PMC:7455781 / 9079-11009 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T62","span":{"begin":11,"end":18},"obj":"Disease"},{"id":"T63","span":{"begin":119,"end":126},"obj":"Disease"},{"id":"T64","span":{"begin":235,"end":242},"obj":"Disease"},{"id":"T65","span":{"begin":520,"end":527},"obj":"Disease"},{"id":"T66","span":{"begin":697,"end":704},"obj":"Disease"},{"id":"T67","span":{"begin":1581,"end":1588},"obj":"Disease"},{"id":"T68","span":{"begin":1865,"end":1872},"obj":"Disease"}],"attributes":[{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"}],"text":"Controlled obesity status: would it be an important clinical message?\nShouldn´t we use more often the term “controlled obesity” for those individuals, not only for Covid-19, but generally speaking, to nearly all diseases associated to obesity? Surely, direct evidence is still scarce, as we pointed out, but this can be a simple message, especially in situations as Covid-19 pandemics, in which is virtually impossible to lose a massive amount of weight in a short period of time.\nThe concept of a metabolically healthy obesity, achieved through moderate weight reductions not enough to reach the BMI of 25 kg/m2 target, is not novel and has been previously proposed as the “low hanging fruit” in obesity treatment [16].\nThe main problem in using this concept is that there is no universal number below which the risk is reduced, since it depends on the individual weight history, which is also subject to recall bias. Other factor that could bias this analysis is the already discussed reverse causation: weight loss could be a proxy of a subclinical disease, in which the overall prognosis would be poor. So, ideally, we should exclude data on those who unintentionally lost weight in the past.\nNonetheless, we believe that attaining self-reported maximal weight would be a relevant clinical information to be considered in future studies with Covid-19 and beyond [17]. If we demonstrate, even with case–control studies, that those who voluntarily lost weight in the past have a better prognosis in Covid-19, we can start providing a simple and achievable message for those with obesity. Data of disease severity on patients who performed bariatric surgery could likewise be useful.\nIf, hopefully, the pandemic vanishes in the future as a vaccine is delivered, we could still use this concept to improve metabolic health and reduce the stigma of individuals with obesity, in which bariatric surgery is not indicated or feasible."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T72","span":{"begin":320,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T73","span":{"begin":427,"end":428},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T74","span":{"begin":457,"end":458},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T75","span":{"begin":496,"end":497},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T76","span":{"begin":638,"end":641},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T77","span":{"begin":1027,"end":1028},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T78","span":{"begin":1038,"end":1039},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T79","span":{"begin":1274,"end":1275},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T80","span":{"begin":1479,"end":1480},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T81","span":{"begin":1534,"end":1535},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T82","span":{"begin":1739,"end":1740},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Controlled obesity status: would it be an important clinical message?\nShouldn´t we use more often the term “controlled obesity” for those individuals, not only for Covid-19, but generally speaking, to nearly all diseases associated to obesity? Surely, direct evidence is still scarce, as we pointed out, but this can be a simple message, especially in situations as Covid-19 pandemics, in which is virtually impossible to lose a massive amount of weight in a short period of time.\nThe concept of a metabolically healthy obesity, achieved through moderate weight reductions not enough to reach the BMI of 25 kg/m2 target, is not novel and has been previously proposed as the “low hanging fruit” in obesity treatment [16].\nThe main problem in using this concept is that there is no universal number below which the risk is reduced, since it depends on the individual weight history, which is also subject to recall bias. Other factor that could bias this analysis is the already discussed reverse causation: weight loss could be a proxy of a subclinical disease, in which the overall prognosis would be poor. So, ideally, we should exclude data on those who unintentionally lost weight in the past.