PMC:7461420 / 33894-34208 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T185","span":{"begin":36,"end":40},"obj":"Body_part"},{"id":"T186","span":{"begin":218,"end":223},"obj":"Body_part"}],"attributes":[{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T400","span":{"begin":34,"end":40},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T401","span":{"begin":185,"end":186},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T402","span":{"begin":213,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T403","span":{"begin":213,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T404","span":{"begin":213,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T405","span":{"begin":218,"end":223},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T406","span":{"begin":312,"end":314},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"text":"Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T304","span":{"begin":114,"end":123},"obj":"Chemical"}],"attributes":[{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T45","span":{"begin":139,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0004175"}],"text":"Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1077","span":{"begin":87,"end":149},"obj":"Gene"},{"id":"1078","span":{"begin":272,"end":284},"obj":"Disease"},{"id":"1079","span":{"begin":213,"end":217},"obj":"CellLine"}],"attributes":[{"id":"A1078","pred":"tao:has_database_id","subj":"1078","obj":"MESH:D064420"},{"id":"A1079","pred":"tao:has_database_id","subj":"1079","obj":"CVCL:0063"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48"}

{"project":"LitCovid-sentences","denotations":[{"id":"T314","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T315","span":{"begin":182,"end":311},"obj":"Sentence"},{"id":"T316","span":{"begin":312,"end":314},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM. In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM. 48"}