PMC:7455781 / 8439-9077 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T14","span":{"begin":294,"end":299},"obj":"Body_part"},{"id":"T15","span":{"begin":349,"end":356},"obj":"Body_part"},{"id":"T16","span":{"begin":532,"end":537},"obj":"Body_part"},{"id":"T17","span":{"begin":539,"end":545},"obj":"Body_part"},{"id":"T18","span":{"begin":550,"end":558},"obj":"Body_part"},{"id":"T19","span":{"begin":573,"end":580},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7198"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma83365"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":520,"end":526},"obj":"Body_part"},{"id":"T9","span":{"begin":532,"end":537},"obj":"Body_part"},{"id":"T10","span":{"begin":550,"end":558},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001264"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T61","span":{"begin":550,"end":558},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0021040"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T59","span":{"begin":324,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T60","span":{"begin":349,"end":356},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T61","span":{"begin":502,"end":505},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T62","span":{"begin":520,"end":526},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T63","span":{"begin":532,"end":537},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T64","span":{"begin":532,"end":537},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T65","span":{"begin":539,"end":545},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T66","span":{"begin":539,"end":545},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T67","span":{"begin":539,"end":545},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T68","span":{"begin":539,"end":545},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T69","span":{"begin":550,"end":558},"obj":"http://purl.obolibrary.org/obo/UBERON_0001264"},{"id":"T70","span":{"begin":573,"end":580},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T71","span":{"begin":608,"end":609},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8","span":{"begin":294,"end":299},"obj":"Chemical"},{"id":"T9","span":{"begin":349,"end":356},"obj":"Chemical"},{"id":"T10","span":{"begin":573,"end":580},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T63","span":{"begin":135,"end":148},"obj":"Phenotype"},{"id":"T64","span":{"begin":349,"end":367},"obj":"Phenotype"},{"id":"T65","span":{"begin":469,"end":480},"obj":"Phenotype"},{"id":"T66","span":{"begin":573,"end":591},"obj":"Phenotype"},{"id":"T67","span":{"begin":626,"end":637},"obj":"Phenotype"}],"attributes":[{"id":"A63","pred":"hp_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/HP_0001824"},{"id":"A64","pred":"hp_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A65","pred":"hp_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/HP_0004324"},{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0004324"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-sentences","denotations":[{"id":"T55","span":{"begin":0,"end":99},"obj":"Sentence"},{"id":"T56","span":{"begin":100,"end":219},"obj":"Sentence"},{"id":"T57","span":{"begin":220,"end":457},"obj":"Sentence"},{"id":"T58","span":{"begin":458,"end":638},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T55","span":{"begin":152,"end":163},"obj":"NCBITaxon:1"},{"id":"T56","span":{"begin":294,"end":299},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T57","span":{"begin":349,"end":356},"obj":"PR:000009054"},{"id":"T58","span":{"begin":372,"end":381},"obj":"GO:0008152"},{"id":"T59","span":{"begin":520,"end":526},"obj":"UBERON:0000062"},{"id":"T60","span":{"begin":532,"end":537},"obj":"UBERON:0002107"},{"id":"T61","span":{"begin":550,"end":558},"obj":"UBERON:0001264"},{"id":"T62","span":{"begin":573,"end":580},"obj":"PR:000009054"},{"id":"T23237","span":{"begin":152,"end":163},"obj":"NCBITaxon:1"},{"id":"T60099","span":{"begin":294,"end":299},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T50219","span":{"begin":349,"end":356},"obj":"PR:000009054"},{"id":"T13249","span":{"begin":372,"end":381},"obj":"GO:0008152"},{"id":"T7023","span":{"begin":520,"end":526},"obj":"UBERON:0000062"},{"id":"T23906","span":{"begin":532,"end":537},"obj":"UBERON:0002107"},{"id":"T81514","span":{"begin":550,"end":558},"obj":"UBERON:0001264"},{"id":"T53687","span":{"begin":573,"end":580},"obj":"PR:000009054"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}

{"project":"LitCovid-PubTator","denotations":[{"id":"207","span":{"begin":349,"end":356},"obj":"Gene"},{"id":"208","span":{"begin":573,"end":580},"obj":"Gene"},{"id":"209","span":{"begin":502,"end":505},"obj":"Gene"},{"id":"210","span":{"begin":324,"end":327},"obj":"Gene"},{"id":"211","span":{"begin":294,"end":299},"obj":"Chemical"}],"attributes":[{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Gene:3630"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"Gene:3630"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"Gene:2195"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"Gene:2195"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D008055"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"An important concept here is that these risk reductions are observed irrespective of baseline BMIs. In this regard, similar percentage weight losses in individuals with very similar basal BMIs can have similar benefits. Why this happens is not exactly known, but is probably related to ectopic lipid deposition and personal fat thresholds, in which insulin resistance and metabolic disturbances appears when the subcutaneous expansion limit is achieved [1]. Continuous weight gain will lead to ectopic fat deposition in organs like liver, muscle and pancreas and increased insulin resistance can also act as a curb to further weight gain."}