201 Chemical denotes tripeptide
1806 23213-23226 Chemical denotes benzothiazole MESH:C005465
1807 23446-23459 Chemical denotes benzothiazole MESH:C005465
1808 23564-23574 Chemical denotes dipeptides MESH:D004151
1809 23656-23665 Chemical denotes P3‐valine
1810 23673-23683 Chemical denotes tripeptide
1811 23763-23775 Chemical denotes N‐arylglycyl
1812 23917-23925 Chemical denotes hydrogen MESH:D006859
1813 23983-23989 Chemical denotes Glu166
1814 24026-24033 Chemical denotes leucine MESH:D007930
1815 24038-24054 Chemical denotes P1'‐benzthiazole
1816 24405-24413 Chemical denotes hydrogen MESH:D006859
1817 24509-24515 Chemical denotes Glu166
1818 24671-24677 Chemical denotes indole MESH:C030374
1819 24683-24693 Chemical denotes benzofuran MESH:C105430
1825 24796-24800 Gene denotes Mpro Gene:8673700
1826 24802-24806 Gene denotes Mpro Gene:8673700
1827 24785-24793 Species denotes SARS‐CoV Tax:694009
1828 24823-24831 Species denotes SARS‐CoV Tax:694009
1829 24833-24878 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
1831 24967-24990 Chemical denotes trifluoromethyl ketones
1839 25315-25319 Gene denotes Mpro Gene:8673700
1840 25304-25312 Species denotes SARS‐CoV Tax:694009
1841 25257-25267 Chemical denotes dipeptides MESH:D004151
1842 25279-25300 Chemical denotes difluoromethyl ketone
1843 25386-25394 Disease denotes infected MESH:D007239
1844 25480-25488 Disease denotes toxicity MESH:D064420
1845 25404-25410 CellLine denotes Caco‐2 CVCL:0025
1853 25563-25567 Gene denotes Mpro Gene:8673700
1854 25680-25684 Gene denotes Mpro Gene:8673700
1855 25688-25696 Species denotes SARS‐CoV Tax:694009
1856 25843-25846 Species denotes SAR Tax:2698737
1857 25552-25560 Species denotes SARS‐CoV Tax:694009
1858 25513-25529 Chemical denotes peptide‐anilides
1859 25641-25652 Chemical denotes niclosamide MESH:D009534
1869 26208-26212 Gene denotes Mpro Gene:8673700
1870 26197-26205 Species denotes SARS‐CoV Tax:694009
1871 26316-26319 Species denotes SAR Tax:2698737
1872 26101-26114 Chemical denotes ketoglutamide
1873 26115-26126 Chemical denotes tripeptides
1874 26426-26434 Chemical denotes hydrogen MESH:D006859
1875 26546-26552 Chemical denotes Cys‐SH
1876 26628-26637 Chemical denotes P1‐lactam
1877 26647-26652 Chemical denotes nitro
1884 26779-26787 Species denotes SARS‐CoV Tax:694009
1885 26802-26810 Species denotes SARS‐CoV Tax:694009
1886 26729-26736 Chemical denotes peptide MESH:D010455
1887 26737-26745 Chemical denotes anilides MESH:D000813
1888 26750-26763 Chemical denotes ketoglutamide
1889 26764-26775 Chemical denotes tripeptides
1900 26940-26944 Gene denotes Mpro Gene:8673700
1901 27039-27043 Gene denotes Mpro Gene:8673700
1902 27215-27219 Gene denotes Mpro Gene:8673700
1903 27164-27168 Gene denotes Mpro Gene:8673700
1904 26929-26937 Species denotes SARS‐CoV Tax:694009
1905 27028-27036 Species denotes SARS‐CoV Tax:694009
1906 27153-27161 Species denotes SARS‐CoV Tax:694009
1907 27256-27265 Chemical denotes hydrogens MESH:D006859
1908 27308-27314 Chemical denotes His142
1909 27319-27324 Chemical denotes His41
1915 27348-27352 Gene denotes Mpro Gene:8673700
1916 27438-27442 Gene denotes Mpro Gene:8673700
1917 27337-27345 Species denotes SARS‐CoV Tax:694009
1918 27408-27436 Species denotes human immunodeficiency virus Tax:12721
1919 27459-27467 Species denotes SARS‐CoV Tax:694009
1921 27552-27556 Gene denotes Mpro Gene:8673700
1925 27672-27676 Gene denotes Mpro Gene:8673700
1926 27661-27669 Species denotes SARS‐CoV Tax:694009
1927 27557-27577 Chemical denotes Benzotriazole esters
1933 27945-27949 Gene denotes Mpro Gene:8673700
1934 27962-27966 Gene denotes Mpro Gene:8673700
1935 27934-27942 Species denotes SARS‐CoV Tax:694009
1936 27983-27991 Species denotes SARS‐CoV Tax:694009
1937 27924-27930 Chemical denotes esters MESH:D004952
1945 28313-28317 Gene denotes Mpro Gene:8673700
1946 28302-28310 Species denotes SARS‐CoV Tax:694009
1947 28082-28101 Chemical denotes benzotriazole ester
1948 28144-28162 Chemical denotes halopyridyl esters
1949 28174-28183 Chemical denotes thiophene MESH:D013876
1950 28185-28190 Chemical denotes furan MESH:C039281
1951 28196-28202 Chemical denotes indole MESH:C030374
1958 28613-28617 Gene denotes Mpro Gene:8673700
1959 28939-28943 Gene denotes Mpro Gene:8673700
1960 28835-28839 Gene denotes Mpro Gene:8673700
1961 28602-28610 Species denotes SARS‐CoV Tax:694009
1962 28826-28834 Species denotes MERS‐CoV Tax:1335626
1963 28510-28543 Chemical denotes halopyridinyl indole carboxylates
1970 29053-29057 Gene denotes Mpro Gene:8673700
1971 29070-29074 Gene denotes Mpro Gene:8673700
1972 28998-29001 Species denotes SAR Tax:2698737
1973 29042-29050 Species denotes SARS‐CoV Tax:694009
1974 29091-29099 Species denotes SARS‐CoV Tax:694009
1975 29005-29038 Chemical denotes halopyridinyl indole carboxylates
1985 29666-29670 Gene denotes Mpro Gene:8673700
1986 29292-29301 Species denotes mammalian Tax:9606
1987 29655-29663 Species denotes SARS‐CoV Tax:694009
1988 29147-29169 Chemical denotes 5‐Halopyridinyl esters
1989 29368-29374 Chemical denotes thiols MESH:D013438
1990 29526-29543 Chemical denotes methylene ketones
1991 29558-29600 Chemical denotes mono‐ and di‐fluorinated methylene ketones
1992 29610-29626 Chemical denotes pyridinyl esters
1993 29406-29418 Disease denotes cytotoxicity MESH:D064420
2000 29885-29889 Gene denotes Mpro Gene:8673700
2001 29902-29906 Gene denotes Mpro Gene:8673700
2002 29874-29882 Species denotes SARS‐CoV Tax:694009
2003 29923-29931 Species denotes SARS‐CoV Tax:694009
2004 29833-29847 Chemical denotes Etacrynic acid MESH:D004976
2005 29852-29858 Chemical denotes isatin MESH:D007510
2028 30106-30110 Gene denotes Mpro Gene:8673700
2029 30500-30504 Gene denotes Mpro Gene:8673700
2030 30355-30359 Gene denotes Mpro Gene:8673700
2031 30226-30230 Gene denotes Mpro Gene:8673700
2032 30095-30103 Species denotes SARS‐CoV Tax:694009
2033 30215-30223 Species denotes SARS‐CoV Tax:694009
2034 30344-30352 Species denotes SARS‐CoV Tax:694009
2035 30387-30390 Species denotes SAR Tax:2698737
2036 30045-30059 Chemical denotes etacrynic acid MESH:D004976
2037 30068-30073 Chemical denotes amide MESH:D000577
2038 30082-30087 Chemical denotes ester MESH:D004952
2039 30150-30171 Chemical denotes Etacrynic carboxamide
2040 30262-30282 Chemical denotes etacrynic acid ester
2041 30414-30420 Chemical denotes chloro
2042 30528-30536 Chemical denotes hydrogen MESH:D006859
2043 30548-30554 Chemical denotes Gln189
2044 30556-30562 Chemical denotes Glu166
2045 30564-30570 Chemical denotes Thr190
2046 30576-30582 Chemical denotes Gln192
2047 30663-30669 Chemical denotes Gly143
2048 30721-30727 Chemical denotes Cys145
2049 30728-30734 Chemical denotes sulfur MESH:D013455
2069 31069-31073 Gene denotes Mpro Gene:8673700
2070 31539-31543 Gene denotes Mpro Gene:8673700
2071 30977-30981 Gene denotes Mpro Gene:8673700
2072 30922-30926 Gene denotes Mpro Gene:8673700
2073 30810-30820 Species denotes rhinovirus Tax:12059
2074 30884-30894 Species denotes rhinovirus Tax:12059
2075 30911-30919 Species denotes SARS‐CoV Tax:694009
2076 30966-30974 Species denotes SARS‐CoV Tax:694009
2077 31058-31066 Species denotes SARS‐CoV Tax:694009
2078 31128-31131 Species denotes SAR Tax:2698737
2079 31528-31536 Species denotes SARS‐CoV Tax:694009
2080 30748-30754 Chemical denotes isatin MESH:D007510
2081 30756-30771 Chemical denotes 2,3‐dioxoindole
2082 31248-31254 Chemical denotes isatin MESH:D007510
2083 31399-31405 Chemical denotes isatin MESH:D007510
2084 31441-31447 Chemical denotes Gly143
2085 31449-31455 Chemical denotes Ser144
2086 31457-31463 Chemical denotes Cys145
2087 31469-31474 Chemical denotes His41
2095 31830-31834 Gene denotes Mpro Gene:8673700
2096 31724-31727 Species denotes SAR Tax:2698737
2097 31819-31827 Species denotes SARS‐CoV Tax:694009
2098 31791-31802 Chemical denotes carboxamide
2099 31912-31918 Chemical denotes Cys145
2100 31993-32004 Chemical denotes carboxamide
2101 32042-32054 Chemical denotes sulfonamides MESH:D013449
2111 32299-32303 Gene denotes Mpro Gene:8673700
2112 32829-32833 Gene denotes Mpro Gene:8673700
2113 32288-32296 Species denotes SARS‐CoV Tax:694009
2114 32545-32549 Species denotes CVB3 Tax:12072
2115 32237-32247 Chemical denotes pyrazolone MESH:C038362
2116 32252-32260 Chemical denotes pyrazole MESH:C031280
2117 32611-32622 Chemical denotes benzylidene
2118 32636-32649 Chemical denotes pyrazolone C4
2119 32857-32877 Chemical denotes carboxyl benzylidene
2126 32968-32972 Gene denotes Mpro Gene:8673700
2127 32985-32989 Gene denotes Mpro Gene:8673700
2128 32957-32965 Species denotes SARS‐CoV Tax:694009
2129 33006-33014 Species denotes SARS‐CoV Tax:694009
2130 32928-32937 Chemical denotes Pyrazoles MESH:D011720
2131 32942-32953 Chemical denotes pyrimidines MESH:D011743
2140 33481-33485 Gene denotes Mpro Gene:8673700
2141 33160-33164 Gene denotes Mpro Gene:8673700
2142 33142-33146 Gene denotes Mpro Gene:8673700
2143 33131-33139 Species denotes SARS‐CoV Tax:694009
2144 33151-33159 Species denotes MERS‐CoV Tax:1335626
2145 33470-33478 Species denotes SARS‐CoV Tax:694009
2146 33100-33110 Chemical denotes pyrazolone MESH:C038362
2147 33444-33454 Chemical denotes pyrimidine MESH:C030986
2152 33718-33722 Gene denotes Mpro Gene:8673700
2153 33707-33715 Species denotes SARS‐CoV Tax:694009
2154 33777-33780 Species denotes SAR Tax:2698737
2155 33648-33657 Chemical denotes dipeptide MESH:D004151
