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PMC:7455510 / 1357-15301 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1182-1193 Body_part denotes solid organ http://purl.org/sig/ont/fma/fma55670
T2 1208-1231 Body_part denotes hematopoietic stem cell http://purl.org/sig/ont/fma/fma86475
T3 1227-1231 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T4 2165-2170 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T5 2723-2746 Body_part denotes hematopoietic stem cell http://purl.org/sig/ont/fma/fma86475
T6 2742-2746 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T7 2789-2794 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T8 2800-2806 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T9 3261-3266 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T10 4227-4232 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T11 4240-4245 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T12 5816-5821 Body_part denotes Liver http://purl.org/sig/ont/fma/fma7197
T13 5857-5863 Body_part denotes Kidney http://purl.org/sig/ont/fma/fma7203
T14 5944-5949 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 6004-6009 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T16 6233-6239 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T17 6299-6310 Body_part denotes Lymphocytes http://purl.org/sig/ont/fma/fma62863
T18 6487-6494 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T19 6606-6611 Body_part denotes Chest http://purl.org/sig/ont/fma/fma9576
T20 7371-7394 Body_part denotes hematopoietic stem cell http://purl.org/sig/ont/fma/fma86475
T21 7390-7394 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 7446-7450 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 7457-7470 Body_part denotes lymphoblastic http://purl.org/sig/ont/fma/fma83030
T24 7489-7493 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25 7500-7513 Body_part denotes lymphoblastic http://purl.org/sig/ont/fma/fma83030
T26 9759-9764 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T27 10674-10692 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T28 10793-10798 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 10820-10824 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T30 10826-10852 Body_part denotes small intestine epithelium http://purl.org/sig/ont/fma/fma62017
T31 10826-10841 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T32 10842-10852 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T33 10878-10889 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T34 10968-10972 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T35 11280-11297 Body_part denotes regulatory T cell http://purl.org/sig/ont/fma/fma84070
T36 11293-11297 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T37 11336-11345 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T38 11369-11381 Body_part denotes interleukins http://purl.org/sig/ont/fma/fma86578
T39 11382-11386 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T40 11400-11411 Body_part denotes granulocyte http://purl.org/sig/ont/fma/fma62854
T41 11439-11449 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T42 11463-11470 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 11512-11519 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 12944-12949 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T45 13281-13288 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 13292-13305 Body_part denotes Interleukin-6 http://purl.org/sig/ont/fma/fma264829
T47 13292-13303 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1188-1193 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T2 2165-2170 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 2789-2794 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 2800-2806 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 3261-3266 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T6 4227-4232 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T7 4240-4245 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T8 5816-5821 Body_part denotes Liver http://purl.obolibrary.org/obo/UBERON_0002107
T9 5857-5863 Body_part denotes Kidney http://purl.obolibrary.org/obo/UBERON_0002113
T10 6233-6239 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T11 6606-6611 Body_part denotes Chest http://purl.obolibrary.org/obo/UBERON_0001443
T12 10674-10692 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T13 10820-10824 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 10826-10841 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T15 10832-10841 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T16 10842-10852 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T17 10878-10889 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T18 10968-10972 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 12944-12949 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 13-21 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 24-33 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 411-419 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 489-504 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T15 512-526 Disease denotes acute leukemia http://purl.obolibrary.org/obo/MONDO_0010643
T16 518-526 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T17 615-624 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 777-785 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1308-1314 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T20 1405-1421 Disease denotes pediatric cancer http://purl.obolibrary.org/obo/MONDO_0006517
T21 1415-1421 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T22 1550-1558 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 1561-1570 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 1789-1797 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 1909-1917 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 2292-2300 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 2432-2440 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 2879-2889 Disease denotes vasculitis http://purl.obolibrary.org/obo/MONDO_0018882
T29 3357-3365 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T30 3384-3391 Disease denotes anosmia http://purl.obolibrary.org/obo/MONDO_0010528
T31 3428-3462 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T32 3649-3652 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T33 3766-3776 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T34 4123-4131 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 4214-4223 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T36 4277-4288 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T37 4712-4723 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T38 5106-5117 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T39 5207-5215 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 5416-5424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 5611-5619 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 5737-5740 Disease denotes PID http://purl.obolibrary.org/obo/MONDO_0000922
T43 5765-5789 Disease denotes Myelodysplastic syndrome http://purl.obolibrary.org/obo/MONDO_0018881|http://purl.obolibrary.org/obo/MONDO_0044873
T45 5795-5800 Disease denotes B-ALL http://purl.obolibrary.org/obo/MONDO_0020511
T46 5801-5806 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512
T48 5807-5815 Disease denotes Melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T49 5832-5842 Disease denotes vasculitis http://purl.obolibrary.org/obo/MONDO_0018882
T50 6153-6156 Disease denotes MMF http://purl.obolibrary.org/obo/MONDO_0018942
T51 6228-6239 Disease denotes Sore throat http://purl.obolibrary.org/obo/MONDO_0002258
T52 7129-7132 Disease denotes MMF http://purl.obolibrary.org/obo/MONDO_0018942
T53 7309-7312 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T54 7407-7410 Disease denotes PID http://purl.obolibrary.org/obo/MONDO_0000922
T55 7419-7435 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T56 7437-7442 Disease denotes B-ALL http://purl.obolibrary.org/obo/MONDO_0020511
T57 7444-7479 Disease denotes B cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0004947|http://purl.obolibrary.org/obo/MONDO_0020511
T59 7451-7479 Disease denotes acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0004967
T60 7457-7479 Disease denotes lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0001018
T61 7471-7479 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T62 7481-7486 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512
T64 7487-7522 Disease denotes T cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0003540|http://purl.obolibrary.org/obo/MONDO_0004963
T66 7494-7522 Disease denotes acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0004967
T67 7500-7522 Disease denotes lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0001018
T68 7514-7522 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T69 7625-7628 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T70 7629-7663 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T71 7665-7668 Disease denotes MMF http://purl.obolibrary.org/obo/MONDO_0018942
T72 7759-7767 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 8638-8641 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T74 8929-8937 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T75 9746-9772 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T76 9787-9795 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T77 9981-9987 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T78 10041-10057 Disease denotes childhood cancer http://purl.obolibrary.org/obo/MONDO_0006517
T79 10051-10057 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T80 10117-10133 Disease denotes childhood cancer http://purl.obolibrary.org/obo/MONDO_0006517
T81 10127-10133 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T82 10419-10427 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 10430-10439 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 10587-10595 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 10694-10702 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 11006-11021 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T87 11012-11021 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T88 11054-11065 Disease denotes Lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T89 11476-11481 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T90 11551-11585 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T91 11883-11894 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T92 12112-12122 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T93 12254-12257 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T94 12840-12848 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 13239-13250 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T5 75-78 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 436-439 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 458-459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 695-698 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T9 755-756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1062-1063 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1188-1193 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T12 1222-1231 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T13 1371-1374 http://purl.obolibrary.org/obo/CLO_0008190 denotes Per
T14 1444-1446 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T15 1468-1471 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T16 1645-1646 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T17 2018-2026 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was
T18 2165-2170 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T19 2165-2170 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T20 2376-2377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 2405-2411 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T22 2527-2528 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T23 2721-2722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 2737-2746 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T25 2787-2788 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 2789-2794 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T27 2789-2794 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T28 2798-2799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 2800-2806 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T30 2800-2806 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T31 2800-2806 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T32 2841-2842 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 2877-2878 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 3058-3059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 3261-3266 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T36 3426-3427 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 4227-4232 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T38 4240-4245 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T39 4240-4245 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T40 5157-5158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 5639-5642 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3 4
T42 5680-5682 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T43 5742-5747 http://purl.obolibrary.org/obo/PR_000001852 denotes CTLA4
