PMC:7455510 / 8704-10217 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T20","span":{"begin":24,"end":47},"obj":"Body_part"},{"id":"T21","span":{"begin":43,"end":47},"obj":"Body_part"},{"id":"T22","span":{"begin":99,"end":103},"obj":"Body_part"},{"id":"T23","span":{"begin":110,"end":123},"obj":"Body_part"},{"id":"T24","span":{"begin":142,"end":146},"obj":"Body_part"},{"id":"T25","span":{"begin":153,"end":166},"obj":"Body_part"}],"attributes":[{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma86475"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma83030"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma83030"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T54","span":{"begin":60,"end":63},"obj":"Disease"},{"id":"T55","span":{"begin":72,"end":88},"obj":"Disease"},{"id":"T56","span":{"begin":90,"end":95},"obj":"Disease"},{"id":"T57","span":{"begin":97,"end":132},"obj":"Disease"},{"id":"T59","span":{"begin":104,"end":132},"obj":"Disease"},{"id":"T60","span":{"begin":110,"end":132},"obj":"Disease"},{"id":"T61","span":{"begin":124,"end":132},"obj":"Disease"},{"id":"T62","span":{"begin":134,"end":139},"obj":"Disease"},{"id":"T64","span":{"begin":140,"end":175},"obj":"Disease"},{"id":"T66","span":{"begin":147,"end":175},"obj":"Disease"},{"id":"T67","span":{"begin":153,"end":175},"obj":"Disease"},{"id":"T68","span":{"begin":167,"end":175},"obj":"Disease"},{"id":"T69","span":{"begin":278,"end":281},"obj":"Disease"},{"id":"T70","span":{"begin":282,"end":316},"obj":"Disease"},{"id":"T71","span":{"begin":318,"end":321},"obj":"Disease"},{"id":"T72","span":{"begin":412,"end":420},"obj":"Disease"},{"id":"T73","span":{"begin":1291,"end":1294},"obj":"Disease"}],"attributes":[{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0000922"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0021094"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0020511"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0004947"},{"id":"A58","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0020511"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0004967"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0001018"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0004963"},{"id":"A63","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0020512"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0003540"},{"id":"A65","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0004963"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0004967"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0001018"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0015540"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0015540"},{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0018942"},{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0015540"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T60","span":{"begin":2,"end":8},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T61","span":{"begin":12,"end":16},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T62","span":{"begin":12,"end":16},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T63","span":{"begin":38,"end":47},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T64","span":{"begin":90,"end":91},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T65","span":{"begin":97,"end":103},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T66","span":{"begin":140,"end":146},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T67","span":{"begin":370,"end":374},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T68","span":{"begin":428,"end":429},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T69","span":{"begin":995,"end":996},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T70","span":{"begin":1108,"end":1109},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T71","span":{"begin":1321,"end":1322},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T72","span":{"begin":1478,"end":1479},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T41","span":{"begin":12,"end":16},"obj":"Chemical"},{"id":"T42","span":{"begin":60,"end":63},"obj":"Chemical"},{"id":"T43","span":{"begin":196,"end":214},"obj":"Chemical"},{"id":"T44","span":{"begin":246,"end":265},"obj":"Chemical"},{"id":"T45","span":{"begin":246,"end":255},"obj":"Chemical"},{"id":"T46","span":{"begin":256,"end":265},"obj":"Chemical"},{"id":"T47","span":{"begin":267,"end":269},"obj":"Chemical"},{"id":"T48","span":{"begin":270,"end":276},"obj":"Chemical"},{"id":"T49","span":{"begin":318,"end":321},"obj":"Chemical"},{"id":"T50","span":{"begin":322,"end":335},"obj":"Chemical"},{"id":"T51","span":{"begin":1256,"end":1269},"obj":"Chemical"},{"id":"T52","span":{"begin":1499,"end":1513},"obj":"Chemical"}],"attributes":[{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_8066"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_145924"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_15379"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_8764"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_62932"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_41879"},{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_17650"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T27","span":{"begin":72,"end":88},"obj":"Phenotype"},{"id":"T28","span":{"begin":99,"end":135},"obj":"Phenotype"},{"id":"T29","span":{"begin":140,"end":175},"obj":"Phenotype"},{"id":"T30","span":{"begin":610,"end":615},"obj":"Phenotype"}],"attributes":[{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002721"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0006727"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0006727"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0001945"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-sentences","denotations":[{"id":"T97","span":{"begin":0,"end":96},"obj":"Sentence"},{"id":"T98","span":{"begin":97,"end":317},"obj":"Sentence"},{"id":"T99","span":{"begin":318,"end":335},"obj":"Sentence"},{"id":"T100","span":{"begin":336,"end":497},"obj":"Sentence"},{"id":"T101","span":{"begin":498,"end":595},"obj":"Sentence"},{"id":"T102","span":{"begin":596,"end":762},"obj":"Sentence"},{"id":"T103","span":{"begin":763,"end":967},"obj":"Sentence"},{"id":"T104","span":{"begin":968,"end":1252},"obj":"Sentence"},{"id":"T105","span":{"begin":1253,"end":1340},"obj":"Sentence"},{"id":"T106","span":{"begin":1341,"end":1513},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T102","span":{"begin":24,"end":37},"obj":"GO:0030097;CL:0000037"},{"id":"T103","span":{"begin":38,"end":47},"obj":"CL:0000037"},{"id":"T104","span":{"begin":97,"end":103},"obj":"CL:0000236"},{"id":"T105","span":{"begin":140,"end":146},"obj":"CL:0000084"},{"id":"T106","span":{"begin":196,"end":214},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T107","span":{"begin":219,"end":236},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T108","span":{"begin":246,"end":255},"obj":"DG_23"},{"id":"T109","span":{"begin":256,"end":265},"obj":"DG_30"},{"id":"T110","span":{"begin":267,"end":269},"obj":"CHEBI:15379;CHEBI:15379"},{"id":"T111","span":{"begin":282,"end":296},"obj":"GO:0030097"},{"id":"T112","span":{"begin":322,"end":335},"obj":"CHEBI:62932;CHEBI:62932"},{"id":"T113","span":{"begin":412,"end":422},"obj":"SP_7"},{"id":"T114","span":{"begin":430,"end":435},"obj":"UBERON:0000004"},{"id":"T115","span":{"begin":635,"end":640},"obj":"UBERON:0001707"},{"id":"T116","span":{"begin":641,"end":645},"obj":"UBERON:0001823"},{"id":"T117","span":{"begin":796,"end":800},"obj":"UBERON:0000165"},{"id":"T118","span":{"begin":970,"end":980},"obj":"DG_28"},{"id":"T119","span":{"begin":1256,"end":1269},"obj":"CHEBI:41879;CHEBI:41879"},{"id":"T120","span":{"begin":1499,"end":1513},"obj":"CHEBI:24751;CHEBI:24751"},{"id":"T55685","span":{"begin":24,"end":37},"obj":"GO:0030097;CL:0000037"},{"id":"T53406","span":{"begin":38,"end":47},"obj":"CL:0000037"},{"id":"T50125","span":{"begin":97,"end":103},"obj":"CL:0000236"},{"id":"T74346","span":{"begin":140,"end":146},"obj":"CL:0000084"},{"id":"T78965","span":{"begin":196,"end":214},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T93758","span":{"begin":219,"end":236},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T25906","span":{"begin":246,"end":255},"obj":"DG_23"},{"id":"T85834","span":{"begin":256,"end":265},"obj":"DG_30"},{"id":"T87655","span":{"begin":267,"end":269},"obj":"CHEBI:15379;CHEBI:15379"},{"id":"T74525","span":{"begin":282,"end":296},"obj":"GO:0030097"},{"id":"T46160","span":{"begin":322,"end":335},"obj":"CHEBI:62932;CHEBI:62932"},{"id":"T4239","span":{"begin":412,"end":422},"obj":"SP_7"},{"id":"T71468","span":{"begin":430,"end":435},"obj":"UBERON:0000004"},{"id":"T51839","span":{"begin":635,"end":640},"obj":"UBERON:0001707"},{"id":"T14851","span":{"begin":641,"end":645},"obj":"UBERON:0001823"},{"id":"T13016","span":{"begin":796,"end":800},"obj":"UBERON:0000165"},{"id":"T62411","span":{"begin":970,"end":980},"obj":"DG_28"},{"id":"T85530","span":{"begin":1256,"end":1269},"obj":"CHEBI:41879;CHEBI:41879"},{"id":"T80219","span":{"begin":1499,"end":1513},"obj":"CHEBI:24751;CHEBI:24751"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}

