PMC:7461420 / 16086-16479 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T94","span":{"begin":230,"end":235},"obj":"Body_part"},{"id":"T95","span":{"begin":366,"end":371},"obj":"Body_part"}],"attributes":[{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"MERS‐4 and MERS‐27 are monoclonal antibodies targeting the RBD of MERS‐CoV S that were discovered in a nonimmune yeast‐display scFv library screening. The more active MERS‐4 potently blocked the infection of DPP4‐expressing Huh‐7 cells with pseudotyped MERS‐CoV (IC50, 0.056 μg/mL). It also prevented MERS‐CoV‐induced cytopathogenic effects in MERS‐infected Vero E6 cells (IC50, 0.5 μg/mL). 42"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T92","span":{"begin":195,"end":204},"obj":"Disease"}],"attributes":[{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"MERS‐4 and MERS‐27 are monoclonal antibodies targeting the RBD of MERS‐CoV S that were discovered in a nonimmune yeast‐display scFv library screening. The more active MERS‐4 potently blocked the infection of DPP4‐expressing Huh‐7 cells with pseudotyped MERS‐CoV (IC50, 0.056 μg/mL). It also prevented MERS‐CoV‐induced cytopathogenic effects in MERS‐infected Vero E6 cells (IC50, 0.5 μg/mL). 42"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T176","span":{"begin":16,"end":18},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T177","span":{"begin":101,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T178","span":{"begin":160,"end":166},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T179","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/CLO_0009989"},{"id":"T180","span":{"begin":230,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T181","span":{"begin":358,"end":371},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"}],"text":"MERS‐4 and MERS‐27 are monoclonal antibodies targeting the RBD of MERS‐CoV S that were discovered in a nonimmune yeast‐display scFv library screening. The more active MERS‐4 potently blocked the infection of DPP4‐expressing Huh‐7 cells with pseudotyped MERS‐CoV (IC50, 0.056 μg/mL). It also prevented MERS‐CoV‐induced cytopathogenic effects in MERS‐infected Vero E6 cells (IC50, 0.5 μg/mL). 42"}

{"project":"LitCovid-PubTator","denotations":[{"id":"541","span":{"begin":208,"end":212},"obj":"Gene"},{"id":"542","span":{"begin":66,"end":74},"obj":"Species"},{"id":"543","span":{"begin":113,"end":118},"obj":"Species"},{"id":"544","span":{"begin":253,"end":261},"obj":"Species"},{"id":"545","span":{"begin":301,"end":309},"obj":"Species"},{"id":"546","span":{"begin":195,"end":204},"obj":"Disease"},{"id":"547","span":{"begin":344,"end":357},"obj":"Disease"},{"id":"548","span":{"begin":224,"end":229},"obj":"CellLine"},{"id":"549","span":{"begin":363,"end":365},"obj":"CellLine"}],"attributes":[{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"Gene:1803"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"Tax:1335626"},{"id":"A543","pred":"tao:has_database_id","subj":"543","obj":"Tax:4932"},{"id":"A544","pred":"tao:has_database_id","subj":"544","obj":"Tax:1335626"},{"id":"A545","pred":"tao:has_database_id","subj":"545","obj":"Tax:1335626"},{"id":"A546","pred":"tao:has_database_id","subj":"546","obj":"MESH:D007239"},{"id":"A547","pred":"tao:has_database_id","subj":"547","obj":"MESH:D018352"},{"id":"A548","pred":"tao:has_database_id","subj":"548","obj":"CVCL:0336"},{"id":"A549","pred":"tao:has_database_id","subj":"549","obj":"CVCL:4582"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"MERS‐4 and MERS‐27 are monoclonal antibodies targeting the RBD of MERS‐CoV S that were discovered in a nonimmune yeast‐display scFv library screening. The more active MERS‐4 potently blocked the infection of DPP4‐expressing Huh‐7 cells with pseudotyped MERS‐CoV (IC50, 0.056 μg/mL). It also prevented MERS‐CoV‐induced cytopathogenic effects in MERS‐infected Vero E6 cells (IC50, 0.5 μg/mL). 42"}

{"project":"LitCovid-sentences","denotations":[{"id":"T165","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"T166","span":{"begin":151,"end":282},"obj":"Sentence"},{"id":"T167","span":{"begin":283,"end":390},"obj":"Sentence"},{"id":"T168","span":{"begin":391,"end":393},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"MERS‐4 and MERS‐27 are monoclonal antibodies targeting the RBD of MERS‐CoV S that were discovered in a nonimmune yeast‐display scFv library screening. The more active MERS‐4 potently blocked the infection of DPP4‐expressing Huh‐7 cells with pseudotyped MERS‐CoV (IC50, 0.056 μg/mL). It also prevented MERS‐CoV‐induced cytopathogenic effects in MERS‐infected Vero E6 cells (IC50, 0.5 μg/mL). 42"}