T44 5795-5796 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T45 5816-5821 http://purl.obolibrary.org/obo/UBERON_0002107 denotes Liver
T46 5816-5821 http://www.ebi.ac.uk/efo/EFO_0000887 denotes Liver
T47 5857-5863 http://purl.obolibrary.org/obo/UBERON_0002113 denotes Kidney
T48 5857-5863 http://www.ebi.ac.uk/efo/EFO_0000927 denotes Kidney
T49 5857-5863 http://www.ebi.ac.uk/efo/EFO_0000929 denotes Kidney
T50 5940-5943 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T51 5944-5949 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T52 6000-6003 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T53 6004-6009 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T54 6357-6360 http://purl.obolibrary.org/obo/CLO_0001007 denotes 380
T55 6429-6431 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T56 6606-6611 http://www.ebi.ac.uk/efo/EFO_0000965 denotes Chest
T57 7219-7221 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T58 7231-7234 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3 4
T59 7294-7297 http://purl.obolibrary.org/obo/UBERON_0003081 denotes lpm
T60 7349-7355 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T61 7359-7363 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T62 7359-7363 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T63 7385-7394 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T64 7437-7438 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T65 7444-7450 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T66 7487-7493 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T67 7717-7721 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3, 4
T68 7775-7776 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 8342-8343 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 8455-8456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71 8668-8669 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 8825-8826 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 9025-9026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 9115-9116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 9380-9381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 9423-9426 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T77 9484-9485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 9646-9647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 9809-9810 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80 10018-10019 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T81 10039-10040 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 10163-10164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 10303-10313 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T84 10658-10666 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T85 10674-10692 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T86 10787-10798 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T87 10814-10819 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T88 10820-10824 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T89 10820-10824 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T90 10826-10841 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T91 10842-10852 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T92 10878-10889 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T93 10968-10972 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T94 10968-10972 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T95 11091-11092 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 11152-11153 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T97 11242-11243 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 11280-11297 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cell
T99 11382-11386 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T100 11400-11437 http://purl.obolibrary.org/obo/PR_000005932 denotes granulocyte-colony-stimulating factor
T101 11544-11546 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T102 11549-11550 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T103 12408-12409 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 12520-12521 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T105 12667-12670 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 12944-12949 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T107 12944-12949 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T108 12950-12954 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T109 13292-13305 http://purl.obolibrary.org/obo/PR_000001393 denotes Interleukin-6
T110 13363-13364 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T111 13466-13469 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 730-735 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T3 767-772 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T4 1014-1016 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T5 1839-1841 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T6 3325-3331 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T7 3548-3561 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T8 3623-3636 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T9 4449-4458 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T10 4490-4508 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T11 4556-4566 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T12 4639-4645 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T13 4792-4803 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T14 4841-4843 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T16 5737-5740 Chemical denotes PID http://purl.obolibrary.org/obo/CHEBI_8066
T17 5827-5831 Chemical denotes ANCA http://purl.obolibrary.org/obo/CHEBI_34507
T18 6023-6037 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T19 6042-6054 Chemical denotes methotrexate http://purl.obolibrary.org/obo/CHEBI_44185|http://purl.obolibrary.org/obo/CHEBI_50681
T21 6078-6088 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T23 6101-6113 Chemical denotes azathioprine http://purl.obolibrary.org/obo/CHEBI_2948
T24 6126-6136 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T26 6138-6151 Chemical denotes mycophenolate http://purl.obolibrary.org/obo/CHEBI_62932
T27 6153-6156 Chemical denotes MMF http://purl.obolibrary.org/obo/CHEBI_8764
T28 6424-6426 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T30 6487-6494 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T31 6535-6543 Chemical denotes Ferritin http://purl.obolibrary.org/obo/CHEBI_82594
T32 6975-6988 Chemical denotes Dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T33 7035-7045 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T35 7074-7086 Chemical denotes azathioprine http://purl.obolibrary.org/obo/CHEBI_2948
T36 7129-7132 Chemical denotes MMF http://purl.obolibrary.org/obo/CHEBI_8764
T37 7145-7155 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T39 7169-7179 Chemical denotes prednisone http://purl.obolibrary.org/obo/CHEBI_8382
T40 7251-7253 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T41 7359-7363 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T42 7407-7410 Chemical denotes PID http://purl.obolibrary.org/obo/CHEBI_8066
T43 7543-7561 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T44 7593-7612 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T45 7593-7602 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T46 7603-7612 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T47 7614-7616 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T48 7617-7623 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T49 7665-7668 Chemical denotes MMF http://purl.obolibrary.org/obo/CHEBI_8764
T50 7669-7682 Chemical denotes mycophenolate http://purl.obolibrary.org/obo/CHEBI_62932
T51 8603-8616 Chemical denotes Dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T52 8846-8860 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T53 9249-9255 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T54 9288-9297 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T55 9928-9945 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T56 10735-10746 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T57 11369-11381 Chemical denotes interleukins http://purl.obolibrary.org/obo/CHEBI_52998
T58 11382-11384 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T60 11388-11390 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T62 11394-11396 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T64 11463-11470 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T65 11512-11519 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T66 12229-12242 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T67 12327-12335 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T68 12743-12752 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T69 13281-13288 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 13446-13455 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T71 13564-13573 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T72 13592-13597 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73 13629-13633 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T74 13711-13733 Chemical denotes calcineurin inhibitors http://purl.obolibrary.org/obo/CHEBI_37153
T75 13711-13722 Chemical denotes calcineurin http://purl.obolibrary.org/obo/CHEBI_53439
T76 13723-13733 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 11482-11490 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T2 11482-11490 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T3 11482-11490 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T4 11482-11490 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T5 13711-13722 http://purl.obolibrary.org/obo/GO_0004723 denotes calcineurin
T6 13711-13722 http://purl.obolibrary.org/obo/GO_0004722 denotes calcineurin

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 489-504 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234
T5 512-526 Phenotype denotes acute leukemia http://purl.obolibrary.org/obo/HP_0002488
T6 1308-1314 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T7 1415-1421 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T8 2879-2889 Phenotype denotes vasculitis http://purl.obolibrary.org/obo/HP_0002633
T9 3146-3151 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T10 3357-3365 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T11 3384-3391 Phenotype denotes anosmia http://purl.obolibrary.org/obo/HP_0000458
T12 3395-3402 Phenotype denotes ageusia http://purl.obolibrary.org/obo/HP_0041051
T13 3501-3506 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T14 4214-4223 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T15 4277-4288 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T16 4292-4304 Phenotype denotes elevated CRP http://purl.obolibrary.org/obo/HP_0011227
T17 4712-4723 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T18 4822-4827 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T19 5106-5117 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T20 5765-5789 Phenotype denotes Myelodysplastic syndrome http://purl.obolibrary.org/obo/HP_0002863
T21 5807-5815 Phenotype denotes Melanoma http://purl.obolibrary.org/obo/HP_0002861
T22 5832-5842 Phenotype denotes vasculitis http://purl.obolibrary.org/obo/HP_0002633
T23 6158-6163 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T24 6193-6198 Phenotype denotes Cough http://purl.obolibrary.org/obo/HP_0012735
T25 6228-6239 Phenotype denotes Sore throat http://purl.obolibrary.org/obo/HP_0033050
T26 6266-6273 Phenotype denotes Dyspnea http://purl.obolibrary.org/obo/HP_0002094
T27 7419-7435 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T28 7446-7482 Phenotype denotes cell acute lymphoblastic leukemia, T http://purl.obolibrary.org/obo/HP_0006727
T29 7487-7522 Phenotype denotes T cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/HP_0006727
T30 7957-7962 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T31 9214-9234 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T32 9746-9772 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T33 9981-9987 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T34 10051-10057 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T35 10127-10133 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T36 10230-10238 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T37 10338-10346 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T38 11012-11021 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T39 11045-11052 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T40 11054-11065 Phenotype denotes Lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T41 11476-11481 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T42 11883-11894 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T43 12013-12029 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106
T44 13096-13101 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T45 13136-13156 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T46 13239-13250 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T47 13252-13268 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T15 0-12 Sentence denotes Introduction
T16 13-140 Sentence denotes SARS-CoV-2 infection in children younger than 10 years of age has been described in around 1% of identified cases in China [1].
