PMC:7461420 / 32615-33262
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T177 | 23-31 | Body_part | denotes | cysteine | http://purl.org/sig/ont/fma/fma82751 |
| T178 | 115-122 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T179 | 160-174 | Body_part | denotes | late endosomes | http://purl.org/sig/ont/fma/fma67467 |
| T180 | 248-252 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T187 | 71-80 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T188 | 317-326 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T372 | 0-5 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T373 | 21-22 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T374 | 56-57 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T375 | 95-105 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T376 | 128-129 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T377 | 242-247 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T378 | 248-252 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T379 | 276-277 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T380 | 328-331 | http://purl.obolibrary.org/obo/CLO_0053001 | denotes | 114 |
| T381 | 582-590 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T296 | 23-31 | Chemical | denotes | cysteine | http://purl.obolibrary.org/obo/CHEBI_15356 |
| T297 | 115-122 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T298 | 211-220 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T299 | 387-396 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1042 | 6-17 | Gene | denotes | cathepsin L | Gene:1514 |
| 1043 | 0-5 | Species | denotes | Human | Tax:9606 |
| 1044 | 357-365 | Chemical | denotes | MDL28170 | MESH:C058076 |
| 1045 | 71-80 | Disease | denotes | infection | MESH:D007239 |
| 1046 | 313-326 | Disease | denotes | CoV infection | MESH:D018352 |
| 1047 | 595-607 | Disease | denotes | cytotoxicity | MESH:D064420 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T303 | 0-175 | Sentence | denotes | Human cathepsin L is a cysteine endopeptidase and plays a key role for infection efficiency by activation of the S protein into a fusogenic state to escape the late endosomes. |
| T304 | 176-327 | Sentence | denotes | Targeting this protease with small molecules could interfere with virus‐cell entry and therefore be a possible intervention strategy for CoV infection. |
| T305 | 328-542 | Sentence | denotes | 114 Bates et al. identified MDL28170 (20; Figure 9) as an antiviral compound that specifically inhibited cathepsin‐L‐mediated substrate cleavage, with an IC50 value of 2.5 nM and EC50 value in the range of 100 nM. |
| T306 | 543-643 | Sentence | denotes | However, despite its potent inhibitory activity, no cytotoxicity data for 20 is currently available. |
| T307 | 644-647 | Sentence | denotes | 115 |