PMC:7461420 / 12694-13531
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T79 | 35-42 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T80 | 115-122 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T81 | 331-335 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T75 | 51-55 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T76 | 76-80 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T77 | 172-176 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T78 | 279-283 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T79 | 580-584 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T80 | 759-763 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 68-70 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | aa |
| T129 | 93-95 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | aa |
| T130 | 123-126 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T131 | 140-142 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T132 | 147-149 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T133 | 147-149 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T134 | 155-157 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T135 | 183-186 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T136 | 187-188 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T137 | 320-325 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T138 | 331-335 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T139 | 386-387 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T78 | 35-42 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T79 | 115-122 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T80 | 147-149 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T81 | 559-561 | Chemical | denotes | EM | http://purl.obolibrary.org/obo/CHEBI_73507 |
| T82 | 666-674 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 455 | 29-34 | Gene | denotes | spike | Gene:43740568 |
| 456 | 109-114 | Gene | denotes | spike | Gene:43740568 |
| 457 | 236-240 | Gene | denotes | ACE2 | Gene:59272 |
| 458 | 481-485 | Gene | denotes | ACE2 | Gene:59272 |
| 459 | 597-601 | Gene | denotes | ACE2 | Gene:59272 |
| 460 | 715-719 | Gene | denotes | ACE2 | Gene:59272 |
| 461 | 591-596 | Gene | denotes | spike | Gene:43740568 |
| 462 | 51-59 | Species | denotes | SARS‐CoV | Tax:694009 |
| 463 | 76-86 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 464 | 172-180 | Species | denotes | SARS‐CoV | Tax:694009 |
| 465 | 279-289 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 466 | 320-325 | Species | denotes | human | Tax:9606 |
| 467 | 580-588 | Species | denotes | SARS‐CoV | Tax:694009 |
| 468 | 759-769 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 469 | 666-674 | Chemical | denotes | hydrogen | MESH:D006859 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T134 | 0-104 | Sentence | denotes | The sequence identity of the spike protein between SARS‐CoV‐1 (1273 aa) and SARS‐CoV‐2 (1253 aa) is 76%. |
| T135 | 105-150 | Sentence | denotes | The spike protein has two regions, S1 and S2. |
| T136 | 151-241 | Sentence | denotes | The S1 region of the SARS‐CoV‐1 has a RBD that forms high‐affinity interactions with ACE2. |
| T137 | 242-344 | Sentence | denotes | The prevailing understanding is that SARS‐CoV‐2 employs this RBD to enter its human host cell as well. |
| T138 | 345-415 | Sentence | denotes | Aligning the two different RBDs revealed a sequence identity of 73.5%. |
| T139 | 416-528 | Sentence | denotes | However, many nonconserved mutations that interact directly with ACE2 are located in the two structural regions. |
| T140 | 529-720 | Sentence | denotes | 31 And both crystal and cryo‐EM structures of the SARS‐CoV‐1 spike‐ACE2 complex have shown that merely residues of regions 1 and 2 form hydrogen bonds and hydrophobic interactions with ACE2. |
| T141 | 721-834 | Sentence | denotes | The mutations in these two regions of SARS‐CoV‐2 will, therefore, likely reduce the number of those interactions. |
| T142 | 835-837 | Sentence | denotes | 32 |