T17 141-254 Sentence denotes Although data on children is still limited, most series agree that cases are mostly mild, even in infants [2, 3].
T18 255-410 Sentence denotes Very little information is available about pediatric patients with underlying diseases, and data in children with immunosuppression is almost non-existent.
T19 411-531 Sentence denotes COVID-19 serious disease has been described in a child with post-chemotherapy agranulocytosis due to acute leukemia [4].
T20 532-794 Sentence denotes Preliminary data from Bergamo [5] indicates that in Italy, practically no cases of infection have been detected in immunosuppressed patients (3 mild cases), which has led them to consider that this group of patients is not a high-risk group for COVID-19 disease.
T21 795-887 Sentence denotes Spain is currently one of the most affected countries with more than 100,000 reported cases.
T22 888-1013 Sentence denotes The first case in Spain was declared on January 31st, 2020, and the first case in Madrid was declared on February 27th, 2020.
T23 1014-1160 Sentence denotes La Paz University Hospital in Madrid, Spain, is a national reference tertiary center for transplanted, oncological, and immunosuppressed children.
T24 1161-1370 Sentence denotes Over 1,300 pediatric solid organ (SOT) and 630 hematopoietic stem cell transplants (HSCT) have been performed in our hospital, and more than 3,200 cancer patients have been treated over more than five decades.
T25 1371-1463 Sentence denotes Per year, we diagnose 100–120 new pediatric cancer patients, and perform 35 HSCT and 65 SOT.
T26 1464-1622 Sentence denotes Our aim was to describe the children with primary or secondary immunosuppression, and SARS-CoV-2 infection attended in our hospital during the month of March.
T27 1624-1644 Sentence denotes Patients and methods
T28 1645-1876 Sentence denotes A retrospective study (1st to 31st of March, 2020) of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 and treated at the University Hospital La Paz, Madrid, Spain, was performed.
T29 1877-1971 Sentence denotes For inclusion in the study, the SARS-CoV-2 polymerase chain reaction (PCR) had to be positive.
T30 1972-2112 Sentence denotes PCR was performed via nasal swabs, and if the test was initially negative but clinical suspicion was high, it was repeated in the next 24 h.
T31 2113-2154 Sentence denotes Inpatients and outpatients were included.
T32 2155-2339 Sentence denotes Symptoms, blood analysis results and radiological data, previous underlying disease, immunosuppressive treatment, treatment received for COVID-19 disease, and evolution were collected.
T33 2341-2348 Sentence denotes Results
T34 2349-2470 Sentence denotes During the month of March, a total of 315 children were tested in our hospital for SARS-CoV-2 and 51 were positive (16%).
T35 2471-2526 Sentence denotes Twenty-eight of the positive cases (55%) were admitted.
T36 2527-2628 Sentence denotes A total of 8 positive cases (15%) were immunosuppressed patients, and 3 were followed as outpatients.
T37 2629-2928 Sentence denotes The underlying pathology was hemato-oncological in most cases (three patients had undergone a hematopoietic stem cell transplant), two patients had undergone a liver or a kidney transplant, and the last case was a girl on chronic hemodialysis with a vasculitis receiving immunosuppressive treatment.
T38 2929-2995 Sentence denotes The median age was 12.6 years (interquartile range: IQR 9.5–12.6).
T39 2996-3101 Sentence denotes All the patients had been on immunosuppressive treatment with a median duration of 24 months (IQR 12–93).
T40 3102-3239 Sentence denotes All had respiratory symptoms, 5 of them had fever, and the majority had slight radiological alterations (only two had focal infiltrates).
T41 3240-3305 Sentence denotes In only one case the chest X-ray worsened during hospitalization.
T42 3306-3366 Sentence denotes One patient needed oxygen therapy and one case had diarrhea.
T43 3367-3403 Sentence denotes None of them had anosmia or ageusia.
T44 3404-3667 Sentence denotes One patient developed a hemophagocytic lymphohistiocytosis-like syndrome (sHLH), with persistent fever, cytopenias, low fibrinogen and elevated triglycerides, and elevated ferritin, and required specific treatment with dexamethasone, as per the HLH-2004 protocol.
T45 3668-4056 Sentence denotes Antiviral treatment was initiated according to our National guidelines, developed by the National Infectious Disease Society (SEIP), in coordination with the National Pediatric Intensive Care Society (SECIP) and the National Pediatric Association (AEP) available at https://www.aeped.es/noticias/documento-manejo-clinico-paciente-pediatrico-y-pacientes-riesgo-con-infeccion-por-sars-cov2.
T46 4057-4323 Sentence denotes Hydroxychloroquine was initiated upon diagnosis (positive PCR for SARS-CoV-2) when there were signs/ symptoms of moderate-severe disease (respiratory signs, pneumonia on chest X ray, blood parameters of severity such as lymphopenia or elevated CRP, D-dimer or Il-6).
T47 4324-4400 Sentence denotes Remdesivir was requested, under compassionate use, in the most severe cases.
T48 4401-4533 Sentence denotes Following theses guidelines, in 5/8 cases, some antiviral treatment was prescribed, with hydroxychloroquine being the most frequent.
T49 4534-4846 Sentence denotes Two patients received remdesivir (the two oncological patients who required admission: patient 1 who had oxygen requirement and patient 4 who had persistent symptoms with severe lymphopenia and elevated inflammatory parameters) and only one patient received tocilizumab due to persistent fever and elevated IL-6.
T50 4847-4918 Sentence denotes There were no significant toxicities following the treatments received.
T51 4919-5066 Sentence denotes Immunosuppressive therapy was decreased or withdrawn in 6 patients (the other two had been off immunosuppression for 1 and 2 months, respectively).
T52 5067-5118 Sentence denotes All but one case developed progressive lymphopenia.
T53 5119-5151 Sentence denotes D-dimer was moderately elevated.
T54 5152-5300 Sentence denotes With a median follow up of 106 days (IQR 103–113) from COVID-19 diagnosis, no child required admission to the pediatric intensive care unit or died.
T55 5301-5425 Sentence denotes At present, all the patients are being followed up as outpatients and have had no further complications related to COVID-19.
T56 5426-5542 Sentence denotes The clinical characteristics of the patients, as well as details on the treatment received, are outlined in Table 1.
T57 5543-5627 Sentence denotes Table 1 Clinical characteristics of immunocompromised children with COVID-19 disease
T58 5628-5650 Sentence denotes Case # 1 2 3 4 5 6 7 8
T59 5651-5692 Sentence denotes Age (years) 15 13 12.6 9 6.7 11 12.6 14.8
T60 5693-5715 Sentence denotes Gender F M M M M M F M
T61 5716-5736 Sentence denotes Primary disease HSCT
T62 5737-5764 Sentence denotes PID (CTLA4 deficiency) HSCT
T63 5765-5794 Sentence denotes Myelodysplastic syndrome HSCT
T64 5795-5843 Sentence denotes B-ALL T-ALL Melanoma Liver Tx C-ANCA vasculitis.
T65 5844-5866 Sentence denotes Hemodialysis Kidney Tx
T66 5867-5939 Sentence denotes Immunosuppressive treatment/targeted therapy None (stopped for 1 month).
T67 5940-5950 Sentence denotes CD4 cells:
T68 5951-5999 Sentence denotes 216/ μL Ruxolitinib None (stopped for 2 months).
