PMC:7454258 / 178294-207806 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 22725-22731 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T2 22916-22925 Body_part denotes Stem Cell http://purl.org/sig/ont/fma/fma63368
T3 22921-22925 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T4 25583-25588 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T5 25646-25651 Body_part denotes BRAIN http://purl.org/sig/ont/fma/fma50801
T6 26094-26099 Body_part denotes BRAIN http://purl.org/sig/ont/fma/fma50801
T7 26320-26325 Body_part denotes BRAIN http://purl.org/sig/ont/fma/fma50801
T33 2872-2877 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490
T34 4609-4613 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T35 7106-7111 Body_part denotes BRAIN http://purl.org/sig/ont/fma/fma50801
T36 10001-10006 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T37 11070-11075 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490
T38 11904-11909 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490
T39 13887-13891 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T48 8873-8878 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T49 10001-10006 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T50 13842-13847 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T51 13887-13891 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T52 15619-15624 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T53 15718-15723 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T54 25583-25588 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T287 2205-2208 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T289 2970-2973 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T290 4785-4788 Disease denotes ODP http://purl.obolibrary.org/obo/MONDO_0007134
T291 8536-8539 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T292 9950-9958 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T293 9960-9967 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T294 9969-9991 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T295 9993-9999 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T296 10999-11002 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T297 11238-11241 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T299 11260-11263 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T301 11755-11758 Disease denotes CMS http://purl.obolibrary.org/obo/MONDO_0018940
T302 20460-20463 Disease denotes HHS http://purl.obolibrary.org/obo/MONDO_0008897|http://purl.obolibrary.org/obo/MONDO_0011549
T304 21273-21277 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 21003-21006 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 21123-21124 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 21695-21696 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 22343-22344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 22916-22925 http://purl.obolibrary.org/obo/CL_0000034 denotes Stem Cell
T6 23055-23058 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 23177-23178 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 23834-23839 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T9 23863-23864 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 24086-24091 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T11 24141-24142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 24160-24161 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 24215-24216 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 24247-24248 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 24350-24360 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T16 24379-24380 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 24423-24424 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 24618-24619 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 24766-24767 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 25218-25219 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 25267-25277 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T22 25293-25298 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T23 25362-25367 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T24 25419-25424 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T25 25583-25588 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T26 25583-25588 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T27 25646-25651 http://purl.obolibrary.org/obo/UBERON_0000955 denotes BRAIN
T28 25646-25651 http://www.ebi.ac.uk/efo/EFO_0000302 denotes BRAIN
T29 25681-25682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 26074-26077 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T31 26094-26099 http://purl.obolibrary.org/obo/UBERON_0000955 denotes BRAIN
T32 26094-26099 http://www.ebi.ac.uk/efo/EFO_0000302 denotes BRAIN
T33 26318-26319 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 26320-26325 http://purl.obolibrary.org/obo/UBERON_0000955 denotes BRAIN
T35 26320-26325 http://www.ebi.ac.uk/efo/EFO_0000302 denotes BRAIN
T36 26409-26410 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 26869-26870 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 26958-26961 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T39 26990-26991 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T40 27252-27253 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T41 27376-27377 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T42 27433-27434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 27459-27460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T44 27493-27498 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T45 27573-27574 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 27729-27730 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T47 27860-27861 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T48 28167-28168 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 28208-28215 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T50 28324-28325 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 28472-28473 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 28648-28649 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 28750-28751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 29251-29258 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T366 397-399 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T367 636-637 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T368 709-711 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T369 809-810 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T370 1238-1248 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T371 1800-1803 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T372 1923-1928 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T373 2057-2058 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T374 2624-2629 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T375 2872-2877 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T376 2872-2877 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T377 2945-2948 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T378 3008-3009 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T379 3534-3544 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T380 3545-3546 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T381 4251-4252 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T382 6366-6376 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T383 6708-6711 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T384 7020-7021 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T385 7031-7038 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T386 7106-7111 http://purl.obolibrary.org/obo/UBERON_0000955 denotes BRAIN
T387 7106-7111 http://www.ebi.ac.uk/efo/EFO_0000302 denotes BRAIN
T388 7165-7170 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T389 7488-7489 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T390 7518-7519 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T391 7859-7866 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T392 8369-8372 http://purl.obolibrary.org/obo/CLO_0001294 denotes 322
T393 8737-8741 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2 A
T51336 8863-8864 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T395 9229-9232 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T396 9370-9376 http://purl.obolibrary.org/obo/UBERON_0007688 denotes fields
