PMC:7456455 / 28157-29160 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T364","span":{"begin":131,"end":135},"obj":"Body_part"},{"id":"T365","span":{"begin":184,"end":194},"obj":"Body_part"},{"id":"T366","span":{"begin":267,"end":275},"obj":"Body_part"},{"id":"T367","span":{"begin":624,"end":633},"obj":"Body_part"},{"id":"T368","span":{"begin":715,"end":723},"obj":"Body_part"},{"id":"T369","span":{"begin":793,"end":801},"obj":"Body_part"},{"id":"T370","span":{"begin":905,"end":913},"obj":"Body_part"}],"attributes":[{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma58235"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma62864"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T186","span":{"begin":149,"end":161},"obj":"Disease"},{"id":"T187","span":{"begin":176,"end":180},"obj":"Disease"},{"id":"T188","span":{"begin":299,"end":302},"obj":"Disease"},{"id":"T189","span":{"begin":318,"end":328},"obj":"Disease"},{"id":"T190","span":{"begin":365,"end":373},"obj":"Disease"},{"id":"T191","span":{"begin":398,"end":406},"obj":"Disease"}],"attributes":[{"id":"A186","pred":"mondo_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/MONDO_0018076"},{"id":"A187","pred":"mondo_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/MONDO_0012268"},{"id":"A188","pred":"mondo_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"},{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T410","span":{"begin":49,"end":50},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T411","span":{"begin":335,"end":338},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T412","span":{"begin":624,"end":633},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T413","span":{"begin":642,"end":644},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T414","span":{"begin":715,"end":723},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T415","span":{"begin":905,"end":913},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T416","span":{"begin":914,"end":924},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T155","span":{"begin":760,"end":766},"obj":"Chemical"},{"id":"T156","span":{"begin":771,"end":779},"obj":"Chemical"},{"id":"T157","span":{"begin":780,"end":791},"obj":"Chemical"}],"attributes":[{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T127","span":{"begin":591,"end":613},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T128","span":{"begin":793,"end":811},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T129","span":{"begin":802,"end":811},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T130","span":{"begin":905,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0042117"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-sentences","denotations":[{"id":"T168","span":{"begin":0,"end":248},"obj":"Sentence"},{"id":"T169","span":{"begin":249,"end":383},"obj":"Sentence"},{"id":"T170","span":{"begin":384,"end":671},"obj":"Sentence"},{"id":"T171","span":{"begin":672,"end":880},"obj":"Sentence"},{"id":"T172","span":{"begin":881,"end":1003},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"2_test","denotations":[{"id":"32861199-30124473-26409860","span":{"begin":244,"end":246},"obj":"30124473"},{"id":"32861199-32579067-26409861","span":{"begin":559,"end":560},"obj":"32579067"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T738","span":{"begin":51,"end":56},"obj":"NCBITaxon:10239"},{"id":"T739","span":{"begin":184,"end":194},"obj":"CL:0000542"},{"id":"T740","span":{"begin":222,"end":232},"obj":"NCBITaxon:11632"},{"id":"T741","span":{"begin":267,"end":275},"obj":"GO:0042571"},{"id":"T742","span":{"begin":307,"end":317},"obj":"NCBITaxon:31032"},{"id":"T743","span":{"begin":365,"end":373},"obj":"SP_7"},{"id":"T744","span":{"begin":398,"end":406},"obj":"SP_7"},{"id":"T745","span":{"begin":407,"end":417},"obj":"GO:0042571"},{"id":"T746","span":{"begin":422,"end":428},"obj":"UBERON:0002405"},{"id":"T747","span":{"begin":429,"end":438},"obj":"GO:0032991"},{"id":"T748","span":{"begin":578,"end":590},"obj":"GO:0065007"},{"id":"T749","span":{"begin":624,"end":633},"obj":"CL:0000576"},{"id":"T750","span":{"begin":715,"end":723},"obj":"CL:0000576"},{"id":"T751","span":{"begin":751,"end":766},"obj":"CHEBI:26523;CHEBI:26523"},{"id":"T752","span":{"begin":780,"end":791},"obj":"CHEBI:25212;CHEBI:25212"},{"id":"T753","span":{"begin":813,"end":825},"obj":"GO:0050817"},{"id":"T754","span":{"begin":830,"end":842},"obj":"GO