T69 6000-6010 Sentence denotes CD4 cells:
T70 6011-6157 Sentence denotes 30/ μL Oral mercaptopurine and methotrexate Trametinib Prednisone, tacrolimus Prednisone, azathioprine Prednisone, tacrolimus, mycophenolate (MMF)
T71 6158-6192 Sentence denotes Fever Yes No Yes Yes No Yes Yes No
T72 6193-6227 Sentence denotes Cough No No No Yes Yes Yes Yes Yes
T73 6228-6265 Sentence denotes Sore throat No Yes No No No No Yes No
T74 6266-6298 Sentence denotes Dyspnea Yes No No No No No No No
T75 6299-6314 Sentence denotes Lymphocytes/mm3
T76 6315-6365 Sentence denotes (minimum value) 730 1210 520 340 2730 970 380 1620
T77 6366-6379 Sentence denotes D-dimer ng/mL
T78 6380-6423 Sentence denotes (maximum value) 301 - 418 1143 370 - 1168 -
T79 6424-6474 Sentence denotes IL-6 pg/mL (maximum value) 9.60 2.30 - 192 - - - -
T80 6475-6534 Sentence denotes C- Reactive Protein (mg/L) 26.2 1.9 18.9 24.6 0.6 0.9 9 106
T81 6535-6605 Sentence denotes Ferritin (mg/dl) Not done Not done 622 1534 Not done Not done 1270 553
T82 6606-6624 Sentence denotes Chest X-ray Normal
T83 6625-6634 Sentence denotes (Previous
T84 6635-6829 Sentence denotes lobectomy) Interstitial infiltrate Interstitial infiltrate Interstitial infiltrate Focal infiltrate Mild parahilar infiltrates Normal initially but focal infiltrate on evolution Focal infiltrate
T85 6830-6883 Sentence denotes Required hospitalization Yes No No Yes No Yes Yes Yes
T86 6884-6898 Sentence denotes Treatment HCQ*
T87 6899-6944 Sentence denotes Remdesivir** IS withdrawal HCQ* IS withdrawal
T88 6945-6949 Sentence denotes HCQ*
T89 6950-6962 Sentence denotes Remdesivir**
T90 6963-6974 Sentence denotes Tocilizumab
T91 6975-7098 Sentence denotes Dexamethasone*** Trametinib withdrawal Reduction in IS (50% tacrolimus reduction) Reduction in IS (azathioprine withdrawal)
T92 7099-7106 Sentence denotes LPV/Rtv
T93 7107-7189 Sentence denotes HCQ* Reduction in IS (MMF withdrawal, tacrolimus decrease and prednisone increase)
T94 7190-7194 Sentence denotes HCQ*
T95 7195-7236 Sentence denotes Duration of stay (days) 11 - - 28 - 3 4 2
T96 7237-7346 Sentence denotes Complications O2 requirement on nasal cannula (maximun 2 lpm) None None HLH-like syndrome None None None None
T97 7347-7443 Sentence denotes F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL:
T98 7444-7664 Sentence denotes B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis.
T99 7665-7682 Sentence denotes MMF mycophenolate
T100 7683-7844 Sentence denotes *HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (< 24 h from consultation at our hospital).
T101 7845-7942 Sentence denotes Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms.
T102 7943-8109 Sentence denotes Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ.
T103 8110-8314 Sentence denotes According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children > 6 years (maximum daily dose 400 mg) for 5 days
T104 8315-8599 Sentence denotes **Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients <40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients >40 kg)
T105 8600-8687 Sentence denotes ***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration:
T106 8688-8860 Sentence denotes 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone
T107 8862-8872 Sentence denotes Discussion
T108 8873-9046 Sentence denotes In this small series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital.
T109 9047-9264 Sentence denotes The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy.
T110 9265-9419 Sentence denotes Most patients received antiviral treatment, and immunosuppressive treatment was decreased or even discontinued for a short period of time in most of them.
T111 9420-9589 Sentence denotes It has been described by most of the authors that children have a milder disease than adults [2, 3] and immunocompromised patients do not seem to evolve differently [5].
T112 9590-9635 Sentence denotes Data in children is practically non-existent.
T113 9636-9838 Sentence denotes Recently, a study carried out by the European Society for Gastroenterology (ESPGHAN), described children with inflammatory bowel disease who presented COVID-19 disease with a mild outpatient course [6].
T114 9839-9970 Sentence denotes In addition, they warned of the risk of developing acute exacerbations of the disease if immunosuppressant treatments were delayed.
T115 9971-10017 Sentence denotes Data from cancer pediatric patients is scarce.
T116 10018-10181 Sentence denotes A recent report from a childhood cancer center in Lombardy, Italy, reported five positive cases in childhood cancer patients and all of them had a mild course [7].
T117 10182-10418 Sentence denotes In fact, the International Society of Pediatric Oncology (SIOP) highlighted that there is no reason to discontinue daily activities in pediatric hematology/oncology units; however, general principles for prevention were recommended [8].
T118 10419-10562 Sentence denotes SARS-CoV-2 infection is proposed to evolve in three phases, causing mortality in the third phase, after 2 or more weeks from symptom onset [9].
T119 10563-10693 Sentence denotes During the early phase, SARS-CoV-2 multiplies and establishes residence in the host, primarily focusing on the respiratory system.
T120 10694-10890 Sentence denotes SARS-CoV-2 binds to its target using the angiotensin-converting enzyme 2 (ACE2), receptor on human cells [10] mainly in human lung, small intestine epithelium, as well as the vascular endothelium.
T121 10891-10942 Sentence denotes This phase presents with mild respiratory symptoms.
T122 10943-11053 Sentence denotes During the second phase, lung involvement is established, with viral pneumonia and the development of hypoxia.
T123 11054-11151 Sentence denotes Lymphopenia appears or increases and a moderate increase in inflammatory markers can be observed.
T124 11152-11232 Sentence denotes A minority of patients will reach the third phase of systemic hyperinflammation.
T125 11233-11548 Sentence denotes There is a decrease in helper, suppressor, and regulatory T cell counts, with increase of inflammatory cytokines and biomarkers such as interleukins IL-2, IL-6, IL-7, granulocyte-colony-stimulating factor, macrophage inflammatory protein 1-α, tumor necrosis factor-α, C-reactive protein, ferritin, and D-dimer [11].
T126 11549-11663 Sentence denotes A hemophagocytic lymphohistiocytosis-like syndrome (sHLH) may occur in patients in this advanced stage of disease.
T127 11664-11850 Sentence denotes The possibility that immunosuppressed patients may not be able to progress to advanced stages of the disease could explain why most behave with mild symptoms, as previously reported [5].
T128 11851-11984 Sentence denotes Although our patients presented lymphopenia, most of them did not have significantly increased D-dimer or Il-6 when it was performed.
T129 11985-12171 Sentence denotes Despite two patients having elevated D-dimer, anticoagulation treatment was not given, as it is not recommended by our Spanish Infectious Disease Society based on the available evidence.
T130 12172-12291 Sentence denotes One of our patients developed sHLH that was treated with dexamethasone as per the HLH-2004 trial and entered remission.
T131 12292-12368 Sentence denotes The patient finished the course of steroids, and had no signs of recurrence.
T132 12369-12519 Sentence denotes Therefore, although most children have a mild-moderate course, it is important to be aware of possible complications that require prompt intervention.
T133 12520-12645 Sentence denotes A problem that must be assessed is the balance between risk and benefit of the suspension of the immunosuppressive treatment.
T134 12646-12764 Sentence denotes We believe that risk has to be individually assessed, as well as the necessity to start specific antiviral treatments.
T135 12765-13050 Sentence denotes Based on our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients, if close monitoring is possible with radiological and blood test controls if necessary, and carefully selecting the patients depending on their individual risk.
T136 13051-13168 Sentence denotes Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress is present.
T137 13169-13307 Sentence denotes Also, it should be considered if there are signs of disease severity (lymphopenia, elevated D-dimer, C-reactive protein or Interleukin-6).
T138 13308-13362 Sentence denotes Depending on the evolution, an sHLH must be ruled out.