T397 9576-9581 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T398 10001-10006 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T399 10001-10006 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T400 10104-10105 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T401 10315-10316 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T402 10607-10608 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T403 10861-10871 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T404 10974-10977 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T47690 11070-11075 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T406 11070-11075 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T407 11461-11471 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T408 11509-11512 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T409 11544-11554 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T410 11611-11617 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T411 11650-11655 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T412 11904-11909 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T413 11904-11909 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T414 12199-12212 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizations
T415 12461-12462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T416 12515-12516 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T417 12790-12802 http://purl.obolibrary.org/obo/OBI_0000968 denotes instrumental
T418 12916-12917 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T419 12945-12955 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T420 13285-13286 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T421 13341-13346 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T422 13563-13566 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T423 13679-13680 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T424 13739-13740 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T425 13797-13798 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T426 13887-13891 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T427 13895-13896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T428 13936-13937 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T429 14018-14020 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T430 14304-14307 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T431 14344-14345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T432 14418-14419 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T433 14473-14474 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T434 15267-15268 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T435 15288-15289 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T436 15305-15306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T437 15392-15393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T438 15459-15460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T439 15555-15558 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T440 15610-15611 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T441 15708-15709 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T442 15796-15799 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T443 15846-15847 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T444 15945-15946 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T445 15980-15981 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T446 16283-16286 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T447 16556-16566 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T448 17894-17895 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T449 18070-18071 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T450 18581-18591 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T451 18733-18738 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T452 19186-19191 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T453 19886-19887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T454 20086-20089 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85152 950-961 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T56091 2205-2208 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T34592 2955-2957 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T9944 8701-8703 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T34985 9292-9296 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T39334 10984-10986 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T885 11238-11241 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T69841 11260-11263 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937
T24085 11586-11588 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T5633 20460-20463 Chemical denotes HHS http://purl.obolibrary.org/obo/CHEBI_88937

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1521 915-923 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T4336 3150-3163 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T82148 9693-9706 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T90327 10689-10702 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T93275 13473-13486 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T3716 18037-18048 http://purl.obolibrary.org/obo/GO_0006412 denotes translation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
784 679-682 Disease denotes NIN
785 796-799 Disease denotes NIN
786 1056-1059 Disease denotes NIN
787 1278-1281 Disease denotes NIN
788 1292-1295 Disease denotes NIN
789 1592-1595 Disease denotes NIN
790 1887-1890 Disease denotes NIN
791 2205-2218 Disease denotes HHS Secretary MESH:D058747
792 2238-2241 Disease denotes NIN
793 2277-2280 Disease denotes NIN
799 7165-7181 Species denotes Human Microbiome Tax:646099
800 2494-2497 Disease denotes NIN
801 4137-4140 Disease denotes NIN
802 4257-4260 Disease denotes NIN
803 4518-4521 Disease denotes NIN
807 8852-8855 Disease denotes NIN
808 9100-9105 Disease denotes NCMHD
809 9206-9211 Disease denotes NIMHD
820 10048-10053 Species denotes child Tax:9606
821 9261-9264 Disease denotes NIN
822 9808-9811 Disease denotes NIN
823 9950-9958 Disease denotes diabetes MESH:D003920
824 9960-9967 Disease denotes obesity MESH:D009765
825 9969-9991 Disease denotes cardiovascular disease MESH:D002318
826 9993-9999 Disease denotes cancer MESH:D009369
827 10084-10087 Disease denotes NIN
828 10264-10267 Disease denotes NIN
829 10545-10548 Disease denotes NIN
836 11650-11655 Species denotes human Tax:9606
837 10736-10739 Disease denotes NIN
838 11205-11208 Disease denotes NIN
839 11356-11359 Disease denotes NIN
840 11726-11729 Disease denotes NIN
841 12069-12072 Disease denotes NIN
849 12284-12287 Disease denotes NIN
850 12443-12446 Disease denotes NIN
851 12547-12550 Disease denotes NIN
852 12777-12780 Disease denotes NIN
853 12939-12942 Disease denotes NIN
854 13604-13607 Disease denotes NIN
855 13730-13733 Disease denotes NIN
857 14187-14190 Disease denotes NIN
860 14823-14826 Disease denotes NIN
861 15215-15218 Disease denotes NIN
866 15465-15468 Disease denotes NIN
867 15602-15605 Disease denotes NIN
868 15728-15731 Disease denotes NIN
869 16139-16144 Disease denotes NIMHD
871 20046-20051 Disease denotes NIMHD
874 21330-21335 Species denotes Women Tax:9606
875 21273-21277 Disease denotes AIDS MESH:D000163
881 23834-23850 Species denotes Human Microbiome Tax:646099
882 24086-24102 Species denotes Human Microbiome Tax:646099
883 25293-25309 Species denotes human microbiome Tax:646099
884 25362-25378 Species denotes Human Microbiome Tax:646099
885 25419-25435 Species denotes Human Microbiome Tax:646099
887 27183-27202 Disease denotes NIH's congressional MESH:D010300
889 27493-27498 Species denotes human Tax:9606
891 29035-29054 Disease denotes NIH's congressional MESH:D010300

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T968 0-71 Sentence denotes Identified NIH strategies for strengthening national nutrition research
T969 72-246 Sentence denotes As the nation's largest funder of research, NIH is one essential (although not exclusive) home for increased authority, coordination, and funding for nutrition science (110).
T970 247-526 Sentence denotes Any new NIH strategy must leverage and amplify, not replace or compete with, existing extramural and intramural nutrition research efforts across the 27 current NIH institutes, centers, or offices or with existing nutrition research across other federal departments and agencies.
