PMC:7456455 / 21766-23041 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T288","span":{"begin":27,"end":38},"obj":"Body_part"},{"id":"T289","span":{"begin":143,"end":147},"obj":"Body_part"},{"id":"T290","span":{"begin":225,"end":235},"obj":"Body_part"},{"id":"T291","span":{"begin":327,"end":331},"obj":"Body_part"},{"id":"T292","span":{"begin":391,"end":397},"obj":"Body_part"},{"id":"T293","span":{"begin":696,"end":709},"obj":"Body_part"},{"id":"T294","span":{"begin":722,"end":732},"obj":"Body_part"},{"id":"T295","span":{"begin":831,"end":836},"obj":"Body_part"},{"id":"T296","span":{"begin":906,"end":916},"obj":"Body_part"},{"id":"T297","span":{"begin":1086,"end":1097},"obj":"Body_part"}],"attributes":[{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A291","pred":"fma_id","subj":"T291","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A292","pred":"fma_id","subj":"T292","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma82779"},{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A296","pred":"fma_id","subj":"T296","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A297","pred":"fma_id","subj":"T297","obj":"http://purl.org/sig/ont/fma/fma63261"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T76","span":{"begin":391,"end":397},"obj":"Body_part"}],"attributes":[{"id":"A76","pred":"uberon_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T149","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"T150","span":{"begin":148,"end":154},"obj":"Disease"},{"id":"T151","span":{"begin":398,"end":404},"obj":"Disease"},{"id":"T152","span":{"begin":1252,"end":1264},"obj":"Disease"}],"attributes":[{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T322","span":{"begin":13,"end":23},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T323","span":{"begin":129,"end":134},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T324","span":{"begin":143,"end":147},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T325","span":{"begin":289,"end":299},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T326","span":{"begin":431,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T327","span":{"begin":443,"end":444},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T328","span":{"begin":534,"end":542},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T329","span":{"begin":544,"end":547},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T330","span":{"begin":831,"end":836},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T331","span":{"begin":874,"end":883},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T332","span":{"begin":950,"end":952},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T333","span":{"begin":1036,"end":1038},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T334","span":{"begin":1036,"end":1038},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T335","span":{"begin":1076,"end":1085},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T92","span":{"begin":255,"end":263},"obj":"Chemical"},{"id":"T93","span":{"begin":327,"end":329},"obj":"Chemical"},{"id":"T95","span":{"begin":665,"end":667},"obj":"Chemical"},{"id":"T97","span":{"begin":687,"end":709},"obj":"Chemical"},{"id":"T98","span":{"begin":696,"end":709},"obj":"Chemical"},{"id":"T99","span":{"begin":804,"end":810},"obj":"Chemical"},{"id":"T100","span":{"begin":917,"end":921},"obj":"Chemical"},{"id":"T101","span":{"begin":1005,"end":1009},"obj":"Chemical"},{"id":"T102","span":{"begin":1036,"end":1038},"obj":"Chemical"},{"id":"T106","span":{"begin":1056,"end":1064},"obj":"Chemical"},{"id":"T107","span":{"begin":1154,"end":1165},"obj":"Chemical"},{"id":"T108","span":{"begin":1170,"end":1180},"obj":"Chemical"}],"attributes":[{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A94","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A96","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_60156"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_16247"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_33292"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_18248"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_51079"},{"id":"A103","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_139019"},{"id":"A104","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_140152"},{"id":"A105","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_34826"},{"id":"A106","pred":"chebi_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A107","pred":"chebi_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T87","span":{"begin":156,"end":165},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T88","span":{"begin":156,"end":165},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T89","span":{"begin":167,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T90","span":{"begin":167,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T91","span":{"begin":167,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T92","span":{"begin":167,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T93","span":{"begin":180,"end":191},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T94","span":{"begin":180,"end":191},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T95","