T139 13363-13485 Sentence denotes A judicious and conservative treatment seems safe and recommended since to date no antiviral treatment has shown efficacy.
T140 13486-13748 Sentence denotes It is particularly relevant to be very careful when recommending any specific antiviral treatment in this group of patients given the numerous drug interactions that may appear with their immunosuppressive treatment, such as calcineurin inhibitors, among others.
T141 13749-13829 Sentence denotes The available tables of pharmacological interactions should always be consulted.
T142 13830-13944 Sentence denotes Other groups should communicate their experience with these patients to offer appropriate treatment and follow-up.

MyTest

Id Subject Object Predicate Lexical cue
32860101-32600305-29215215 251-252 32600305 denotes 3
32860101-32600305-29215216 9517-9518 32600305 denotes 3

2_test

Id Subject Object Predicate Lexical cue
32860101-32600305-29215215 251-252 32600305 denotes 3
32860101-32600305-29215216 9517-9518 32600305 denotes 3

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T16 13-23 SP_7 denotes SARS-CoV-2
T17 369-386 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T18 411-419 SP_7 denotes COVID-19
T19 777-785 SP_7 denotes COVID-19
T20 1188-1193 UBERON:0000062 denotes organ
T21 1208-1221 GO:0030097;CL:0000037 denotes hematopoietic
T22 1222-1231 CL:0000037 denotes stem cell
T23 1527-1544 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T24 1550-1560 SP_7 denotes SARS-CoV-2
T25 1757-1774 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T26 1789-1799 SP_7 denotes SARS-CoV-2
T27 1909-1919 SP_7 denotes SARS-CoV-2
T28 1994-1999 UBERON:0000004 denotes nasal
T29 2165-2170 UBERON:0000178 denotes blood
T30 2240-2257 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T31 2292-2300 SP_7 denotes COVID-19
T32 2432-2442 SP_7 denotes SARS-CoV-2
T33 2658-2664 GO:0030097 denotes hemato
T34 2723-2736 GO:0030097;CL:0000037 denotes hematopoietic
T35 2737-2746 CL:0000037 denotes stem cell
T36 2789-2794 UBERON:0002107 denotes liver
T37 2800-2806 UBERON:0002113 denotes kidney
T38 2900-2917 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T39 3025-3042 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T40 3110-3121 UBERON:0001004 denotes respiratory
T41 3261-3266 UBERON:0001443 denotes chest
T42 3428-3442 GO:0030097 denotes hemophagocytic
T43 3524-3534 GO:0005577 denotes fibrinogen
T44 3548-3561 CHEBI:17855;CHEBI:17855 denotes triglycerides
T45 3623-3636 CHEBI:41879;CHEBI:41879 denotes dexamethasone
T46 4046-4055 SP_7 denotes sars-cov2
T47 4057-4075 CHEBI:5801;DG_20;CHEBI:5801 denotes Hydroxychloroquine
T48 4123-4133 SP_7 denotes SARS-CoV-2
T49 4195-4206 UBERON:0001004 denotes respiratory
T50 4227-4232 UBERON:0001443 denotes chest
T51 4240-4245 UBERON:0000178 denotes blood
T52 4317-4321 PR:000001393 denotes Il-6
T53 4324-4334 DG_28 denotes Remdesivir
T54 4490-4508 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T55 4556-4566 DG_28 denotes remdesivir
T56 4792-4803 DG_35 denotes tocilizumab
T57 4841-4845 PR:000001393 denotes IL-6
T58 5014-5031 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T59 5207-5215 SP_7 denotes COVID-19
T60 5295-5299 GO:0016265 denotes died
T61 5416-5424 SP_7 denotes COVID-19
T91 5611-5619 SP_7 denotes COVID-19
T92 5742-5747 PR:000001852 denotes CTLA4
T93 5765-5780 CL:0000763 denotes Myelodysplastic
T97 6963-6974 DG_35 denotes Tocilizumab
T98 6975-6988 CHEBI:41879;CHEBI:41879 denotes Dexamethasone
T99 7074-7086 CHEBI:2948;CHEBI:2948 denotes azathioprine
T100 7145-7155 CHEBI:15891;CHEBI:15891 denotes tacrolimus
T101 7169-7179 CHEBI:8382;CHEBI:8382 denotes prednisone
T102 7371-7384 GO:0030097;CL:0000037 denotes hematopoietic
T103 7385-7394 CL:0000037 denotes stem cell
T104 7444-7450 CL:0000236 denotes B cell
T105 7487-7493 CL:0000084 denotes T cell
T106 7543-7561 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T107 7566-7583 CHEBI:35705;CHEBI:35705 denotes immunosuppressors
T108 7593-7602 DG_23 denotes lopinavir
T109 7603-7612 DG_30 denotes ritonavir
T110 7614-7616 CHEBI:15379;CHEBI:15379 denotes O2
T111 7629-7643 GO:0030097 denotes hemophagocytic
T112 7669-7682 CHEBI:62932;CHEBI:62932 denotes mycophenolate
T113 7759-7769 SP_7 denotes SARS-CoV-2
T114 7777-7782 UBERON:0000004 denotes nasal
T115 7982-7987 UBERON:0001707 denotes nasal
T116 7988-7992 UBERON:0001823 denotes swab
T117 8143-8147 UBERON:0000165 denotes oral
T118 8317-8327 DG_28 denotes Remdesivir
T119 8603-8616 CHEBI:41879;CHEBI:41879 denotes Dexamethasone
T120 8846-8860 CHEBI:24751;CHEBI:24751 denotes hydrocortisone
T121 8929-8937 SP_7 denotes COVID-19
T122 9214-9225 UBERON:0001004 denotes respiratory
T123 9313-9330 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T124 9506-9512 UBERON:0007023 denotes adults
T125 9746-9764 UBERON:0000160 denotes inflammatory bowel
T126 9787-9795 SP_7 denotes COVID-19
T127 9928-9945 CHEBI:35705;CHEBI:35705 denotes immunosuppressant
T128 10419-10429 SP_7 denotes SARS-CoV-2
T129 10587-10597 SP_7 denotes SARS-CoV-2
T130 10674-10692 UBERON:0001004 denotes respiratory system
T131 10694-10704 SP_7 denotes SARS-CoV-2
T132 10735-10766 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T133 10768-10772 G_3;PG_10;PR:000003622 denotes ACE2
T134 10787-10792 SP_6;NCBITaxon:9606 denotes human
T135 10814-10819 SP_6;NCBITaxon:9606 denotes human
T136 10820-10824 UBERON:0002048 denotes lung
T137 10826-10852 UBERON:0001902 denotes small intestine epithelium
T138 10878-10889 UBERON:0001986 denotes endothelium
T139 10921-10932 UBERON:0001004 denotes respiratory
T140 10968-10972 UBERON:0002048 denotes lung
T141 11006-11011 NCBITaxon:10239 denotes viral
T142 11280-11290 GO:0065007;CL:0000815 denotes regulatory
T143 11291-11297 CL:0000815 denotes T cell
T144 11382-11386 PR:000001379 denotes IL-2
T145 11390-11392 PR:000001393 denotes -6
T146 11394-11398 PR:000001317 denotes IL-7
T147 11400-11411 CL:0000094;PR:000005932 denotes granulocyte
T148 11411-11437 PR:000005932 denotes -colony-stimulating factor
T149 11439-11449 CL:0000235;PR:000002123 denotes macrophage
T150 11450-11474 PR:000002123 denotes inflammatory protein 1-α
T151 11476-11499 PR:000000134 denotes tumor necrosis factor-α
T152 11551-11565 GO:0030097 denotes hemophagocytic