2161 33925-33929 Gene denotes Mpro Gene:8673700
2162 33942-33946 Gene denotes Mpro Gene:8673700
2163 33914-33922 Species denotes SARS‐CoV Tax:694009
2164 33963-33971 Species denotes SARS‐CoV Tax:694009
2165 33889-33898 Chemical denotes dipeptide MESH:D004151
2179 34457-34461 Gene denotes Mpro Gene:8673700
2180 34347-34351 Gene denotes Mpro Gene:8673700
2181 34296-34300 Gene denotes Mpro Gene:8673700
2182 34077-34081 Gene denotes Mpro Gene:8673700
2183 34066-34074 Species denotes SARS‐CoV Tax:694009
2184 34285-34293 Species denotes SARS‐CoV Tax:694009
2185 34446-34454 Species denotes SARS‐CoV Tax:694009
2186 34315-34322 Chemical denotes (R)‐123
2187 34428-34435 Chemical denotes (R)‐123
2188 34539-34546 Chemical denotes (R)‐123
2189 34596-34604 Disease denotes infected MESH:D007239
2190 34609-34633 Disease denotes SARS‐CoV‐1 infected Vero MESH:C000657245
2191 34634-34636 CellLine denotes E6 CVCL:4582
2197 34732-34736 Gene denotes Mpro Gene:8673700
2198 34785-34789 Gene denotes Mpro Gene:8673700
2199 34721-34729 Species denotes SARS‐CoV Tax:694009
2200 34806-34814 Species denotes SARS‐CoV Tax:694009
2201 34816-34861 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
2209 35134-35138 Gene denotes P1 3 Gene:440926
2210 34953-34956 Species denotes SAR Tax:2698737
2211 35019-35028 Chemical denotes imidazole MESH:C029899
2212 35039-35052 Chemical denotes 5‐chlorofuran
2213 35087-35095 Chemical denotes lead 123
2214 35168-35178 Chemical denotes pyridazine MESH:C062482
2215 35189-35197 Chemical denotes pyrazine MESH:D011719
2221 35335-35339 Gene denotes Mpro Gene:8673700
2222 35471-35475 Gene denotes Mpro Gene:8673700
2223 35324-35332 Species denotes SARS‐CoV Tax:694009
2224 35460-35468 Species denotes SARS‐CoV Tax:694009
2225 35360-35373 Chemical denotes benzotriazole MESH:C012771
2231 35520-35524 Gene denotes Mpro Gene:8673700
2232 35575-35579 Gene denotes Mpro Gene:8673700
2233 35509-35517 Species denotes SARS‐CoV Tax:694009
2234 35596-35604 Species denotes SARS‐CoV Tax:694009
2235 35551-35564 Chemical denotes benzotriazole MESH:C012771
2243 35652-35655 Species denotes SAR Tax:2698737
2244 35680-35693 Chemical denotes benzotriazole MESH:C012771
2245 35779-35802 Chemical denotes 4‐phenyl‐1,2,3‐triazole
2246 35895-35904 Chemical denotes acetamide MESH:C030686
2247 35953-35962 Chemical denotes thiophene MESH:D013876
2248 35995-36009 Chemical denotes i‐propyl amide
2249 36019-36034 Chemical denotes cyclobutylamide
2257 36296-36300 Gene denotes Mpro Gene:8673700
2258 36285-36293 Species denotes SARS‐CoV Tax:694009
2259 36427-36443 Species denotes Torreya nucifera Tax:50189
2260 36487-36496 Chemical denotes biflavone
2261 36498-36511 Chemical denotes amentoflavone MESH:C011164
2262 36660-36666 Chemical denotes Val186
2263 36671-36677 Chemical denotes Gln192
2269 36813-36829 Gene denotes 3C‐like protease
2270 36786-36794 Species denotes SARS‐CoV Tax:694009
2271 36831-36839 Species denotes SARS‐CoV Tax:694009
2272 36719-36726 Chemical denotes Flavone MESH:C043562
2273 36731-36740 Chemical denotes terpenoid MESH:D013729
2287 36963-36967 Gene denotes Mpro Gene:8673700
2288 37207-37227 Species denotes Tripterygium regelii Tax:123485
2289 37308-37311 Species denotes SAR Tax:2698737
2290 36954-36962 Species denotes SARS‐CoV Tax:694009
2291 36918-36928 Chemical denotes terpenoids MESH:D013729
2292 37005-37015 Chemical denotes ferruginol MESH:C431074
2293 37094-37109 Chemical denotes quinone‐methide MESH:C068040
2294 37110-37123 Chemical denotes triterpenoids MESH:D014315
2295 37124-37133 Chemical denotes celastrol MESH:C050414
2296 37141-37153 Chemical denotes pritimererin
2297 37165-37174 Chemical denotes tingenone MESH:C009492
2298 37186-37194 Chemical denotes methanol MESH:D000432
2299 37365-37372 Chemical denotes quinone MESH:C004532
2307 37719-37723 Gene denotes Mpro Gene:8673700
2308 37623-37627 Gene denotes Mpro Gene:8673700
2309 37708-37716 Species denotes SARS‐CoV Tax:694009
2310 37612-37620 Species denotes SARS‐CoV Tax:694009
2311 37565-37577 Chemical denotes diterpenoids MESH:D004224
2312 37647-37661 Chemical denotes betulinic acid MESH:C002070
2313 37672-37679 Chemical denotes savinin MESH:C425325
2318 37861-37866 Gene denotes CLpro
2319 37849-37857 Species denotes SARS‐CoV Tax:694009
2320 37879-37886 Chemical denotes sulfone MESH:D013450
2321 37895-37911 Chemical denotes dihydroimidazole
2326 38176-38180 Gene denotes Mpro Gene:8673700
2327 38201-38205 Gene denotes Mpro Gene:8673700
2328 38165-38173 Species denotes SARS‐CoV Tax:694009
2329 38222-38230 Species denotes SARS‐CoV Tax:694009
2334 38474-38478 Gene denotes Mpro Gene:8673700
2335 38463-38471 Species denotes SARS‐CoV Tax:694009
2336 38800-38808 Species denotes SARS‐CoV Tax:694009
2337 38662-38670 Species denotes SARS‐CoV Tax:694009
2346 39152-39156 Gene denotes Mpro Gene:8673700
2347 38945-38949 Gene denotes Mpro Gene:8673700
2348 39003-39007 Gene denotes Mpro Gene:8673700
2349 38992-39000 Species denotes SARS‐CoV Tax:694009
2350 39141-39151 Species denotes SARS‐CoV‐2 Tax:2697049
2351 39076-39086 Species denotes SARS‐CoV‐2 Tax:2697049
2352 38868-38877 Chemical denotes serotonin MESH:D012701
2353 38889-38899 Chemical denotes cinanserin MESH:D002928
2356 39198-39202 Gene denotes Mpro Gene:8673700
2357 39204-39208 Gene denotes Mpro Gene:8673700
2363 39290-39300 Chemical denotes disulfiram MESH:D004221
2364 39311-39319 Chemical denotes carmofur MESH:C017367
2365 39338-39345 Chemical denotes ebselen MESH:C042986
2366 39353-39361 Chemical denotes shikonin MESH:C016101
2367 39391-39396 Chemical denotes PX‐12 MESH:C412893
2374 39509-39513 Gene denotes Mpro Gene:8673700
2375 39642-39646 Gene denotes Mpro Gene:8673700
2376 39964-39968 Gene denotes Mpro Gene:8673700
2377 39953-39963 Species denotes SARS‐CoV‐2 Tax:2697049
2378 39541-39547 Chemical denotes Cys145
2379 39813-39820 Chemical denotes Ebselen MESH:C042986
2382 40132-40140 Disease denotes toxicity MESH:D064420
2383 40320-40334 Disease denotes CoV infections MESH:D018352
2385 40342-40353 Species denotes Coronavirus Tax:11118
2390 40386-40390 Gene denotes Mpro Gene:8673700
2391 40593-40597 Gene denotes nsp1 Gene:10045
2392 40598-40602 Gene denotes nsp3 Gene:10044
2393 40620-40624 Gene denotes nsp3 Gene:10044
2404 40911-40928 Gene denotes cysteine protease Gene:1508
2405 40989-40995 Chemical denotes Cys112
2406 40996-41002 Chemical denotes His273
2407 41003-41009 Chemical denotes Asp287
2408 41011-41017 Chemical denotes Cys112
2409 41048-41054 Chemical denotes His273
2410 41079-41085 Chemical denotes Asp287
2411 41092-41098 Chemical denotes His273
2412 41134-41137 Chemical denotes His MESH:D006639
2413 41153-41156 Chemical denotes Cys MESH:D003545
2418 41227-41235 Species denotes SARS‐CoV Tax:694009
2419 41450-41458 Species denotes SARS‐CoV Tax:694009
2420 41682-41685 Species denotes SAR Tax:2698737
2421 41268-41279 Chemical denotes naphthalene MESH:C031721
2426 42239-42259 Gene denotes papain‐like protease
2427 42173-42181 Species denotes SARS‐CoV Tax:694009
2428 42261-42269 Species denotes SARS‐CoV Tax:694009
2429 42210-42221 Chemical denotes naphthalene MESH:C031721
2432 42393-42398 Chemical denotes amide MESH:D000577
2433 42444-42453 Chemical denotes benzamide MESH:C037689
2436 42802-42810 Species denotes SARS‐CoV Tax:694009
2437 42970-42975 Chemical denotes PLpro
2440 43763-43771 Species denotes SARS‐CoV Tax:694009
2441 43618-43648 Chemical denotes m‐fluoro‐substituted benzamide
2452 44295-44325 Gene denotes ubiquitin C‐terminal hydrolase Gene:7345
2453 44328-44335 Gene denotes hUCH‐L1 Gene:7345
2454 44342-44349 Gene denotes hUCH‐L3 Gene:7347
2455 43964-43972 Species denotes SARS‐CoV Tax:694009
2456 44001-44009 Species denotes MERS‐CoV Tax:1335626
2457 44101-44109 Species denotes MERS‐CoV Tax:1335626
2458 44155-44163 Species denotes SARS‐CoV Tax:694009
2459 44219-44227 Species denotes SARS‐CoV Tax:694009
2460 44240-44248 Species denotes MERS‐CoV Tax:1335626
2461 44266-44271 Species denotes human Tax:9606
2464 44426-44446 Gene denotes papain‐like protease
2465 44448-44456 Species denotes SARS‐CoV Tax:694009
2470 44576-44584 Species denotes SARS‐CoV Tax:694009
2471 44532-44542 Chemical denotes thiopurine
2472 44553-44566 Chemical denotes 6‐thioguanine MESH:D013866
2473 44732-44740 Disease denotes toxicity MESH:D064420
2480 44890-44898 Species denotes SARS‐CoV Tax:694009
2481 45012-45020 Species denotes SARS‐CoV Tax:694009
2482 45092-45100 Species denotes SARS‐CoV Tax:694009
2483 45306-45314 Species denotes SARS‐CoV Tax:694009
2484 44859-44869 Chemical denotes tanshinone MESH:C021751
2485 45233-45242 Chemical denotes flavonoid MESH:D005419
2492 45456-45469 Species denotes B. Papyrifera Tax:172644
2493 45478-45486 Species denotes SARS‐CoV Tax:694009
2494 45497-45505 Species denotes MERS‐CoV Tax:1335626
2495 45587-45595 Species denotes SARS‐CoV Tax:694009
2496 45608-45616 Species denotes MERS‐CoV Tax:1335626
2497 45430-45441 Chemical denotes polyphenols MESH:D059808
2501 45717-45725 Species denotes SARS‐CoV Tax:694009
2502 45666-45676 Chemical denotes Disulfiram MESH:D004221
2503 45808-45816 Chemical denotes cysteine MESH:D003545

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T328 0-30 Sentence denotes 3 PROTEASES AS A DRUG TARGETS
T329 31-166 Sentence denotes Papain‐like protease (PLpro), and, predominantly, Mpro are required for the proteolytic cleavage of polyproteins produced by the virus.
