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PMC:7454258 / 70090-82869 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T32 2132-2141 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T33 2234-2243 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T162 1444-1447 Disease denotes ARS http://purl.obolibrary.org/obo/MONDO_0014648
T163 1516-1519 Disease denotes ARS http://purl.obolibrary.org/obo/MONDO_0014648
T164 5243-5246 Disease denotes ARS http://purl.obolibrary.org/obo/MONDO_0014648
T165 6241-6244 Disease denotes ARS http://purl.obolibrary.org/obo/MONDO_0014648
T166 6696-6699 Disease denotes ARS http://purl.obolibrary.org/obo/MONDO_0014648
T167 7846-7849 Disease denotes ARS http://purl.obolibrary.org/obo/MONDO_0014648
T168 7990-7993 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T170 10547-10554 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T94206 193-196 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T71558 282-292 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T20159 414-419 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T54354 442-443 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19937 666-669 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T13863 670-671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90781 678-683 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T50462 985-986 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67702 1286-1287 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78107 1440-1447 http://purl.obolibrary.org/obo/CLO_0001912 denotes the ARS
T62204 1512-1519 http://purl.obolibrary.org/obo/CLO_0001912 denotes The ARS
T63550 1521-1526 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T82218 1600-1601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T44087 1647-1652 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T2651 2095-2102 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T12838 2185-2192 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T25244 2196-2201 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T70287 2499-2500 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4039 2501-2506 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T2717 2741-2742 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46374 3140-3142 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T92479 3520-3523 http://purl.obolibrary.org/obo/CLO_0003376 denotes FNS
T62655 3608-3611 http://purl.obolibrary.org/obo/CLO_0003376 denotes FNS
T60022 3882-3885 http://purl.obolibrary.org/obo/CLO_0003376 denotes FNS
T74992 4111-4117 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T13335 4312-4313 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99243 4492-4496 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T81178 4669-4672 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T20969 4875-4878 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T78812 4928-4931 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T92234 5239-5246 http://purl.obolibrary.org/obo/CLO_0001912 denotes the ARS
T37237 5258-5263 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T49033 5359-5364 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T52173 5395-5398 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T66900 5452-5455 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T59505 5654-5656 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T7931 5691-5692 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T32384 6390-6395 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T60656 6486-6489 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T49440 6868-6871 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T48311 6992-6995 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T85367 7109-7110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23373 7147-7148 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59007 7257-7267 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T73262 7316-7317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98894 7450-7453 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T54089 7492-7497 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T86542 7553-7554 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98861 7555-7560 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T31965 7653-7654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45118 7660-7665 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T22758 7749-7754 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T28299 7782-7785 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T88821 7795-7801 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T2444 7888-7891 http://purl.obolibrary.org/obo/CLO_0003376 denotes FNS
T18986 7933-7934 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87123 8025-8028 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T28678 8108-8118 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T20274 8689-8695 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T95496 8723-8729 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T43281 9760-9761 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38745 9794-9795 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T7027 9929-9930 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76665 10032-10042 http://purl.obolibrary.org/obo/BFO_0000030 denotes objectives
T36362 10098-10108 http://purl.obolibrary.org/obo/BFO_0000030 denotes objectives
T88896 10755-10760 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T97167 10826-10829 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T47841 10830-10840 http://purl.obolibrary.org/obo/BFO_0000030 denotes objectives
T52808 11229-11239 http://purl.obolibrary.org/obo/BFO_0000030 denotes objectives
T19613 11261-11262 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23415 11298-11299 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94854 12452-12453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20410 12489-12490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T14 4328-4331 Chemical denotes GDP http://purl.obolibrary.org/obo/CHEBI_17552|http://purl.obolibrary.org/obo/CHEBI_58189
T91137 4502-4516 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T93237 6732-6734 Chemical denotes FY http://purl.obolibrary.org/obo/CHEBI_73637