T971 527-598 Sentence denotes Key identified strategies are summarized in Table 4 and reviewed below.
T972 600-635 Sentence denotes New National Institute of Nutrition
T973 636-795 Sentence denotes A new NIH National Institute of Nutrition (NIN) would be additive to the 27 current institutes and centers leading research within NIH (Supplemental Figure 8).
T974 796-1055 Sentence denotes NIN would be a crucial new asset for NIH to accomplish its mission “to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability” (321).
T975 1056-1249 Sentence denotes NIN would be tasked with leading innovative, cross-cutting, and foundational research on nutrition and health, including intramural and extramural programs and training and outreach activities.
T976 1250-1439 Sentence denotes Under the leadership of the NIN Director, NIN would help guide strategic planning, coordination, and review of nutrition research across NIH and with other federal departments and agencies.
T977 1440-1591 Sentence denotes This would increase harmonization, collaboration, and leveraging of all nutrition-related research programs across NIH institutes, centers and offices.
T978 1592-1843 Sentence denotes NIN priority areas and funding should be coordinated with, additive to, and synergistic with existing NIH nutrition research efforts, such as within NIDDK, NHLBI, and NCI, among others, as well as with USDA, CDC, FDA, DoD, VHA, and NASA, among others.
T979 1844-2056 Sentence denotes Rather than “silo-ing” nutrition research, NIN would help craft strategies and focus areas that span across, support, and/or are not covered by specific interest areas of other federal nutrition research efforts.
T980 2057-2291 Sentence denotes A new NIH National Advisory Council on Nutrition Research—comprising research experts, health professionals, and community members—would advise the HHS Secretary, NIH Director, and NIN Director on matters related to the NIN's mission.
T981 2292-2394 Sentence denotes TABLE 4 Key strategies within the NIH for strengthening and accelerating national nutrition research1
T982 2395-2456 Sentence denotes Option Description Advantages Disadvantages Paths forward
T983 2457-2614 Sentence denotes New National Institute of Nutrition (NIN)2 Leads research, coordination, training, outreach on foundational and cross-cutting topics in nutrition and health
T984 2615-2708 Sentence denotes Additive focus areas and funding to existing NIH and other federal nutrition research efforts
T985 2709-2812 Sentence denotes Harmonizes and leverages other nutrition and related research at NIH and other agencies and departments
T986 2813-2973 Sentence denotes Strong partner to inform, collaborate on, and help address joint research needs of other departments and agencies, e.g., USDA, FDA, CDC, DoD, VA, USAID, and CMS
T987 2974-3059 Sentence denotes Promotes and supports training of a diverse 21st century nutrition research workforce
T988 3060-3184 Sentence denotes Guides and supports training of health care professionals for clinical care and basic and translational science in nutrition
T989 3185-3259 Sentence denotes Translates and disseminates sound nutrition science findings to the public
T990 3260-3377 Sentence denotes Fosters innovative external collaborations and partnerships Strong leadership, robust infrastructure, and investment
T991 3378-3465 Sentence denotes Can better address nutrition science that is cross-cutting rather than disease specific
T992 3466-3544 Sentence denotes Includes extramural and intramural research, training, and outreach activities
T993 3545-3723 Sentence denotes A long-term structure, leading to unanticipated positive returns, outlasting shorter-term options, and evolving appropriately with changing science and needs of the US population
T994 3724-3809 Sentence denotes Meaningful external advisory mechanism to solicit diverse relevant insights and input
T995 3810-4011 Sentence denotes Strong return on investment, in line with or exceeding other NIH research investments Requires new, additive appropriations to prevent reductions in any ongoing NIH or other federal nutrition research
T996 4012-4057 Sentence denotes Could increase silo-ing of nutrition research
T997 4058-4159 Sentence denotes Would need to navigate potentially entrenched cultures and perspectives around NIN nutrition research
T998 4160-4375 Sentence denotes Without new appropriations, could increase competition for resources Congress establishes a new NIN by statute, with dedicated appropriations and updating the current cap on the number of NIH institutes and centers
T999 4376-4521 Sentence denotes Congressional inquiry and/or appropriations could explore the current status of federal nutrition research and potential options including an NIN
T1000 4522-4732 Sentence denotes New NIH Office for Nutrition Research Restores the NIDDK Office of Nutrition Research back into the NIH Office of the Director (within the Division of Program Coordination, Planning, and Strategic Initiatives)
T1001 4733-4888 Sentence denotes Modeled after the NIH Office of Disease Prevention (ODP), Office of Dietary Supplements (ODS), or Office of Behavioral and Social Sciences Research (OBSSR)
T1002 4889-5146 Sentence denotes Would lead efforts to build and coordinate new collaborative relationships and synergies within NIH, with other federal agencies and departments, and with external stakeholders including public-private partnerships to drive nutrition research and innovation
T1003 5147-5207 Sentence denotes Plan and coordinate trans-NIH nutrition research initiatives
T1004 5208-5411 Sentence denotes Lead cooperative efforts to identify and stimulate priority areas of science, provide guidance on rigorous methodology, offer trainings, and increase the impact, visibility, and dissemination of findings
