PMC:7443692 / 1866-3254 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7443692","sourcedb":"PMC","sourceid":"7443692","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7443692","text":"The SARS-CoV-2 coronavirus, a positive-sense single-stranded RNA virus, is responsible for the severe acute respiratory syndrome referred to as COVID-19 that was first reported in China in December 2019 (Zhou et al., 2020). In approximately six months, this betacoronavirus has spread globally, with more than 14 million people testing positive worldwide resulting in greater than 600,000 deaths as of July 20, 2020 (https://coronavirus.jhu.edu/map.html). The SARS-CoV-2 coronavirus is highly similar (nearly 80% identical at the genomic level) to SARS-CoV-1, which was responsible for the severe acute respiratory syndrome outbreak that began in 2002 (Lu et al., 2020; Zhong et al., 2003). Furthermore, human SARS-CoV-2 at the whole-genome level is \u003e95% identical to a bat coronavirus (RaTG13), the natural reservoir host for multiple coronaviruses (Xia, 2020; Zhang et al., 2020; Zhou et al., 2020). Given the rapid appearance and spread of this virus, there is no current validated vaccine or SARS-CoV-2-specific targeting therapy that is clinically approved, although statins, heparin, and steroids look promising for lowering fatality rates, and antivirals likely reduce the duration of symptomatic disease presentation (Alijotas-Reig et al., 2020; Beigel et al., 2020; Beun et al., 2020; Dashti-Khavidaki and Khalili, 2020; Fedson et al., 2020; Shi et al., 2020; Tang et al., 2020).","tracks":[{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T11","span":{"begin":61,"end":64},"obj":"Chemical"},{"id":"T12","span":{"begin":1072,"end":1079},"obj":"Chemical"},{"id":"T13","span":{"begin":1081,"end":1088},"obj":"Chemical"},{"id":"T14","span":{"begin":1094,"end":1102},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_87631"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T10","span":{"begin":4,"end":14},"obj":"Species"},{"id":"T11","span":{"begin":61,"end":70},"obj":"Species"},{"id":"T12","span":{"begin":95,"end":128},"obj":"Species"},{"id":"T13","span":{"begin":144,"end":152},"obj":"Species"},{"id":"T14","span":{"begin":258,"end":273},"obj":"Species"},{"id":"T15","span":{"begin":460,"end":470},"obj":"Species"},{"id":"T16","span":{"begin":548,"end":556},"obj":"Species"},{"id":"T17","span":{"begin":590,"end":623},"obj":"Species"},{"id":"T18","span":{"begin":704,"end":718},"obj":"Species"},{"id":"T19","span":{"begin":770,"end":794},"obj":"Species"},{"id":"T20","span":{"begin":996,"end":1006},"obj":"Species"}],"attributes":[{"id":"A20","pred":"ncbi_taxonomy_id","subj":"T20","obj":"NCBItxid:2697049"},{"id":"A13","pred":"ncbi_taxonomy_id","subj":"T13","obj":"NCBItxid:2697049"},{"id":"A15","pred":"ncbi_taxonomy_id","subj":"T15","obj":"NCBItxid:2697049"},{"id":"A14","pred":"ncbi_taxonomy_id","subj":"T14","obj":"NCBItxid:694002"},{"id":"A18","pred":"ncbi_taxonomy_id","subj":"T18","obj":"NCBItxid:694009"},{"id":"A12","pred":"ncbi_taxonomy_id","subj":"T12","obj":"NCBItxid:694009"},{"id":"A16","pred":"ncbi_taxonomy_id","subj":"T16","obj":"NCBItxid:694009"},{"id":"A17","pred":"ncbi_taxonomy_id","subj":"T17","obj":"NCBItxid:694009"},{"id":"A10","pred":"ncbi_taxonomy_id","subj":"T10","obj":"NCBItxid:2697049"},{"id":"A19","pred":"ncbi_taxonomy_id","subj":"T19","obj":"NCBItxid:2709072"},{"id":"A11","pred":"ncbi_taxonomy_id","subj":"T11","obj":"NCBItxid:2559587"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T14","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T15","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T16","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T17","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T18","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T19","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T20","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":223},"obj":"Sentence"},{"id":"T