T70114 6781-6784 Chemical denotes Pro http://purl.obolibrary.org/obo/CHEBI_50342
T19 7990-7993 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T62439 10195-10199 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T61665 10229-10242 Chemical denotes micronutrient http://purl.obolibrary.org/obo/CHEBI_27027
T45999 11190-11194 Chemical denotes fuel http://purl.obolibrary.org/obo/CHEBI_33292
T17815 12735-12743 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T8662 12752-12757 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T37 1757-1770 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T38 2285-2291 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T39 2809-2825 http://purl.obolibrary.org/obo/GO_0042755 denotes eating behaviors
T40 2809-2815 http://purl.obolibrary.org/obo/GO_0007631 denotes eating
T41 3351-3362 http://purl.obolibrary.org/obo/GO_0065007 denotes regulations
T42 4886-4892 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T43 8426-8437 http://purl.obolibrary.org/obo/GO_0065007 denotes regulations
T44 10471-10477 http://purl.obolibrary.org/obo/GO_0007631 denotes eating

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
461 414-419 Species denotes human Tax:9606
468 1521-1526 Species denotes Human Tax:9606
469 1647-1652 Species denotes Human Tax:9606
470 2196-2201 Species denotes human Tax:9606
471 1792-1796 Chemical denotes NIFA
472 2382-2386 Chemical denotes NIFA
473 2435-2439 Chemical denotes NIFA
476 5258-5263 Species denotes human Tax:9606
477 5359-5364 Species denotes Human Tax:9606
479 6390-6395 Species denotes human Tax:9606
484 7492-7497 Species denotes human Tax:9606
485 7555-7560 Species denotes Human Tax:9606
486 7660-7665 Species denotes Human Tax:9606
487 7749-7754 Species denotes Human Tax:9606
496 10300-10305 Species denotes women Tax:9606
497 10337-10344 Species denotes infants Tax:9606
498 10346-10354 Species denotes children Tax:9606
499 10755-10760 Species denotes human Tax:9606
500 12752-12757 Chemical denotes water MESH:D014867
501 10547-10554 Disease denotes obesity MESH:D009765
502 10572-10588 Disease denotes chronic diseases MESH:D002908
503 12675-12684 Disease denotes food loss MESH:D000855

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T390 0-4 Sentence denotes USDA
T391 5-198 Sentence denotes Starting in 1895, Dr. Wilbur Atwater's pioneering work at USDA laid much of the groundwork for modern nutrition science in the US as well as many current USDA nutrition research programs (132).
T392 199-334 Sentence denotes The USDA is the second largest federal funder of nutrition-relevant research, with activities across multiple agencies (Table 1) (133).
T393 335-651 Sentence denotes The Farm Bill requires the Secretary of USDA to establish and support food and human nutrition research as a distinct mission of the Department, including coordinating nutrition research within the Department and with agencies across the federal government, as well as using formalized mechanisms for external input.
T394 652-801 Sentence denotes The USDA also has a major focus on implementing federal nutrition programs to segments of the public, which constitute the majority of USDA's budget.
T395 802-1146 Sentence denotes The importance of the nutrition assistance and associated nutrition education programs for improving food security and health and preventing disease in low-income populations creates a particularly important need to integrate and connect nutrition research from within and outside USDA to inform and guide policy development for these programs.
T396 1147-1410 Sentence denotes The agencies in USDA's Research, Education, and Economics (REE) mission area work to integrate research, analysis, and education to create a safe, sustainable, competitive US food and agricultural system and strong, healthy communities, families, and youth (134).
T397 1411-1511 Sentence denotes REE science agencies include the ARS, NIFA, ERS, and National Agricultural Statistics Service (135).
T398 1512-1791 Sentence denotes The ARS’ Human Nutrition Program emphasizes food-based approaches for health, including a core network of 6 internationally recognized Human Nutrition Research Centers with scientists, equipment, and facilities for long-term, multidisciplinary, translational research (136, 137).
T399 1792-2044 Sentence denotes NIFA supports postsecondary education at 113 land-grant colleges and universities (Public Law 37–130), as well as 21 historically black colleges and universities (Public Law 51–841) and 37 tribal colleges and universities (Public Law 89–329) (138–141).
T400 2045-2434 Sentence denotes While federal funding for these schools initially focused on agricultural research and extension, over time these schools have increasingly focused on human nutrition and food research and extension nutrition education, although the recent growth in research is largely through additional competitive grant mechanisms rather than direct NIFA support to the Agricultural Experiment Station.
T401 2435-2905 Sentence denotes NIFA further supports extramural nutrition research, often with a focus on integrating agricultural considerations with promotion of health and decreasing health disparities; this work includes funding projects aiming to identify environmental and behavioral factors that act as barriers to consumption of a high-quality diet, while identifying factors that promote healthy eating behaviors (e.g., increasing home access and availability of fruits and vegetables) (142).
T402 2906-3149 Sentence denotes The ERS’ food and nutrition research aims to study demographic, social, economic, and informational determinants of adequacy and healthfulness of the American diet, related health outcomes, and corresponding health care expenditures (11, 143).
T403 3150-3487 Sentence denotes This research includes examining interactions among consumers, food industry, and government as they relate to the food supply, markets, and access; food choice and its impact on diet quality; federal regulations and other aspects of food policy; and the USDA's nutrition assistance programs in meeting public policy and nutrition goals.