T1005 5412-5554 Sentence denotes Director of the NIH Office of Nutrition Research would also serve as the Associate Director of Nutrition Research Legislation is not required
T1006 5555-5661 Sentence denotes Elevates the leadership, staffing, resources, and capacities of this important area within and outside NIH
T1007 5662-5808 Sentence denotes Reestablishes close communication and coordination with the NIH Director and the other divisions and offices within the NIH Office of the Director
T1008 5809-5886 Sentence denotes Increases capacity and expertise for dissemination of sound nutrition science
T1009 5887-5933 Sentence denotes Can engage strong external advisory mechanisms
T1010 5934-5989 Sentence denotes Some dedicated funding to stimulate research across NIH
T1011 5990-6030 Sentence denotes Not viewed as serving only one institute
T1012 6031-6403 Sentence denotes Ability to transition to an NIH center and/or institute over time Size and resources of such an office remain relatively limited for substantially needed strategic planning, cross-governmental collaboration, public communication, assistance with the DGAs, DRIs, and national monitoring and surveillance, food and nutrition regulatory activities, and external partnerships
T1013 6404-6489 Sentence denotes Insufficient independent funding to stimulate major extramural or intramural research
T1014 6490-6601 Sentence denotes Inadequate authority and resources to support new national training of scientists and health care professionals
T1015 6602-6781 Sentence denotes Budgets, staff sizes, and influence can vary widely between offices and fluctuate over time NIH Director has discretion to restore this office into the NIH Office of the Director
T1016 6782-6904 Sentence denotes Congress can authorize (ideally with new appropriations) the creation of this office within the NIH Office of the Director
T1017 6905-7062 Sentence denotes New Trans-NIH Initiative(s) in Nutrition Research An initiative across multiple NIH institutes and centers around a specific focused priority research topic
T1018 7063-7189 Sentence denotes Modeled after several examples such as the BRAIN Initiative, “All of Us” Research Program, or the NIH Human Microbiome Project
T1019 7190-7269 Sentence denotes Can be supported by dedicated staff within NIH and other federal working groups
T1020 7270-7371 Sentence denotes Dedicated funding to support intramural and extramural research, training, and technology development
T1021 7372-7460 Sentence denotes Can help create new or enhanced public–private partnerships Legislation is not required
T1022 7461-7499 Sentence denotes Helps galvanize NIH around a key topic
T1023 7500-7685 Sentence denotes Often preceded by a comprehensive and separately useful review of relevant leadership, staffing, funding, external advisory mechanisms, and collaborative approaches available across NIH
T1024 7686-7788 Sentence denotes Brings new strategic planning, workgroups, funding opportunities, training, and technology development
T1025 7789-7951 Sentence denotes Valuable when combined with other NIH options, above Only covers one focused topic, while needs and opportunities across nutrition research are broad and complex
T1026 7952-8078 Sentence denotes Unlikely to provide the sustained leadership, coordination, and resources to grasp the critical science gaps and opportunities
T1027 8079-8211 Sentence denotes Generally time-limited and not sustained Can be established by the NIH Office of the Director with support from the NIH Common Fund
T1028 8212-8280 Sentence denotes Can be established by Congressional authorization and appropriations
T1029 8281-8374 Sentence denotes 1 These strategies include key organizational structures successfully used within NIH (322).
T1030 8375-8535 Sentence denotes Importantly, these different options are not mutually exclusive, but can be implemented in combination to create synergies and leverage complementary strengths.
T1031 8536-8736 Sentence denotes CMS, Centers for Medicare and Medicaid Services; DGAs, Dietary Guidelines for Americans; DoD, Department of Defense; USAID, US Agency for International Development; VA, Department of Veterans Affairs.
T1032 8737-9260 Sentence denotes 2 A new NIH National Center for Nutrition Research (NCNR) could also be proposed, broadly similar to the proposed NIN but on a smaller scale—for example, modeled after the path of the Office of Research on Minority Health (ORMH) within the NIH Office of the Director (Public Law 103–43) that led to the National Center on Minority Health and Health Disparities (NCMHD) (Public Law 106–525) that led to the National Institute on Minority Health and Health Disparities (NIMHD) (Public Law 111–148) (see Supplemental Text 3).
T1033 9261-9543 Sentence denotes NIN would expand the knowledge base of research on diet-related illnesses and their intersections with other fields through strategic planning, coordination, and evaluation of NIH nutrition research and through conduct and support of research in nutrition science and related areas.
T1034 9544-9807 Sentence denotes Relevant cross-cutting areas of focus could include many priority areas from genetic, molecular, and biological science to clinical, behavioral, and translational research, as well as research on health systems, workforce development, and health equity (Table 2).
T1035 9808-10071 Sentence denotes NIN's efforts would support, expand, and amplify key science relevant to other NIH institutes, centers, and offices, such as on nutrition and diabetes, obesity, cardiovascular disease, cancer, brain health, minority health and disparities, child health, and more.