{"project":"LitCovid-PubTator","denotations":[{"id":"178","span":{"begin":192,"end":214},"obj":"Chemical"},{"id":"179","span":{"begin":238,"end":245},"obj":"Chemical"},{"id":"180","span":{"begin":246,"end":265},"obj":"Chemical"},{"id":"181","span":{"begin":267,"end":276},"obj":"Chemical"},{"id":"182","span":{"begin":318,"end":321},"obj":"Chemical"},{"id":"183","span":{"begin":322,"end":335},"obj":"Chemical"},{"id":"184","span":{"begin":60,"end":88},"obj":"Disease"},{"id":"185","span":{"begin":110,"end":132},"obj":"Disease"},{"id":"186","span":{"begin":134,"end":175},"obj":"Disease"},{"id":"187","span":{"begin":278,"end":316},"obj":"Disease"},{"id":"200","span":{"begin":358,"end":366},"obj":"Species"},{"id":"201","span":{"begin":412,"end":422},"obj":"Species"},{"id":"202","span":{"begin":498,"end":506},"obj":"Species"},{"id":"203","span":{"begin":596,"end":603},"obj":"Species"},{"id":"204","span":{"begin":664,"end":671},"obj":"Species"},{"id":"205","span":{"begin":910,"end":918},"obj":"Species"},{"id":"206","span":{"begin":337,"end":340},"obj":"Chemical"},{"id":"207","span":{"begin":693,"end":700},"obj":"Chemical"},{"id":"208","span":{"begin":758,"end":761},"obj":"Chemical"},{"id":"209","span":{"begin":822,"end":825},"obj":"Chemical"},{"id":"210","span":{"begin":875,"end":878},"obj":"Chemical"},{"id":"211","span":{"begin":610,"end":615},"obj":"Disease"},{"id":"217","span":{"begin":1016,"end":1023},"obj":"Species"},{"id":"218","span":{"begin":1041,"end":1048},"obj":"Species"},{"id":"219","span":{"begin":1158,"end":1166},"obj":"Species"},{"id":"220","span":{"begin":1236,"end":1244},"obj":"Species"},{"id":"221","span":{"begin":970,"end":980},"obj":"Chemical"},{"id":"223","span":{"begin":1256,"end":1269},"obj":"Chemical"}],"attributes":[{"id":"A180","pred":"tao:has_database_id","subj":"180","obj":"MESH:C558899"},{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"MESH:D010100"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"MESH:D009173"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"MESH:D009173"},{"id":"A184","pred":"tao:has_database_id","subj":"184","obj":"MESH:D000081207"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"MESH:D054198"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"MESH:D054218"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"MESH:D051359"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Tax:9606"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Tax:2697049"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Tax:9606"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"Tax:9606"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"Tax:9606"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"Tax:9606"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"MESH:D006886"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"MESH:D006886"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D006886"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"MESH:D006886"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D005334"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Tax:9606"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Tax:9606"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Tax:9606"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Tax:9606"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"MESH:C000606551"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"MESH:D003907"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL: B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis. MMF mycophenolate\n*HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (\u003c 24 h from consultation at our hospital). Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms. Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ. According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children \u003e 6 years (maximum daily dose 400 mg) for 5 days\n**Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients \u003c40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients \u003e40 kg)\n***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration: 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone"}