T330 167-253 Sentence denotes Together they produce 16 nsp that are involved in viral replication and transcription.
T331 254-442 Sentence denotes 122 PLpro is responsible for cleavage at the first three positions of its polyprotein to produce three nsp, while Mpro cleaves at no less than 11 conserved sites, releasing nsp4 to nsp16.
T332 443-578 Sentence denotes Mpro‐mediated cleavage generates functional proteins like RdRP, RNA binding proteins, exoribonuclease, helicase, and methyltransferase.
T333 579-718 Sentence denotes 123 The indispensable role of Mpro for the viral life cycle and infection process makes Mpro an ideal target for anti‐coronaviral therapy.
T334 720-740 Sentence denotes 3.1 Mpro inhibitors
T335 742-783 Sentence denotes 3.1.1 Structure and function of CoV Mpro
T336 784-824 Sentence denotes Mpro is a homodimeric cysteine protease.
T337 825-871 Sentence denotes The SARS‐CoV‐1 Mpro consists of three domains:
T338 872-1050 Sentence denotes I (residues 8–101), and II (residues 102–184), which are β‐barrel domains that shape the chymotrypsin‐like structure, while domain III (residues 201–306) is made up by α‐helices.
T339 1051-1225 Sentence denotes 124 The CoV Mpro active site uses a catalytic dyad (Cys145‐His41), in which cysteine acts as the nucleophile in the proteolysis while histidine behaves as general acid‐base.
T340 1226-1303 Sentence denotes The peptide substrate or inhibitor binds in a cleft between domains I and II.
T341 1304-1307 Sentence denotes 125
T342 1308-1456 Sentence denotes As far as the development of new therapeutics against SARS‐ and MERS‐CoV infection is concerned, efforts have mainly focused on protease inhibitors.
T343 1457-1549 Sentence denotes These enzymes are highly attractive drug targets because they are so essential to the virus.
T344 1550-1689 Sentence denotes Peptides, peptidomimetics, and even small molecules can inhibit them, which leads to markedly reduced viral transmission and pathogenicity.
T345 1690-1881 Sentence denotes Although most of the reported molecules display only weak anti‐CoV activity, several of studies elucidated structure–activity relationships that can be used to further improve their activity.
T346 1882-1906 Sentence denotes 100 , 126 , 127 , 128
T347 1908-1948 Sentence denotes 3.1.2 Substrate‐derived Mpro inhibitors
T348 1949-2039 Sentence denotes To date, no approved drugs or vaccines are available for treating a coronavirus infection.
T349 2040-2225 Sentence denotes In a race to identify chemotherapeutic options, various approaches, such as chemical synthesis, testing of natural products, and virtual screening of compound libraries, have been used.
T350 2226-2322 Sentence denotes The systematic design of inhibitors of CoV Mpro was essentially based on the enzyme's substrate.
T351 2323-2516 Sentence denotes In general, a substrate can be transformed into a good inhibitor by modifying part of its sequence such that it binds to the catalytic cysteine in either a reversible or an irreversible manner.
T352 2517-2654 Sentence denotes Peptide inhibitors are designed by attaching a reactive group (also known as warhead group) to peptides that mimic the natural substrate.
T353 2655-2800 Sentence denotes The partial peptide substrate sequence for SARS‐CoV‐1 Mpro is mentioned in Figure 10, indicating the specific subsite of each amino acid residue.
T354 2801-2858 Sentence denotes Figure 10 A, SARS‐CoV‐1 Mpro partial substrate sequence.
T355 2859-2911 Sentence denotes B, (Overlay) structures of SARS‐CoV Mpro inhibitors.
T356 2912-3043 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com]
T357 3045-3103 Sentence denotes 3.1.3 Inhibitors with Michael acceptor as a warhead group
T358 3104-3361 Sentence denotes The disclosure of the first crystal structure of the SARS‐CoV‐1 Mpro in complex with a peptidic inhibitor Cbz‐Val‐Asn‐Ser‐Thr‐Leu‐Gln‐chloromethyl ketone (also known as hexapeptide chloromethyl ketone; 28) 125 provided clues for the substrate‐based design.
T359 3362-3637 Sentence denotes Although it is a substrate analog for the porcine transmissible gastroenteritis CoV (TGEV) Mpro, it offers a structural explanation for the P1‐Gln entering into the specific subsite S1 pocket and decreased P2‐leucine specificity in the hydrophobic S2 site of SARS‐CoV‐1 Mpro.
T360 3638-3808 Sentence denotes Additionally, rupintrivir (29; AG7088), a peptidomimetic inhibitor of human rhinovirus 3C protease is oriented similar to inhibitor 28 in the binding pocket of TGEV Mpro.
T361 3809-3911 Sentence denotes 129 These two molecules became prototype compounds for the development of SARS‐CoV‐1 Mpro inhibitors.
T362 3912-4020 Sentence denotes Compound 29 was only weakly active against SARS‐CoV‐1 Mpro (IC50, 800 µM) also in cellular antiviral assays.
T363 4021-4134 Sentence denotes 130 However, systematic structural modifications led to a series of analogs that show moderate to good activity.
T364 4135-4257 Sentence denotes 131 For example, compound 30 (Figure 11), in which the P1‐lactam was replaced by a phenyl ring, showed moderate activity.
T365 4258-4367 Sentence denotes Compound 31, in which the larger P2 p‐fluorophenyl was replaced with a phenyl group, was even more effective.
T366 4368-4500 Sentence denotes By taking 29 as a lead, Ghosh et al. designed new molecules mainly focusing on the replacement of the large P2 p‐fluorobenzyl group.
T367 4501-4721 Sentence denotes Two of the resulting structures with P2‐benzyl (32) and prenyl (33) moieties showed decent inhibitory potencies at both enzymatic (K inact, 0.014 and 0.045 min−1, respectively) and cell‐based (IC50, 45 and 70 µM) assays.
T368 4722-4812 Sentence denotes 132 Besides, no cytotoxicity was observed for these compounds up to 100 µM concentration.
T369 4813-4863 Sentence denotes However, 32 and 33 were inactive at MERS‐CoV Mpro.
T370 4864-5056 Sentence denotes 133 The same research group further modified the molecule with the introduction of P4 Boc‐serine, to establish additional hydrogen bond interactions as described in compound 34 (IC50, 75 µM).
T371 5057-5128 Sentence denotes Unfortunately, the activity of the resulting compound was not improved.
T372 5129-5277 Sentence denotes Further modification of the isobutyl group in compound 34 to isoprenyl group in compound 35 displayed potent activity with K i = 3.6 µM (Figure 11).
T373 5278-5280 Sentence denotes 14
T374 5281-5364 Sentence denotes Figure 11 SARS‐CoV Mpro inhibitors containing Michael acceptor as a warhead group.
T375 5365-5472 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus On the other hand, Yang et al.
T376 5473-5552 Sentence denotes 134 reported a series of peptide inhibitors with a greater inhibitory potency.
T377 5553-5622 Sentence denotes In general, they systematically changed the backbone of inhibitor 29.
T378 5623-5732 Sentence denotes As a result, they were able to identify more specific residues for each subsite (compounds 36–38; Figure 12):
T379 5733-6054 Sentence denotes At first, the P1‐lactam ring was identified as a more specific moiety for the S1‐site, forming multiple hydrogen‐bond interactions with the enzyme as can be seen in the crystal structure (36); P2‐leucine showed a fourfold increased inhibitory activity when compared to the P2‐phenylalanine or ‐4‐fluorophenylalanine (37).
T380 6055-6151 Sentence denotes A lipophilic tert‐butyl residue was recognized to be a better P3‐moiety than the P3‐valine (38).
