PMC:7443692 / 35556-36194 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7443692","sourcedb":"PMC","sourceid":"7443692","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7443692","text":"We have defined the glycomics-informed, site-specific microheterogeneity of 22 sites of N-linked glycosylation per monomer on a SARS-CoV-2 trimer and the six sites of N-linked glycosylation on a soluble version of its human ACE2 receptor by using a combination of mass spectrometry approaches coupled with evolutionary and variant sequence analyses to provide a detailed understanding of the glycosylation states of these glycoproteins (Figures 1, 2, 3, 4, 5, and 6). Our results suggest essential roles for glycosylation in mediating receptor binding, antigenic shielding, and potentially the evolution/divergence of these glycoproteins.","tracks":[{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T200","span":{"begin":422,"end":435},"obj":"Chemical"},{"id":"T201","span":{"begin":624,"end":637},"obj":"Chemical"}],"attributes":[{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"subj":"T200","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T201","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T97","span":{"begin":128,"end":138},"obj":"Species"},{"id":"T98","span":{"begin":218,"end":223},"obj":"Species"}],"attributes":[{"id":"A98","pred":"ncbi_taxonomy_id","subj":"T98","obj":"NCBItxid:9606"},{"id":"A97","pred":"ncbi_taxonomy_id","subj":"T97","obj":"NCBItxid:2697049"},{"subj":"T97","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T98","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T224","span":{"begin":0,"end":467},"obj":"Sentence"},{"id":"T225","span":{"begin":468,"end":638},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T224","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T225","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T64","span":{"begin":128,"end":138},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T64","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2304","span":{"begin":224,"end":228},"obj":"Protein"},{"id":"T2305","span":{"begin":422,"end":435},"obj":"Protein"},{"id":"T2390","span":{"begin":624,"end":637},"obj":"Protein"}],"attributes":[{"id":"A2304","pred":"uniprot_id","subj":"T2304","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2305","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q9QSP1"},{"id":"A2306","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q9QJT6"},{"id":"A2307","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q9JGT4"},{"id":"A2308","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q9IPJ6"},{"id":"A2309","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q9DIC6"},{"id":"A2310","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q91DS0"},{"id":"A2311","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q91C28"},{"id":"A2312","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8QQA2"},{"id":"A2313","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8QPE5"},{"id":"A2314","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8QPE4"},{"id":"A2315","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8QPE3"},{"id":"A2316","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8JTH0"},{"id":"A2317","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8BDV6"},{"id":"A2318","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8B6J6"},{"id":"A2319","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8B0I1"},{"id":"A2320","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8B0H6"},{"id":"A2321","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q8B0H1"},{"id":"A2322","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q89669"},{"id":"A2323","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q85213"},{"id":"A2324","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q82706"},{"id":"A2325","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q82683"},{"id":"A2326","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q82020"},{"id":"A2327","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q787B5"},{"id":"A2328","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q77SK0"},{"id":"A2329","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q77N36"},{"id":"A2330","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q76G52"},{"id":"A2331","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q75T09"},{"id":"A2332","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q6X1D5"},{"id":"A2333","pred":"uniprot_id","subj":"T2305","obj":"https://www.uniprot.org/uniprot/Q6X1D1"},{"id":"A2334","pred":"unipr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