\nNonetheless, we believe that attaining self-reported maximal weight would be a relevant clinical information to be considered in future studies with Covid-19 and beyond [17]. If we demonstrate, even with case–control studies, that those who voluntarily lost weight in the past have a better prognosis in Covid-19, we can start providing a simple and achievable message for those with obesity. Data of disease severity on patients who performed bariatric surgery could likewise be useful.\nIf, hopefully, the pandemic vanishes in the future as a vaccine is delivered, we could still use this concept to improve metabolic health and reduce the stigma of individuals with obesity, in which bariatric surgery is not indicated or feasible."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T68","span":{"begin":11,"end":18},"obj":"Phenotype"},{"id":"T69","span":{"begin":119,"end":126},"obj":"Phenotype"},{"id":"T70","span":{"begin":235,"end":242},"obj":"Phenotype"},{"id":"T71","span":{"begin":520,"end":527},"obj":"Phenotype"},{"id":"T72","span":{"begin":697,"end":704},"obj":"Phenotype"},{"id":"T73","span":{"begin":1006,"end":1017},"obj":"Phenotype"},{"id":"T74","span":{"begin":1581,"end":1588},"obj":"Phenotype"},{"id":"T75","span":{"begin":1865,"end":1872},"obj":"Phenotype"}],"attributes":[{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A70","pred":"hp_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A71","pred":"hp_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A73","pred":"hp_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/HP_0001824"},{"id":"A74","pred":"hp_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A75","pred":"hp_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/HP_0001513"}],"text":"Controlled obesity status: would it be an important clinical message?\nShouldn´t we use more often the term “controlled obesity” for those individuals, not only for Covid-19, but generally speaking, to nearly all diseases associated to obesity? Surely, direct evidence is still scarce, as we pointed out, but this can be a simple message, especially in situations as Covid-19 pandemics, in which is virtually impossible to lose a massive amount of weight in a short period of time.\nThe concept of a metabolically healthy obesity, achieved through moderate weight reductions not enough to reach the BMI of 25 kg/m2 target, is not novel and has been previously proposed as the “low hanging fruit” in obesity treatment [16].\nThe main problem in using this concept is that there is no universal number below which the risk is reduced, since it depends on the individual weight history, which is also subject to recall bias. Other factor that could bias this analysis is the already discussed reverse causation: weight loss could be a proxy of a subclinical disease, in which the overall prognosis would be poor. So, ideally, we should exclude data on those who unintentionally lost weight in the past.\nNonetheless, we believe that attaining self-reported maximal weight would be a relevant clinical information to be considered in future studies with Covid-19 and beyond [17]. If we demonstrate, even with case–control studies, that those who voluntarily lost weight in the past have a better prognosis in Covid-19, we can start providing a simple and achievable message for those with obesity. Data of disease severity on patients who performed bariatric surgery could likewise be useful.\nIf, hopefully, the pandemic vanishes in the future as a vaccine is delivered, we could still use this concept to improve metabolic health and reduce the stigma of individuals with obesity, in which bariatric surgery is not indicated or feasible."}

{"project":"LitCovid-sentences","denotations":[{"id":"T59","span":{"begin":0,"end":69},"obj":"Sentence"},{"id":"T60","span":{"begin":70,"end":243},"obj":"Sentence"},{"id":"T61","span":{"begin":244,"end":480},"obj":"Sentence"},{"id":"T62","span":{"begin":481,"end":720},"obj":"Sentence"},{"id":"T63","span":{"begin":721,"end":918},"obj":"Sentence"},{"id":"T64","span":{"begin":919,"end":1106},"obj":"Sentence"},{"id":"T65","span":{"begin":1107,"end":1196},"obj":"Sentence"},{"id":"T66","span":{"begin":1197,"end":1371},"obj":"Sentence"},{"id":"T67","span":{"begin":1372,"end":1589},"obj":"Sentence"},{"id":"T68","span":{"begin":1590,"end":1684},"obj":"Sentence"},{"id":"T69","span":{"begin":1685,"end":1930},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Controlled obesity status: would it be an important clinical message?