T381 6152-6286 Sentence denotes Finally, the replacement of P4‐methylisoxazole with a benzyloxy group was the best option for activity enhancement (compare 29 vs 36).
T382 6287-6378 Sentence denotes They all showed moderate to high antiviral activity against HCoV‐229E in cell‐based assays.
T383 6379-6466 Sentence denotes Figure 12 Broad‐spectral antiviral compounds containing a Michael acceptor Shie et al.
T384 6467-6595 Sentence denotes 131 reported another series of peptide inhibitors with comparatively reduced molecular weight to increase drug‐like properties.
T385 6596-6687 Sentence denotes These pseudo‐C2‐symmetric inhibitors consist of a Phe‐Phe‐dipeptidic α,β‐unsaturated ester.
T386 6688-6802 Sentence denotes One of these inhibitors (39) had an outstanding inhibitory activity with an EC50 value of 0.52 µM (see Figure 12).
T387 6803-6885 Sentence denotes Besides, it displayed remarkable antiviral activity with an EC50 value of 0.18 µM.
T388 6886-7000 Sentence denotes Structurally, the presence of 4‐dimethylamine on the phenyl ring was found to be crucial for activity enhancement.
T389 7001-7136 Sentence denotes Another peptidic drug with a Michael acceptor was N3 (40), which was reported to inhibit SARS‐CoV‐1 3CLpro (K i, 9.0 µM) by Yang et al.
T390 7137-7308 Sentence denotes It was observed to be a broad‐spectrum antiviral compound, also inhibiting other CoVs, such as MERS‐CoV Mpro (IC50, 0.28µM), 135 HCoV‐229E, HCoV‐NL63, and HCoV‐HKU1 Mpro.
T391 7309-7431 Sentence denotes 135 , 136 , 137 , 138 It has also exhibited high antiviral activity in an animal model of infectious bronchitis virus.
T392 7432-7475 Sentence denotes 137 The CC50 of 40 is greater than 133 μM.
T393 7476-7546 Sentence denotes SARS‐CoV‐2 shares only 82% of its genome with its relative SARS‐CoV‐1.
T394 7547-7643 Sentence denotes However, essential viral enzymes of both species show sequence similarities of greater than 90%.
T395 7644-7763 Sentence denotes 137 , 139 , 140 , 141 , 142 SARS‐CoV‐2 3CLpro is highly similar to SARS‐CoV‐1 3CLpro, sharing 96% of its sequence.
T396 7764-7859 Sentence denotes Therefore, one could expect that SARS‐CoV‐1 Mpro inhibitors are active against SARS‐CoV‐2 Mpro.
T397 7860-8015 Sentence denotes Compound 40 was found to be active against SARS‐CoV‐2 Mpro and its value of kobs/[I] for the COVID‐19 virus Mpro was determined to be 11 300 ± 880 M−1·s−1.
T398 8016-8108 Sentence denotes 143 Peptide N3 was co‐crystalized with SARS‐CoV‐1 Mpro at 2.1 Å resolution (see Figure 13).
T399 8109-8199 Sentence denotes Its binding mode to SARS‐CoV‐2 Mpro is highly similar to that of other CoV main proteases.
T400 8200-8328 Sentence denotes Some key features include the Cys‐His catalytic dyad and the substrate‐binding pocket situated in a gap between domain I and II.
T401 8329-8515 Sentence denotes Figure 13 The crystal structure of COVID‐19 virus Mpro in complex with N3. (A) Representation of the dimeric Mpro‐inhibitor complex. (B) Surface representation of the homodimer of Mpro.
T402 8516-8669 Sentence denotes Protomer A (blue), protomer B (salmon), compound N3 is presented as green sticks. (C) Schematic view of compound N3 (40) in the substrate‐binding pocket.
T403 8670-8944 Sentence denotes 143 Mpro, main protease [Color figure can be viewed at wileyonlinelibrary.com] In general, inhibitors possessing a Michael acceptor group as a warhead moiety could form an irreversible (covalent) bond with the catalytic cysteine residue in the following manner (Figure 14):
T404 8945-9048 Sentence denotes First, the cysteine residue undergoes 1,4‐addition at the inhibitor's Michael acceptor group (warhead).
T405 9049-9197 Sentence denotes Rapid protonation of the α‐carbanion from His‐H+ leads to the covalent bond formation between the warhead of the inhibitor and the cysteine residue.
T406 9198-9315 Sentence denotes Figure 14 Mechanism of inhibitors with Michael acceptor group [Color figure can be viewed at wileyonlinelibrary.com]
T407 9317-9367 Sentence denotes 3.1.4 Inhibitors with aldehyde as a warhead group
T408 9368-9677 Sentence denotes Although the above‐described inhibitors with 1,4‐Michael acceptors (e.g., α,β‐vinyl ethyl ester, –CH═CH–C(O)–OEt) showed enzymatic or cell‐based in‐vitro activities, they can be cleaved to their carboxylic acids by plasma esterases; for instance, AG7088 (29) was inactive in the plasma of rodents and rabbits.
T409 9678-9771 Sentence denotes 144 , 145 Therefore, scientists explored different reactive groups that are stable in vivo.
T410 9772-9904 Sentence denotes Based on the highly potent 1,4‐Michael‐acceptor‐based inhibitor 38, which they had previously developed (see Figure 15), Yang et al.
T411 9905-10000 Sentence denotes 134 designed a peptide with a new efficient cysteine‐reactive group, using an aldehyde moiety.
T412 10001-10154 Sentence denotes In addition, the P2‐leucine and the Michael groups of 38 were modified by a cyclohexyl unit and aldehyde group respectively to improve cellular activity.
T413 10155-10274 Sentence denotes Indeed, the resulting peptide‐aldehyde 41 (Figure 15) showed remarkable activity against SARS‐CoV‐1 and HCoV‐229E Mpro.
T414 10275-10420 Sentence denotes 134 It displayed promising antiviral activities decreasing viral load by 4.7 log (at 5 µM) for SARS‐CoV‐1 and 5.2 log (at 1.2 µM) for HCoV‐229E.
T415 10421-10549 Sentence denotes This compound was stable in rat, mouse, and human plasma (even after 120 min, more than 70% of it remained in respective cells).
T416 10550-10637 Sentence denotes Figure 15 SARS‐CoV‐1 and MERS‐CoV Mpro inhibitors with peptide aldehyde functionality.
T417 10638-10727 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Kumar et al.
T418 10728-10818 Sentence denotes 146 reported another series of peptide‐aldehyde inhibitors with reduced molecular weight.
T419 10819-10872 Sentence denotes Selected examples (42, 43) are depicted in Figure 15.
T420 10873-11002 Sentence denotes They were potent, cell‐membrane permeable, dual Mpro inhibitors of SARS‐CoV‐1 and MERS‐CoV, without cytotoxicity (CC50 > 100 µM).
T421 11003-11135 Sentence denotes Compound 43, in particular, revealed highly potent activity against SARS‐CoV‐1 Mpro (IC50, 0.2 µM) and MERS‐CoV Mpro (IC50, 1.7 µM).
T422 11136-11272 Sentence denotes It displayed antiviral activity (EC50, 0.06 µM) lowering the viral load and the secretion of virus particles in MERS‐CoV‐infected cells.
T423 11273-11360 Sentence denotes Also, it displayed broad‐spectrum antiviral activity against other human α‐ and β‐CoVs.
T424 11361-11467 Sentence denotes Akaji et al. discovered a series of SARS‐CoV‐1 Mpro inhibitors derived from its natural peptide substrate.
T425 11468-11583 Sentence denotes Initially, they designed a pentapeptide (Ac‐Ser‐Val‐Leu‐N(CH3)2Gln‐CHO, 44) with Mpro inhibitory activity of 37 µM.
T426 11584-11689 Sentence denotes 147 SAR studies of 44 led to inhibitor containing P1‐imidazole with improved potency (45; IC50, 5.7 µM).
T427 11690-11953 Sentence denotes Further systematic structural modifications, primarily concentrating on P1‐, P2‐, and P4‐moieties, driven by X‐ray structure‐based analyses of the Mpro‐inhibitor complex, led to the identification of inhibitor 46 with remarkable inhibitory activity (IC50, 98 nM).
T428 11954-12053 Sentence denotes The crystal structure of Mpro with 46 revealed significant binding interactions in the active site.
T429 12054-12219 Sentence denotes The P1‐imidazole nitrogen atom created a hydrogen bond with the histidine residue's imidazole nitrogen, and the P2‐cyclohexyl moiety fitted well into the S2‐subsite.
T430 12220-12311 Sentence denotes This compound was characterized as a competitive inhibitor without covalent bond formation.
T431 12312-12505 Sentence denotes The same research group disclosed a novel series of peptide inhibitors containing a decahydroisoquinoline moiety in place of P2‐cyclohexyl of 46 to reduce the peptidic nature of the inhibitors.
T432 12506-12552 Sentence denotes A few examples (47–51) are shown in Figure 16.
T433 12553-12637 Sentence denotes Among them, 49 was moderately more active against SARS‐CoV Mpro when compared to 46.
T434 12638-12834 Sentence denotes 148 The X‐ray structure of Mpro in complex with 49 revealed that the P2‐decahydroisoquinoline moiety was fittingly placed in the S2‐subsite, while the P1‐imidazole moiety occupied the S1‐subsite.
T435 12835-12974 Sentence denotes With these key residues located appropriately in their respective pockets, the terminal functional group fits tightly into the active site.
T436 12975-13211 Sentence denotes Figure 16 Peptide inhibitors containing cyclohexyl and decahydroisoquinoline groups [Color figure can be viewed at wileyonlinelibrary.com] This group further extended their study to find inhibitors that interact with S2 to S4 subsites.
T437 13212-13359 Sentence denotes Taking 49 as a lead, they designed a new compound, by combining a nonprime substituent at the decahydroisoquinoline moiety, as shown in example 52.
T438 13360-13457 Sentence denotes 149 The resulting 52 showed more than twofold increased Mpro inhibitory activity compared to 49.
T439 13458-13549 Sentence denotes This indicates that the additional interactions at S2–S4 sites enhance inhibitory activity.
T440 13550-13706 Sentence denotes Rather recently, the same research group explored the ability of octahydroisochromene to interact with the hydrophobic S2 pocket as an innovative P2‐moiety.
T441 13707-13799 Sentence denotes 150 To identify the best specific configuration, all possible diastereomers were evaluated.