T1036 10072-10263 Sentence denotes Within NIH, NIN would represent a natural authority and partner to support and coordinate cross-cutting intramural research that complements existing nutrition research portfolios across NIH.
T1037 10264-10473 Sentence denotes NIN would also promote and support the training of a diverse 21st century nutrition science workforce, including in cross-disciplinary priority areas like quantitative methods, personalization, and technology.
T1038 10474-10735 Sentence denotes Given NIH's roles in supporting training of health care professionals, NIN would also guide and support innovative programs to build a cadre of well-trained health professionals for both clinical care and basic and translational science in nutrition (269, 323).
T1039 10736-11017 Sentence denotes NIN would provide required leadership, staff, expertise, and resources to build meaningful partnerships on nutrition-related activities and research priorities of other federal departments and agencies, in particular USDA as well as FDA, CDC, DoD, VA, USAID, and CMS, among others.
T1040 11018-11204 Sentence denotes For example, this role could include development of joint requests with USDA for applications investigating the interlinkages between food, nutrition, health, and agricultural practices.
T1041 11205-11355 Sentence denotes NIN would support the efforts of HHS ODPHP in the USDA–HHS partnership to review evidence and, importantly, address new scientific needs for the DGAs.
T1042 11356-11725 Sentence denotes NIN would similarly support collaborative new science to inform the DRIs, FDA food safety and regulatory activities, USDA nutrition assistance programs, CDC surveillance and public health activities, USAID priorities, and DoD and VA research needs for US active-duty forces (including enhanced human performance and military readiness), military families, and veterans.
T1043 11726-11898 Sentence denotes NIN would inform and support CMS and CMMI efforts, such as “Food is Medicine” interventions to reduce diet-related illness and associated health care costs (268, 324, 325).
T1044 11899-12068 Sentence denotes Such joint initiatives will have the greatest impact if nutrition research at these other departments and agencies were simultaneously strengthened with new investments.
T1045 12069-12271 Sentence denotes NIN would also lead and have the required staff capacity to engage meaningfully in public–private partnerships and with nonprofit organizations and international entities such as the WHO and World Bank.
T1046 12273-12283 Sentence denotes Advantages
T1047 12284-12442 Sentence denotes NIN would add strong authority, infrastructure, investment, and external advisory mechanisms for nutrition research to the nation's largest funder of science.
T1048 12443-12546 Sentence denotes NIN would require a Federal Advisory Committee (Council) and would have a budget and funding authority.
T1049 12547-12759 Sentence denotes NIN would allow NIH to better address nutrition science that is cross-cutting rather than disease-specific, both across institutes, centers, and offices within NIH and with other federal departments and agencies.
T1050 12760-12912 Sentence denotes For example, the NIN would be instrumental in implementing and achieving the goals of the new 2020–2030 Strategic Plan for NIH Nutrition Research (129).
T1051 12913-13284 Sentence denotes As a long-term structure, NIN's activities and benefits would provide both expected and unexpected returns over many decades, outlasting shorter-term options such as cross-agency initiatives and changing priorities of individual administrations, and evolving appropriately with changes in science, food systems, nutritional needs, and disease conditions of the US public.
T1052 13285-13559 Sentence denotes A new institute could help maintain the strength of NIH focus on laboratory and clinical research in nutrition while, at the same time, facilitating expansion to research efforts to other translational priorities across NIH and across other federal departments and agencies.
T1053 13560-13710 Sentence denotes As has been seen with NIH research overall, NIN's coordinated leadership, structure, and capacity would likely provide a strong ROI to the US economy.
T1054 13711-13904 Sentence denotes The combination of NIN plus a new cross-governmental approach (Table 3) would provide a powerful strategy to address the scope and scale of the challenges and opportunities we face as a nation.
T1055 13906-13919 Sentence denotes Disadvantages
T1056 13920-14186 Sentence denotes The addition of a new institute would require legislative action to increase the current limit of 27 NIH institutes and centers (Public Law 109–482) and provide additive new appropriations to prevent reductions in any ongoing NIH or other federal nutrition research.
T1057 14187-14407 Sentence denotes NIN could increase silo-ing of nutrition research or divestment in nutrition research from other parts of NIH, which has historically been and should remain a component of almost all NIH institutes, offices, and centers.
T1058 14408-14608 Sentence denotes Even with a remit to coordinate and complement existing efforts, a new institute would need to navigate potentially entrenched cultures and perspectives around the “home” of certain areas of research.
T1059 14609-14764 Sentence denotes Congressional appropriations for expanded nutrition research funding within and outside NIH would be needed to prevent increased competition for resources.
T1060 14766-14778 Sentence denotes Path forward
T1061 14779-14966 Sentence denotes Congress can authorize the establishment of NIN, updating the cap (Public Law 109–482) on the total number of NIH institutes and centers and providing new, additive appropriations to NIH.
T1062 14967-15219 Sentence denotes As an intermediary step, Congress could submit an inquiry to appropriate federal departments and agencies, host hearings, as well as appropriate funds, to explore the current status of federal nutrition research and potential options including the NIN.