:0042730"},{"id":"T755","span":{"begin":905,"end":913},"obj":"CL:0000576;GO:0042117"},{"id":"T756","span":{"begin":914,"end":924},"obj":"GO:0042117"},{"id":"T757","span":{"begin":958,"end":964},"obj":"UBERON:0002405"},{"id":"T56473","span":{"begin":23,"end":31},"obj":"SP_7"},{"id":"T17708","span":{"begin":32,"end":42},"obj":"GO:0042571"},{"id":"T96260","span":{"begin":47,"end":52},"obj":"UBERON:0002405"},{"id":"T16932","span":{"begin":53,"end":62},"obj":"GO:0032991"},{"id":"T83618","span":{"begin":203,"end":215},"obj":"GO:0065007"},{"id":"T85390","span":{"begin":249,"end":258},"obj":"CL:0000576"},{"id":"T77058","span":{"begin":340,"end":348},"obj":"CL:0000576"},{"id":"T19955","span":{"begin":376,"end":391},"obj":"CHEBI:26523;CHEBI:26523"},{"id":"T66101","span":{"begin":405,"end":414},"obj":"CHEBI:25212;CHEBI:25212"},{"id":"T29197","span":{"begin":437,"end":449},"obj":"GO:0050817"},{"id":"T33371","span":{"begin":454,"end":466},"obj":"GO:0042730"},{"id":"T53024","span":{"begin":528,"end":536},"obj":"CL:0000576;GO:0042117"},{"id":"T82110","span":{"begin":537,"end":547},"obj":"GO:0042117"},{"id":"T1808","span":{"begin":581,"end":586},"obj":"UBERON:0002405"},{"id":"T95891","span":{"begin":659,"end":668},"obj":"SP_7"},{"id":"T4324","span":{"begin":680,"end":687},"obj":"NCBITaxon:10239"},{"id":"T24700","span":{"begin":705,"end":718},"obj":"NCBITaxon:11118"},{"id":"T44459","span":{"begin":834,"end":844},"obj":"GO:0010467"},{"id":"T84932","span":{"begin":854,"end":858},"obj":"G_3;PG_10;PR:000003622"},{"id":"T46796","span":{"begin":864,"end":869},"obj":"NCBITaxon:10239;GO:0035376"},{"id":"T33366","span":{"begin":870,"end":876},"obj":"GO:0035376"},{"id":"T51478","span":{"begin":943,"end":948},"obj":"NCBITaxon:10239"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"LitCovid-PubTator","denotations":[{"id":"666","span":{"begin":162,"end":170},"obj":"Species"},{"id":"667","span":{"begin":760,"end":766},"obj":"Chemical"},{"id":"668","span":{"begin":771,"end":779},"obj":"Chemical"},{"id":"669","span":{"begin":18,"end":30},"obj":"Disease"},{"id":"670","span":{"begin":149,"end":161},"obj":"Disease"},{"id":"671","span":{"begin":176,"end":180},"obj":"Disease"},{"id":"672","span":{"begin":307,"end":328},"obj":"Disease"},{"id":"673","span":{"begin":365,"end":373},"obj":"Disease"},{"id":"674","span":{"begin":398,"end":406},"obj":"Disease"},{"id":"675","span":{"begin":867,"end":879},"obj":"Disease"}],"attributes":[{"id":"A666","pred":"tao:has_database_id","subj":"666","obj":"Tax:9606"},{"id":"A667","pred":"tao:has_database_id","subj":"667","obj":"MESH:D010100"},{"id":"A668","pred":"tao:has_database_id","subj":"668","obj":"MESH:D009584"},{"id":"A670","pred":"tao:has_database_id","subj":"670","obj":"MESH:D014376"},{"id":"A671","pred":"tao:has_database_id","subj":"671","obj":"MESH:D000163"},{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"MESH:D018177"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"MESH:C000657245"},{"id":"A674","pred":"tao:has_database_id","subj":"674","obj":"MESH:C000657245"},{"id":"A675","pred":"tao:has_database_id","subj":"675","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}

{"project":"MyTest","denotations":[{"id":"32861199-30124473-26409860","span":{"begin":244,"end":246},"obj":"30124473"},{"id":"32861199-32579067-26409861","span":{"begin":559,"end":560},"obj":"32579067"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Reconstitution of lymphopaenia may contribute to a viral-induced storm resembling the Immune Reconstitution Inflammatory Syndrome (IRIS) observed in tuberculosis patients with AIDS as lymphocyte counts recover during anti-retroviral treatment [76]. The phenomenon of antibody-dependent enhancement (ADE) of flavivirus infections [10], has not been demonstrated for COVID-19, to date. However, anti COVID-19 antibodies and immune complexes, induced by prior vaccination, during the course of the disease or by passive transfer of IVIg or pools of “elite” mab [5,71], may enhance dysregulated inflammatory responses of primed monocytes through Fc- and complement receptors. This entails characterization of ITAM/ITIM monocyte FcR functions, analysis of reactive oxygen and nitrogen metabolites, cytokine secretion, procoagulant and fibrinolytic responses, and cellular cytotoxicity. Longitudinal studies of monocyte activation and cost/benefit analysis of any immune interventions are therefore mandatory."}