span":{"begin":327,"end":342},"obj":"http://purl.obolibrary.org/obo/GO_0032612"},{"id":"T96","span":{"begin":359,"end":368},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T97","span":{"begin":423,"end":441},"obj":"http://purl.obolibrary.org/obo/GO_0006919"},{"id":"T98","span":{"begin":608,"end":629},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T99","span":{"begin":733,"end":743},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T100","span":{"begin":1106,"end":1117},"obj":"http://purl.obolibrary.org/obo/GO_0050817"},{"id":"T101","span":{"begin":1122,"end":1141},"obj":"http://purl.obolibrary.org/obo/GO_0006956"},{"id":"T102","span":{"begin":1252,"end":1264},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-sentences","denotations":[{"id":"T129","span":{"begin":0,"end":274},"obj":"Sentence"},{"id":"T130","span":{"begin":275,"end":442},"obj":"Sentence"},{"id":"T131","span":{"begin":443,"end":675},"obj":"Sentence"},{"id":"T132","span":{"begin":676,"end":777},"obj":"Sentence"},{"id":"T133","span":{"begin":778,"end":905},"obj":"Sentence"},{"id":"T134","span":{"begin":906,"end":1075},"obj":"Sentence"},{"id":"T135","span":{"begin":1076,"end":1275},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T36","span":{"begin":971,"end":978},"obj":"Phenotype"},{"id":"T37","span":{"begin":1269,"end":1274},"obj":"Phenotype"}],"attributes":[{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0000969"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"2_test","denotations":[{"id":"32861199-31768073-26409851","span":{"begin":773,"end":775},"obj":"31768073"},{"id":"32861199-29045901-26409852","span":{"begin":901,"end":903},"obj":"29045901"},{"id":"32861199-30428148-26409853","span":{"begin":950,"end":952},"obj":"30428148"},{"id":"32861199-30275460-26409854","span":{"begin":997,"end":999},"obj":"30275460"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T581","span":{"begin":0,"end":12},"obj":"GO:0065007"},{"id":"T582","span":{"begin":13,"end":26},"obj":"GO:0042116"},{"id":"T583","span":{"begin":27,"end":38},"obj":"CL:0000235"},{"id":"T584","span":{"begin":80,"end":90},"obj":"GO:0007596"},{"id":"T585","span":{"begin":110,"end":118},"obj":"SP_7"},{"id":"T586","span":{"begin":156,"end":165},"obj":"GO:0006915"},{"id":"T587","span":{"begin":225,"end":235},"obj":"CL:0000235"},{"id":"T588","span":{"begin":255,"end":263},"obj":"CHEBI:35224;CHEBI:35224"},{"id":"T589","span":{"begin":327,"end":342},"obj":"GO:0032612"},{"id":"T590","span":{"begin":391,"end":397},"obj":"UBERON:0000479"},{"id":"T591","span":{"begin":423,"end":441},"obj":"GO:0006919"},{"id":"T592","span":{"begin":514,"end":529},"obj":"GO:1990774"},{"id":"T593","span":{"begin":657,"end":660},"obj":"PR:000000134"},{"id":"T594","span":{"begin":665,"end":669},"obj":"PR:000001393"},{"id":"T595","span":{"begin":687,"end":695},"obj":"MOP:0000568;CHEBI:60156;CHEBI:60156"},{"id":"T596","span":{"begin":696,"end":709},"obj":"CHEBI:60156;CHEBI:60156"},{"id":"T597","span":{"begin":722,"end":732},"obj":"CL:0000235;GO:0042116"},{"id":"T598","span":{"begin":733,"end":743},"obj":"GO:0008152"},{"id":"T599","span":{"begin":791,"end":803},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T600","span":{"begin":804,"end":810},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T601","span":{"begin":825,"end":830},"obj":"GO:0016265"},{"id":"T602","span":{"begin":838,"end":842},"obj":"PR:000001889"},{"id":"T603","span":{"begin":863,"end":873},"obj":"GO:0017156"},{"id":"T604","span":{"begin":874,"end":883},"obj":"GO:0006909;CL:0000234"},{"id":"T605","span":{"begin":906,"end":916},"obj":"CL:0000235"},{"id":"T606","span":{"begin":980,"end":985},"obj":"PR:000014721"},{"id":"T607","span":{"begin":1056,"end":1064},"obj":"CHEBI:35224;CHEBI:35224"},{"id":"T608","span":{"begin":1086,"end":1097},"obj":"CL:0000235"},{"id":"T609","span":{"begin":1106,"end":1117},"obj":"GO:0050817"},{"id":"T610","span":{"begin":1195,"end":1206},"obj":"GO:0065007"},{"id":"T78218","span":{"begin":17,"end":23},"obj":"UBERON:0000479"},{"id":"T72096","span":{"begin":49,"end":67},"obj":"GO:0006919"},{"id":"T53568","span":{"begin":140,"end":155},"obj":"GO:1990774"},{"id":"T5276","span":{"begin":283,"end":286},"obj":"PR:000000134"},{"id":"T5329","span":{"begin":291,"end":295},"obj":"PR:000001393"},{"id":"T2479","span":{"begin":313,"end":320},"obj":"MOP:0000568;CHEBI:60156;CHEBI:60156"},{"id":"T33873","span":{"begin":321,"end":333},"obj":"CHEBI:60156;CHEBI:60156"},{"id":"T53122","span":{"begin":346,"end":356},"obj":"CL:0000235;GO:0042116"},{"id":"T25190","span":{"begin":357,"end":365},"obj":"GO:0008152"},{"id":"T73139","span":{"begin":413,"end":425},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T84389","span":{"begin":426,"end":431},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T30001","span":{"begin":446,"end":451},"obj":"GO:0016265"},{"id":"T48070","span":{"begin":459,"end":463},"obj":"PR:000001889"},{"id":"T66249","span":{"begin":484,"end":494},"obj":"GO:0017156"},{"id":"T79219","span":{"begin":495,"end":504},"obj":"GO:0006909;CL:0000234"},{"id":"T76392","span":{"begin":527,"end":537},"obj":"CL:0000235"},{"id":"T27888","span":{"begin":600,"end":605},"obj":"PR:000014721