T1063 15221-15263 Sentence denotes New National Center for Nutrition Research
T1064 15264-15539 Sentence denotes As a smaller model than a new institute, a new NIH National Center for Nutrition Research (NCNR) could be created, representing a 28th institute or center at NIH that would be broadly similar to a new NIN, although with less stature, staff, and funding (Supplemental Text 3).
T1065 15540-15625 Sentence denotes The NCNR could aim to accomplish many of the same goals as an NIN, on a lesser scale.
T1066 15626-15732 Sentence denotes Advantages, disadvantages, and the path forward for NCNR are likewise similar, on a reduced scale, to NIN.
T1067 15733-15833 Sentence denotes Long term, the NCNR could further evolve into an institute, as has happened to other centers at NIH.
T1068 15834-16054 Sentence denotes However, if a research area is of sufficient national priority that it may transition into an institute within a decade or less, then starting as a center can be inefficient, compared with directly creating an institute.
T1069 16055-16304 Sentence denotes For example, both the National Institute of Minority Health and Health Disparities (NIMHD) and National Institute of Nursing Research (NINR) were founded as centers but transitioned into institutes within ≤10 y (Public Laws 111–148, 99–158, 103–43).
T1070 16306-16355 Sentence denotes New NIH ONR within the NIH Office of the Director
T1071 16356-16573 Sentence denotes This option would return ONR to the NIH Office of the Director (Supplemental Figure 9) (326), the central entity for setting NIH policy and planning and for managing and coordinating NIH programs and activities (327).
T1072 16574-16721 Sentence denotes Multiple offices and divisions within the NIH Office of the Director function together to identify opportunities and needs across the agency (328).
T1073 16722-16859 Sentence denotes The NIH ONR can be modeled after other Congressionally mandated offices within the NIH Office of the Director (see “Path forward” below).
T1074 16860-17044 Sentence denotes Each of these lead and coordinate trans-NIH efforts, guided by an Office director, dedicated expert staff (ranging from 15 to 30 full-time employees), and specific budgetary resources.
T1075 17045-17268 Sentence denotes Like the NIH Office of Disease Prevention Director who also serves as the Associate Director for Prevention (Public Law 99–158), the Director of the NIH ONR would also serve as the Associate Director for Nutrition Research.
T1076 17269-17543 Sentence denotes The NIH ONR would lead efforts to build and coordinate new collaborative relationships and synergies within the NIH, with other federal departments and agencies, and with external stakeholders including public–private partnerships to drive nutrition research and innovation.
T1077 17544-17766 Sentence denotes The NIH ONR would lead cooperative efforts to identify and stimulate priority areas of science, provide guidance on rigorous methodology, offer trainings, and increase the impact, visibility, and dissemination of findings.
T1078 17767-18090 Sentence denotes The new office would plan and coordinate relevant trans-NIH initiatives (see below), such as supported by the NIH Common Fund, a “venture” fund within the NIH Office of the Director, which aims to propel high-risk, high-reward research to speed scientific discovery and translation to improve health at a faster pace (329).
T1079 18091-18223 Sentence denotes The new office would develop approaches and resources to support analyses and reporting of nutrition research portfolios across NIH.
T1080 18225-18235 Sentence denotes Advantages
T1081 18236-18402 Sentence denotes Restoring the ONR into the NIH Office of the Director would elevate the leadership, staffing, resources, and capacities of this important area within and outside NIH.
T1082 18403-18634 Sentence denotes This structure would reestablish close communication and coordination with the NIH Director, other divisions and offices within the NIH Office of the Director, and the nutrition activities across all the NIH institutes and centers.
T1083 18635-18805 Sentence denotes This is particularly important for identification and prioritization of concrete, timely research focus areas, given the breadth of areas and topics touched by nutrition.
T1084 18806-19085 Sentence denotes This office would have some dedicated funds to help stimulate priority research across NIH and encourage NIH institutes, centers, and other offices to direct or pool their funds toward common priority areas and would not be dependent on or viewed as serving any single institute.
T1085 19086-19260 Sentence denotes This office could help stimulate new, flexible appropriations for the NIH Office of the Director to focus broadly on nutrition priority areas, outside the Common Fund per se.
T1086 19261-19561 Sentence denotes In addition to research strategy and harmonization, the new office director and staff (including communications specialists, present in other similar NIH Office of the Director Offices) would increase capacity and expertise for dissemination of nutrition science to the public and other stakeholders.
T1087 19562-19780 Sentence denotes This office could engage strong external advisory mechanisms, strengthening input from other federal departments and agencies, academic institutions, advocacy groups, state and local governments, and community members.
T1088 19781-20091 Sentence denotes Based on Congressional prioritization of new national research areas, such an office can transition into a center (e.g., National Center for Complementary and Integrative Health; Public Laws 103–42, 105–277, 113–235) or an institute (e.g., NINR, Public Law 103–43; NIMHD, Public Laws 103–43, 106–525, 111–148).
