PMC:7443692 / 902-1388 JSONTXT

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T6","span":{"begin":414,"end":424},"obj":"Species"},{"id":"T7","span":{"begin":478,"end":483},"obj":"Species"}],"attributes":[{"id":"A6","pred":"ncbi_taxonomy_id","subj":"T6","obj":"NCBItxid:2697049"},{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:9606"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T8","span":{"begin":155,"end":310},"obj":"Sentence"},{"id":"T9","span":{"begin":312,"end":330},"obj":"Sentence"},{"id":"T10","span":{"begin":332,"end":342},"obj":"Sentence"},{"id":"T11","span":{"begin":343,"end":430},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T3","span":{"begin":294,"end":309},"obj":"Disease"},{"id":"T4","span":{"begin":414,"end":424},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T276","span":{"begin":126,"end":130},"obj":"Protein"}],"attributes":[{"id":"A276","pred":"uniprot_id","subj":"T276","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T6","span":{"begin":300,"end":309},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T7","span":{"begin":346,"end":350},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T8","span":{"begin":405,"end":410},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T9","span":{"begin":438,"end":443},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T8","span":{"begin":225,"end":233},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T2","span":{"begin":63,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T3","span":{"begin":140,"end":153},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T4","span":{"begin":294,"end":309},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T2","span":{"begin":63,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T3","span":{"begin":140,"end":153},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T4","span":{"begin":294,"end":309},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T21","span":{"begin":23,"end":28},"obj":"NCBITaxon:10239"},{"id":"T22","span":{"begin":126,"end":130},"obj":"G_3;PG_10;PR:000003622"},{"id":"T23","span":{"begin":197,"end":206},"obj":"CHEBI:60816;CHEBI:60816"},{"id":"T24","span":{"begin":225,"end":233},"obj":"GO:0042571"},{"id":"T25","span":{"begin":294,"end":299},"obj":"NCBITaxon:10239"},{"id":"T26","span":{"begin":414,"end":424},"obj":"SP_7"},{"id":"T27","span":{"begin":478,"end":483},"obj":"SP_6;NCBITaxon:9606;PG_10"}],"text":"lustrate the impact of viral evolution and divergence on Spike glycosylation, as well as the influence of natural variants on ACE2 receptor glycosylation. Taken together, these data can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human AC"}