PMC:7445716 / 82844-83676 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T659","span":{"begin":275,"end":278},"obj":"Body_part"},{"id":"T660","span":{"begin":282,"end":285},"obj":"Body_part"}],"attributes":[{"id":"A659","pred":"fma_id","subj":"T659","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A660","pred":"fma_id","subj":"T660","obj":"http://purl.org/sig/ont/fma/fma20935"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T256","span":{"begin":487,"end":510},"obj":"Body_part"}],"attributes":[{"id":"A256","pred":"uberon_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/UBERON_0001004"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T780","span":{"begin":98,"end":106},"obj":"Disease"},{"id":"T781","span":{"begin":118,"end":121},"obj":"Disease"},{"id":"T782","span":{"begin":156,"end":159},"obj":"Disease"},{"id":"T783","span":{"begin":163,"end":167},"obj":"Disease"},{"id":"T784","span":{"begin":179,"end":182},"obj":"Disease"},{"id":"T785","span":{"begin":264,"end":272},"obj":"Disease"},{"id":"T786","span":{"begin":315,"end":325},"obj":"Disease"},{"id":"T787","span":{"begin":371,"end":381},"obj":"Disease"},{"id":"T788","span":{"begin":428,"end":436},"obj":"Disease"},{"id":"T789","span":{"begin":584,"end":592},"obj":"Disease"},{"id":"T790","span":{"begin":634,"end":637},"obj":"Disease"}],"attributes":[{"id":"A780","pred":"mondo_id","subj":"T780","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A781","pred":"mondo_id","subj":"T781","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"},{"id":"A782","pred":"mondo_id","subj":"T782","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"},{"id":"A783","pred":"mondo_id","subj":"T783","obj":"http://purl.obolibrary.org/obo/MONDO_0018661"},{"id":"A784","pred":"mondo_id","subj":"T784","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"},{"id":"A785","pred":"mondo_id","subj":"T785","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A786","pred":"mondo_id","subj":"T786","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A787","pred":"mondo_id","subj":"T787","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A788","pred":"mondo_id","subj":"T788","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A789","pred":"mondo_id","subj":"T789","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A790","pred":"mondo_id","subj":"T790","obj":"http://purl.obolibrary.org/obo/MONDO_0016218"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T725","span":{"begin":298,"end":299},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T726","span":{"begin":364,"end":365},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T727","span":{"begin":464,"end":465},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T728","span":{"begin":487,"end":510},"obj":"http://purl.obolibrary.org/obo/UBERON_0001004"},{"id":"T729","span":{"begin":527,"end":528},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T730","span":{"begin":595,"end":602},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T731","span":{"begin":668,"end":671},"obj":"http://purl.obolibrary.org/obo/PR_000001343"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1265","span":{"begin":263,"end":273},"obj":"Species"},{"id":"1266","span":{"begin":469,"end":477},"obj":"Species"},{"id":"1267","span":{"begin":583,"end":593},"obj":"Species"},{"id":"1268","span":{"begin":609,"end":617},"obj":"Species"},{"id":"1269","span":{"begin":486,"end":497},"obj":"Species"},{"id":"1270","span":{"begin":97,"end":105},"obj":"Disease"},{"id":"1271","span":{"begin":427,"end":435},"obj":"Disease"}],"attributes":[{"id":"A1265","pred":"tao:has_database_id","subj":"1265","obj":"Tax:2697049"},{"id":"A1266","pred":"tao:has_database_id","subj":"1266","obj":"Tax:9606"},{"id":"A1267","pred":"tao:has_database_id","subj":"1267","obj":"Tax:2697049"},{"id":"A1268","pred":"tao:has_database_id","subj":"1268","obj":"Tax:9606"},{"id":"A1269","pred":"tao:has_database_id","subj":"1269","obj":"Tax:12814"},{"id":"A1270","pred":"tao:has_database_id","subj":"1270","obj":"MESH:C000657245"},{"id":"A1271","pred":"tao:has_database_id","subj":"1271","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}

{"project":"LitCovid-sentences","denotations":[{"id":"T486","span":{"begin":0,"end":183},"obj":"Sentence"},{"id":"T487","span":{"begin":184,"end":386},"obj":"Sentence"},{"id":"T488","span":{"begin":387,"end":716},"obj":"Sentence"},{"id":"T489","span":{"begin":717,"end":832},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1213","span":{"begin":98,"end":106},"obj":"SP_7"},{"id":"T1214","span":{"begin":239,"end":243},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T1215","span":{"begin":264,"end":274},"obj":"SP_7"},{"id":"T1216","span":{"begin":326,"end":332},"obj":"UBERON:0002405"},{"id":"T1217","span":{"begin":428,"end":436},"obj":"SP_7"},{"id":"T1218","span":{"begin":487,"end":498},"obj":"UBERON:0001004"},{"id":"T1219","span":{"begin":584,"end":594},"obj":"SP_7"},{"id":"T22424","span":{"begin":487,"end":498},"obj":"UBERON:0001004"},{"id":"T35952","span":{"begin":98,"end":106},"obj":"SP_7"},{"id":"T10464","span":{"begin":239,"end":243},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T20024","span":{"begin":264,"end":274},"obj":"SP_7"},{"id":"T44216","span":{"begin":326,"end":332},"obj":"UBERON:0002405"},{"id":"T81009","span":{"begin":428,"end":436},"obj":"SP_7"},{"id":"T15187","span":{"begin":487,"end":498},"obj":"UBERON:0001004"},{"id":"T29502","span":{"begin":584,"end":594},"obj":"SP_7"}],"text":"In conclusion, based on the systematic review of 73 cases, we showed that the clinical picture of COVID-19-associated GBS seems to resemble that of classic GBS or Zika-associated GBS. Moreover, the chronological evolution, the response to IVIG, and the absence of SARS-CoV-2 RNA in CSF may suggest a prominent post-infectious immune-mediated mechanism rather than a para-infectious one. Although most cases were symptomatic for COVID-19, the preliminary report of a few patients without respiratory or systemic symptoms raises a significant healthcare issue, namely the importance of SARS-CoV-2 testing in all patients with suspected GBS during the pandemic, with the aim to provide an eventual rapid case isolation. Nevertheless, only further analyses on more comprehensive cohorts could help in clarifying better all these issues."}