18","span":{"begin":224,"end":455},"obj":"Sentence"},{"id":"T19","span":{"begin":456,"end":690},"obj":"Sentence"},{"id":"T20","span":{"begin":691,"end":901},"obj":"Sentence"},{"id":"T21","span":{"begin":902,"end":1388},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T17","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T18","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T19","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T20","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T21","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T6","span":{"begin":4,"end":14},"obj":"Disease"},{"id":"T7","span":{"begin":95,"end":128},"obj":"Disease"},{"id":"T8","span":{"begin":144,"end":152},"obj":"Disease"},{"id":"T9","span":{"begin":460,"end":470},"obj":"Disease"},{"id":"T10","span":{"begin":548,"end":556},"obj":"Disease"},{"id":"T11","span":{"begin":590,"end":623},"obj":"Disease"},{"id":"T12","span":{"begin":710,"end":720},"obj":"Disease"},{"id":"T13","span":{"begin":996,"end":1006},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T6","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T10","span":{"begin":65,"end":70},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T11","span":{"begin":818,"end":822},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T12","span":{"begin":948,"end":953},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T13","span":{"begin":1151,"end":1161},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"},{"id":"T14","span":{"begin":1204,"end":1211},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"attributes":[{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T14","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T12","span":{"begin":61,"end":64},"obj":"Body_part"},{"id":"T13","span":{"begin":734,"end":740},"obj":"Body_part"},{"id":"T14","span":{"begin":1081,"end":1088},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma82839"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T14","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"2_test","denotations":[{"id":"32841605-32015507-19659456","span":{"begin":217,"end":221},"obj":"32015507"},{"id":"32841605-32007145-19659457","span":{"begin":664,"end":668},"obj":"32007145"},{"id":"32841605-14585636-19659458","span":{"begin":684,"end":688},"obj":"14585636"},{"id":"32841605-32197085-19659459","span":{"begin":876,"end":880},"obj":"32197085"},{"id":"32841605-32015507-19659460","span":{"begin":895,"end":899},"obj":"32015507"},{"id":"32841605-32376394-19659461","span":{"begin":1248,"end":1252},"obj":"32376394"},{"id":"32841605-32311843-19659462","span":{"begin":1288,"end":1292},"obj":"32311843"},{"id":"32841605-32267560-19659463","span":{"begin":1324,"end":1328},"obj":"32267560"},{"id":"32841605-32566561-19659464","span":{"begin":1363,"end":1367},"obj":"32566561"},{"id":"32841605-32220112-19659465","span":{"begin":1382,"end":1386},"obj":"32220112"}],"attributes":[{"subj":"32841605-32015507-19659456","pred":"source","obj":"2_test"},{"subj":"32841605-32007145-19659457","pred":"source","obj":"2_test"},{"subj":"32841605-14585636-19659458","pred":"source","obj":"2_test"},{"subj":"32841605-32197085-19659459","pred":"source","obj":"2_test"},{"subj":"32841605-32015507-19659460","pred":"source","obj":"2_test"},{"subj":"32841605-32376394-19659461","pred":"source","obj":"2_test"},{"subj":"32841605-32311843-19659462","pred":"source","obj":"2_test"},{"subj":"32841605-32267560-19659463","pred":"source","obj":"2_test"},{"subj":"32841605-32566561-19659464","pred":"source","obj":"2_test"},{"subj":"32841605-32220112-19659465","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-CHEBI","color":"#ec93b0","default":true},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#93caec"},{"id":"LitCovid-sample-sentences","color":"#e4ec93"},{"id":"LitCovid-sample-PD-MONDO","color":"#da93ec"},{"id":"LitCovid-sample-PD-IDO","color":"#93ecc0"},{"id":"LitCovid-sample-PD-FMA","color":"#eca593"},{"id":"2_test","color":"#939aec"}]}]}}