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PMC:7454258 / 97318-104988 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T81564 4678-4683 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T51004 4684-4691 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T15201 4706-4711 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T9581 4726-4731 Body_part denotes waist http://purl.org/sig/ont/fma/fma228775
T10333 5017-5022 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T45281 5042-5047 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T50 422-427 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T35 4574-4579 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T36 4678-4683 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T37 4706-4711 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T38 5017-5022 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T39 5042-5047 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T187 319-322 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T189 433-436 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T191 672-675 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T193 2867-2870 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T195 5003-5010 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T196 5012-5031 Disease denotes high blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T197 5312-5315 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T199 6633-6645 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T200 6647-6654 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T201 6660-6675 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T202 6667-6675 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T59888 2063-2066 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T90769 2395-2396 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71155 2919-2923 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T44661 3263-3264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57436 3402-3403 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61298 3580-3587 http://purl.obolibrary.org/obo/CLO_0009985 denotes focuses
T68765 3642-3648 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T21046 3954-3956 http://purl.obolibrary.org/obo/CLO_0007815 denotes mo
T2324 4158-4163 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T20172 4398-4403 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T30730 4678-4683 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T88373 4678-4683 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T77388 4706-4711 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T93943 4706-4711 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T9287 4772-4777 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T59944 5017-5022 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T42369 5017-5022 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T16018 5042-5047 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T75644 5042-5047 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T99223 5278-5288 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T3127 5518-5531 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizations
T45829 5846-5850 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T82149 5846-5850 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T53952 5895-5908 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizations
T16870 5922-5925 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T30298 6089-6092 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T45347 6301-6314 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizations
T55006 7218-7219 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T80365 7324-7333 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T493 5-6 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T494 48-56 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T495 336-337 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T496 401-402 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T497 422-427 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T498 422-427 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T499 633-639 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T500 1591-1594 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T501 1778-1781 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T91551 319-322 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T42211 433-436 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T34324 672-675 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T70118 1412-1416 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T53827 2867-2870 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T44573 4684-4691 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T97910 4693-4704 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T45598 5048-5059 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T67279 5312-5315 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
537 672-693 Disease denotes HHS Office of Disease MESH:D058747
542 3642-3648 Species denotes humans Tax:9606
543 3923-3930 Species denotes infants Tax:9606
544 3961-3966 Species denotes women Tax:9606
545 3305-3309 Chemical denotes CNPP
556 4952-4960 Species denotes patients Tax:9606
557 6247-6255 Species denotes patients Tax:9606
558 6387-6393 Species denotes People Tax:9606
559 4684-4691 Chemical denotes glucose MESH:D005947
560 4693-4704 Chemical denotes cholesterol MESH:D002784
561 5048-5059 Chemical denotes cholesterol MESH:D002784
562 5003-5010 Disease denotes obesity MESH:D009765
563 6633-6645 Disease denotes hypertension MESH:D006973
564 6647-6654 Disease denotes obesity MESH:D009765
565 6660-6675 Disease denotes type 2 diabetes MESH:D003924