T404 3488-3603 Sentence denotes The Food and Nutrition Service (FNS) is the only agency of the Food, Nutrition, and Consumer Services mission area.
T405 3604-3813 Sentence denotes The FNS administers 15 domestic nutrition assistance programs, conducts some limited research, and makes use of nutrition research sponsored by other federal agencies to help assess and improve these programs.
T406 3814-4161 Sentence denotes And, as discussed in the cross-governmental section below, the USDA FNS Center for Nutrition Policy and Promotion (CNPP) conducts the evidence analysis for the DGAs, including nutrition evidence systematic reviews, data analysis, and food pattern modeling, and develops the corresponding consumer-facing education tools (e.g., MyPlate) (144, 145).
T407 4162-4300 Sentence denotes USDA investments in research and statistics, including nutrition, have fallen below 1980s levels in constant dollars (Figure 3) (12, 146).
T408 4301-4555 Sentence denotes Indeed, as a percentage of GDP, public investment in agrifood (agriculture and food combined) research and development (4.2%) and particularly food research and development (1%) was lower in 2018 than pharmaceutical research and development (4.9%) (147).
T409 4556-4674 Sentence denotes The US fell behind China in public agricultural research in 2009, and now only invests half the amount as China (148).
T410 4675-4880 Sentence denotes US public sector funding for agricultural research and development is also lower than India, Western Europe, and the Asia-Pacific region including Canada, using constant 2011 purchasing-power parity (148).
T411 4881-4993 Sentence denotes Yet, growth in productivity in the farm sector has come almost exclusively from science-based innovations (146).
T412 4994-5199 Sentence denotes Declines in US public funding for food and agriculture research and development “risks national competitiveness, long-term cutting-edge scientific discovery, and the next generation talent pipeline” (147).
T413 5200-5457 Sentence denotes Specific to nutrition, as one example, the ARS budget for human nutrition research and monitoring, including funding for 6 important extramural and intramural Human Nutrition Centers nationally, has been flat since 1980 in constant dollars (Figure 5) (132).
T414 5458-5690 Sentence denotes In addition, 2 USDA research and statistical agencies that include nutrition research—ERS and NIFA—were relocated to Kansas City, Missouri, at the start of fiscal year 2020 and lost 50% (ERS) and 71% (NIFA) of their workforce (149).
T415 5691-6029 Sentence denotes A recent Congressional Research Service analysis reported the leadership positions at NIFA and ERS have been staffed primarily by acting officials since the relocation and indicated that Congress may be interested in how NIFA and ERS are meeting their responsibilities with reduced workforces and as new staff are potentially hired (150).
T416 6030-6215 Sentence denotes These trends demonstrate declining investments in science to advance US food and agriculture to increase health, sustain our natural resources, and stimulate rural economic development.
T417 6216-6506 Sentence denotes FIGURE 5 Trends in USDA ARS investments for total nutrition research based on data from the USDA, Hathi Trust, and the Government Publishing Office (12) (top panel) and for human nutrition research and monitoring for fiscal years 1978–2010 based on data from the USDA (132) (bottom panel).
T418 6507-6695 Sentence denotes In the bottom panel, shaded bars represent absolute yearly funding (millions of dollars) and open bars represent funding adjusted to 1978 dollars (https://data.bls.gov/cgi-bin/cpicalc.pl).
T419 6696-6748 Sentence denotes ARS, Agricultural Research Service; FY, fiscal year.
T420 6749-6858 Sentence denotes Top panel adapted from POLITICO Pro Datapoint (12), with graphic design support courtesy of Ink&Pixel Agency.
T421 6859-6997 Sentence denotes The USDA has aimed to coordinate nutrition research within and outside the department in many different ways (Supplemental Table 4) (132).
T422 6998-7465 Sentence denotes The Food Security Act of 1985 (Public Law 99–198) required the Secretary of Agriculture to submit to Congress “a comprehensive plan for implementing a national nutrition research program, including recommendations relating to research directions, educational activities, and funding levels necessary to carry out such a plan.” This plan was submitted to Congress in 1986, but no new legislative mandates or change in mission resulted from this report (132, 151, 152).
T423 7466-7744 Sentence denotes In 1993, USDA revised its human nutrition program coordination structure and developed a Human Nutrition Policy Committee that reported to the Secretary's Policy Coordination Council and a USDA Human Nutrition Coordinating Committee (HNCC) that reported to the Policy Committee.
T424 7745-7823 Sentence denotes The Human Nutrition Policy Committee has not been active since the late 1990s.
