PMC:7443692 / 31015-32563
Annnotations
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T188 | 299-311 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T82 | 443-448 | Species | denotes | human | NCBItxid:9606 |
T83 | 721-727 | Species | denotes | humans | NCBItxid:9605 |
T84 | 774-779 | Species | denotes | human | NCBItxid:9606 |
T85 | 1018-1023 | Species | denotes | Human | NCBItxid:9606 |
T86 | 1199-1204 | Species | denotes | human | NCBItxid:9606 |
T87 | 1223-1228 | Species | denotes | human | NCBItxid:9606 |
T88 | 1448-1453 | Species | denotes | human | NCBItxid:9606 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T184 | 0-125 | Sentence | denotes | We integrated our glycomics, glycoproteomics, and population variant analyses results with a 3D model of Ace 2 (based on PDB: |
T185 | 126-275 | Sentence | denotes | 6M0J (Lan et al., 2020; see STAR Methods for details) to generate two versions of the soluble glycosylated ACE2 for visualization and MD simulations. |
T186 | 276-494 | Sentence | denotes | We visualized the ACE2 glycoprotein with the Abundance glycoform model simulated at each site as well as highlighting the naturally occurring variants observed in the human population (Figure 6 A; Video S2; Table S11). |
T187 | 495-615 | Sentence | denotes | Note, that the Abundance glycoform model and the Oxford Class glycoform model for ACE2 are identical (Tables S1 and S8). |
T188 | 616-803 | Sentence | denotes | Notably, one site of N-linked glycosylation (N546) is predicted to not be present in three out of 10,000 humans based on naturally occurring variation in the human population (Table S11). |
T189 | 804-873 | Sentence | denotes | We also modeled ACE2 using the Processed glycoform model (Figure 6B). |
T190 | 874-961 | Sentence | denotes | In both models, the interaction domain with S is defined (Figures 6A and 6B; Video S2). |
T191 | 962-1028 | Sentence | denotes | Figure 6 3D Structural Modeling of Glycosylated Soluble Human ACE2 |
T192 | 1029-1210 | Sentence | denotes | Results from glycomics and glycoproteomics experiments were combined with results from bioinformatics analyses and used to model several versions of glycosylated soluble human ACE2. |
T193 | 1211-1343 | Sentence | denotes | (A) Soluble human ACE2 model from MD simulations displaying abundance glycoforms, interaction surface with S, and sequence variants. |
T194 | 1344-1435 | Sentence | denotes | N546 variant is boxed that would remove N-linked glycosylation at that site (see Video S2). |
T195 | 1436-1548 | Sentence | denotes | (B) Soluble human ACE2 model from MD simulations displaying processed glycoforms and interaction surface with S. |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T59 | 154-158 | Disease | denotes | STAR | http://purl.obolibrary.org/obo/MONDO_0010408 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T2035 | 154-158 | Protein | denotes | STAR | https://www.uniprot.org/uniprot/Q9GMD0|https://www.uniprot.org/uniprot/Q9DG10|https://www.uniprot.org/uniprot/Q9DG09|https://www.uniprot.org/uniprot/Q9DG08|https://www.uniprot.org/uniprot/Q9DEB4|https://www.uniprot.org/uniprot/Q9DE06|https://www.uniprot.org/uniprot/Q9D2G1|https://www.uniprot.org/uniprot/Q95259|https://www.uniprot.org/uniprot/Q924Y5|https://www.uniprot.org/uniprot/Q543A5|https://www.uniprot.org/uniprot/Q53Z33|https://www.uniprot.org/uniprot/Q501Q7|https://www.uniprot.org/uniprot/Q2YDI1|https://www.uniprot.org/uniprot/Q28996|https://www.uniprot.org/uniprot/Q28918|https://www.uniprot.org/uniprot/Q16396|https://www.uniprot.org/uniprot/P97826|https://www.uniprot.org/uniprot/P97628|https://www.uniprot.org/uniprot/P79245|https://www.uniprot.org/uniprot/P70114|https://www.uniprot.org/uniprot/P58864|https://www.uniprot.org/uniprot/P51557|https://www.uniprot.org/uniprot/P49675|https://www.uniprot.org/uniprot/O46689 |
T2059 | 233-237 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2060 | 294-298 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2061 | 299-311 | Protein | denotes | glycoprotein | https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8 |
T2146 | 489-492 | Protein | denotes | S11 | https://www.uniprot.org/uniprot/Q9NTB1|https://www.uniprot.org/uniprot/Q9BTX0|https://www.uniprot.org/uniprot/Q9BTE4|https://www.uniprot.org/uniprot/Q5JRR2|https://www.uniprot.org/uniprot/Q14136|https://www.uniprot.org/uniprot/P98175|https://www.uniprot.org/uniprot/C4AM81|https://www.uniprot.org/uniprot/A0A0A0MR66 |
T2154 | 577-581 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2155 | 798-801 | Protein | denotes | S11 | https://www.uniprot.org/uniprot/Q9NTB1|https://www.uniprot.org/uniprot/Q9BTX0|https://www.uniprot.org/uniprot/Q9BTE4|https://www.uniprot.org/uniprot/Q5JRR2|https://www.uniprot.org/uniprot/Q14136|https://www.uniprot.org/uniprot/P98175|https://www.uniprot.org/uniprot/C4AM81|https://www.uniprot.org/uniprot/A0A0A0MR66 |
T2163 | 820-824 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2164 | 1024-1028 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2165 | 1205-1209 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2166 | 1229-1233 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
T2167 | 1454-1458 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T91 | 365-369 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
T92 | 629-633 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
T93 | 1415-1419 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T98 | 299-311 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T74 | 646-659 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
T75 | 1393-1406 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T70 | 646-659 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
T71 | 1393-1406 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32841605-32225176-19659520 | 144-148 | 32225176 | denotes | 2020 |