PMC:7461420 / 33582-33923 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T181","span":{"begin":100,"end":106},"obj":"Body_part"},{"id":"T182","span":{"begin":112,"end":117},"obj":"Body_part"},{"id":"T183","span":{"begin":183,"end":200},"obj":"Body_part"},{"id":"T184","span":{"begin":195,"end":200},"obj":"Body_part"}],"attributes":[{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":" nM). Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells. This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM. This data offers a new promising point for the treatment of SARS and Ebola virus infections. 116\nScreening of ~14 000 compound"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":100,"end":106},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":" nM). Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells. This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM. This data offers a new promising point for the treatment of SARS and Ebola virus infections. 116\nScreening of ~14 000 compound"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T190","span":{"begin":44,"end":49},"obj":"Disease"},{"id":"T191","span":{"begin":50,"end":65},"obj":"Disease"},{"id":"T192","span":{"begin":56,"end":65},"obj":"Disease"},{"id":"T193","span":{"begin":275,"end":279},"obj":"Disease"},{"id":"T194","span":{"begin":284,"end":289},"obj":"Disease"},{"id":"T195","span":{"begin":290,"end":306},"obj":"Disease"}],"attributes":[{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0005737"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A192","pred":"mondo_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A193","pred":"mondo_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0005737"},{"id":"A195","pred":"mondo_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"}],"text":" nM). Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells. This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM. This data offers a new promising point for the treatment of SARS and Ebola virus infections. 116\nScreening of ~14 000 compound"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T386","span":{"begin":15,"end":17},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T387","span":{"begin":50,"end":55},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T388","span":{"begin":84,"end":89},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T389","span":{"begin":90,"end":106},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T390","span":{"begin":107,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T391","span":{"begin":107,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T392","span":{"begin":107,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T393","span":{"begin":112,"end":117},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T394","span":{"begin":170,"end":175},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T395","span":{"begin":176,"end":182},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T396","span":{"begin":183,"end":200},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T397","span":{"begin":232,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T398","span":{"begin":290,"end":295},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T399","span":{"begin":308,"end":311},"obj":"http://purl.obolibrary.org/obo/CLO_0001046"}],"text":" nM). Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells. This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM. This data offers a new promising point for the treatment of SARS and Ebola virus infections. 116\nScreening of ~14 000 compound"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1065","span":{"begin":84,"end":89},"obj":"Species"},{"id":"1066","span":{"begin":170,"end":175},"obj":"Species"},{"id":"1069","span":{"begin":50,"end":65},"obj":"Disease"},{"id":"1070","span":{"begin":90,"end":106},"obj":"Disease"},{"id":"1071","span":{"begin":158,"end":166},"obj":"Disease"},{"id":"1072","span":{"begin":284,"end":306},"obj":"Disease"},{"id":"1073","span":{"begin":107,"end":111},"obj":"CellLine"}],"attributes":[{"id":"A1065","pred":"tao:has_database_id","subj":"1065","obj":"Tax:9606"},{"id":"A1066","pred":"tao:has_database_id","subj":"1066","obj":"Tax:9606"},{"id":"A1069","pred":"tao:has_database_id","subj":"1069","obj":"MESH:D001102"},{"id":"A1070","pred":"tao:has_database_id","subj":"1070","obj":"MESH:D007674"},{"id":"A1071","pred":"tao:has_database_id","subj":"1071","obj":"MESH:D064420"},{"id":"A1072","pred":"tao:has_database_id","subj":"1072","obj":"MESH:D019142"},{"id":"A1073","pred":"tao:has_database_id","subj":"1073","obj":"CVCL:0063"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" nM). Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells. This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM. This data offers a new promising point for the treatment of SARS and Ebola virus infections. 116\nScreening of ~14 000 compound"}

{"project":"LitCovid-sentences","denotations":[{"id":"T310","span":{"begin":6,"end":118},"obj":"Sentence"},{"id":"T311","span":{"begin":119,"end":214},"obj":"Sentence"},{"id":"T312","span":{"begin":215,"end":307},"obj":"Sentence"},{"id":"T313","span":{"begin":308,"end":311},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" nM). Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells. This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM. This data offers a new promising point for the treatment of SARS and Ebola virus infections. 116\nScreening of ~14 000 compound"}