PMC:7454258 / 180586-187554 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T33 580-585 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490
T34 2317-2321 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T35 4814-4819 Body_part denotes BRAIN http://purl.org/sig/ont/fma/fma50801

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T48 6581-6586 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T289 678-681 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T290 2493-2496 Disease denotes ODP http://purl.obolibrary.org/obo/MONDO_0007134
T291 6244-6247 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T374 332-337 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T375 580-585 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T376 580-585 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T377 653-656 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T378 716-717 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T379 1242-1252 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T380 1253-1254 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T381 1959-1960 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T382 4074-4084 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T383 4416-4419 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T384 4728-4729 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T385 4739-4746 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T386 4814-4819 http://purl.obolibrary.org/obo/UBERON_0000955 denotes BRAIN
T387 4814-4819 http://www.ebi.ac.uk/efo/EFO_0000302 denotes BRAIN
T388 4873-4878 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T389 5196-5197 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T390 5226-5227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T391 5567-5574 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T392 6077-6080 http://purl.obolibrary.org/obo/CLO_0001294 denotes 322
T393 6445-6449 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2 A
T51336 6571-6572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T395 6937-6940 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T34592 663-665 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T9944 6409-6411 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4336 858-871 http://purl.obolibrary.org/obo/GO_0006412 denotes translational

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
799 4873-4889 Species denotes Human Microbiome Tax:646099
800 202-205 Disease denotes NIN
801 1845-1848 Disease denotes NIN
802 1965-1968 Disease denotes NIN
803 2226-2229 Disease denotes NIN
807 6560-6563 Disease denotes NIN
808 6808-6813 Disease denotes NCMHD
809 6914-6919 Disease denotes NIMHD