T442 13800-13985 Sentence denotes It was found that the molecule with (1S,3S)‐octahydroisochromene 53–56 could secure the optimal position of the P1‐imidazole as well as the aldehyde functional group at the active site.
T443 13986-14148 Sentence denotes Additionally, the N‐butyl side chain attached to the 1‐position of the fused ring system was recognized to be important for establishing hydrophobic interactions.
T444 14149-14172 Sentence denotes In 2018, Groutas et al.
T445 14173-14305 Sentence denotes 151 disclosed a novel class of dual MERS‐CoV and SARS‐CoV‐1 Mpro inhibitors that contain a P3‐piperidine moiety (58–59; Figure 17).
T446 14306-14532 Sentence denotes These inhibitors were derived from the dipeptidic‐aldehyde bisulfite adduct 57 (GC376), which was clinically studied as a protease inhibitor for its efficacy against CoVs such as the feline infectious peritonitis virus (FIPV).
T447 14533-14666 Sentence denotes Compounds 58 and 59 showed potent antiviral activity toward MERS‐CoV in cell‐based bioassays (EC50, 0.5 µM for 58 and 0.8 µM for 59).
T448 14667-14802 Sentence denotes SAR studies revealed that the piperidine moiety engaged in favorable hydrophobic interactions at the S3 and S4 pockets of the protease.
T449 14803-15045 Sentence denotes Figure 17 Inhibitors with aldehyde, aldehyde bisulfite adduct, and epoxide warhead group The X‐ray crystal structures of MERS‐CoV 3CLpro in complex with inhibitor 59 showed that the piperidine ring is likely projecting toward the S4 subsite.
T450 15046-15127 Sentence denotes Additionally, 59 was engaged in backbone H‐bonds with Gln192, Gln167, and Glu169.
T451 15128-15276 Sentence denotes Azapeptide epoxides (APEs) are another class of SARS‐CoV‐1 Mpro inhibitors, although they were originally developed for clan CD cysteine peptidases.
T452 15277-15428 Sentence denotes 152 , 153 The epoxide S,S‐diastereomer 60 (K inact/K i, 1900 (±400) M−1·s−1; Figure 17) exhibited the best inhibitory activity against SARS‐CoV Mpro.
T453 15429-15572 Sentence denotes 154 The X‐ray structure of Mpro in complex with 60 confirmed the formation of a covalent bond between the cysteine‐S atom and the epoxide C‐3.
T454 15573-15653 Sentence denotes It is worth noting that the S,S‐configured epoxide is required for the activity.
T455 15654-15894 Sentence denotes Very recently, Dai et al. designed and synthesized two novel peptidomimetic SARS‐CoV‐2 Mpro inhibitors 61 and 62 (Figure 18) which exhibited extremely high inhibitory activity on purified Mpro with IC50 values of 50 and 40 nM, respectively.
T456 15895-16029 Sentence denotes Furthermore, the group observed high antiviral activity of both compounds in cell‐based assays (61: EC50, 0.42 µM; 62: EC50, 0.33 µM).
T457 16030-16183 Sentence denotes X‐ray structures were determined for both derivatives in complex with SARS‐CoV‐2 Mpro at 1.5 Å, providing detailed information about the binding pockets.
T458 16184-16340 Sentence denotes Similar to related molecules that employ the aldehyde moiety as a warhead, a covalent bond with the active‐site Cys145 was demonstrated for both structures.
T459 16341-16402 Sentence denotes Cytotoxicity assays revealed CC50 values greater than 100 µM.
T460 16403-16406 Sentence denotes 155
T461 16407-16482 Sentence denotes Figure 18 Peptidomimetic SARS‐CoV‐2 Mpro inhibitors with P3‐indole moiety.
T462 16483-16559 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus
T463 16561-16588 Sentence denotes 3.1.5 Ketoamide inhibitors
T464 16589-16759 Sentence denotes Liu et al. reported dipeptidic α‐ketoamides as broad‐spectrum antiviral agents against the main proteases of human α and β‐CoVs as well as the 3C protease of enterovirus.
T465 16760-17013 Sentence denotes The α‐ketoamide warhead group was promising, as it provides two hydrogen bond acceptors—one from the keto and one from the amide oxygen—whereas other warhead groups, such as Michael acceptor esters and aldehydes, provide only one hydrogen bond acceptor.
T466 17014-17110 Sentence denotes Compound 63 was identified as SARS‐CoV Mpro inhibitor with an IC50 value of 1.95 µM (Figure 19).
T467 17111-17114 Sentence denotes 156
T468 17115-17173 Sentence denotes Figure 19 Ketoamide inhibitors targeting SARS‐CoV‐2 Mpro.
T469 17174-17447 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Taking 63 as a lead, aided by its X‐ray structure in complex with SARS‐CoV‐1, HCoV‐NL63, and coxsackievirus Mpros, systematic structural modifications were investigated, focusing on the P2‐moiety.
T470 17448-17637 Sentence denotes As a result, the replacement of P2‐phenyl with P2‐cyclohexyl (64) was found to be the best substitution, while P2‐cyclopentyl (65) showed similar potency against the enzyme SARS‐CoV‐1 Mpro.
T471 17638-17797 Sentence denotes In Huh7 cells, 64 also showed strong antiviral activity with an EC50 of 400 pM, but in Vero cells the antiviral activity of 64 was drastically reduced to 5 µM.
T472 17798-17901 Sentence denotes This compound also exhibited antiviral activity against a range of enteroviruses in various cell lines.
T473 17902-18044 Sentence denotes Due to the high similarity between SARS‐CoV‐1 Mpro and SARS‐CoV‐2 Mpro authors speculated that 64 was likely to inhibit the new virus as well.
T474 18045-18151 Sentence denotes Zhang et al. recently reported this molecule as a SARS‐CoV‐2 Mpro inhibitor with an IC50 value of 0.18 µM.
T475 18152-18325 Sentence denotes They first resolved the unliganded crystal structure of SARS‐CoV‐2 Mpro (Figure 20), 157 which is largely identical to that of SARS‐CoV‐1 Mpro with a 96% sequence identity.
T476 18326-18467 Sentence denotes Compound 64 was docked to SARS‐CoV‐2 Mpro, and a series of structural modifications were performed to improve its pharmacokinetic properties.
T477 18468-18724 Sentence denotes Specifically, masking the P2‐P3 amide bond with the pyridone ring could improve plasma half‐life; and exchanging the lipophilic cinnamoyl residue for the less lipophilic Boc group, could increase plasma solubility and reduce its binding to plasma proteins.
T478 18725-18773 Sentence denotes Figure 20 Crystal structure of SARS‐CoV‐2 Mpro.
T479 18774-19034 Sentence denotes 157 Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com] Indeed, the resulting 66 had a ~3‐fold improved plasma half‐life in mice when compared to the lead 65 (from 18 min to 1 h).
T480 19035-19240 Sentence denotes The in vitro kinetic plasma solubility has been increased by a factor of ~19 (from 6 µM for the lead to 112 µM for best derivative), and the thermodynamic solubility by a factor of ~13 (from 41 to 530 µM).
T481 19241-19305 Sentence denotes Compound 66 also showed reduced binding to mouse plasma protein.
T482 19306-19483 Sentence denotes However, compared to the lead (IC50, 0.18 µM), the structural modifications caused a reduction of activity against SARS‐CoV‐2 Mpro (IC50, 2.39 µM) and enteroviral 3 C proteases.
T483 19484-19628 Sentence denotes Nevertheless, the introduction of a cyclopropyl group as in 67 instead of P2‐cyclohexyl enhanced the antiviral activity against β‐coronaviruses.
T484 19629-19712 Sentence denotes Compound 67 (Figure 19) inhibited purified SARS‐CoV‐2 Mpro with an IC50 of 0.67 µM.
T485 19713-19818 Sentence denotes It also inhibited SARS‐CoV‐1 Mpro (IC50, 0.90 µM) and MERS‐CoV Mpro (IC50, 0.58 µM) with similar potency.
T486 19819-19897 Sentence denotes It was effective against SARS‐CoV‐1 replication with an EC50 value of 1.75 µM.
T487 19898-20133 Sentence denotes In SARS‐CoV‐2 infected human Calu3 cells, it inhibited the viral replication with an EC50 of 4–5 µM, when in fact the Boc‐unprotected 68 was inactive, suggesting a bulky hydrophobic group is necessary for cellular membrane penetration.
T488 20134-20291 Sentence denotes On the other hand, increasing hydrophobicity of molecules should be pondered carefully, as it can increase plasma protein binding as it was described for 64.
T489 20292-20438 Sentence denotes The pharmacokinetic properties of 67 revealed striking lung tropism and was suitable for inhalation in mice without any perceived adverse effects.
T490 20439-20540 Sentence denotes Compound 67 was cocrystallized with the enzyme in two different forms at 1.95 and 2.20 Å (Figure 21).
T491 20541-20719 Sentence denotes The key feature observed from this crystal structure was that the inhibitor binds to the shallow substrate‐binding site at the surface of each protomer, between domains I and II.
T492 20720-21015 Sentence denotes The thioketal that resulted from the nucleophilic Cys145 attacking the inhibitor, is stabilized by a H‐bond from His41, whereas the amide oxygen of 67 accepts a H‐bond from the main‐chain amides of Gly143, Cys145, and in part, Ser144 that make up the cysteine protease's canonical oxyanion hole.
T493 21016-21203 Sentence denotes 157 The P1 lactam moiety is deeply embedded in the S1 pocket where the lactam nitrogen donates a three‐center H‐bond to the main chain oxygen of the Phe140 and the carboxylate of Glu166.
T494 21204-21249 Sentence denotes The carbonyl oxygen forms a H‐bond to His163.
T495 21250-21301 Sentence denotes The P2‐cyclopropyl moiety fits into the S2 subsite.
T496 21302-21393 Sentence denotes The P3‐P2 pyridone moiety occupies the space normally filled by the substrate's main chain.
T497 21394-21574 Sentence denotes The Boc group is not situated in the canonical S4 site, rather it is located near Pro168, which explains why the removal of the Boc group as in 68 weakened the inhibitory activity.
T498 21575-21631 Sentence denotes Figure 21 Crystal structure of 67 with SARS‐CoV‐2 Mpro.
T499 21632-21763 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com]
T500 21765-21808 Sentence denotes 3.1.6 Inhibitors with electrophilic ketone
T501 21809-22143 Sentence denotes It was envisioned that a fluorinated ketone moiety could be utilized as a warhead for targeting proteases, because it forms a thermodynamically stable hemiketal or hemithioketal after nucleophilic attack by Ser‐OH or Cys‐SH residues, which are present in the active sites of serine or cysteine proteases, respectively (see Figure 22).