T1089 20093-20106 Sentence denotes Disadvantages
T1090 20107-20570 Sentence denotes The size and resources of such an office would remain limited to coordinating and developing nutrition strategy across all NIH institutes, centers, and offices, inform and collaborate with other federal departments and agencies engaged in nutrition-relevant research and programming, assist with communication to the public, work with ODPHP in the USDA–HHS partnership to develop the DGAs, and meaningfully engage in public–private or other external partnerships.
T1091 20571-20691 Sentence denotes Such an office does not generally have sufficient independent funding to promote major extramural or intramural science.
T1092 20692-20845 Sentence denotes Such an office does not have sufficient authority or resources to support national training of new scientists and health care professionals in nutrition.
T1093 20846-20971 Sentence denotes An office's budget, staff size, and influence can vary widely across offices and over time depending on other NIH priorities.
T1094 20973-20985 Sentence denotes Path forward
T1095 20986-21077 Sentence denotes The NIH Director has discretion to restore this office into the NIH Office of the Director.
T1096 21078-21561 Sentence denotes Congress can also pass legislation to create a new Office of Nutrition Research within the NIH Office of the Director, similar to other Congressionally mandated offices such as the NIH Office of AIDS Research (Public Law 103–43), Office of Research on Women's Health (Public Law 103–340), Office of Behavioral and Social Sciences Research (330) (Public Law 103–43), Office of Disease Prevention (331) (Public Law 99–158), and Office of Dietary Supplements (332) (Public Law 103–417).
T1097 21563-21612 Sentence denotes New trans-NIH initiative(s) in nutrition research
T1098 21613-21724 Sentence denotes Trans-NIH initiatives are efforts to promote collaborative research across NIH in a particular area of science.
T1099 21725-21829 Sentence denotes These initiatives can originate from the NIH Director; NIH institutes, centers, or offices; or Congress.
T1100 21830-21935 Sentence denotes Some of these initiatives engage with external stakeholders such as businesses and nonprofit foundations.
T1101 21936-22015 Sentence denotes The funding, leadership, and structures for trans-NIH initiatives tend to vary.
T1102 22016-22319 Sentence denotes Generally, trans-NIH programs utilize the same mechanisms of grant funding that NIH currently offers: research grants (R series), career development awards (K series), research training and fellowships (T & F series), program project/center grants (P series), and resource grants (various series) (333).
T1103 22320-23034 Sentence denotes NIH currently supports a variety of broad-reaching programs that are trans-NIH in nature; examples include Biomedical Information Science and Technology Institute (BISTI), NIH Blueprint for Neuroscience Research, Research Supplements to Promote Diversity in Health-Related Research, Administrative Supplements to Existing NIH Grants and Cooperative Agreements, New and Early Stage Investigators Policies, Genome-Wide Association Studies, NIH Common Fund, NIH Basic Behavioral and Social Science Research Opportunity Network (OppNet), Presidential Early Career Award for Scientists and Engineers, Stem Cell Information (PECASE), and the Trans-NIH Countermeasures Against Chemical Threats (CounterACT) program (333).
T1104 23035-23153 Sentence denotes The NIH Common Fund has emerged as one approach to support trans-NIH programs and uses the same mechanisms of support.
T1105 23154-23375 Sentence denotes The NIH Common Fund is a specific component of the NIH budget and is managed by the Office of Strategic Coordination/Division of Program Coordination, Planning, and Strategic Coordination/Office of the NIH Director (329).
T1106 23376-23664 Sentence denotes Common Fund programs are short-term (usually ∼5 y), goal-driven strategic investments that are “intended to change paradigms, develop innovative tools and technologies, and/or provide fundamental foundations for research that can be used by the broad biomedical research community” (329).
T1107 23665-23809 Sentence denotes Then, an NIH institute, center, or office or multiple institutes, centers, and offices must continue the support of these time-limited programs.
T1108 23810-23943 Sentence denotes As one example, the NIH Human Microbiome Project was a trans-NIH initiative supported by the NIH Common Fund from 2007 to 2016 (334).
T1109 23944-23999 Sentence denotes This project aimed to expand science on the microbiome.
T1110 24000-24191 Sentence denotes Initially funded as an initiative of the NIH Roadmap for Biomedical Research, the NIH Human Microbiome Project was originally established as a 5-y project with a budget of $150 million (335).
T1111 24192-24343 Sentence denotes The project began with a “jumpstart” phase in 2007 and a set of grants was funded in mid-2009 and additional demonstration project grants were awarded.
T1112 24344-24585 Sentence denotes These activities were supported by a Data Analysis and Coordination Center and a set of additional grants was awarded for developing new technologies, new software tools, and studying the ethical, legal, and social implications of this work.
T1113 24586-24650 Sentence denotes The grantees worked together in a highly cooperative consortium.
T1114 24651-24840 Sentence denotes Ultimately, this 10-y $215 million project spanned >20 of the NIH institutes, centers, and offices and resulted in a >40-fold increase in nonproject investment in microbiome research (336).
T1115 24841-24961 Sentence denotes That is, individual or multiple institutes, centers, and offices used program announcements or request for applications.
T1116 24962-25149 Sentence denotes Some of these funding mechanisms were supported by the Common Fund and others were additional commitments by the participating NIH institutes, centers, and offices from their own budgets.
