PMC:7443692 / 30921-32627
Annnotations
LitCovid-sample-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T188 | 393-405 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
LitCovid-sample-PD-NCBITaxon
| Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
|---|---|---|---|---|---|
| T82 | 537-542 | Species | denotes | human | NCBItxid:9606 |
| T83 | 815-821 | Species | denotes | humans | NCBItxid:9605 |
| T84 | 868-873 | Species | denotes | human | NCBItxid:9606 |
| T85 | 1112-1117 | Species | denotes | Human | NCBItxid:9606 |
| T86 | 1293-1298 | Species | denotes | human | NCBItxid:9606 |
| T87 | 1317-1322 | Species | denotes | human | NCBItxid:9606 |
| T88 | 1542-1547 | Species | denotes | human | NCBItxid:9606 |
LitCovid-sample-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T183 | 0-93 | Sentence | denotes | 3D Structural Modeling of Glycosylated, Soluble, ACE2-Highlighting Glycosylation and Variants |
| T184 | 94-219 | Sentence | denotes | We integrated our glycomics, glycoproteomics, and population variant analyses results with a 3D model of Ace 2 (based on PDB: |
| T185 | 220-369 | Sentence | denotes | 6M0J (Lan et al., 2020; see STAR Methods for details) to generate two versions of the soluble glycosylated ACE2 for visualization and MD simulations. |
| T186 | 370-588 | Sentence | denotes | We visualized the ACE2 glycoprotein with the Abundance glycoform model simulated at each site as well as highlighting the naturally occurring variants observed in the human population (Figure 6 A; Video S2; Table S11). |
| T187 | 589-709 | Sentence | denotes | Note, that the Abundance glycoform model and the Oxford Class glycoform model for ACE2 are identical (Tables S1 and S8). |
| T188 | 710-897 | Sentence | denotes | Notably, one site of N-linked glycosylation (N546) is predicted to not be present in three out of 10,000 humans based on naturally occurring variation in the human population (Table S11). |
| T189 | 898-967 | Sentence | denotes | We also modeled ACE2 using the Processed glycoform model (Figure 6B). |
| T190 | 968-1055 | Sentence | denotes | In both models, the interaction domain with S is defined (Figures 6A and 6B; Video S2). |
| T191 | 1056-1122 | Sentence | denotes | Figure 6 3D Structural Modeling of Glycosylated Soluble Human ACE2 |
| T192 | 1123-1304 | Sentence | denotes | Results from glycomics and glycoproteomics experiments were combined with results from bioinformatics analyses and used to model several versions of glycosylated soluble human ACE2. |
| T193 | 1305-1437 | Sentence | denotes | (A) Soluble human ACE2 model from MD simulations displaying abundance glycoforms, interaction surface with S, and sequence variants. |
| T194 | 1438-1529 | Sentence | denotes | N546 variant is boxed that would remove N-linked glycosylation at that site (see Video S2). |
| T195 | 1530-1642 | Sentence | denotes | (B) Soluble human ACE2 model from MD simulations displaying processed glycoforms and interaction surface with S. |
| T196 | 1643-1652 | Sentence | denotes | Video S2. |
| T197 | 1653-1706 | Sentence | denotes | Glycosylated ACE2 with Variants, Related to Figure 6A |
LitCovid-sample-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T59 | 248-252 | Disease | denotes | STAR | http://purl.obolibrary.org/obo/MONDO_0010408 |
LitCovid-sample-UniProt
| Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
|---|---|---|---|---|---|
| T2034 | 49-53 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2035 | 248-252 | Protein | denotes | STAR | https://www.uniprot.org/uniprot/Q9GMD0|https://www.uniprot.org/uniprot/Q9DG10|https://www.uniprot.org/uniprot/Q9DG09|https://www.uniprot.org/uniprot/Q9DG08|https://www.uniprot.org/uniprot/Q9DEB4|https://www.uniprot.org/uniprot/Q9DE06|https://www.uniprot.org/uniprot/Q9D2G1|https://www.uniprot.org/uniprot/Q95259|https://www.uniprot.org/uniprot/Q924Y5|https://www.uniprot.org/uniprot/Q543A5|https://www.uniprot.org/uniprot/Q53Z33|https://www.uniprot.org/uniprot/Q501Q7|https://www.uniprot.org/uniprot/Q2YDI1|https://www.uniprot.org/uniprot/Q28996|https://www.uniprot.org/uniprot/Q28918|https://www.uniprot.org/uniprot/Q16396|https://www.uniprot.org/uniprot/P97826|https://www.uniprot.org/uniprot/P97628|https://www.uniprot.org/uniprot/P79245|https://www.uniprot.org/uniprot/P70114|https://www.uniprot.org/uniprot/P58864|https://www.uniprot.org/uniprot/P51557|https://www.uniprot.org/uniprot/P49675|https://www.uniprot.org/uniprot/O46689 |
| T2059 | 327-331 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2060 | 388-392 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2061 | 393-405 | Protein | denotes | glycoprotein | https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8 |
| T2146 | 583-586 | Protein | denotes | S11 | https://www.uniprot.org/uniprot/Q9NTB1|https://www.uniprot.org/uniprot/Q9BTX0|https://www.uniprot.org/uniprot/Q9BTE4|https://www.uniprot.org/uniprot/Q5JRR2|https://www.uniprot.org/uniprot/Q14136|https://www.uniprot.org/uniprot/P98175|https://www.uniprot.org/uniprot/C4AM81|https://www.uniprot.org/uniprot/A0A0A0MR66 |
| T2154 | 671-675 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2155 | 892-895 | Protein | denotes | S11 | https://www.uniprot.org/uniprot/Q9NTB1|https://www.uniprot.org/uniprot/Q9BTX0|https://www.uniprot.org/uniprot/Q9BTE4|https://www.uniprot.org/uniprot/Q5JRR2|https://www.uniprot.org/uniprot/Q14136|https://www.uniprot.org/uniprot/P98175|https://www.uniprot.org/uniprot/C4AM81|https://www.uniprot.org/uniprot/A0A0A0MR66 |
| T2163 | 914-918 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2164 | 1118-1122 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2165 | 1299-1303 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2166 | 1323-1327 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2167 | 1548-1552 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T2168 | 1666-1670 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
LitCovid-sample-PD-IDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T91 | 459-463 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
| T92 | 723-727 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
| T93 | 1509-1513 | http://purl.obolibrary.org/obo/BFO_0000029 | denotes | site |
LitCovid-sample-PD-FMA
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T98 | 393-405 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-sample-PD-GO-BP-0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T73 | 67-80 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | Glycosylation |
| T74 | 740-753 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T75 | 1487-1500 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sample-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T69 | 67-80 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | Glycosylation |
| T70 | 740-753 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T71 | 1487-1500 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32841605-32225176-19659520 | 238-242 | 32225176 | denotes | 2020 |