\nShouldn´t we use more often the term “controlled obesity” for those individuals, not only for Covid-19, but generally speaking, to nearly all diseases associated to obesity? Surely, direct evidence is still scarce, as we pointed out, but this can be a simple message, especially in situations as Covid-19 pandemics, in which is virtually impossible to lose a massive amount of weight in a short period of time.\nThe concept of a metabolically healthy obesity, achieved through moderate weight reductions not enough to reach the BMI of 25 kg/m2 target, is not novel and has been previously proposed as the “low hanging fruit” in obesity treatment [16].\nThe main problem in using this concept is that there is no universal number below which the risk is reduced, since it depends on the individual weight history, which is also subject to recall bias. Other factor that could bias this analysis is the already discussed reverse causation: weight loss could be a proxy of a subclinical disease, in which the overall prognosis would be poor. So, ideally, we should exclude data on those who unintentionally lost weight in the past.\nNonetheless, we believe that attaining self-reported maximal weight would be a relevant clinical information to be considered in future studies with Covid-19 and beyond [17]. If we demonstrate, even with case–control studies, that those who voluntarily lost weight in the past have a better prognosis in Covid-19, we can start providing a simple and achievable message for those with obesity. Data of disease severity on patients who performed bariatric surgery could likewise be useful.\nIf, hopefully, the pandemic vanishes in the future as a vaccine is delivered, we could still use this concept to improve metabolic health and reduce the stigma of individuals with obesity, in which bariatric surgery is not indicated or feasible."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T63","span":{"begin":0,"end":10},"obj":"GO:0065007"},{"id":"T64","span":{"begin":61,"end":68},"obj":"CHEBI:33695;CHEBI:33695"},{"id":"T65","span":{"begin":138,"end":149},"obj":"NCBITaxon:1"},{"id":"T66","span":{"begin":164,"end":172},"obj":"SP_7"},{"id":"T67","span":{"begin":329,"end":336},"obj":"CHEBI:33695;CHEBI:33695"},{"id":"T68","span":{"begin":366,"end":374},"obj":"SP_7"},{"id":"T69","span":{"begin":498,"end":511},"obj":"GO:0008152"},{"id":"T70","span":{"begin":906,"end":912},"obj":"GO:0007613"},{"id":"T71","span":{"begin":1346,"end":1354},"obj":"SP_7"},{"id":"T72","span":{"begin":1501,"end":1509},"obj":"SP_7"},{"id":"T73","span":{"begin":1558,"end":1565},"obj":"CHEBI:33695;CHEBI:33695"},{"id":"T74","span":{"begin":1806,"end":1815},"obj":"GO:0008152"},{"id":"T75","span":{"begin":1848,"end":1859},"obj":"NCBITaxon:1"},{"id":"T44434","span":{"begin":0,"end":10},"obj":"GO:0065007"},{"id":"T14688","span":{"begin":61,"end":68},"obj":"CHEBI:33695;CHEBI:33695"},{"id":"T27577","span":{"begin":138,"end":149},"obj":"NCBITaxon:1"},{"id":"T64393","span":{"begin":164,"end":172},"obj":"SP_7"},{"id":"T31050","span":{"begin":329,"end":336},"obj":"CHEBI:33695;CHEBI:33695"},{"id":"T21110","span":{"begin":366,"end":374},"obj":"SP_7"},{"id":"T67972","span":{"begin":498,"end":511},"obj":"GO:0008152"},{"id":"T99478","span":{"begin":906,"end":912},"obj":"GO:0007613"},{"id":"T34366","span":{"begin":1346,"end":1354},"obj":"SP_7"},{"id":"T81047","span":{"begin":1501,"end":1509},"obj":"SP_7"},{"id":"T77457","span":{"begin":1558,"end":1565},"obj":"CHEBI:33695;CHEBI:33695"},{"id":"T46518","span":{"begin":1806,"end":1815},"obj":"GO:0008152"},{"id":"T88321","span":{"begin":1848,"end":1859},"obj":"NCBITaxon:1"}],"text":"Controlled obesity status: would it be an important clinical message?\nShouldn´t we use more often the term “controlled obesity” for those individuals, not only for Covid-19, but generally speaking, to nearly all diseases associated to obesity? Surely, direct evidence is still scarce, as we pointed out, but this can be a simple message, especially in situations as Covid-19 pandemics, in which is virtually impossible to lose a massive amount of weight in a short period of time.\nThe concept of a metabolically healthy obesity, achieved through moderate weight reductions not enough to reach the BMI of 25 kg/m2 target, is not novel and has been previously proposed as the “low hanging fruit” in obesity treatment [16].\nThe main problem in using this concept is that there is no universal number below which the risk is reduced, since it depends on the individual weight history, which is also subject to recall bias. Other factor that could bias this analysis is the already discussed reverse causation: weight loss could be a proxy of a subclinical disease, in which the overall prognosis would be poor. So, ideally, we should exclude data on those who unintentionally lost weight in the past.