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PMC:7461420 / 32568-35550 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T177 70-78 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T178 162-169 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T179 207-221 Body_part denotes late endosomes http://purl.org/sig/ont/fma/fma67467
T180 295-299 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T181 1114-1120 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T182 1126-1131 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 1197-1214 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T184 1209-1214 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 1362-1366 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T186 1544-1549 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T187 1849-1853 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T188 1880-1884 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T189 2118-2125 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 2201-2208 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T191 2252-2257 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T192 2442-2455 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T193 2442-2446 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T194 2736-2741 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 1114-1120 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T22 1880-1884 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T187 118-127 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T188 364-373 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T189 855-859 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 1058-1063 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T191 1064-1079 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T192 1070-1079 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T193 1289-1293 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 1298-1303 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T195 1304-1320 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T196 2714-2718 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T197 2832-2836 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T198 2942-2946 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 2953-2962 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T372 47-52 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T373 68-69 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T374 103-104 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T375 142-152 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T376 175-176 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T377 289-294 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T378 295-299 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T379 323-324 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T380 375-378 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T381 629-637 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T382 743-751 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T383 812-814 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T384 867-868 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T385 971-973 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T386 1029-1031 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T387 1064-1069 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T388 1098-1103 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T389 1104-1120 http://www.ebi.ac.uk/efo/EFO_0000927 denotes embryonic kidney
T390 1121-1125 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T391 1121-1125 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T392 1121-1125 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T393 1126-1131 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T394 1184-1189 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T395 1190-1196 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T396 1197-1214 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T397 1246-1247 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T398 1304-1309 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T399 1322-1325 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T400 1360-1366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T401 1511-1512 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T402 1539-1543 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T403 1539-1543 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T404 1539-1543 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T405 1544-1549 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T406 1638-1640 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T407 1748-1751 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T408 1786-1792 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T409 1849-1853 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T410 2019-2025 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T411 2244-2257 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T412 2362-2364 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T413 2392-2393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T414 2436-2441 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T415 2442-2446 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T416 2447-2455 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T417 2545-2546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T418 2736-2741 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T419 2748-2749 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T420 2917-2919 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T421 2979-2982 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T293 11-20 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T294 24-46 Chemical denotes cathepsin L inhibitors http://purl.obolibrary.org/obo/CHEBI_70821
T295 36-46 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T296 70-78 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T297 162-169 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T298 258-267 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T299 434-443 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T300 705-727 Chemical denotes Cathepsin L inhibitors http://purl.obolibrary.org/obo/CHEBI_70821
