PMC:7461420 / 27046-27458 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T136","span":{"begin":33,"end":37},"obj":"Body_part"},{"id":"T137","span":{"begin":79,"end":86},"obj":"Body_part"},{"id":"T138","span":{"begin":116,"end":121},"obj":"Body_part"},{"id":"T139","span":{"begin":299,"end":303},"obj":"Body_part"}],"attributes":[{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T152","span":{"begin":242,"end":251},"obj":"Disease"},{"id":"T153","span":{"begin":392,"end":396},"obj":"Disease"}],"attributes":[{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A153","pred":"mondo_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T294","span":{"begin":20,"end":21},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T295","span":{"begin":22,"end":27},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T296","span":{"begin":33,"end":37},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T297","span":{"begin":116,"end":121},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T298","span":{"begin":130,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T299","span":{"begin":197,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T300","span":{"begin":288,"end":293},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T301","span":{"begin":299,"end":303},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T302","span":{"begin":354,"end":355},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T248","span":{"begin":79,"end":86},"obj":"Chemical"},{"id":"T249","span":{"begin":214,"end":228},"obj":"Chemical"},{"id":"T250","span":{"begin":214,"end":223},"obj":"Chemical"},{"id":"T251","span":{"begin":224,"end":228},"obj":"Chemical"}],"attributes":[{"id":"A248","pred":"chebi_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T27","span":{"begin":33,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0140253"},{"id":"T28","span":{"begin":33,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0045026"},{"id":"T29","span":{"begin":33,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0000768"},{"id":"T30","span":{"begin":33,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0000747"},{"id":"T31","span":{"begin":299,"end":310},"obj":"http://purl.obolibrary.org/obo/GO_0140253"},{"id":"T32","span":{"begin":299,"end":310},"obj":"http://purl.obolibrary.org/obo/GO_0045026"},{"id":"T33","span":{"begin":299,"end":310},"obj":"http://purl.obolibrary.org/obo/GO_0000768"},{"id":"T34","span":{"begin":299,"end":310},"obj":"http://purl.obolibrary.org/obo/GO_0000747"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}

{"project":"LitCovid-PubTator","denotations":[{"id":"877","span":{"begin":103,"end":107},"obj":"Gene"},{"id":"878","span":{"begin":392,"end":402},"obj":"Species"},{"id":"879","span":{"begin":242,"end":251},"obj":"Species"},{"id":"880","span":{"begin":160,"end":170},"obj":"Chemical"},{"id":"881","span":{"begin":187,"end":194},"obj":"Chemical"}],"attributes":[{"id":"A877","pred":"tao:has_database_id","subj":"877","obj":"Gene:59272"},{"id":"A878","pred":"tao:has_database_id","subj":"878","obj":"Tax:2697049"},{"id":"A879","pred":"tao:has_database_id","subj":"879","obj":"Tax:11309"},{"id":"A880","pred":"tao:has_database_id","subj":"880","obj":"MESH:C086979"},{"id":"A881","pred":"tao:has_database_id","subj":"881","obj":"MESH:C086979"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}

{"project":"LitCovid-sentences","denotations":[{"id":"T255","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T256","span":{"begin":160,"end":311},"obj":"Sentence"},{"id":"T257","span":{"begin":312,"end":403},"obj":"Sentence"},{"id":"T258","span":{"begin":404,"end":412},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy. Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion. 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2. 87 , 88"}