PMC:7455781 / 7351-7871 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T7","span":{"begin":250,"end":257},"obj":"Body_part"},{"id":"T8","span":{"begin":325,"end":330},"obj":"Body_part"},{"id":"T9","span":{"begin":371,"end":376},"obj":"Body_part"},{"id":"T10","span":{"begin":428,"end":433},"obj":"Body_part"},{"id":"T11","span":{"begin":474,"end":479},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma7197"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":325,"end":330},"obj":"Body_part"},{"id":"T4","span":{"begin":371,"end":376},"obj":"Body_part"},{"id":"T5","span":{"begin":428,"end":433},"obj":"Body_part"},{"id":"T6","span":{"begin":474,"end":479},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T52","span":{"begin":464,"end":487},"obj":"Disease"},{"id":"T53","span":{"begin":474,"end":487},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0043693"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005154"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T41","span":{"begin":232,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T42","span":{"begin":250,"end":257},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T43","span":{"begin":325,"end":330},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T44","span":{"begin":325,"end":330},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T45","span":{"begin":352,"end":355},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T46","span":{"begin":371,"end":376},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T47","span":{"begin":371,"end":376},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T48","span":{"begin":377,"end":380},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T49","span":{"begin":403,"end":406},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T50","span":{"begin":407,"end":408},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51","span":{"begin":428,"end":433},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T52","span":{"begin":428,"end":433},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T53","span":{"begin":474,"end":479},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T54","span":{"begin":474,"end":479},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T5","span":{"begin":250,"end":257},"obj":"Chemical"},{"id":"T6","span":{"begin":310,"end":323},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_17855"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T49","span":{"begin":6,"end":17},"obj":"Phenotype"},{"id":"T50","span":{"begin":105,"end":116},"obj":"Phenotype"},{"id":"T51","span":{"begin":211,"end":222},"obj":"Phenotype"},{"id":"T52","span":{"begin":250,"end":268},"obj":"Phenotype"},{"id":"T53","span":{"begin":391,"end":402},"obj":"Phenotype"},{"id":"T54","span":{"begin":428,"end":442},"obj":"Phenotype"},{"id":"T55","span":{"begin":474,"end":487},"obj":"Phenotype"}],"attributes":[{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0001824"},{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/HP_0001824"},{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0001824"},{"id":"A52","pred":"hp_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A53","pred":"hp_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/HP_0001824"},{"id":"A54","pred":"hp_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/HP_0001395"},{"id":"A55","pred":"hp_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/HP_0001392"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-sentences","denotations":[{"id":"T48","span":{"begin":0,"end":192},"obj":"Sentence"},{"id":"T49","span":{"begin":193,"end":386},"obj":"Sentence"},{"id":"T50","span":{"begin":387,"end":520},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T43","span":{"begin":126,"end":140},"obj":"UBERON:0004535"},{"id":"T44","span":{"begin":250,"end":257},"obj":"PR:000009054"},{"id":"T45","span":{"begin":310,"end":323},"obj":"CHEBI:17855;CHEBI:17855"},{"id":"T46","span":{"begin":325,"end":330},"obj":"UBERON:0000178"},{"id":"T47","span":{"begin":371,"end":376},"obj":"UBERON:0002107"},{"id":"T48","span":{"begin":428,"end":433},"obj":"UBERON:0002107"},{"id":"T49","span":{"begin":474,"end":479},"obj":"UBERON:0002107"},{"id":"T17560","span":{"begin":126,"end":140},"obj":"UBERON:0004535"},{"id":"T24097","span":{"begin":250,"end":257},"obj":"PR:000009054"},{"id":"T3497","span":{"begin":310,"end":323},"obj":"CHEBI:17855;CHEBI:17855"},{"id":"T98936","span":{"begin":325,"end":330},"obj":"UBERON:0000178"},{"id":"T29562","span":{"begin":371,"end":376},"obj":"UBERON:0002107"},{"id":"T4780","span":{"begin":428,"end":433},"obj":"UBERON:0002107"},{"id":"T3897","span":{"begin":474,"end":479},"obj":"UBERON:0002107"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"LitCovid-PubTator","denotations":[{"id":"166","span":{"begin":250,"end":257},"obj":"Gene"},{"id":"167","span":{"begin":377,"end":380},"obj":"Gene"},{"id":"168","span":{"begin":352,"end":355},"obj":"Gene"},{"id":"169","span":{"begin":446,"end":454},"obj":"Species"},{"id":"170","span":{"begin":310,"end":323},"obj":"Chemical"},{"id":"171","span":{"begin":6,"end":17},"obj":"Disease"},{"id":"172","span":{"begin":105,"end":116},"obj":"Disease"},{"id":"173","span":{"begin":211,"end":222},"obj":"Disease"},{"id":"174","span":{"begin":300,"end":308},"obj":"Disease"},{"id":"175","span":{"begin":391,"end":402},"obj":"Disease"},{"id":"176","span":{"begin":434,"end":442},"obj":"Disease"},{"id":"177","span":{"begin":460,"end":487},"obj":"Disease"}],"attributes":[{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Gene:3630"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Gene:2195"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Gene:2195"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Tax:9606"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"MESH:D014280"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"MESH:D015431"},{"id":"A172","pred":"tao:has_database_id","subj":"172","obj":"MESH:D015431"},{"id":"A173","pred":"tao:has_database_id","subj":"173","obj":"MESH:D015431"},{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"MESH:D015431"},{"id":"A176","pred":"tao:has_database_id","subj":"176","obj":"MESH:D005355"},{"id":"A177","pred":"tao:has_database_id","subj":"177","obj":"MESH:D008108"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}

{"project":"2_test","denotations":[{"id":"32860606-28455679-58965981","span":{"begin":188,"end":190},"obj":"28455679"},{"id":"32860606-28455679-58965982","span":{"begin":382,"end":384},"obj":"28455679"}],"text":"Since weight loss to “normalize” BMI is rarely achieved, there is good evidence that clinical achievable weight loss improves cardiovascular risk factors and several substitutive markers [14]. For example, 5–7% weight loss leads to a reduction in in insulin resistance and consequently, reduction in glycemia, triglycerides, blood pressure and ectopic fat deposition, as liver fat [14]. 10% weight loss has a dramatic effect on liver fibrosis in patients with non-alcoholic liver disease, and several other risk markers."}