PMC:7461420 / 34535-34826 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T189","span":{"begin":151,"end":158},"obj":"Body_part"},{"id":"T190","span":{"begin":234,"end":241},"obj":"Body_part"},{"id":"T191","span":{"begin":285,"end":290},"obj":"Body_part"}],"attributes":[{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T410","span":{"begin":52,"end":58},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T411","span":{"begin":277,"end":290},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"}],"text":"Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T307","span":{"begin":25,"end":31},"obj":"Chemical"},{"id":"T309","span":{"begin":151,"end":158},"obj":"Chemical"},{"id":"T310","span":{"begin":234,"end":241},"obj":"Chemical"}],"attributes":[{"id":"A307","pred":"chebi_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/CHEBI_42223"},{"id":"A308","pred":"chebi_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/CHEBI_77659"},{"id":"A309","pred":"chebi_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A310","pred":"chebi_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1087","span":{"begin":164,"end":168},"obj":"Gene"},{"id":"1088","span":{"begin":74,"end":95},"obj":"Species"},{"id":"1089","span":{"begin":100,"end":116},"obj":"Species"},{"id":"1090","span":{"begin":25,"end":31},"obj":"Chemical"},{"id":"1092","span":{"begin":0,"end":6},"obj":"Disease"},{"id":"1093","span":{"begin":282,"end":284},"obj":"CellLine"}],"attributes":[{"id":"A1087","pred":"tao:has_database_id","subj":"1087","obj":"Gene:59272"},{"id":"A1088","pred":"tao:has_database_id","subj":"1088","obj":"Tax:76025"},{"id":"A1089","pred":"tao:has_database_id","subj":"1089","obj":"Tax:137220"},{"id":"A1090","pred":"tao:has_database_id","subj":"1090","obj":"MESH:D004642"},{"id":"A1093","pred":"tao:has_database_id","subj":"1093","obj":"CVCL:4582"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells."}

{"project":"LitCovid-sentences","denotations":[{"id":"T320","span":{"begin":0,"end":291},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells."}