T153 11957-11961 PR:000001393 denotes Il-6
T154 12031-12046 GO:0050817 denotes anticoagulation
T155 12229-12242 CHEBI:41879;CHEBI:41879 denotes dexamethasone
T156 12327-12335 CHEBI:35341;CHEBI:35341 denotes steroids
T157 12617-12634 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T158 12818-12835 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T159 12840-12848 SP_7 denotes COVID-19
T160 12944-12949 UBERON:0000178 denotes blood
T161 13136-13147 UBERON:0001004 denotes respiratory
T162 13270-13288 PR:000005897 denotes C-reactive protein
T163 13292-13305 PR:000001393 denotes Interleukin-6
T164 13629-13633 CHEBI:23888;CHEBI:23888 denotes drug
T165 13674-13691 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T166 13723-13733 CHEBI:35222;CHEBI:35222 denotes inhibitors
T167 13773-13788 CHEBI:52217;CHEBI:52217 denotes pharmacological
T14 10419-10429 SP_7 denotes SARS-CoV-2
T22728 12818-12835 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T46509 13674-13691 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T36004 474-482 SP_7 denotes t-chemot
T99054 611-621 SP_7 denotes of infect
T73137 837-843 GO:0030097 denotes d coun
T11476 902-915 GO:0030097;CL:0000037 denotes in Spain was
T67219 916-925 CL:0000037 denotes declared
T60255 969-974 UBERON:0002107 denotes Madr
T12929 980-986 UBERON:0002113 denotes decla
T76174 1081-1097 CHEBI:35705;CHEBI:35705 denotes e tertiary cente
T28832 1208-1224 CHEBI:35705;CHEBI:35705 denotes hematopoietic st
T91845 1293-1303 UBERON:0001004 denotes ore than 3
T12408 1443-1448 UBERON:0001443 denotes 35 H
T68453 1613-1628 GO:0030097 denotes of March. Pati
T35915 1712-1722 GO:0005577 denotes than 15 y
T70309 1736-1749 CHEBI:17855;CHEBI:17855 denotes primary or se
T77126 1812-1825 CHEBI:41879;CHEBI:41879 denotes at the Univer
T55342 2237-2247 SP_7 denotes e, immunos
T56862 2249-2267 CHEBI:5801;DG_20;CHEBI:5801 denotes pressive treatment
T46340 2315-2325 SP_7 denotes volution w
T92145 2388-2400 UBERON:0001004 denotes 15 children
T58391 2421-2427 UBERON:0001443 denotes spital
T36914 2435-2440 UBERON:0000178 denotes S-CoV
T41321 2512-2516 PR:000001393 denotes were
T12110 2519-2529 DG_28 denotes mitted. A
T46885 2686-2704 CHEBI:5801;DG_20;CHEBI:5801 denotes ases (three patien
T36685 2752-2762 DG_28 denotes plant), tw
T45851 2989-3000 DG_35 denotes 12.6). All
T82400 3039-3043 PR:000001393 denotes ive
T78751 3211-3227 CHEBI:35705;CHEBI:35705 denotes two had focal i
T22801 3404-3412 SP_7 denotes One pati
T64764 3490-3494 GO:0016265 denotes pers
T84702 3611-3619 SP_7 denotes atment w
T62 3799-3807 SP_7 denotes , in coo
T63 3900-3905 PR:000001852 denotes ic As
T64 4501-4505 PR:000001393 denotes roqu
T65 4690-4702 UBERON:0005169 denotes symptoms wi
T66 4926-4936 DG_28 denotes uppressive
T67 4972-4982 DG_28 denotes in 6 patie
T68 5054-5063 CHEBI:15891;CHEBI:15891 denotes spectivel
T69 5091-5103 CHEBI:2948;CHEBI:2948 denotes ed progressi
T70 5159-5168 CHEBI:15891;CHEBI:15891 denotes median fo
T71 5182-5192 CHEBI:8382;CHEBI:8382 denotes days (IQR
T72 5272-5277 UBERON:0000004 denotes inten
T73 5363-5376 GO:0030097;CL:0000037 denotes nts and have
T74 5377-5386 CL:0000037 denotes ad no fur
T75 5435-5441 CL:0000236 denotes cal ch
T76 5478-5484 CL:0000084 denotes l as d
T77 5536-5554 DG_20;CHEBI:5801;CHEBI:5801 denotes ble 1. Table 1 Cli
T78 5586-5594 DG_23 denotes ompromis
T79 5595-5606 DG_30 denotes d children
T80 5608-5610 CHEBI:15379;CHEBI:15379 denotes th
T81 5623-5637 GO:0030097 denotes ease Case # 1
T82 5663-5676 CHEBI:62932;CHEBI:62932 denotes 15 13 12.6 9
T83 5752-5762 SP_7 denotes ciency) HS
T84 5770-5775 UBERON:0000004 denotes dyspl
T85 5975-5980 UBERON:0001707 denotes (sto
T86 5981-5985 UBERON:0001823 denotes ped
T87 6138-6142 UBERON:0000165 denotes myco
T88 6307-6317 DG_28 denotes tes/mm3 (m
T89 6597-6610 CHEBI:41879;CHEBI:41879 denotes 1270 553 Ches
T90 6840-6855 CHEBI:35350;CHEBI:35350 denotes ospitalization
T95220 6921-6929 SP_7 denotes awal HCQ
T76668 6948-6953 PR:000001852 denotes * Rem
T83378 6971-6986 CL:0000763 denotes mab Dexamethaso
T95008 7039-7051 CL:0000542 denotes olimus reduc
T45414 7132-7142 DG_28 denotes withdrawa
T54245 7165-7175 DG_28 denotes and predni
T94900 7178-7189 DG_35 denotes e increase)
T76258 7190-7203 CHEBI:41879;CHEBI:41879 denotes HCQ* Duration
T95049 7224-7236 CHEBI:2948;CHEBI:2948 denotes - 28 - 3 4 2
T71044 7298-7307 CHEBI:15891;CHEBI:15891 denotes None Non
T41068 7321-7331 CHEBI:8382;CHEBI:8382 denotes drome None
T55685 7371-7384 GO:0030097;CL:0000037 denotes hematopoietic
T53406 7385-7394 CL:0000037 denotes stem cell
T50125 7444-7450 CL:0000236 denotes B cell
T74346 7487-7493 CL:0000084 denotes T cell
T78965 7543-7561 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T93758 7566-7583 CHEBI:35705;CHEBI:35705 denotes immunosuppressors
T25906 7593-7602 DG_23 denotes lopinavir
T85834 7603-7612 DG_30 denotes ritonavir
T87655 7614-7616 CHEBI:15379;CHEBI:15379 denotes O2
T74525 7629-7643 GO:0030097 denotes hemophagocytic
T46160 7669-7682 CHEBI:62932;CHEBI:62932 denotes mycophenolate
T4239 7759-7769 SP_7 denotes SARS-CoV-2
T71468 7777-7782 UBERON:0000004 denotes nasal
T51839 7982-7987 UBERON:0001707 denotes nasal
T14851 7988-7992 UBERON:0001823 denotes swab
T13016 8143-8147 UBERON:0000165 denotes oral
T62411 8317-8327 DG_28 denotes Remdesivir
T85530 8603-8616 CHEBI:41879;CHEBI:41879 denotes Dexamethasone
T80219 8846-8860 CHEBI:24751;CHEBI:24751 denotes hydrocortisone
T18376 8929-8937 SP_7 denotes COVID-19
T16128 9214-9225 UBERON:0001004 denotes respiratory
T46329 9313-9330 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T17443 9506-9512 UBERON:0007023 denotes adults
T37301 9746-9764 UBERON:0000160 denotes inflammatory bowel
T92613 9787-9795 SP_7 denotes COVID-19
T68218 9928-9945 CHEBI:35705;CHEBI:35705 denotes immunosuppressant
T99144 10419-10429 SP_7 denotes SARS-CoV-2
T9138 10587-10597 SP_7 denotes SARS-CoV-2
T32640 10674-10692 UBERON:0001004 denotes respiratory system
T43999 10694-10704 SP_7 denotes SARS-CoV-2
T92465 10735-10766 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T71916 10768-10772 G_3;PG_10;PR:000003622 denotes ACE2
T76315 10787-10792 SP_6;NCBITaxon:9606 denotes human
T31203 10814-10819 SP_6;NCBITaxon:9606 denotes human
T74681 10820-10824 UBERON:0002048 denotes lung
