PMC:7445677 / 6455-7791 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7445677","sourcedb":"PMC","sourceid":"7445677","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7445677","text":"Despite findings from studies in the general population, there is great heterogeneity of neurological presentation for individual patients with viral illnesses, so a minority of COVID-19 patients may present with neurological signs and symptoms. SARS-CoV-2 has been reported in the brains from both patients and experimental animals,12,13 supporting that clinical manifestations may be related to direct SARS-CoV-2 infection. There are numerous comprehensive reviews of neurological involvement with COVID-19,14-18 outlining findings of headache, anosmia and ageusia, impaired consciousness, seizures, stroke and vascular events, and peripheral nerve disorders including Guillain-Barré syndrome. In an expert consensus of neurologists from China,12 COVID-19-related neurological signs and symptoms include stroke, headache, seizures, impaired consciousness, and myalgias. A few patients developed symptoms of neuropathy, for example, paresthesia and bowel/bladder function disturbance. The report stresses that a significant number of patients present without fever, which is confirmed in other studies.19 Other clinical directives include the importance of treating clinical signs and symptoms appropriately if testing results for SARS-CoV-2 are ambiguous or unavailable, and that some patients had leukopenia before onset of 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