PMC:7461420 / 34209-35181
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T187 | 208-212 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T188 | 239-243 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T189 | 477-484 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T190 | 560-567 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T191 | 611-616 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T192 | 801-814 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T193 | 801-805 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T22 | 239-243 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T407 | 107-110 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T408 | 145-151 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T409 | 208-212 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T410 | 378-384 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T411 | 603-616 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cells |
| T412 | 721-723 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T413 | 751-752 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T414 | 795-800 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T415 | 801-805 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T416 | 806-814 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T417 | 904-905 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T305 | 81-91 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T306 | 188-192 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T307 | 351-357 | Chemical | denotes | emodin | http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659 |
| T309 | 477-484 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T310 | 560-567 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T311 | 753-762 | Chemical | denotes | benzamide | http://purl.obolibrary.org/obo/CHEBI_28179 |
| T312 | 846-855 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46 | 213-219 | http://purl.obolibrary.org/obo/GO_0098739 | denotes | uptake |
| T47 | 213-219 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
| T48 | 806-821 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1087 | 490-494 | Gene | denotes | ACE2 | Gene:59272 |
| 1088 | 400-421 | Species | denotes | Polygonum multiflorum | Tax:76025 |
| 1089 | 426-442 | Species | denotes | Rheum officinale | Tax:137220 |
| 1090 | 351-357 | Chemical | denotes | emodin | MESH:D004642 |
| 1091 | 753-762 | Chemical | denotes | benzamide | MESH:C037689 |
| 1092 | 326-332 | Disease | denotes | Hsiang | |
| 1093 | 608-610 | CellLine | denotes | E6 | CVCL:4582 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T317 | 0-92 | Sentence | denotes | Phenotypic screening approaches led to the identification of several viral entry inhibitors. |
| T318 | 93-220 | Sentence | denotes | This approach has the advantage of finding cellular‐active compounds, providing information on drug solubility and cell uptake. |
| T319 | 221-325 | Sentence | denotes | 117 On the other hand, it is limited in terms of capacity compared to in silico target‐based screening. |
| T320 | 326-617 | Sentence | denotes | Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells. |
| T321 | 618-697 | Sentence | denotes | However, the mechanism of action of this compound still needs to be determined. |
| T322 | 698-720 | Sentence | denotes | 118 Sarafianos et al. |
| T323 | 721-972 | Sentence | denotes | 48 found that SSAA09E3 (25), a benzamide derivative of 24, could prevent virus‐cell membrane fusion in pseudotype‐based and antiviral‐based assays, with an EC50 value of 9.7 µM, but a CC50 value of 20 µM indicates additional unknown cellular targets. |