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PMC:7443692 / 31015-32563 JSONTXT

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LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T188 299-311 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T82 443-448 Species denotes human NCBItxid:9606
T83 721-727 Species denotes humans NCBItxid:9605
T84 774-779 Species denotes human NCBItxid:9606
T85 1018-1023 Species denotes Human NCBItxid:9606
T86 1199-1204 Species denotes human NCBItxid:9606
T87 1223-1228 Species denotes human NCBItxid:9606
T88 1448-1453 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T184 0-125 Sentence denotes We integrated our glycomics, glycoproteomics, and population variant analyses results with a 3D model of Ace 2 (based on PDB:
T185 126-275 Sentence denotes 6M0J (Lan et al., 2020; see STAR Methods for details) to generate two versions of the soluble glycosylated ACE2 for visualization and MD simulations.
T186 276-494 Sentence denotes We visualized the ACE2 glycoprotein with the Abundance glycoform model simulated at each site as well as highlighting the naturally occurring variants observed in the human population (Figure 6 A; Video S2; Table S11).
T187 495-615 Sentence denotes Note, that the Abundance glycoform model and the Oxford Class glycoform model for ACE2 are identical (Tables S1 and S8).
T188 616-803 Sentence denotes Notably, one site of N-linked glycosylation (N546) is predicted to not be present in three out of 10,000 humans based on naturally occurring variation in the human population (Table S11).
T189 804-873 Sentence denotes We also modeled ACE2 using the Processed glycoform model (Figure 6B).
T190 874-961 Sentence denotes In both models, the interaction domain with S is defined (Figures 6A and 6B; Video S2).
T191 962-1028 Sentence denotes Figure 6 3D Structural Modeling of Glycosylated Soluble Human ACE2
T192 1029-1210 Sentence denotes Results from glycomics and glycoproteomics experiments were combined with results from bioinformatics analyses and used to model several versions of glycosylated soluble human ACE2.
T193 1211-1343 Sentence denotes (A) Soluble human ACE2 model from MD simulations displaying abundance glycoforms, interaction surface with S, and sequence variants.
T194 1344-1435 Sentence denotes N546 variant is boxed that would remove N-linked glycosylation at that site (see Video S2).
T195 1436-1548 Sentence denotes (B) Soluble human ACE2 model from MD simulations displaying processed glycoforms and interaction surface with S.

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T59 154-158 Disease denotes STAR http://purl.obolibrary.org/obo/MONDO_0010408

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2035 154-158 Protein denotes STAR https://www.uniprot.org/uniprot/Q9GMD0|https://www.uniprot.org/uniprot/Q9DG10|https://www.uniprot.org/uniprot/Q9DG09|https://www.uniprot.org/uniprot/Q9DG08|https://www.uniprot.org/uniprot/Q9DEB4|https://www.uniprot.org/uniprot/Q9DE06|https://www.uniprot.org/uniprot/Q9D2G1|https://www.uniprot.org/uniprot/Q95259|https://www.uniprot.org/uniprot/Q924Y5|https://www.uniprot.org/uniprot/Q543A5|https://www.uniprot.org/uniprot/Q53Z33|https://www.uniprot.org/uniprot/Q501Q7|https://www.uniprot.org/uniprot/Q2YDI1|https://www.uniprot.org/uniprot/Q28996|https://www.uniprot.org/uniprot/Q28918|https://www.uniprot.org/uniprot/Q16396|https://www.uniprot.org/uniprot/P97826|https://www.uniprot.org/uniprot/P97628|https://www.uniprot.org/uniprot/P79245|https://www.uniprot.org/uniprot/P70114|https://www.uniprot.org/uniprot/P58864|https://www.uniprot.org/uniprot/P51557|https://www.uniprot.org/uniprot/P49675|https://www.uniprot.org/uniprot/O46689
T2059 233-237 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2060 294-298 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2061 299-311 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2146 489-492 Protein denotes S11 https://www.uniprot.org/uniprot/Q9NTB1|https://www.uniprot.org/uniprot/Q9BTX0|https://www.uniprot.org/uniprot/Q9BTE4|https://www.uniprot.org/uniprot/Q5JRR2|https://www.uniprot.org/uniprot/Q14136|https://www.uniprot.org/uniprot/P98175|https://www.uniprot.org/uniprot/C4AM81|https://www.uniprot.org/uniprot/A0A0A0MR66
T2154 577-581 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2155 798-801 Protein denotes S11 https://www.uniprot.org/uniprot/Q9NTB1|https://www.uniprot.org/uniprot/Q9BTX0|https://www.uniprot.org/uniprot/Q9BTE4|https://www.uniprot.org/uniprot/Q5JRR2|https://www.uniprot.org/uniprot/Q14136|https://www.uniprot.org/uniprot/P98175|https://www.uniprot.org/uniprot/C4AM81|https://www.uniprot.org/uniprot/A0A0A0MR66
T2163 820-824 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2164 1024-1028 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2165 1205-1209 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2166 1229-1233 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2167 1454-1458 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T91 365-369 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T92 629-633 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T93 1415-1419 http://purl.obolibrary.org/obo/BFO_0000029 denotes site

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T98 299-311 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T74 646-659 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T75 1393-1406 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T70 646-659 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T71 1393-1406 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

2_test

Id Subject Object Predicate Lexical cue
32841605-32225176-19659520 144-148 32225176 denotes 2020