T301 717-727 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T302 733-742 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T303 841-851 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T304 1440-1449 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T305 1722-1732 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T306 1829-1833 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T307 1992-1998 Chemical denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659
T309 2118-2125 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T310 2201-2208 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T311 2394-2403 Chemical denotes benzamide http://purl.obolibrary.org/obo/CHEBI_28179
T312 2487-2496 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T313 2680-2689 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T314 2899-2908 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T45 1465-1475 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T46 1854-1860 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T47 1854-1860 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T48 2447-2462 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T49 2850-2859 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1035 24-35 Gene denotes cathepsin L Gene:1514
1042 53-64 Gene denotes cathepsin L Gene:1514
1043 47-52 Species denotes Human Tax:9606
1044 404-412 Chemical denotes MDL28170 MESH:C058076
1045 118-127 Disease denotes infection MESH:D007239
1046 360-373 Disease denotes CoV infection MESH:D018352
1047 642-654 Disease denotes cytotoxicity MESH:D064420
1049 705-716 Gene denotes Cathepsin L Gene:1514
1062 869-880 Gene denotes cathepsin L Gene:1514
1063 923-934 Gene denotes cathepsin L Gene:1514
1064 855-863 Species denotes SARS‐CoV Tax:694009
1065 1098-1103 Species denotes human Tax:9606
1066 1184-1189 Species denotes human Tax:9606
1067 776-779 Disease denotes CID
1068 798-801 Disease denotes CID
1069 1064-1079 Disease denotes virus infection MESH:D001102
1070 1104-1120 Disease denotes embryonic kidney MESH:D007674
1071 1172-1180 Disease denotes toxicity MESH:D064420
1072 1298-1320 Disease denotes Ebola virus infections MESH:D019142
1073 1121-1125 CellLine denotes 293T CVCL:0063
1077 1413-1475 Gene denotes SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase
1078 1598-1610 Disease denotes cytotoxicity MESH:D064420
1079 1539-1543 CellLine denotes 293T CVCL:0063
1087 2131-2135 Gene denotes ACE2 Gene:59272
1088 2041-2062 Species denotes Polygonum multiflorum Tax:76025
1089 2067-2083 Species denotes Rheum officinale Tax:137220
1090 1992-1998 Chemical denotes emodin MESH:D004642
1091 2394-2403 Chemical denotes benzamide MESH:C037689
1092 1967-1973 Disease denotes Hsiang
1093 2249-2251 CellLine denotes E6 CVCL:4582
1100 2889-2898 Gene denotes Cathepsin
1101 2714-2722 Species denotes SARS‐CoV Tax:694009
1102 2832-2840 Species denotes SARS‐CoV Tax:694009
1103 2929-2937 Species denotes MERS‐CoV Tax:1335626
1104 2909-2915 Chemical denotes E‐64‐D
1105 2942-2962 Disease denotes SARS‐CoV‐1 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T302 0-46 Sentence denotes 2.4 Small‐molecules as cathepsin L inhibitors
T303 47-222 Sentence denotes Human cathepsin L is a cysteine endopeptidase and plays a key role for infection efficiency by activation of the S protein into a fusogenic state to escape the late endosomes.
T304 223-374 Sentence denotes Targeting this protease with small molecules could interfere with virus‐cell entry and therefore be a possible intervention strategy for CoV infection.
T305 375-589 Sentence denotes 114 Bates et al. identified MDL28170 (20; Figure 9) as an antiviral compound that specifically inhibited cathepsin‐L‐mediated substrate cleavage, with an IC50 value of 2.5 nM and EC50 value in the range of 100 nM.
T306 590-690 Sentence denotes However, despite its potent inhibitory activity, no cytotoxicity data for 20 is currently available.
T307 691-694 Sentence denotes 115
T308 695-898 Sentence denotes Figure 9 Cathepsin L inhibitors with antiviral activity Diamond et al. reported CID 16725315 (21) and CID 23631927 (22; Figure 9) as viral entry inhibitors of SARS‐CoV in a cathepsin L inhibition assay.
T309 899-1019 Sentence denotes Compound 21 could block cathepsin L with an IC50 value of 6.9 nM, while 22 showed slightly weaker potency (IC50, 56 nM).
T310 1020-1132 Sentence denotes Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells.
T311 1133-1228 Sentence denotes This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM.
T312 1229-1321 Sentence denotes This data offers a new promising point for the treatment of SARS and Ebola virus infections.
T313 1322-1325 Sentence denotes 116
T314 1326-1507 Sentence denotes Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM.
T315 1508-1637 Sentence denotes In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM.
T316 1638-1640 Sentence denotes 48
T317 1641-1733 Sentence denotes Phenotypic screening approaches led to the identification of several viral entry inhibitors.
T318 1734-1861 Sentence denotes This approach has the advantage of finding cellular‐active compounds, providing information on drug solubility and cell uptake.
T319 1862-1966 Sentence denotes 117 On the other hand, it is limited in terms of capacity compared to in silico target‐based screening.
T320 1967-2258 Sentence denotes Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells.
T321 2259-2338 Sentence denotes However, the mechanism of action of this compound still needs to be determined.
T322 2339-2361 Sentence denotes 118 Sarafianos et al.
T323 2362-2613 Sentence denotes 48 found that SSAA09E3 (25), a benzamide derivative of 24, could prevent virus‐cell membrane fusion in pseudotype‐based and antiviral‐based assays, with an EC50 value of 9.7 µM, but a CC50 value of 20 µM indicates additional unknown cellular targets.
T324 2614-2776 Sentence denotes VE607 (26) was identified among 50 240 structurally diverse small molecules to specifically inhibit SARS‐CoV‐1 entry into cells using a phenotype‐based screening.
T325 2777-2883 Sentence denotes Its EC50 value was reported at 3.0 µM and it inhibited SARS‐CoV‐1 plaque formation with an EC50 of 1.6 µM.
T326 2884-2971 Sentence denotes 119 Cathepsin inhibitor E‐64‐D (27) blocked MERS‐CoV and SARS‐CoV‐1 infection as well.
T327 2972-2982 Sentence denotes 120 , 121