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T513 0-4 Sentence denotes DGAs
T514 5-164 Sentence denotes A key cross-departmental nutrition-related activity is the DGAs, the cornerstone for many federal nutrition programs and policies (Supplemental Table 8) (179).
T515 165-323 Sentence denotes The National Nutrition Monitoring and Related Research Act of 1990 (Public Law 101–445) requires the DGAs be reviewed by the Secretaries of both USDA and HHS.
T516 324-514 Sentence denotes Since 1995, a memorandum of understanding between the 2 departments provides a framework for this joint USDA–HHS endeavor, with each department alternating in leading each 5-y edition (180).
T517 515-667 Sentence denotes Regardless of departmental lead, the USDA CNPP conducts the evidence analysis and develops the corresponding consumer-facing education tools (144, 145).
T518 668-829 Sentence denotes The HHS Office of Disease Prevention and Health Promotion (ODPHP) aims to provide technical expertise and develop DGA-related resources for health professionals.
T519 830-926 Sentence denotes Both agencies’ efforts are constrained by limited funding and staff dedicated to the DGAs (144).
T520 927-1226 Sentence denotes In mandating the DGAs, Congress (Public Law 101–445) did not authorize or appropriate any regular funding for the DGA process nor, importantly, for the fundamental research, monitoring, and surveillance processes necessary for developing and translating dietary guidance, among other national needs.
T521 1227-1456 Sentence denotes For example, there is no consistent funding source to develop the nation's DRIs, which are foundational to the DGAs, nor to ensure sufficient research to develop the necessary evidence base for updates of either the DGAs or DRIs.
T522 1457-1596 Sentence denotes Successive DGACs from the 1980 edition onwards have documented persistent, major research gaps for setting evidence-based guidelines (181).
T523 1597-1787 Sentence denotes Consistent funding also does not exist to review the impact of the DGAs on the public's understanding of nutrition, food choices, or health, or on the impact on other stakeholders (181–183).
T524 1788-2072 Sentence denotes In response to concerns that the DGA process may require updated processes and coordination, in 2016 Congress instructed the National Academies of Sciences, Engineering, and Medicine (NASEM) to review and make recommendations to the process for updating the DGAs (Public Law 114–113).
T525 2073-2191 Sentence denotes First, in February 2017, NASEM released “Optimizing the Process for Establishing the Dietary Guidelines for Americans:
T526 2192-2221 Sentence denotes The Selection Process” (184).
T527 2222-2417 Sentence denotes This report provided recommendations for how the advisory committee process can be improved to provide more transparency, eliminate bias, and include committee members with a range of viewpoints.
T528 2418-2562 Sentence denotes The second report released in September 2017 was entitled “Redesigning the Process for Establishing the Dietary Guidelines for Americans” (182).
T529 2563-2857 Sentence denotes This report identified the following specific opportunities for improvement in the DGA process: more consistent interpretation of purpose and target audiences of the DGA, greater transparency of the overall process, and more rigorous methodological approaches to the evaluation of the evidence.
T530 2858-3177 Sentence denotes The USDA-HHS responded to NASEM recommendations in September 2018 indicating changes they will be making in the development of the 2020–2025 DGAs, such as asking for public comments on the topics and scientific questions to be examined in the review of the evidence supporting the development of the next edition (185).
T531 3178-3365 Sentence denotes In part to respond to these recommendations, the FY2019 appropriations bill provided a one-time allocation of $12.3 million to CNPP, divided over 3 y, to support the 2020–2025 DGAs (186).
T532 3366-3521 Sentence denotes These one-time funds are supporting a limited set of systematic reviews of published evidence, but not any new research to address critical knowledge gaps.
T533 3522-3778 Sentence denotes As previously noted, only ∼1.3% of NIH-supported research focuses on diet for the prevention or treatment of disease in humans, and furthermore, among these, only about half of the projects relate to key research gaps identified by the 2015 DGAC (117–119).
T534 3779-4136 Sentence denotes In addition, while the 2014 Farm Bill (Public Law 113–79) mandated that the DGAs include, for the first time, food-based nutrition guidance for infants and toddlers aged 0–24 mo and women who are pregnant or lactating (prior DGAs did not include or consider these critical populations), no funding was authorized or appropriated to support this new mandate.
T535 4137-4355 Sentence denotes Given the first-ever focus of the 2020–2025 DGAs on these important populations, it is expected that the 2020 DGAC will identify even more knowledge gaps for setting national dietary guidance than prior editions (187).
T536 4356-4547 Sentence denotes In 1990, Congress specified that the DGAs focus on the general public, not on specific nutritional recommendations for individuals suffering from diet-related conditions (Public Law 101–445).
T537 4548-4747 Sentence denotes However, highlighting the scale and scope of diet-related illness, only 12% of US adults are metabolically healthy (as defined by blood glucose, cholesterol, blood pressure, and waist circumference).
T538 4748-4860 Sentence denotes Thus, the DGAs’ general focus may exclude the specific dietary needs of the great majority of the US population.
T539 4861-5085 Sentence denotes Until 2014, the NIH supported the development of evidence reviews and dietary guidance for patients with health issues such as overweight and obesity, high blood pressure, and high blood cholesterol, among others (188, 189).
T540 5086-5175 Sentence denotes These reviews were used by DGACs with input and endorsement from >25 professional groups.
T541 5176-5467 Sentence denotes The NIH ceased these reports in 2014, in part because the CDC's mandate deals with disease prevention activities and the mandate of the HHS Agency for Healthcare Research and Quality (AHRQ) includes development of systematic evidence reviews to inform clinical practice guidelines (189–191).
T542 5468-5688 Sentence denotes Certain nongovernmental professional and clinical organizations provide nutrition guidance for populations with or at risk for various chronic conditions, but these various recommendations are not coordinated (192, 193).
T543 5689-5909 Sentence denotes The current 2020 DGAC process excludes—for the first time—the use of existing high-quality nongovernmental systematic reviews and meta-analyses conducted by peer-reviewed researchers and major professional organizations.
T544 5910-6134 Sentence denotes Little work has been done to understand the short- or long-term implications of NIH's shift in 2014 away from dietary guidance for populations with disease conditions, or whether CDC and AHRQ efforts are addressing this gap.
T545 6135-6292 Sentence denotes Thus, currently no federal entity takes the lead on the development of evidence reviews or dietary guidance for patients with diet-related health conditions.
T546 6293-6768 Sentence denotes Several organizations, including AND, the National Association for the Advancement of Colored People, and the National Hispanic Medical Association, recently formed the Food4Health Alliance to advocate for additional federal nutrition guidelines tailored to the needs of tens of millions of Americans who have diet-related diseases such as hypertension, obesity, and type 2 diabetes—conditions that also disproportionately affect minorities and underserved communities (194).
T547 6769-7217 Sentence denotes In addition to the lack of consistent funding and staff for the evidence reviews, fundamental research, monitoring, and surveillance processes needed to develop and translate dietary guidance, concerns have been raised that the process of updating the DGAs every 5 y is not protected from political or external influences (e.g., political appointees, Congress, food and beverage industries, agribusiness interests, advocacy groups) (182, 184, 195).
T548 7218-7670 Sentence denotes A coordinated federal approach and authority for nutrition research could help strengthen the process for objective and independent development, review, and dissemination of the best science evidence to the American public in the DGAs for both healthy individuals and those with major diet-related illnesses, as well as for the evaluation of corresponding intended and unintended impacts of these guidelines and needed changes to improve these impacts.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T88 4988-4998 Phenotype denotes overweight http://purl.obolibrary.org/obo/HP_0025502
T89 5003-5010 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T90 5012-5031 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T91 6633-6645 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T92 6647-6654 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T93 6660-6675 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978

2_test

Id Subject Object Predicate Lexical cue
32687145-23706352-2017896 1591-1594 23706352 denotes 181
32687145-23706352-2017897 1782-1785 23706352 denotes 183
32687145-30458950-2017898 3773-3776 30458950 denotes 119
32687145-30982878-2017899 4350-4353 30982878 denotes 187