PMC:7456455 / 29177-30161 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T371","span":{"begin":908,"end":913},"obj":"Body_part"},{"id":"T372","span":{"begin":952,"end":962},"obj":"Body_part"},{"id":"T373","span":{"begin":967,"end":978},"obj":"Body_part"}],"attributes":[{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A373","pred":"fma_id","subj":"T373","obj":"http://purl.org/sig/ont/fma/fma63261"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T192","span":{"begin":19,"end":23},"obj":"Disease"},{"id":"T193","span":{"begin":443,"end":461},"obj":"Disease"},{"id":"T194","span":{"begin":642,"end":651},"obj":"Disease"},{"id":"T195","span":{"begin":795,"end":807},"obj":"Disease"},{"id":"T196","span":{"begin":861,"end":879},"obj":"Disease"}],"attributes":[{"id":"A192","pred":"mondo_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A193","pred":"mondo_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A195","pred":"mondo_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0004955"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T417","span":{"begin":40,"end":47},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T418","span":{"begin":128,"end":129},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T419","span":{"begin":162,"end":163},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T420","span":{"begin":221,"end":222},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T421","span":{"begin":301,"end":306},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T422","span":{"begin":689,"end":690},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T423","span":{"begin":952,"end":962},"obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"T424","span":{"begin":980,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T158","span":{"begin":731,"end":742},"obj":"Chemical"},{"id":"T159","span":{"begin":908,"end":913},"obj":"Chemical"}],"attributes":[{"id":"A158","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T131","span":{"begin":743,"end":753},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T132","span":{"begin":908,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0006629"},{"id":"T133","span":{"begin":914,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0008152"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T174","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T175","span":{"begin":162,"end":244},"obj":"Sentence"},{"id":"T176","span":{"begin":245,"end":307},"obj":"Sentence"},{"id":"T177","span":{"begin":308,"end":501},"obj":"Sentence"},{"id":"T178","span":{"begin":502,"end":596},"obj":"Sentence"},{"id":"T179","span":{"begin":597,"end":836},"obj":"Sentence"},{"id":"T180","span":{"begin":837,"end":984},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T46","span":{"begin":795,"end":807},"obj":"Phenotype"}],"attributes":[{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0000822"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"2_test","denotations":[{"id":"32861199-32145185-26409862","span":{"begin":158,"end":159},"obj":"32145185"},{"id":"32861199-25612251-26409863","span":{"begin":980,"end":982},"obj":"25612251"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T758","span":{"begin":19,"end":28},"obj":"SP_7"},{"id":"T759","span":{"begin":40,"end":47},"obj":"NCBITaxon:10239"},{"id":"T760","span":{"begin":65,"end":78},"obj":"NCBITaxon:11118"},{"id":"T761","span":{"begin":193,"end":203},"obj":"GO:0010467"},{"id":"T762","span":{"begin":213,"end":217},"obj":"G_3;PG_10;PR:000003622"},{"id":"T763","span":{"begin":223,"end":228},"obj":"NCBITaxon:10239;GO:0035376"},{"id":"T764","span":{"begin":229,"end":234},"obj":"GO:0035376"},{"id":"T765","span":{"begin":301,"end":306},"obj":"NCBITaxon:10239"},{"id":"T766","span":{"begin":743,"end":753},"obj":"GO:0065007"},{"id":"T767","span":{"begin":812,"end":826},"obj":"UBERON:0004535"},{"id":"T768","span":{"begin":861,"end":870},"obj":"GO:0008152"},{"id":"T769","span":{"begin":908,"end":913},"obj":"CHEBI