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T981 0-102 Sentence denotes TABLE 4 Key strategies within the NIH for strengthening and accelerating national nutrition research1
T982 103-164 Sentence denotes Option Description Advantages Disadvantages Paths forward
T983 165-322 Sentence denotes New National Institute of Nutrition (NIN)2 Leads research, coordination, training, outreach on foundational and cross-cutting topics in nutrition and health
T984 323-416 Sentence denotes Additive focus areas and funding to existing NIH and other federal nutrition research efforts
T985 417-520 Sentence denotes Harmonizes and leverages other nutrition and related research at NIH and other agencies and departments
T986 521-681 Sentence denotes Strong partner to inform, collaborate on, and help address joint research needs of other departments and agencies, e.g., USDA, FDA, CDC, DoD, VA, USAID, and CMS
T987 682-767 Sentence denotes Promotes and supports training of a diverse 21st century nutrition research workforce
T988 768-892 Sentence denotes Guides and supports training of health care professionals for clinical care and basic and translational science in nutrition
T989 893-967 Sentence denotes Translates and disseminates sound nutrition science findings to the public
T990 968-1085 Sentence denotes Fosters innovative external collaborations and partnerships Strong leadership, robust infrastructure, and investment
T991 1086-1173 Sentence denotes Can better address nutrition science that is cross-cutting rather than disease specific
T992 1174-1252 Sentence denotes Includes extramural and intramural research, training, and outreach activities
T993 1253-1431 Sentence denotes A long-term structure, leading to unanticipated positive returns, outlasting shorter-term options, and evolving appropriately with changing science and needs of the US population
T994 1432-1517 Sentence denotes Meaningful external advisory mechanism to solicit diverse relevant insights and input
T995 1518-1719 Sentence denotes Strong return on investment, in line with or exceeding other NIH research investments Requires new, additive appropriations to prevent reductions in any ongoing NIH or other federal nutrition research
T996 1720-1765 Sentence denotes Could increase silo-ing of nutrition research
T997 1766-1867 Sentence denotes Would need to navigate potentially entrenched cultures and perspectives around NIN nutrition research
T998 1868-2083 Sentence denotes Without new appropriations, could increase competition for resources Congress establishes a new NIN by statute, with dedicated appropriations and updating the current cap on the number of NIH institutes and centers
T999 2084-2229 Sentence denotes Congressional inquiry and/or appropriations could explore the current status of federal nutrition research and potential options including an NIN
T1000 2230-2440 Sentence denotes New NIH Office for Nutrition Research Restores the NIDDK Office of Nutrition Research back into the NIH Office of the Director (within the Division of Program Coordination, Planning, and Strategic Initiatives)
T1001 2441-2596 Sentence denotes Modeled after the NIH Office of Disease Prevention (ODP), Office of Dietary Supplements (ODS), or Office of Behavioral and Social Sciences Research (OBSSR)
T1002 2597-2854 Sentence denotes Would lead efforts to build and coordinate new collaborative relationships and synergies within NIH, with other federal agencies and departments, and with external stakeholders including public-private partnerships to drive nutrition research and innovation
T1003 2855-2915 Sentence denotes Plan and coordinate trans-NIH nutrition research initiatives
T1004 2916-3119 Sentence denotes Lead cooperative efforts to identify and stimulate priority areas of science, provide guidance on rigorous methodology, offer trainings, and increase the impact, visibility, and dissemination of findings
T1005 3120-3262 Sentence denotes Director of the NIH Office of Nutrition Research would also serve as the Associate Director of Nutrition Research Legislation is not required
T1006 3263-3369 Sentence denotes Elevates the leadership, staffing, resources, and capacities of this important area within and outside NIH
T1007 3370-3516 Sentence denotes Reestablishes close communication and coordination with the NIH Director and the other divisions and offices within the NIH Office of the Director
T1008 3517-3594 Sentence denotes Increases capacity and expertise for dissemination of sound nutrition science
T1009 3595-3641 Sentence denotes Can engage strong external advisory mechanisms
T1010 3642-3697 Sentence denotes Some dedicated funding to stimulate research across NIH
T1011 3698-3738 Sentence denotes Not viewed as serving only one institute
T1012 3739-4111 Sentence denotes Ability to transition to an NIH center and/or institute over time Size and resources of such an office remain relatively limited for substantially needed strategic planning, cross-governmental collaboration, public communication, assistance with the DGAs, DRIs, and national monitoring and surveillance, food and nutrition regulatory activities, and external partnerships
T1013 4112-4197 Sentence denotes Insufficient independent funding to stimulate major extramural or intramural research
T1014 4198-4309 Sentence denotes Inadequate authority and resources to support new national training of scientists and health care professionals
T1015 4310-4489 Sentence denotes Budgets, staff sizes, and influence can vary widely between offices and fluctuate over time NIH Director has discretion to restore this office into the NIH Office of the Director
T1016 4490-4612 Sentence denotes Congress can authorize (ideally with new appropriations) the creation of this office within the NIH Office of the Director
T1017 4613-4770 Sentence denotes New Trans-NIH Initiative(s) in Nutrition Research An initiative across multiple NIH institutes and centers around a specific focused priority research topic
T1018 4771-4897 Sentence denotes Modeled after several examples such as the BRAIN Initiative, “All of Us” Research Program, or the NIH Human Microbiome Project
T1019 4898-4977 Sentence denotes Can be supported by dedicated staff within NIH and other federal working groups
T1020 4978-5079 Sentence denotes Dedicated funding to support intramural and extramural research, training, and technology development
T1021 5080-5168 Sentence denotes Can help create new or enhanced public–private partnerships Legislation is not required
T1022 5169-5207 Sentence denotes Helps galvanize NIH around a key topic
T1023 5208-5393 Sentence denotes Often preceded by a comprehensive and separately useful review of relevant leadership, staffing, funding, external advisory mechanisms, and collaborative approaches available across NIH
T1024 5394-5496 Sentence denotes Brings new strategic planning, workgroups, funding opportunities, training, and technology development
T1025 5497-5659 Sentence denotes Valuable when combined with other NIH options, above Only covers one focused topic, while needs and opportunities across nutrition research are broad and complex
T1026 5660-5786 Sentence denotes Unlikely to provide the sustained leadership, coordination, and resources to grasp the critical science gaps and opportunities
T1027 5787-5919 Sentence denotes Generally time-limited and not sustained Can be established by the NIH Office of the Director with support from the NIH Common Fund
T1028 5920-5988 Sentence denotes Can be established by Congressional authorization and appropriations
T1029 5989-6082 Sentence denotes 1 These strategies include key organizational structures successfully used within NIH (322).
T1030 6083-6243 Sentence denotes Importantly, these different options are not mutually exclusive, but can be implemented in combination to create synergies and leverage complementary strengths.
T1031 6244-6444 Sentence denotes CMS, Centers for Medicare and Medicaid Services; DGAs, Dietary Guidelines for Americans; DoD, Department of Defense; USAID, US Agency for International Development; VA, Department of Veterans Affairs.
T1032 6445-6968 Sentence denotes 2 A new NIH National Center for Nutrition Research (NCNR) could also be proposed, broadly similar to the proposed NIN but on a smaller scale—for example, modeled after the path of the Office of Research on Minority Health (ORMH) within the NIH Office of the Director (Public Law 103–43) that led to the National Center on Minority Health and Health Disparities (NCMHD) (Public Law 106–525) that led to the National Institute on Minority Health and Health Disparities (NIMHD) (Public Law 111–148) (see Supplemental Text 3).