\nNonetheless, we believe that attaining self-reported maximal weight would be a relevant clinical information to be considered in future studies with Covid-19 and beyond [17]. If we demonstrate, even with case–control studies, that those who voluntarily lost weight in the past have a better prognosis in Covid-19, we can start providing a simple and achievable message for those with obesity. Data of disease severity on patients who performed bariatric surgery could likewise be useful.\nIf, hopefully, the pandemic vanishes in the future as a vaccine is delivered, we could still use this concept to improve metabolic health and reduce the stigma of individuals with obesity, in which bariatric surgery is not indicated or feasible."}

{"project":"LitCovid-PubTator","denotations":[{"id":"213","span":{"begin":11,"end":25},"obj":"Disease"},{"id":"218","span":{"begin":119,"end":126},"obj":"Disease"},{"id":"219","span":{"begin":164,"end":172},"obj":"Disease"},{"id":"220","span":{"begin":235,"end":242},"obj":"Disease"},{"id":"221","span":{"begin":366,"end":374},"obj":"Disease"},{"id":"224","span":{"begin":520,"end":527},"obj":"Disease"},{"id":"225","span":{"begin":697,"end":704},"obj":"Disease"},{"id":"227","span":{"begin":1006,"end":1017},"obj":"Disease"},{"id":"232","span":{"begin":1618,"end":1626},"obj":"Species"},{"id":"233","span":{"begin":1346,"end":1354},"obj":"Disease"},{"id":"234","span":{"begin":1501,"end":1509},"obj":"Disease"},{"id":"235","span":{"begin":1581,"end":1588},"obj":"Disease"},{"id":"237","span":{"begin":1865,"end":1872},"obj":"Disease"}],"attributes":[{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D009765"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"MESH:D009765"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"MESH:C000657245"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"MESH:D009765"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"MESH:C000657245"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"MESH:D009765"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"MESH:D009765"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"MESH:D015431"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Tax:9606"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"MESH:C000657245"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:C000657245"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D009765"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D009765"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Controlled obesity status: would it be an important clinical message?\nShouldn´t we use more often the term “controlled obesity” for those individuals, not only for Covid-19, but generally speaking, to nearly all diseases associated to obesity? Surely, direct evidence is still scarce, as we pointed out, but this can be a simple message, especially in situations as Covid-19 pandemics, in which is virtually impossible to lose a massive amount of weight in a short period of time.\nThe concept of a metabolically healthy obesity, achieved through moderate weight reductions not enough to reach the BMI of 25 kg/m2 target, is not novel and has been previously proposed as the “low hanging fruit” in obesity treatment [16].\nThe main problem in using this concept is that there is no universal number below which the risk is reduced, since it depends on the individual weight history, which is also subject to recall bias. Other factor that could bias this analysis is the already discussed reverse causation: weight loss could be a proxy of a subclinical disease, in which the overall prognosis would be poor. So, ideally, we should exclude data on those who unintentionally lost weight in the past.\nNonetheless, we believe that attaining self-reported maximal weight would be a relevant clinical information to be considered in future studies with Covid-19 and beyond [17]. If we demonstrate, even with case–control studies, that those who voluntarily lost weight in the past have a better prognosis in Covid-19, we can start providing a simple and achievable message for those with obesity. Data of disease severity on patients who performed bariatric surgery could likewise be useful.\nIf, hopefully, the pandemic vanishes in the future as a vaccine is delivered, we could still use this concept to improve metabolic health and reduce the stigma of individuals with obesity, in which bariatric surgery is not indicated or feasible."}