T502 22144-22432 Sentence denotes Figure 22 Peptide inhibitors containing electrophilic ketone warheads [Color figure can be viewed at wileyonlinelibrary.com] Initially, Hayashi et al. reported a series of natural‐substrate‐derived peptide inhibitors containing a trifluoromethyl ketone warhead targeting SARS‐CoV‐1 Mpro.
T503 22433-22535 Sentence denotes Compound 69 (Figure 22) was the best of the series with a K i value of 116 µM against SARS‐CoV‐1 Mpro.
T504 22536-22715 Sentence denotes 158 It was sequentially modified mainly focusing on the warhead moiety since the formation of a cyclic structure prevented the nucleophilic attack by cysteine at the active site.
T505 22716-22864 Sentence denotes This study led to the discovery of 70 containing a P1‐lactam and P1'‐thiazole moiety with a >50‐fold increase in inhibitory activity compared to 69.
T506 22865-22997 Sentence denotes 159 Docking studies of 70 to Mpro highlighted key H‐bond interactions with backbone amino acid residues Cys143, Ser144, and Cys145.
T507 22998-23135 Sentence denotes The nitrogen atom of the thiazole warhead moiety also engaged in H‐bond interactions, and the P1‐lactam nicely fitted into the S1‐pocket.
T508 23136-23303 Sentence denotes Continued computer‐assisted structural design led to a tripeptide containing benzothiazole as a warhead group and an m‐N,N‐dimethylaminophenyl group as P4‐moiety (71).
T509 23304-23404 Sentence denotes 160 This compound was extremely potent in inhibiting Mpro of SARS‐CoV‐1 with a K i value of 3.1 nM.
T510 23405-23503 Sentence denotes Docking studies of 71 confirmed that the benzothiazole group was tightly bound to the active site.
T511 23504-23651 Sentence denotes Consequently, the same research group disclosed a series of dipeptides with reduced molecular weight in an attempt to improve drug‐like properties.
T512 23652-23736 Sentence denotes The P3‐valine in the tripeptide 71 was exchanged for a variety of functional groups.
T513 23737-23804 Sentence denotes 161 The study determined N‐arylglycyl to be the optimal P3‐moiety.
T514 23805-23856 Sentence denotes Compound 72 displayed the best inhibitory activity.
T515 23857-24081 Sentence denotes Docking studies of 72 to the protease highlighted the amino hydrogen of the P3‐N‐phenyl glycyl forming a H‐bond with backbone Glu166 of Mpro, in addition to the best P2‐leucine and P1'‐benzthiazole moieties (see Figure 23A).
T516 24082-24321 Sentence denotes Further structural optimization at the P3‐N‐arylglycyl moiety found the indole‐2 carbonyl group to be one of the best P3‐moeities, thus reaching inhibitors with low nanomolar potency, for example 73 (K i, 0.006 µM) against SARS‐CoV‐1 Mpro.
T517 24322-24533 Sentence denotes 162 Docking studies of compound 73 to the protease revealed that the indole amino hydrogen and the carbonyl group attached to the 2‐position formed H‐bond interactions with the backbone Glu166 (see Figure 23B).
T518 24534-24733 Sentence denotes These interactions are of great importance, seeing as shifting the position of the carbonyl group from position 2 to 3, or replacing the indole with benzofuran drastically reduced inhibitory potency.
T519 24734-24801 Sentence denotes Figure 23 (A) Docking poses of 72 and (B) 73 with SARS‐CoV‐1 Mpro.
T520 24802-24991 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com] Zhao et al. reported a series of trifluoromethyl ketones.
T521 24992-25148 Sentence denotes Among them, 74, which has the same sequence as the peptide substrate from sites P1 to P4, exhibited moderate inhibitory activity with an IC50value of 10 µM.
T522 25149-25217 Sentence denotes Inhibitor 74 also displayed time‐dependent inhibition (K i, 0.3 µM).
T523 25218-25221 Sentence denotes 163
T524 25222-25331 Sentence denotes Zhang et al. described a series of dipeptides containing difluoromethyl ketone as SARS‐CoV‐1 Mpro inhibitors.
T525 25332-25454 Sentence denotes Compound 75 displayed the best inhibitory activity in infected Vero and Caco‐2 cell cultures with an IC50 value of 2.5 µM.
T526 25455-25489 Sentence denotes It also exhibited little toxicity.
T527 25490-25493 Sentence denotes 164
T528 25494-25594 Sentence denotes A library of small peptide‐anilides was developed as anti‐SARS‐CoV‐1 Mpro agents (77–80; Figure 23).
T529 25595-25699 Sentence denotes These inhibitors were basically designed from niclosamide (76) which was inactive at Mpro of SARS‐CoV‐1.
T530 25700-25775 Sentence denotes Proper structural modifications led to the discovery of 77 (IC50, 0.06 µM).
T531 25776-25842 Sentence denotes It behaved as a competitive, noncovalent inhibitor (K i, 0.03 µM).
T532 25843-25990 Sentence denotes SAR investigations pointed out that the N,N‐dimethyl group on the phenyl ring, and electron‐withdrawing groups at the warhead phenyl are important.
T533 25991-26078 Sentence denotes Structural modification of 77 resulted in compounds 78 – 80 displaying reduced potency.
T534 26079-26082 Sentence denotes 165
T535 26083-26243 Sentence denotes A novel series of ketoglutamide tripeptides bearing a phthalhydrazido warhead group were identified as reversible SARS‐CoV‐1 Mpro inhibitors (81–84; Figure 24).
T536 26244-26315 Sentence denotes 166 Among them, compound 83 showed the best inhibition (IC50, 0.6 µM).
T537 26316-26572 Sentence denotes SAR studies revealed the presence of β and β'‐amino functionality adjacent to the keto and the intramolecular hydrogen bond to the carbonyl group made the keto center more electrophilic and inclined to build a hemithioacetal with Cys‐SH at the active site.
T538 26573-26711 Sentence denotes Additionally, the hydrophobic P3‐benzyloxy moiety, the P1‐lactam, and the nitro group significantly contributed to the activity increment.
T539 26712-26801 Sentence denotes Figure 24 Small peptide anilides and ketoglutamide tripeptides as SARS‐CoV‐1 inhibitors.
T540 26802-26869 Sentence denotes SARS‐CoV, severe acute respiratory syndrome coronavirus Wang et al.
T541 26870-27006 Sentence denotes 167 described the development of selective and reversible SARS‐CoV‐1 Mpro inhibitors derived from HIV proteases inhibitors (Figure 25).
T542 27007-27105 Sentence denotes The compound 85 as a SARS‐CoV‐1 Mpro lead inhibitor was continuously modified to obtain 86 and 87.
T543 27106-27189 Sentence denotes These derivatives were highly selective toward SARS‐CoV‐1 Mpro versus HIV protease.
T544 27190-27325 Sentence denotes Docking studies of 87 to Mpro demonstrated that both indole amino hydrogens establish H‐bond networks with side chain His142 and His41.
T545 27326-27402 Sentence denotes Figure 25 SARS‐CoV‐1 Mpro inhibitors derived from HIV proteases inhibitors.
T546 27403-27514 Sentence denotes HIV, human immunodeficiency virus; Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus
T547 27516-27556 Sentence denotes 3.1.7 Small molecule inhibitors of Mpro
T548 27557-27677 Sentence denotes Benzotriazole esters (88–91; Figure 26) were discovered as novel nonpeptidic irreversible inhibitors of SARS‐CoV‐1 Mpro.
T549 27678-27795 Sentence denotes 168 Among them, 91 exhibited the best enzymatic inhibitory activity, but no antiviral activity in cell‐based assays.
T550 27796-27905 Sentence denotes The covalent binding mode of 91 was confirmed by electrospray ionization mass spectrometry (ESI‐MS) analyses.
T551 27906-27961 Sentence denotes Figure 26 Active esters as SARS‐CoV‐1 Mpro inhibitors.
T552 27962-28231 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus With a slight structural modification from benzotriazole ester, Zhang et al. reported a series of active halopyridyl esters containing thiophene, furan, and indole moieties (92–95; Figure 26).
T553 28232-28318 Sentence denotes Among them, 93 displayed the highest enzymatic inhibitory activity at SARS‐CoV‐1 Mpro.
T554 28319-28390 Sentence denotes 169 However, no antiviral activity for this compound was communicated.
T555 28391-28460 Sentence denotes The irreversible binding mode of 93 was confirmed by ESI‐MS analysis.
T556 28461-28471 Sentence denotes 170 , 171
T557 28472-28484 Sentence denotes Ghosh et al.
T558 28485-28660 Sentence denotes 172 studied the SARs of halopyridinyl indole carboxylates and identified a series of analogs (96–101; Figure 27) as SARS‐CoV‐1 Mpro inhibitors in the nanomolar potency range.
T559 28661-28780 Sentence denotes The best derivative (100) had high enzymatic inhibitory potency (IC50, 0.030 µM) and antiviral activity (EC50, 6.9 µM).
T560 28781-28899 Sentence denotes Compound 97 was also observed to inhibit the MERS‐CoV Mpro both in enzymatic and cell‐based (EC50, 12.5 µM) bioassays.
T561 28900-28986 Sentence denotes 173 This molecule covalently modified Mpro, which was confirmed by MALDI‐TOF studies.
T562 28987-29069 Sentence denotes Figure 27 SAR of halopyridinyl indole carboxylates as SARS‐CoV‐1 Mpro inhibitors.
T563 29070-29308 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus 5‐Halopyridinyl esters are troublesome drug candidates because of their potential for rapid hydrolysis by various esterases and other enzymes in mammalian cells.
T564 29309-29419 Sentence denotes They can potentially also react nonspecifically with other thiols and nucleophiles, a recipe for cytotoxicity.
T565 29420-29500 Sentence denotes To bypass this problem by developing stable noncovalent inhibitors, Zhang et al.
T566 29501-29682 Sentence denotes 174 reported a group of methylene ketones and analogous mono‐ and di‐fluorinated methylene ketones based on pyridinyl esters (102 and 103; Figure 28) as SARS‐CoV‐1 Mpro inhibitors.
T567 29683-29821 Sentence denotes Enzymatic investigations and ESI‐MS experiments illustrate that those inhibitors bind to their target in a noncovalent, reversible manner.
T568 29822-29901 Sentence denotes Figure 28 Etacrynic acid and isatin derivatives as SARS‐CoV‐1 Mpro inhibitors.