T50061 10826-10852 UBERON:0001902 denotes small intestine epithelium
T30049 10878-10889 UBERON:0001986 denotes endothelium
T27899 10921-10932 UBERON:0001004 denotes respiratory
T94732 10968-10972 UBERON:0002048 denotes lung
T19924 11006-11011 NCBITaxon:10239 denotes viral
T51374 11280-11290 GO:0065007;CL:0000815 denotes regulatory
T18928 11291-11297 CL:0000815 denotes T cell
T17487 11382-11386 PR:000001379 denotes IL-2
T3917 11390-11392 PR:000001393 denotes -6
T29269 11394-11398 PR:000001317 denotes IL-7
T89744 11400-11411 CL:0000094;PR:000005932 denotes granulocyte
T69790 11411-11437 PR:000005932 denotes -colony-stimulating factor
T42852 11439-11449 CL:0000235;PR:000002123 denotes macrophage
T75791 11450-11474 PR:000002123 denotes inflammatory protein 1-α
T95062 11476-11499 PR:000000134 denotes tumor necrosis factor-α
T17748 11551-11565 GO:0030097 denotes hemophagocytic
T76398 11957-11961 PR:000001393 denotes Il-6
T42967 12031-12046 GO:0050817 denotes anticoagulation
T30209 12229-12242 CHEBI:41879;CHEBI:41879 denotes dexamethasone
T24327 12327-12335 CHEBI:35341;CHEBI:35341 denotes steroids
T20603 12617-12634 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T80687 12818-12835 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T7555 12840-12848 SP_7 denotes COVID-19
T24066 12944-12949 UBERON:0000178 denotes blood
T98129 13136-13147 UBERON:0001004 denotes respiratory
T34959 13270-13288 PR:000005897 denotes C-reactive protein
T28648 13292-13305 PR:000001393 denotes Interleukin-6
T99212 13629-13633 CHEBI:23888;CHEBI:23888 denotes drug
T3749 13674-13691 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T58609 13723-13733 CHEBI:35222;CHEBI:35222 denotes inhibitors
T96758 13773-13788 CHEBI:52217;CHEBI:52217 denotes pharmacological

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
60 37-45 Species denotes children Tax:9606
61 158-166 Species denotes children Tax:9606
62 239-246 Species denotes infants Tax:9606
63 308-316 Species denotes patients Tax:9606
64 355-363 Species denotes children Tax:9606
65 460-465 Species denotes child Tax:9606
66 664-672 Species denotes patients Tax:9606
67 739-747 Species denotes patients Tax:9606
68 13-33 Disease denotes SARS-CoV-2 infection MESH:C000657245
69 411-419 Disease denotes COVID-19 MESH:C000657245
70 489-504 Disease denotes agranulocytosis MESH:D000380
71 512-526 Disease denotes acute leukemia MESH:D015470
72 615-624 Disease denotes infection MESH:D007239
73 777-785 Disease denotes COVID-19 MESH:C000657245
81 1151-1159 Species denotes children Tax:9606
82 1315-1323 Species denotes patients Tax:9606
83 1422-1430 Species denotes patients Tax:9606
84 1492-1500 Species denotes children Tax:9606
85 1308-1314 Disease denotes cancer MESH:D009369
86 1415-1421 Disease denotes cancer MESH:D009369
87 1550-1570 Disease denotes SARS-CoV-2 infection MESH:C000657245
89 1624-1632 Species denotes Patients Tax:9606
94 1699-1707 Species denotes children Tax:9606
95 1789-1799 Species denotes SARS-CoV-2 Tax:2697049
96 1909-1919 Species denotes SARS-CoV-2 Tax:2697049
97 1775-1783 Disease denotes infected MESH:D007239
99 2292-2300 Disease denotes COVID-19 MESH:C000657245
132 5742-5747 Gene denotes CTLA4 Gene:1493
133 5940-5943 Gene denotes CD4 Gene:920
134 6000-6003 Gene denotes CD4 Gene:920
135 6424-6428 Gene denotes IL-6 Gene:3569
136 6475-6494 Gene denotes C- Reactive Protein Gene:1401
137 5959-5970 Chemical denotes Ruxolitinib MESH:C540383
138 6023-6037 Chemical denotes mercaptopurine MESH:D015122
139 6042-6054 Chemical denotes methotrexate MESH:D008727
140 6055-6065 Chemical denotes Trametinib MESH:C560077
141 6066-6076 Chemical denotes Prednisone MESH:D011241
142 6078-6088 Chemical denotes tacrolimus MESH:D016559
143 6089-6099 Chemical denotes Prednisone MESH:D011241
144 6101-6113 Chemical denotes azathioprine MESH:D001379
145 6114-6124 Chemical denotes Prednisone MESH:D011241
146 6126-6136 Chemical denotes tacrolimus MESH:D016559
147 6138-6151 Chemical denotes mycophenolate MESH:D009173
148 6153-6156 Chemical denotes MMF MESH:D009173
149 6894-6897 Chemical denotes HCQ MESH:D006886
150 6899-6909 Chemical denotes Remdesivir MESH:C000606551
151 6926-6929 Chemical denotes HCQ MESH:D006886
152 6934-6948 Chemical denotes withdrawal HCQ
153 6950-6960 Chemical denotes Remdesivir MESH:C000606551
154 6963-6988 Chemical denotes Tocilizumab Dexamethasone
155 6992-7002 Chemical denotes Trametinib MESH:C560077
156 7035-7045 Chemical denotes tacrolimus MESH:D016559
157 7074-7086 Chemical denotes azathioprine MESH:D001379
158 7145-7155 Chemical denotes tacrolimus MESH:D016559
159 7169-7179 Chemical denotes prednisone MESH:D011241
160 7251-7253 Chemical denotes O2 MESH:D010100
161 6158-6163 Disease denotes Fever MESH:D005334
162 6193-6198 Disease denotes Cough MESH:D003371
163 6266-6273 Disease denotes Dyspnea MESH:D004417
166 5597-5605 Species denotes children Tax:9606
167 5611-5619 Disease denotes COVID-19 MESH:C000657245
178 7539-7561 Chemical denotes HCQ hydroxychloroquine
179 7585-7592 Chemical denotes LPV/Rtv
180 7593-7612 Chemical denotes lopinavir/ritonavir MESH:C558899
181 7614-7623 Chemical denotes O2 oxygen MESH:D010100
182 7665-7668 Chemical denotes MMF MESH:D009173
183 7669-7682 Chemical denotes mycophenolate MESH:D009173
184 7407-7435 Disease denotes PID primary immunodeficiency MESH:D000081207
185 7457-7479 Disease denotes lymphoblastic leukemia MESH:D054198
186 7481-7522 Disease denotes T-ALL T cell acute lymphoblastic leukemia MESH:D054218
187 7625-7663 Disease denotes HLH hemophagocytic lymphohistiocytosis MESH:D051359
200 7705-7713 Species denotes patients Tax:9606
201 7759-7769 Species denotes SARS-CoV-2 Tax:2697049
202 7845-7853 Species denotes Patients Tax:9606
203 7943-7950 Species denotes Patient Tax:9606
204 8011-8018 Species denotes patient Tax:9606
205 8257-8265 Species denotes children Tax:9606
206 7684-7687 Chemical denotes HCQ MESH:D006886
207 8040-8047 Chemical denotes LPV/Rtv
208 8105-8108 Chemical denotes HCQ MESH:D006886
209 8169-8172 Chemical denotes HCQ MESH:D006886
210 8222-8225 Chemical denotes HCQ MESH:D006886
211 7957-7962 Disease denotes fever MESH:D005334
217 8363-8370 Species denotes patient Tax:9606
218 8388-8395 Species denotes patient Tax:9606
219 8505-8513 Species denotes patients Tax:9606