"},{"id":"T61225","span":{"begin":676,"end":684},"obj":"CHEBI:35224;CHEBI:35224"},{"id":"T18886","span":{"begin":708,"end":719},"obj":"CL:0000235"},{"id":"T72865","span":{"begin":728,"end":741},"obj":"GO:0050817"},{"id":"T34267","span":{"begin":820,"end":831},"obj":"GO:0065007"},{"id":"T13599","span":{"begin":962,"end":972},"obj":"CL:0000235"},{"id":"T82611","span":{"begin":974,"end":980},"obj":"NCBITaxon:10239"},{"id":"T96076","span":{"begin":1007,"end":1015},"obj":"GO:0042571"},{"id":"T93508","span":{"begin":1075,"end":1083},"obj":"CL:0000775"},{"id":"T83799","span":{"begin":1103,"end":1112},"obj":"UBERON:0001977"},{"id":"T21930","span":{"begin":1146,"end":1156},"obj":"CL:0000235"},{"id":"T68542","span":{"begin":1175,"end":1178},"obj":"GO:0071735"},{"id":"T6400","span":{"begin":1197,"end":1200},"obj":"PR:000003065"},{"id":"T36403","span":{"begin":1234,"end":1244},"obj":"GO:0042571"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"LitCovid-PubTator","denotations":[{"id":"528","span":{"begin":327,"end":331},"obj":"Gene"},{"id":"529","span":{"begin":501,"end":505},"obj":"Gene"},{"id":"530","span":{"begin":514,"end":518},"obj":"Gene"},{"id":"531","span":{"begin":657,"end":660},"obj":"Gene"},{"id":"532","span":{"begin":665,"end":669},"obj":"Gene"},{"id":"533","span":{"begin":838,"end":842},"obj":"Gene"},{"id":"534","span":{"begin":980,"end":985},"obj":"Gene"},{"id":"535","span":{"begin":1170,"end":1180},"obj":"Gene"},{"id":"536","span":{"begin":110,"end":134},"obj":"Species"},{"id":"537","span":{"begin":696,"end":709},"obj":"Chemical"},{"id":"538","span":{"begin":804,"end":810},"obj":"Chemical"},{"id":"539","span":{"begin":1005,"end":1009},"obj":"Chemical"},{"id":"540","span":{"begin":80,"end":90},"obj":"Disease"},{"id":"541","span":{"begin":143,"end":154},"obj":"Disease"},{"id":"542","span":{"begin":167,"end":175},"obj":"Disease"},{"id":"543","span":{"begin":180,"end":191},"obj":"Disease"},{"id":"544","span":{"begin":580,"end":588},"obj":"Disease"},{"id":"545","span":{"begin":971,"end":978},"obj":"Disease"},{"id":"546","span":{"begin":1252,"end":1264},"obj":"Disease"},{"id":"547","span":{"begin":1269,"end":1274},"obj":"Disease"}],"attributes":[{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Gene:3552"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"Gene:3439"},{"id":"A530","pred":"tao:has_database_id","subj":"530","obj":"Gene:3439"},{"id":"A531","pred":"tao:has_database_id","subj":"531","obj":"Gene:7124"},{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"Gene:3569"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"Gene:929"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"Gene:3091"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"Gene:3827"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"Tax:2697049"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"MESH:D010743"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"MESH:D008055"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"MESH:D007501"},{"id":"A540","pred":"tao:has_database_id","subj":"540","obj":"MESH:D013927"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"MESH:D009081"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"MESH:D009336"},{"id":"A545","pred":"tao:has_database_id","subj":"545","obj":"MESH:D000860"},{"id":"A546","pred":"tao:has_database_id","subj":"546","obj":"MESH:D007249"},{"id":"A547","pred":"tao:has_database_id","subj":"547","obj":"MESH:D004487"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}

{"project":"MyTest","denotations":[{"id":"32861199-31768073-26409851","span":{"begin":773,"end":775},"obj":"31768073"},{"id":"32861199-29045901-26409852","span":{"begin":901,"end":903},"obj":"29045901"},{"id":"32861199-30428148-26409853","span":{"begin":950,"end":952},"obj":"30428148"},{"id":"32861199-30275460-26409854","span":{"begin":997,"end":999},"obj":"30275460"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Dysregulated activation of macrophages contributes to the hyperinflammatory and thrombotic pathways of severe COVID-19 [3,24,67].Virus-induced cell injury, apoptosis, necrosis and necroptosis are sensed by distinct, opposing macrophage receptor-dependent effector responses. These include activating and inhibitory pathways of IL-1 production, processing and secretion [52,57], triggered by tissue injury, inflammasome and caspase activation. A highly impaired type1 IFN response, characterized by no IFNβ and low IFNα production and activity, has been associated with persistent viraemia and an exacerbated inflammatory response, partially driven by NFkB, TNF and IL-6 [56]. Endogenous oxidized phospholipids reprogramme macrophage metabolism and boost hyperinflammation [68]. By capturing inflammatory lipids released from dying cells, CD14 induces inflammasome-dependent phagocyte hyperactivation [69]. Macrophage fuel production and utilization [36] are sensitive to hypoxia, HIF-1 responses [70] and iron availability, influencing M1 polarization and effector functions. Activated macrophages trigger coagulation and complement cascades, as well as angiotensin and bradykinin pathways that dysregulate vascular tone and permeability, exacerbating inflammation and edema."}