T569 29902-30144 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus An HPLC‐based screening of electrophilic compounds identified the etacrynic acid‐derived amide 106 and ester 107 as SARS‐CoV‐1 Mpro inhibitors with moderate potency.
T570 30145-30386 Sentence denotes 175 Etacrynic carboxamide (105; K i, 35.3 µM) bound more strongly to SARS‐CoV‐1 Mpro than to papain protease, while etacrynic acid ester 104 was more active at papain protease (K i, 3.2 µM) than at SARS‐CoV‐1 Mpro (K i, 45.8 µM; Figure 28).
T571 30387-30473 Sentence denotes SAR studies suggested that chloro substituents were necessary for protease inhibition.
T572 30474-30613 Sentence denotes Docking studies of 105 to Mpro revealed that it forms hydrogen bonds with Gln189, Glu166, Thr190, and Gln192 with its terminal amino group.
T573 30614-30735 Sentence denotes The Michael system carbonyl group interacts with Gly143, and the reactive double bond remained next to the Cys145 sulfur.
T574 30736-30833 Sentence denotes Previously, isatin (2,3‐dioxoindole) derivatives were observed to inhibit rhinovirus 3C protease.
T575 30834-30982 Sentence denotes 176 Due to the structural similarity between the rhinovirus 3C protease and SARS‐CoV‐1 Mpro, these derivatives were tested against SARS‐CoV‐1 Mpro.
T576 30983-31122 Sentence denotes Among them, 106 (IC50, 0.95 µM) and 107 (IC50, 0.98 µM) exhibited the best SARS‐CoV‐1 Mpro inhibitory activity in the low micromolar range.
T577 31123-31281 Sentence denotes 176 SAR studies suggested that the inhibition efficiency was mainly reliant on hydrophobic and electronic properties of the isatin core substitution pattern.
T578 31282-31370 Sentence denotes Docking studies revealed that the molecules fit well in the active site of the protease.
T579 31371-31475 Sentence denotes Both carbonyl groups of the isatin core engaged in H‐bonds with NH of Gly143, Ser144, Cys145, and His41.
T580 31476-31698 Sentence denotes Compounds 106 and 107 176 were more selective for SARS‐CoV‐1 Mpro than other proteases like papain (106, 103 µM; 107, 87.24 µM), chymotrypsin (106, ~1 mM; 107, 10.4 µM), and trypsin (106, 362 µM; 107, 243 µM; Figure 28).
T581 31699-31769 Sentence denotes Zhou et al. extended the SAR studies for further activity improvement.
T582 31770-31855 Sentence denotes Compound 108 bearing carboxamide showed the best SARS‐CoV‐1 Mpro inhibitory activity.
T583 31856-31946 Sentence denotes However, this derivative did not bind covalently to the Cys145 residue of the active site.
T584 31947-32084 Sentence denotes 177 Further structural investigations at the carboxamide of 108 with a variety of substituted sulfonamides did not improve the activity.
T585 32085-32142 Sentence denotes Compound 109 was the best one of that series (Figure 28).
T586 32143-32146 Sentence denotes 178
T587 32147-32315 Sentence denotes The modification of 110, identified by high‐throughput screening (HTS; Figure 29), led to pyrazolone and pyrazole derivatives 111 and 112 as SARS‐CoV‐1 Mpro inhibitors.
T588 32316-32367 Sentence denotes 179 , 180 Taking these as leads, Ramajeyam et al.
T589 32368-32488 Sentence denotes 181 reported compounds 112–114 to be the best‐performing inhibitors of the series(IC50 5.5, 6.8, 8.4 µM, respectively).
T590 32489-32556 Sentence denotes They also observed moderate inhibitory activity against CVB3 3Cpro.
T591 32557-32721 Sentence denotes Structure‐functionality analyses illustrated that the benzylidene ring next to pyrazolone C4 in addition to electron‐withdrawing groups, favors inhibitory activity.
T592 32722-32916 Sentence denotes Molecular modeling studies of 112 predicted that for its inhibitory function, the N1‐phenyl residue in the Mpro S1 site as well as the carboxyl benzylidene moiety in the S3 pocket are important.
T593 32917-32984 Sentence denotes Figure 29 Pyrazoles and pyrimidines as SARS‐CoV‐1 Mpro inhibitors.
T594 32985-33197 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29).
T595 33198-33277 Sentence denotes 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities.
T596 33278-33395 Sentence denotes Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively).
T597 33396-33507 Sentence denotes 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121).
T598 33508-33578 Sentence denotes Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM.
T599 33579-33582 Sentence denotes 181
T600 33583-33764 Sentence denotes HTS of NIH molecular libraries (~293 000 substances) yielded the dipeptide 122 containing 3‐pyridyl as hit compound against SARS‐CoV‐1 Mpro with an IC50 value of 2.2 µM (Figure 30).
T601 33765-33859 Sentence denotes Preliminary SAR studies identified 123 and 124 as the most promising inhibitors of the series.
T602 33860-33870 Sentence denotes 184 , 185
T603 33871-33941 Sentence denotes Figure 30 Simple dipeptide derivatives as SARS‐CoV‐1 Mpro inhibitors.
T604 33942-34215 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus The X‐ray crystal structure of 123 attached to SARS‐CoV‐1 Mpro highlighted the compound's identical orientation in the pocket to that of established covalent peptidomimetic inhibitors (Figure 31).
T605 34216-34301 Sentence denotes The compound with an R‐configuration occupied the S3‐S1' subsites of SARS‐CoV‐1 Mpro.
T606 34302-34643 Sentence denotes Indeed, only (R)‐123 was able to inhibit the Mpro enzyme with an IC50 value of 1.5 µM, while the (S)‐enantiomer was inactive. (R)‐123 inhibited SARS‐CoV‐1 Mpro in a competitive manner (K i, 1.6 µM) with a noncovalent mode of inhibition. (R)‐123 also showed antiviral activity (12.9 µM) in mock infected and SARS‐CoV‐1 infected Vero E6 cells.
T607 34644-34745 Sentence denotes Figure 31 The X‐ray crystal structure of 123 bound to the binding pocket of SARS‐CoV‐1 Mpro (PDB ID:
T608 34746-34752 Sentence denotes 3V3M).
T609 34753-34784 Sentence denotes Pockets S1'–S3 are highlighted.
T610 34785-35108 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com] To enhance the inhibitory activity, SAR study efforts around P1' of 123 provided compounds containing imidazole (125) and 5‐chlorofuran (126) with equipotent activity to lead 123 (Figure 30).
T611 35109-35262 Sentence denotes Next, the exploration of P1 3‐pyridyl unit of 123 revealed pyridazine (127) and pyrazine (128) which were only tolerated, albeit without any improvement.
T612 35263-35497 Sentence denotes The same group of researchers discovered potent, noncovalent SARS‐CoV‐1 Mpro blockers based on a benzotriazole scaffold in an MLPCN screening, 186 resulting in hit compound 129 (Figure 32) with a SARS‐CoV‐1 Mpro IC50 value of 6.2 µM.
T613 35498-35574 Sentence denotes Figure 32 SARS‐CoV‐1 Mpro inhibitors containing the benzotriazole scaffold.
T614 35575-35743 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus SAR studies focusing on the benzotriazole moiety of 129 were performed to improve activity.
T615 35744-35865 Sentence denotes The replacement of this group with 4‐phenyl‐1,2,3‐triazole (as in 130) was somewhat tolerated (IC50 of 11 µM; Figure 32).
T616 35866-36086 Sentence denotes Further modifications to the acetamide (P2‐P1' region) resulted in molecules bearing a thiophene ring on one side and a branched i‐propyl amide (131) or cyclobutylamide (132) on the other—reaching IC50 values below 5 µM.
T617 36087-36220 Sentence denotes To cut overall molecular weight of the inhibitors, P3‐truncation was performed, which led to potent derivatives (133–137; Figure 32).
T618 36221-36284 Sentence denotes Compound 137 displayed extremely high inhibition (IC50, 51 nM).
T619 36285-36355 Sentence denotes SARS‐CoV‐1 Mpro inhibitors were also discovered from medicinal plants.
T620 36356-36375 Sentence denotes In 2011, Ryu et al.
T621 36376-36451 Sentence denotes 187 disclosed a range of inhibitors obtained from Torreya nucifera leaves.
T622 36452-36605 Sentence denotes Of all the isolated chemicals, the biflavone, amentoflavone (138; Figure 33), was identified as a potent noncompetitive inhibitor with an IC50 of 8.3 µM.
T623 36606-36707 Sentence denotes Docking studies of 138 identified the interactions of Val186 and Gln192 as major sites at the target.
T624 36708-36804 Sentence denotes Figure 33 Flavone and terpenoid derivatives with inhibitory activity against SARS‐CoV‐1 3CLpro.
T625 36805-36987 Sentence denotes 3CLpro, 3C‐like protease; SARS‐CoV, severe acute respiratory syndrome coronavirus They also isolated a series of terpenoids from T. nucifera as anti‐SARS‐CoV Mpro agents (Figure 33).
T626 36988-37065 Sentence denotes 187 Among them, ferruginol (139; IC50 49.6 µM) was the most active compound.
T627 37066-37307 Sentence denotes Additionally, they isolated quinone‐methide triterpenoids celastrol (140), pritimererin (141), and tingenone (142) from methanol extracts of Tripterygium regelii which exhibited fair inhibition activity (IC50 2.6, 9.9, 5.5 µM, respectively).
T628 37308-37442 Sentence denotes SAR studies indicated that for effective inhibition, the quinone‐methide group in ring A and the more lipophilic ring E were critical.
T629 37443-37525 Sentence denotes All compounds were characterized as competitive inhibitors using kinetic analyses.
T630 37526-37536 Sentence denotes Wen et al.
T631 37537-37635 Sentence denotes 188 reported abietane‐type diterpenoids and lignoids with a powerful anti‐SARS‐CoV‐1 Mpro effect.
T632 37636-37771 Sentence denotes Especially betulinic acid (143) and savinin (144) effectively inhibited SARS‐CoV‐1 Mpro (K i 8.2 µM, 9.1 µM, respectively) (Figure 33).
T633 37772-37819 Sentence denotes These inhibitors acted in a competitive manner.
T634 37820-38008 Sentence denotes Lu et al. discovered two hit SARS‐CoV‐1 3CLpro inhibitors, sulfone 145 and dihydroimidazole 146, by structure‐based virtual screening of a compound library of 58 855 chemicals (Figure 34).
T635 38009-38140 Sentence denotes 189 The central structural elements of the hits, determined in docking experiments, were then used for additional analog searches.