T425 7824-7994 Sentence denotes HNCC is chaired by an ARS representative and vice-chaired by an FNS representative and includes members from a variety of USDA agencies with additional liaisons from HHS.
T426 7995-8053 Sentence denotes Over the last 2 decades, HNCC has generally met quarterly.
T427 8054-8203 Sentence denotes Each March, HNCC coordinates National Nutrition Month activities at USDA and functions as the steering committee for the website Nutrition.gov (153).
T428 8204-8651 Sentence denotes USDA Office of the Chief Scientist (OCS) was established by Congress in 2008 (Public Law 110–234) “to provide strategic coordination of the science that informs USDA's and the federal government's decisions, policies, and regulations that impact all aspects of US food and agriculture and related landscapes and communities.” (154) The OCS advises USDA's Chief Scientist and the Secretary of Agriculture in multiple areas, including the following:
T429 8652-8928 Sentence denotes Agricultural Systems and Technology; Animal Health and Production, and Animal Products; Plant Health and Production, and Plant Products; Renewable Energy, Natural Resources, and Environment; Food Safety, Nutrition, and Health; and Agricultural Economics and Rural Communities.
T430 8929-9072 Sentence denotes By statute, OCS is primarily staffed by detailed staff from other departments and agencies across the government for potentially up to 3 years.
T431 9073-9255 Sentence denotes In 2017, OCS hosted the first-of-its-kind USDA Intra-Departmental Nutrition Workshop Series and identified major gaps and needs to strengthen coordination of USDA nutrition research.
T432 9256-9672 Sentence denotes These gaps and needs included the following: assessing existing and potential new means of coordination and collaboration; developing new interdepartmental working groups and interest groups; identifying new and improved ways to enhance coordination with USDA food safety efforts; better utilizing the HNCC; and hosting overviews of USDA nutrition relevant databases and related data science trainings and resources.
T433 9673-9793 Sentence denotes The chair of this workshop series was detailed to OCS for 1 y and completed the detail a few months after this workshop.
T434 9794-9904 Sentence denotes A 2019 GAO report noted there are currently no plans for another intradepartmental meeting on nutrition (155).
T435 9905-10064 Sentence denotes In 2020, USDA put forth a new Science Blueprint for the next 5 y to help promote synergy across the department for prioritized objectives and strategies (156).
T436 10065-10798 Sentence denotes This Blueprint includes specific objectives in nutrition and health promotion, such as to develop and update the current evidence base to promote proper macro- and micronutrient intake among critical age groups or life stages, such as women who are pregnant or lactating, infants, children, adolescents, working-age adults, tribal members, and seniors; provide guidance and incentives to promote healthier eating patterns so that the US can reduce incidence of, and morbidity from, obesity and diet-related chronic diseases; promote food systems that reduce the prevalence and severity of food insecurity; and expand understanding about the impacts of USDA nutrition assistance programs on human health, communities, and the economy.
T437 10799-11204 Sentence denotes The USDA Science Blueprint has objectives related to infrastructure, innovation, and well-being: to develop and evaluate methods to increase access to low-cost and nutritious food as well as sustain efficient agriculture and bioeconomy systems in rural communities; and to evaluate alternative systems that may improve the quality, resiliency, and sustainability of food, fiber, forest, and fuel supplies.
T438 11205-12247 Sentence denotes The USDA also set forth objectives to work toward being a “beacon for science”: to encourage a global conversation and facilitate such discussion within decision-making bodies about literacy in agriculture, food, forestry, health, and science; advocate globally for the development of science-based, international and domestic standards, regulatory approaches, and policies, including those guiding the development of new and emerging technologies; develop an effective and diverse US agriculture workforce that contributes to safer, healthier, vibrant, sustainable, and innovative communities; enhance the capacities of USDA and other institutions in workforce development, with attention towards developing scientists and practitioners familiar with developing technologies and innovative practices; and develop and expand degree, certificate, curriculum, and youth programs that integrate science, technology, engineering, and mathematics (STEM) into instruction, considering real-world challenges relevant to agriculture and food science.
T439 12248-12391 Sentence denotes How new federal funding streams, leadership, or coordination structures may help achieve these laudable goals were not addressed in the report.
T440 12392-12631 Sentence denotes On 20 February 2020, the Secretary of Agriculture put forth a new Agriculture Innovation Agenda, a department-wide initiative to align resources, programs, and research to position American agriculture to better meet future global demands.
T441 12632-12779 Sentence denotes Benchmarks of success included reducing US food loss and waste by 50% by the year 2030 and reducing US nutrient loss in water by 30% by 2050 (157).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T84 10547-10554 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513