PMC:7456203 / 1129-2280 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T8","span":{"begin":0,"end":5},"obj":"Body_part"},{"id":"T9","span":{"begin":225,"end":231},"obj":"Body_part"},{"id":"T10","span":{"begin":249,"end":267},"obj":"Body_part"},{"id":"T11","span":{"begin":667,"end":672},"obj":"Body_part"},{"id":"T12","span":{"begin":870,"end":876},"obj":"Body_part"},{"id":"T13","span":{"begin":894,"end":912},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma61109"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma83716"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma61109"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma83716"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":0,"end":5},"obj":"Body_part"},{"id":"T10","span":{"begin":225,"end":231},"obj":"Body_part"},{"id":"T11","span":{"begin":249,"end":267},"obj":"Body_part"},{"id":"T12","span":{"begin":667,"end":672},"obj":"Body_part"},{"id":"T13","span":{"begin":870,"end":876},"obj":"Body_part"},{"id":"T14","span":{"begin":894,"end":912},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001851"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000315"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001851"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000315"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T8","span":{"begin":556,"end":564},"obj":"Disease"},{"id":"T9","span":{"begin":725,"end":733},"obj":"Disease"},{"id":"T10","span":{"begin":734,"end":743},"obj":"Disease"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005053"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T22","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T23","span":{"begin":0,"end":5},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T24","span":{"begin":225,"end":231},"obj":"http://purl.obolibrary.org/obo/UBERON_0001851"},{"id":"T25","span":{"begin":667,"end":672},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T26","span":{"begin":667,"end":672},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T27","span":{"begin":745,"end":746},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":750,"end":754},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T29","span":{"begin":750,"end":754},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T30","span":{"begin":870,"end":876},"obj":"http://purl.obolibrary.org/obo/UBERON_0001851"},{"id":"T31","span":{"begin":1004,"end":1008},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T32","span":{"begin":1004,"end":1008},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":143},"obj":"Sentence"},{"id":"T10","span":{"begin":144,"end":416},"obj":"Sentence"},{"id":"T11","span":{"begin":417,"end":617},"obj":"Sentence"},{"id":"T12","span":{"begin":618,"end":749},"obj":"Sentence"},{"id":"T13","span":{"begin":750,"end":1003},"obj":"Sentence"},{"id":"T14","span":{"begin":1004,"end":1151},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T19","span":{"begin":0,"end":5},"obj":"UBERON:0000955"},{"id":"T20","span":{"begin":225,"end":231},"obj":"UBERON:0001851"},{"id":"T21","span":{"begin":249,"end":261},"obj":"UBERON:0000315"},{"id":"T22","span":{"begin":455,"end":463},"obj":"UBERON:0001851"},{"id":"T23","span":{"begin":464,"end":475},"obj":"UBERON:0003893"},{"id":"T24","span":{"begin":667,"end":672},"obj":"UBERON:0000955"},{"id":"T25","span":{"begin":725,"end":733},"obj":"SP_7"},{"id":"T26","span":{"begin":870,"end":876},"obj":"UBERON:0001851"},{"id":"T27","span":{"begin":894,"end":906},"obj":"UBERON:0003893"},{"id":"T28","span":{"begin":1050,"end":1058},"obj":"UBERON:0001851"},{"id":"T11423","span":{"begin":0,"end":5},"obj":"UBERON:0000955"},{"id":"T7142","span":{"begin":225,"end":231},"obj":"UBERON:0001851"},{"id":"T79533","span":{"begin":249,"end":261},"obj":"UBERON:0000315"},{"id":"T53896","span":{"begin":455,"end":463},"obj":"UBERON:0001851"},{"id":"T58678","span":{"begin":464,"end":475},"obj":"UBERON:0003893"},{"id":"T1325","span":{"begin":667,"end":672},"obj":"UBERON:0000955"},{"id":"T70127","span":{"begin":725,"end":733},"obj":"SP_7"},{"id":"T54385","span":{"begin":870,"end":876},"obj":"UBERON:0001851"},{"id":"T1625","span":{"begin":894,"end":906},"obj":"UBERON:0003893"},{"id":"T38270","span":{"begin":1050,"end":1058},"obj":"UBERON:0001851"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"36","span":{"begin":704,"end":712},"obj":"Species"},{"id":"37","span":{"begin":725,"end":733},"obj":"Disease"},{"id":"38","span":{"begin":734,"end":743},"obj":"Disease"},{"id":"39","span":{"begin":824,"end":835},"obj":"Disease"},{"id":"44","span":{"begin":325,"end":333},"obj":"Species"},{"id":"45","span":{"begin":193,"end":204},"obj":"Disease"},{"id":"46","span":{"begin":556,"end":564},"obj":"Disease"},{"id":"47","span":{"begin":571,"end":582},"obj":"Disease"}],"attributes":[{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Tax:9606"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:D007239"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D006470"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"Tax:9606"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D006470"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:D007511"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D006470"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1). The remaining two cases (8.6%) showed cortical–subcortical areas of hypoattenuation with sulcal effacement, consistent with acute–subacute ischemia, with hemorrhagic transformation in one case (4.3%).\nFig. 1 Plain (left column) and contrast-enhanced brain CT scans (right column) in two patients with severe COVID-19 infection. a–f: Male, 62 years old, with multifocal, linear hyperdensities suggestive for hemorrhages (open arrows), involving both the cortex and the adjacent subarachnoid space, with very subtle superficial enhancement after contrast administration (arrowheads). g–l: Male, 65 years old, with superficial areas of cortical hyperdensity (open arrows) with faint enhancement after contrast administration (arrowheads)"}