PMC:7461420 / 21454-21808
Annnotations
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T248 | 32-33 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T249 | 250-251 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T201 | 154-163 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T202 | 183-192 | Chemical | denotes | aziridine | http://purl.obolibrary.org/obo/CHEBI_30969 |
| T203 | 193-203 | Chemical | denotes | ethanamine | http://purl.obolibrary.org/obo/CHEBI_15862 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 697 | 75-79 | Gene | denotes | ACE2 | Gene:59272 |
| 698 | 164-203 | Chemical | denotes | N‐(2‐aminoethyl)‐1 aziridine‐ethanamine | |
| 699 | 301-313 | Disease | denotes | cytotoxicity | MESH:D064420 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T209 | 0-266 | Sentence | denotes | Virtual screening combined with a molecular docking approach targeting the ACE2 catalytic site with around 140 000 compounds led to the identification of inhibitor N‐(2‐aminoethyl)‐1 aziridine‐ethanamine (7; Figure 6) with an IC50 value of 57 µM and a K i of 459 µM. |
| T210 | 267-351 | Sentence | denotes | However, no information about the cytotoxicity of this compound is available so far. |
| T211 | 352-354 | Sentence | denotes | 62 |