:18059;CHEBI:18059;GO:0006629"},{"id":"T770","span":{"begin":914,"end":924},"obj":"GO:0006629"},{"id":"T771","span":{"begin":952,"end":962},"obj":"CL:0000136"},{"id":"T772","span":{"begin":967,"end":978},"obj":"CL:0000235"},{"id":"T52248","span":{"begin":368,"end":378},"obj":"GO:0065007"},{"id":"T39145","span":{"begin":437,"end":451},"obj":"UBERON:0004535"},{"id":"T54472","span":{"begin":486,"end":493},"obj":"GO:0008152"},{"id":"T9956","span":{"begin":531,"end":535},"obj":"CHEBI:18059;CHEBI:18059;GO:0006629"},{"id":"T61482","span":{"begin":536,"end":544},"obj":"GO:0006629"},{"id":"T56239","span":{"begin":572,"end":582},"obj":"CL:0000136"},{"id":"T35010","span":{"begin":587,"end":598},"obj":"CL:0000235"},{"id":"T95714","span":{"begin":629,"end":639},"obj":"GO:0005634;CL:0000113"},{"id":"T94342","span":{"begin":640,"end":649},"obj":"CL:0000113"},{"id":"T11208","span":{"begin":679,"end":688},"obj":"CL:0000576"},{"id":"T49373","span":{"begin":690,"end":701},"obj":"CL:0000094"},{"id":"T86009","span":{"begin":706,"end":715},"obj":"GO:0030425;CL:0000451"},{"id":"T95857","span":{"begin":716,"end":720},"obj":"CL:0000451"},{"id":"T87726","span":{"begin":726,"end":735},"obj":"CL:0000576"},{"id":"T69224","span":{"begin":760,"end":768},"obj":"SP_7"},{"id":"T53111","span":{"begin":782,"end":790},"obj":"CL:0000576;GO:0042117"},{"id":"T29204","span":{"begin":791,"end":801},"obj":"GO:0042117"},{"id":"T71138","span":{"begin":893,"end":902},"obj":"CL:0000576"},{"id":"T97182","span":{"begin":928,"end":932},"obj":"PR:000005930"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"684","span":{"begin":213,"end":217},"obj":"Gene"},{"id":"685","span":{"begin":19,"end":28},"obj":"Species"},{"id":"686","span":{"begin":65,"end":78},"obj":"Species"},{"id":"687","span":{"begin":908,"end":913},"obj":"Chemical"},{"id":"688","span":{"begin":443,"end":461},"obj":"Disease"},{"id":"689","span":{"begin":642,"end":651},"obj":"Disease"},{"id":"690","span":{"begin":795,"end":807},"obj":"Disease"},{"id":"691","span":{"begin":861,"end":879},"obj":"Disease"}],"attributes":[{"id":"A684","pred":"tao:has_database_id","subj":"684","obj":"Gene:59272"},{"id":"A685","pred":"tao:has_database_id","subj":"685","obj":"Tax:2697049"},{"id":"A686","pred":"tao:has_database_id","subj":"686","obj":"Tax:11118"},{"id":"A687","pred":"tao:has_database_id","subj":"687","obj":"MESH:D008055"},{"id":"A688","pred":"tao:has_database_id","subj":"688","obj":"MESH:D003141"},{"id":"A689","pred":"tao:has_database_id","subj":"689","obj":"MESH:D007239"},{"id":"A690","pred":"tao:has_database_id","subj":"690","obj":"MESH:D006973"},{"id":"A691","pred":"tao:has_database_id","subj":"691","obj":"MESH:D024821"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}

{"project":"MyTest","denotations":[{"id":"32861199-32145185-26409862","span":{"begin":158,"end":159},"obj":"32145185"},{"id":"32861199-25612251-26409863","span":{"begin":980,"end":982},"obj":"25612251"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"What distinguishes SARS-CoV2 from other viruses, including other coronaviruses, although the hyperinflammatory storm is clearly a feature of its forerunners [6]. A strong candidate must be the expression level of ACE2 as a viral entry receptor. The host also determines the outcome of exposure to the virus. In his prescient views of the role of the external and internal host environment, Rene Dubos differed from the standard germ theory of infectious disease, as necessary, but not sufficient [77]. The pre- and post- clinical features of the present pandemic illustrate this concept superbly. Although host susceptibility and severity of infection are clearly multifactorial, there is a thread from the role of its receptor in angiotensin regulation, vascular tone and permeability, through hypertension and cardiovascular function. The connection with the metabolic syndrome suggests an unknown link to lipid metabolism, including interactions of adipocytes and macrophages [35]."}