T636 38141-38200 Sentence denotes Figure 34 Structure of SARS‐CoV‐1 Mpro inhibitors 145–149.
T637 38201-38351 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Computational similarity screening discovered 21 analogs from these hits.
T638 38352-38449 Sentence denotes Among them, the two best compounds 147 and 148 display IC50 values of 0.3 and 3 µM, respectively.
T639 38450-38567 Sentence denotes A variety of SARS‐CoV‐1 Mpro inhibitors have been identified through virtual screening (VS) as an alternative to HTS.
T640 38568-38682 Sentence denotes VS of 50 240 structurally diverse small molecules allowed to identify 104 molecules with anti‐SARS‐CoV‐1 activity.
T641 38683-38834 Sentence denotes Compound 149 (Figure 34) demonstrated potent enzyme inhibition (IC50, 2.5 μM) and an EC50 of 7 μM in Vero cell‐based SARS‐CoV‐1 plaque reduction assays
T642 38835-38950 Sentence denotes Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro.
T643 38951-39035 Sentence denotes It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM.
T644 39036-39158 Sentence denotes 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro).
T645 39159-39203 Sentence denotes Figure 35 Covalent bond inhibitors of Mpro.
T646 39204-39415 Sentence denotes Mpro, main protease Their HTS yielded seven primary hits including the approved drugs disulfiram (151) and carmofur (152), as well as ebselen (153), shikonin (154), tideglusib (155), and PX‐12 (156) (Figure 35).
T647 39416-39570 Sentence denotes Using MS/MS analysis, they deduced that ebselen (153) and 156 are irreversible inhibitors of Mpro by covalently attaching to Cys145 of the catalytic dyad.
T648 39571-39647 Sentence denotes Molecular docking was used to illustrate how 151, 154, and 155 bind to Mpro.
T649 39648-39812 Sentence denotes Antiviral activity assays, using real‐time reverse transcription‐PCR, indicated that ebselen and inhibitor “N3” (40; Figure 12) had the strongest antiviral effects.
T650 39813-39927 Sentence denotes Ebselen displayed an EC50 value of 4.67 µM, and “N3” showed an EC50 value of 16.77 µM in a plaque‐reduction assay.
T651 39928-39993 Sentence denotes Ebselen's IC50 value for SARS‐CoV‐2 Mpro was reported at 0.67 µM.
T652 39994-40062 Sentence denotes The activity data of remaining compounds is summarized in Figure 35.
T653 40063-40141 Sentence denotes Ebselen has been studied for an array of diseases and has a very low toxicity.
T654 40142-40213 Sentence denotes 191 , 192 , 193 Its safety has been demonstrated in clinical trials.
T655 40214-40335 Sentence denotes 191 , 192 , 194 It can therefore be considered a promising molecule for the treatment or prevention of CoV infections.
T656 40337-40370 Sentence denotes 3.2 Coronavirus PLpro inhibitors
T657 40371-40499 Sentence denotes Along with the Mpro, papain‐like protease (PLpro) also cleaves polyproteins which is an important process for viral replication.
T658 40500-40604 Sentence denotes PLpro cleaves at the first three positions creating three nonstructural functional proteins (nsp1‐nsp3).
T659 40605-40688 Sentence denotes In particular, nsp3 is central for the generation of the viral replication complex.
T660 40689-40899 Sentence denotes The multifunctionality of PLpro in deubiquitinating, de‐ISGylation (ISG: interferon‐stimulated gene), 195 , 196 and in the evasion of the innate immune response make PLpro an attractive antiviral drug target.
T661 40900-41010 Sentence denotes PLpro is a cysteine protease and its active site contains a catalytic triad composing of Cys112‐His273‐Asp287.
T662 41011-41078 Sentence denotes Cys112 behaves as a nucleophile, and His273 is a general acid‐base.
T663 41079-41160 Sentence denotes Asp287 helps His273 to align perfectly, thus promoting His to deprotonate Cys‐SH.
T664 41161-41173 Sentence denotes Ghosh et al.
T665 41174-41289 Sentence denotes 197 contributed significantly to the development of SARS‐CoV‐1 PLpro inhibitors based on the naphthalene scaffold.
T666 41290-41422 Sentence denotes Two lead compounds 157 and 158 (Figure 36) were identified by an HTS of a chemical library containing greater than 50 000 compounds.
T667 41423-41519 Sentence denotes They both inhibit PLpro of SARS‐CoV‐1 at a moderate potency (IC50 20.1 and 59 µM, respectively).
T668 41520-41670 Sentence denotes The (R)‐enantiomer of compound 157 was found to be a greater than twofold more potent inhibitor of PLpro when compared with its racemic mixture (157).
T669 41671-41909 Sentence denotes Subsequent SAR studies highlighted the 2‐naphthyl substitution as an important structural requirement rather than at the position 1 of the naphthyl ring in addition to the presence of o‐methyl and m‐amino groups, in the other phenyl ring.
T670 41910-42058 Sentence denotes Compound 159 displayed the best inhibitory activity of PLpro (IC50, 0.6 µM) and acts in a noncovalent reversible manner with a K i value of 0.49 µM.
T671 42059-42161 Sentence denotes 198 Compound 159 also showed moderate antiviral activity in Vero cells with an EC50 value of 14.5 µM.
T672 42162-42231 Sentence denotes Figure 36 SARS‐CoV‐1 PLpro inhibitors based on naphthalene scaffold.
T673 42232-42469 Sentence denotes PLpro, papain‐like protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Compound 159 was further scrutinized by investigating the importance of the amide NH, and the effect of the substituent on the benzamide ring (160–164).
T674 42470-42656 Sentence denotes Among them, compounds 163 and 164 exhibited the most potent enzymatic (163: IC50, 0.46 µM; 164: IC50, 1.23 µM) and cell‐based antiviral (163: EC50, 6.0 µM; 164: EC50, 5.2 µM) activities.
T675 42657-42720 Sentence denotes Next, the same group studied the SARs for compound 158 further.
T676 42721-42881 Sentence denotes This led to the discovery of compound 165 with high PLpro inhibitory activity of SARS‐CoV‐1 (IC50, 0.32 µM) and antiviral activity (EC50, 9.1 µM) in Vero cells.
T677 42882-42976 Sentence denotes 199 The mode of action of 165 was found to be a noncovalent, competitive inhibition of PLpro.
T678 42977-43108 Sentence denotes Unlike the previous series, the stereochemistry at the α‐methyl group did not make a significant difference in inhibition of PLpro.
T679 43109-43318 Sentence denotes For example, both (S)‐ and (R)‐methyl inhibitors, 165 (IC50, 0.32 µM; EC50, 9.1 µM and 166 (IC50, 0.56 µM; EC50, 9.1 µM), respectively, shared equipotent inhibitory activity in enzymatic and cell‐based assays.
T680 43319-43389 Sentence denotes Further SARs of 159 and 165 were investigated to improve the activity.
T681 43390-43529 Sentence denotes However, no significant improvement in the activity was observed for the prepared compounds either in the enzymatic or cell‐based bioassay.
T682 43530-43601 Sentence denotes Compounds 167–169 (Figure 36) displayed the best inhibitory activities.
T683 43602-43744 Sentence denotes Especially, the m‐fluoro‐substituted benzamide derivative 168 (IC50, 0.15 µM; EC50, 5.4 µM) showed the best inhibition activity against PLpro.
T684 43745-43801 Sentence denotes It also inhibited SARS‐CoV‐1 in the cell‐based bioassay.
T685 43802-43881 Sentence denotes Both compounds 168 and 169 were metabolically more stable when compared to 167.
T686 43882-44041 Sentence denotes HTS of a chemical library of 25000 molecules identified 170 (Figure 37) as a dual SARS‐CoV‐1 PLpro (IC50, 10.9 µM) and MERS‐CoV PLpro (IC50, 6.2 µM) inhibitor.
T687 44042-44172 Sentence denotes 200 This compound acts via competitive inhibition against MERS‐CoV PLpro, yet via allosteric inhibition against SARS‐CoV‐1 PLpro.
T688 44173-44351 Sentence denotes This compound also exhibited a preference for SARS‐CoV‐1 PLpro and MERS‐CoV PLpro versus two human homologs of the PLpro, ubiquitin C‐terminal hydrolase, (hUCH‐L1) and (hUCH‐L3).
T689 44352-44418 Sentence denotes Figure 37 Broad spectral PLpro inhibitors from different sources.
T690 44419-44515 Sentence denotes PLpro, papain‐like protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Chou et al.
T691 44516-44659 Sentence denotes 201 identified thiopurine (171) and 6‐thioguanine (172) as SARS‐CoV‐1 PLpro inhibitors by the screening of a library containing 160 compounds.
T692 44660-44718 Sentence denotes The thiocarbonyl group was important for PLpro inhibition.
T693 44719-44821 Sentence denotes However, the toxicity of these anticancer agents limits their therapeutic utility as anti‐SARS agents.
T694 44822-44842 Sentence denotes In 2012, Park et al.
T695 44843-44946 Sentence denotes 202 reported a tanshinone derivative 173 as a SARS‐CoV‐1 PLpro inhibitor with an IC50 value of 0.8 µM.
T696 44947-45029 Sentence denotes The same research group also described diarylheptanoids blocking SARS‐CoV‐1 PLpro.
T697 45030-45136 Sentence denotes In particular compound 174 performed as the best inhibitor of SARS‐CoV PLpro with an IC50 value of 4.1 µM.
T698 45137-45216 Sentence denotes An α,β‐unsaturated carbonyl functionality was crucial for effective inhibition.
T699 45217-45363 Sentence denotes The geranylated flavonoid 175 was another plant‐derived natural product, which displayed SARS‐CoV‐1 PLpro inhibition with an IC50 value of 5.0 µM.
T700 45364-45367 Sentence denotes 203
T701 45368-45388 Sentence denotes In 2017, Park et al.
T702 45389-45458 Sentence denotes 204 assessed the inhibitory activity of polyphenols isolated from B.
T703 45459-45512 Sentence denotes Papyrifera against SARS‐CoV PLpro and MERS‐CoV PLpro.
T704 45513-45665 Sentence denotes Two of them (176 and 177 Figure 37) displayed moderate inhibition at both SARS‐CoV‐1 PLpro and MERS‐CoV PLpro with a noncompetitive mechanism of action.
T705 45666-45900 Sentence denotes Disulfiram (151; Figure 35) was also reported as a SARS‐CoV‐1 PLpro inhibitor (IC50, 24.1 µM), 205 probably by reacting with the active site cysteine, thereby covalently modifying the enzyme target, as was reported for other targets.