PMC:7456455 / 24539-25430 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T316","span":{"begin":98,"end":103},"obj":"Body_part"},{"id":"T317","span":{"begin":228,"end":232},"obj":"Body_part"},{"id":"T318","span":{"begin":278,"end":282},"obj":"Body_part"},{"id":"T319","span":{"begin":283,"end":287},"obj":"Body_part"},{"id":"T320","span":{"begin":300,"end":334},"obj":"Body_part"},{"id":"T321","span":{"begin":329,"end":334},"obj":"Body_part"},{"id":"T322","span":{"begin":442,"end":446},"obj":"Body_part"},{"id":"T323","span":{"begin":449,"end":458},"obj":"Body_part"},{"id":"T324","span":{"begin":498,"end":507},"obj":"Body_part"},{"id":"T325","span":{"begin":512,"end":518},"obj":"Body_part"},{"id":"T326","span":{"begin":519,"end":530},"obj":"Body_part"},{"id":"T327","span":{"begin":605,"end":616},"obj":"Body_part"},{"id":"T328","span":{"begin":725,"end":736},"obj":"Body_part"}],"attributes":[{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma86713"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma63261"}],"text":"Recovery can be prolonged after severe infection, involving fever, lethargy, scarring and loss of organ function. Italiani and colleagues profiled the course of resolving versus persistent inflammation with special reference to IL-1 family molecules [57]. An independent single cell mRNA analysis of peripheral blood mononuclear cells during early recovery of COVID-19 infection [23], revealed an increased ratio and level of classical CD14++IL-1β+ monocytes. Further studies are needed to compare monocytes and tissue macrophages after mild or severe infection and to establish whether repolarisation of macrophages from M1 to an M2 phenotype can promote resolution and recovery after COVID-19. After helminth infection, M2 macrophages express resistin, which protects against LPS-induced toxic shock [74]. New or repurposed therapies may be able to modify the sequelae of severe infection."}

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{"project":"2_test","denotations":[{"id":"32861199-32377375-26409856","span":{"begin":380,"end":382},"obj":"32377375"},{"id":"32861199-29133417-26409857","span":{"begin":803,"end":805},"obj":"29133417"}],"text":"Recovery can be prolonged after severe infection, involving fever, lethargy, scarring and loss of organ function. Italiani and colleagues profiled the course of resolving versus persistent inflammation with special reference to IL-1 family molecules [57]. An independent single cell mRNA analysis of peripheral blood mononuclear cells during early recovery of COVID-19 infection [23], revealed an increased ratio and level of classical CD14++IL-1β+ monocytes. Further studies are needed to compare monocytes and tissue macrophages after mild or severe infection and to establish whether repolarisation of macrophages from M1 to an M2 phenotype can promote resolution and recovery after COVID-19. After helminth infection, M2 macrophages express resistin, which protects against LPS-induced toxic shock [74]. New or repurposed therapies may be able to modify the sequelae of severe infection."}

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