220 8583-8591 Species denotes patients Tax:9606
221 8317-8327 Chemical denotes Remdesivir MESH:C000606551
223 8603-8616 Chemical denotes Dexamethasone MESH:D003907
276 4301-4304 Gene denotes CRP Gene:1401
277 4317-4321 Gene denotes Il-6 Gene:3569
278 4841-4845 Gene denotes IL-6 Gene:3569
279 3524-3534 Gene denotes fibrinogen Gene:2244
280 2391-2399 Species denotes children Tax:9606
281 2432-2442 Species denotes SARS-CoV-2 Tax:2697049
282 2583-2591 Species denotes patients Tax:9606
283 2698-2706 Species denotes patients Tax:9606
284 2764-2772 Species denotes patients Tax:9606
285 2843-2847 Species denotes girl Tax:9606
286 3004-3012 Species denotes patients Tax:9606
287 3310-3317 Species denotes patient Tax:9606
288 3408-3415 Species denotes patient Tax:9606
289 4046-4055 Species denotes sars-cov2 Tax:2697049
290 4123-4133 Species denotes SARS-CoV-2 Tax:2697049
291 4538-4546 Species denotes patients Tax:9606
292 4588-4596 Species denotes patients Tax:9606
293 4621-4628 Species denotes patient Tax:9606
294 4662-4669 Species denotes patient Tax:9606
295 4775-4782 Species denotes patient Tax:9606
296 4977-4985 Species denotes patients Tax:9606
297 5230-5235 Species denotes child Tax:9606
298 5321-5329 Species denotes patients Tax:9606
299 5462-5470 Species denotes patients Tax:9606
300 3325-3331 Chemical denotes oxygen MESH:D010100
301 3548-3561 Chemical denotes triglycerides MESH:D014280
302 3623-3636 Chemical denotes dexamethasone MESH:D003907
303 4057-4075 Chemical denotes Hydroxychloroquine MESH:D006886
304 4324-4334 Chemical denotes Remdesivir MESH:C000606551
305 4490-4508 Chemical denotes hydroxychloroquine MESH:D006886
306 4556-4566 Chemical denotes remdesivir MESH:C000606551
307 4639-4645 Chemical denotes oxygen MESH:D010100
308 4792-4803 Chemical denotes tocilizumab MESH:C502936
309 2879-2889 Disease denotes vasculitis MESH:D014657
310 3110-3130 Disease denotes respiratory symptoms MESH:D012818
311 3146-3151 Disease denotes fever MESH:D005334
312 3357-3365 Disease denotes diarrhea MESH:D003967
313 3384-3391 Disease denotes anosmia MESH:D000857
314 3395-3402 Disease denotes ageusia MESH:D000370
315 3428-3476 Disease denotes hemophagocytic lymphohistiocytosis-like syndrome MESH:D051359
316 3501-3506 Disease denotes fever MESH:D005334
317 3508-3518 Disease denotes cytopenias MESH:D006402
318 3766-3784 Disease denotes Infectious Disease MESH:D003141
319 4214-4223 Disease denotes pneumonia MESH:D011014
320 4277-4288 Disease denotes lymphopenia MESH:D008231
321 4712-4723 Disease denotes lymphopenia MESH:D008231
322 4822-4827 Disease denotes fever MESH:D005334
323 4873-4883 Disease denotes toxicities MESH:D064420
324 5106-5117 Disease denotes lymphopenia MESH:D008231
325 5207-5215 Disease denotes COVID-19 MESH:C000657245
326 5295-5299 Disease denotes died MESH:D003643
327 5416-5424 Disease denotes COVID-19 MESH:C000657245
335 8915-8923 Species denotes patients Tax:9606
336 9013-9021 Species denotes children Tax:9606
337 9270-9278 Species denotes patients Tax:9606
338 9249-9255 Chemical denotes oxygen MESH:D010100
339 8929-8937 Disease denotes COVID-19 MESH:C000657245
340 9133-9149 Disease denotes febrile syndrome MESH:D000071072
341 9214-9234 Disease denotes respiratory distress MESH:D012128
354 9470-9478 Species denotes children Tax:9606
355 9542-9550 Species denotes patients Tax:9606
356 9598-9606 Species denotes children Tax:9606
357 9732-9740 Species denotes children Tax:9606
358 9816-9826 Species denotes outpatient Tax:9606
359 9998-10006 Species denotes patients Tax:9606
360 10134-10142 Species denotes patients Tax:9606
361 9746-9772 Disease denotes inflammatory bowel disease MESH:D015212
362 9787-9795 Disease denotes COVID-19 MESH:C000657245
363 9981-9987 Disease denotes cancer MESH:D009369
364 10051-10057 Disease denotes cancer MESH:D009369
365 10127-10133 Disease denotes cancer MESH:D009369
388 10735-10766 Gene denotes angiotensin-converting enzyme 2 Gene:59272
389 10768-10772 Gene denotes ACE2 Gene:59272
390 11382-11386 Gene denotes IL-2 Gene:3558
391 11388-11392 Gene denotes IL-6 Gene:3569
392 11394-11398 Gene denotes IL-7 Gene:3574
393 11400-11437 Gene denotes granulocyte-colony-stimulating factor Gene:1440
394 11439-11474 Gene denotes macrophage inflammatory protein 1-α Gene:1230
395 11476-11499 Gene denotes tumor necrosis factor-α Gene:7124
396 11501-11519 Gene denotes C-reactive protein Gene:1401
397 10587-10597 Species denotes SARS-CoV-2 Tax:2697049
398 10694-10704 Species denotes SARS-CoV-2 Tax:2697049
399 10787-10792 Species denotes human Tax:9606
400 10814-10819 Species denotes human Tax:9606
401 11166-11174 Species denotes patients Tax:9606
402 11620-11628 Species denotes patients Tax:9606
403 10419-10439 Disease denotes SARS-CoV-2 infection MESH:C000657245
404 10487-10496 Disease denotes mortality MESH:D003643
405 10921-10941 Disease denotes respiratory symptoms MESH:D012818
406 11006-11021 Disease denotes viral pneumonia
407 11045-11052 Disease denotes hypoxia MESH:D000860
408 11054-11065 Disease denotes Lymphopenia MESH:D008231
409 11551-11599 Disease denotes hemophagocytic lymphohistiocytosis-like syndrome MESH:D051359
421 11957-11961 Gene denotes Il-6 Gene:3569
422 11702-11710 Species denotes patients Tax:9606
423 11864-11872 Species denotes patients Tax:9606
424 11997-12005 Species denotes patients Tax:9606
425 12183-12191 Species denotes patients Tax:9606
426 12296-12303 Species denotes patient Tax:9606
427 12394-12402 Species denotes children Tax:9606
428 12229-12242 Chemical denotes dexamethasone MESH:D003907
429 12327-12335 Chemical denotes steroids MESH:D013256
430 11883-11894 Disease denotes lymphopenia MESH:D008231
431 12112-12130 Disease denotes Infectious Disease MESH:D003141
441 13270-13288 Gene denotes C-reactive protein Gene:1401
442 13292-13305 Gene denotes Interleukin-6 Gene:3569
443 12804-12812 Species denotes children Tax:9606
444 13006-13014 Species denotes patients Tax:9606
445 13601-13609 Species denotes patients Tax:9606
446 12840-12848 Disease denotes COVID-19 MESH:C000657245
447 13096-13101 Disease denotes fever MESH:D005334
448 13136-13156 Disease denotes respiratory distress MESH:D012128
449 13239-13250 Disease denotes lymphopenia MESH:D008231
451 13890-13898 Species denotes patients Tax:9606