PMC:7456455 / 12842-13765 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T151","span":{"begin":78,"end":88},"obj":"Body_part"},{"id":"T152","span":{"begin":130,"end":142},"obj":"Body_part"},{"id":"T153","span":{"begin":355,"end":365},"obj":"Body_part"},{"id":"T154","span":{"begin":423,"end":428},"obj":"Body_part"},{"id":"T155","span":{"begin":633,"end":644},"obj":"Body_part"},{"id":"T156","span":{"begin":801,"end":809},"obj":"Body_part"}],"attributes":[{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma84055"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T91","span":{"begin":502,"end":510},"obj":"Disease"},{"id":"T92","span":{"begin":515,"end":522},"obj":"Disease"},{"id":"T93","span":{"begin":558,"end":567},"obj":"Disease"},{"id":"T94","span":{"begin":676,"end":685},"obj":"Disease"},{"id":"T95","span":{"begin":826,"end":846},"obj":"Disease"},{"id":"T96","span":{"begin":837,"end":846},"obj":"Disease"},{"id":"T97","span":{"begin":883,"end":891},"obj":"Disease"}],"attributes":[{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0008383"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0005578"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T186","span":{"begin":188,"end":195},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T187","span":{"begin":197,"end":199},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T55","span":{"begin":414,"end":421},"obj":"Chemical"},{"id":"T56","span":{"begin":429,"end":440},"obj":"Chemical"},{"id":"T57","span":{"begin":465,"end":489},"obj":"Chemical"}],"attributes":[{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_87631"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_77966"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_67079"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T78","span":{"begin":0,"end":308},"obj":"Sentence"},{"id":"T79","span":{"begin":309,"end":568},"obj":"Sentence"},{"id":"T80","span":{"begin":569,"end":780},"obj":"Sentence"},{"id":"T81","span":{"begin":781,"end":923},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":515,"end":522},"obj":"Phenotype"},{"id":"T16","span":{"begin":551,"end":567},"obj":"Phenotype"},{"id":"T17","span":{"begin":826,"end":846},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0032169"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0001370"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"2_test","denotations":[{"id":"32861199-32471903-26409836","span":{"begin":919,"end":921},"obj":"32471903"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T342","span":{"begin":78,"end":88},"obj":"CL:0000235"},{"id":"T343","span":{"begin":112,"end":116},"obj":"G_3;PG_10;PR:000003622"},{"id":"T344","span":{"begin":130,"end":142},"obj":"GO:0000805"},{"id":"T345","span":{"begin":206,"end":213},"obj":"SO:0000704"},{"id":"T346","span":{"begin":355,"end":365},"obj":"CL:0000235"},{"id":"T347","span":{"begin":383,"end":392},"obj":"GO:0008152"},{"id":"T348","span":{"begin":465,"end":489},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T349","span":{"begin":491,"end":498},"obj":"GO:0065007"},{"id":"T350","span":{"begin":569,"end":584},"obj":"CHEBI:24261;CHEBI:24261"},{"id":"T351","span":{"begin":633,"end":644},"obj":"CL:0000235"},{"id":"T352","span":{"begin":797,"end":800},"obj":"PR:000000134"},{"id":"T353","span":{"begin":801,"end":809},"obj":"GO:0042571"},{"id":"T354","span":{"begin":883,"end":891},"obj":"SP_7"},{"id":"T86532","span":{"begin":8,"end":15},"obj":"GO:0008152"},{"id":"T16078","span":{"begin":89,"end":113},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T33048","span":{"begin":115,"end":122},"obj":"GO:0065007"},{"id":"T79788","span":{"begin":193,"end":208},"obj":"CHEBI:24261;CHEBI:24261"},{"id":"T23053","span":{"begin":257,"end":268},"obj":"CL:0000235"},{"id":"T37006","span":{"begin":423,"end":426},"obj":"PR:000000134"},{"id":"T45785","span":{"begin":427,"end":435},"obj":"GO:0042571"},{"id":"T98912","span":{"begin":509,"end":517},"obj":"SP_7"},{"id":"T1551","span":{"begin":598,"end":608},"obj":"CL:0000235"},{"id":"T81873","span":{"begin":771,"end":782},"obj":"CL:0000235"},{"id":"T46842","span":{"begin":812,"end":819},"obj":"UBERON:0002405"},{"id":"T36057","span":{"begin":824,"end":831},"obj":"GO:0008152"},{"id":"T22109","span":{"begin":854,"end":861},"obj":"SO:0000704"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"287","span":{"begin":112,"end":116},"obj":"Gene"},{"id":"288","span":{"begin":797,"end":800},"obj":"Gene"},{"id":"289","span":{"begin":447,"end":460},"obj":"Disease"},{"id":"290","span":{"begin":502,"end":510},"obj":"Disease"},{"id":"291","span":{"begin":515,"end":522},"obj":"Disease"},{"id":"292","span":{"begin":558,"end":567},"obj":"Disease"},{"id":"293","span":{"begin":676,"end":685},"obj":"Disease"},{"id":"294","span":{"begin":826,"end":846},"obj":"Disease"},{"id":"295","span":{"begin":883,"end":891},"obj":"Disease"}],"attributes":[{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Gene:59272"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Gene:7124"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"MESH:D006973"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"MESH:D003920"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"MESH:D009765"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"MESH:D007239"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"MESH:D007239"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"MESH:D001172"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}

{"project":"MyTest","denotations":[{"id":"32861199-32471903-26409836","span":{"begin":919,"end":921},"obj":"32471903"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Comorbidities are likely to be multifactorial, and not all display an obvious macrophage link; for example, the ACE2 locus on the X chromosome [47] may contribute to the decreased risk of females [48], but genetic and environmental factors underlying gender, racial and individual disparities remain unclear. Therapeutics for many comorbidities impact on macrophage inflammatory and metabolic functions, including statins, sugar stabilizers, anti-hypertensives and anti-inflammatory agents; control of diabetes and obesity are important in preventing severe infection. Glucocorticoids, which have potent anti-inflammatory effects on macrophages, are contra-indicated in early infection, while protecting against severe disease; timing of administration is therefore critical [49]. The use of anti-TNF antibody in treatment of rheumatoid arthritis, protects against subsequent severe COVID-19 requiring hospitalization [50]."}