T1117 25150-25401 Sentence denotes The Trans-NIH Microbiome Working Group established in 2012 provided a forum for coordinating NIH extramural research activities related to the human microbiome and continues to coordinate this work after the NIH Human Microbiome Project was completed.
T1118 25402-25578 Sentence denotes Notably, the NIH Human Microbiome Project identified several potential priority areas around food and the microbiome, but these topics have not yet been systematically pursued.
T1119 25579-25874 Sentence denotes The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is an example of a trans-NIH initiative (337), supported by staff within NIH and across federal working groups and providing funding for intramural and extramural research, training, and technology development.
T1120 25875-26089 Sentence denotes Between 2013 and 2019, this initiative supported >700 research projects totaling ∼$1.3 billion through support across the NIH, including appropriations through the 21st Century Cures Act (Public Law 114–255) (337).
T1121 26090-26193 Sentence denotes The BRAIN initiative is managed by 10 NIH institutes and centers, with coordination at multiple levels.
T1122 26194-26429 Sentence denotes Extramural program staff and institute and center directors meet regularly to integrate strategic planning, management, and a BRAIN Multi-Council Working Group and Neuroethics Working Group provide further input on a variety of issues.
T1123 26430-26619 Sentence denotes Another trans-NIH example is the All of US Research Program (Public Law 115–31), directly supported through annual appropriations from Congress ($1.5 billion over 10 y) (Public Law 115–31).
T1124 26620-26800 Sentence denotes This initiative, supported and overseen by NIH, arose from recommendations by the NIH's Precision Medicine Initiative Working Group of the Advisory Committee to the Director (338).
T1125 26801-26989 Sentence denotes The program staff are based in the NIH Office of the Director, with a Trans-NIH Liaisons Coordinating Team made up of scientific leaders from across NIH and has an external advisory panel.
T1126 26990-27251 Sentence denotes A potential trans-NIH program in Precision Nutrition is being considered as an NIH Common Fund program for fiscal year 2021 (131, 339), and the NIH Director included Precision Nutrition in the NIH's congressional budget justification for fiscal year 2021 (131).
T1127 27252-27334 Sentence denotes A new Program Director in the NIDDK ONR was hired in 2020 to lead this initiative.
T1128 27336-27346 Sentence denotes Advantages
T1129 27347-27375 Sentence denotes Legislation is not required.
T1130 27376-27526 Sentence denotes A trans-NIH initiative can help galvanize NIH to develop a coordinated approach to a specific topic on nutrition and human health (e.g., see Table 2).
T1131 27527-27728 Sentence denotes Such an effort would generally be preceded by a careful—and separately useful—review of relevant NIH leadership, staffing, funding, external advisory mechanisms, and collaborative approaches available.
T1132 27729-27859 Sentence denotes A trans-NIH initiative brings new strategic planning, working groups, funding opportunities, training, and technology development.
T1133 27860-27988 Sentence denotes A trans-NIH initiative is complementary to other NIH and cross-governmental strategies to strengthen federal nutrition research.
T1134 27989-28070 Sentence denotes Such initiatives can also help build new or enhanced public–private partnerships.
T1135 28072-28085 Sentence denotes Disadvantages
T1136 28086-28263 Sentence denotes The needs and opportunities across nutrition research are broad and complex, and a new trans-NIH initiative would cover 1 focused topic, such as, if funded, precision nutrition.
T1137 28264-28544 Sentence denotes Addressing the science gaps and opportunities for nutrition—a leading cause of disease in the US—will require greater and more sustained authority, coordination, resources, and collaboration than provided by a single initiative, especially one only limited to precision nutrition.
T1138 28545-28687 Sentence denotes Trans-NIH initiatives are generally time-limited, difficult to sustain, and not easily communicated to a broad range of external stakeholders.
T1139 28688-28879 Sentence denotes The long-term success of such initiatives can be dependent on a single leading NIH institute, center, and/or office to commit to carry that area of work forward after the initial investments.
T1140 28881-28893 Sentence denotes Path forward
T1141 28894-29103 Sentence denotes The NIH Director could propose new trans-NIH budget initiatives for Congress to review; as noted earlier, Precision Nutrition is proposed in NIH's congressional budget justification for fiscal year 2021 (131).
T1142 29104-29293 Sentence denotes Congress could authorize and appropriate funds for this proposed initiative or put forth support for another or additional trans-NIH initiative(s) focused on ≥1 areas of nutrition research.
T1143 29294-29390 Sentence denotes NIH institutes, centers, and offices can develop and collectively support trans-NIH initiatives.
T1144 29391-29512 Sentence denotes External support through the private and nongovernment sectors can also be mobilized through public–private partnerships.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T111 9960-9967 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T112 9969-9991 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T113 9993-9999 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

2_test

Id Subject Object Predicate Lexical cue
32687145-31728505-2017941 10730-10733 31728505 denotes 323
32687145-19819907-2017942 24186-24189 19819907 denotes 335
32687145-30808411-2017943 24835-24838 30808411 denotes 336