PMC:7443692 / 1234-1586 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T8","span":{"begin":307,"end":314},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T6","span":{"begin":82,"end":92},"obj":"Species"},{"id":"T7","span":{"begin":146,"end":151},"obj":"Species"}],"attributes":[{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:9606"},{"id":"A6","pred":"ncbi_taxonomy_id","subj":"T6","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T10","span":{"begin":0,"end":10},"obj":"Sentence"},{"id":"T11","span":{"begin":11,"end":98},"obj":"Sentence"},{"id":"T12","span":{"begin":99,"end":179},"obj":"Sentence"},{"id":"T13","span":{"begin":180,"end":270},"obj":"Sentence"},{"id":"T14","span":{"begin":271,"end":352},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T4","span":{"begin":82,"end":92},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T277","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T278","span":{"begin":227,"end":231},"obj":"Protein"}],"attributes":[{"id":"A277","pred":"uniprot_id","subj":"T277","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A278","pred":"uniprot_id","subj":"T278","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T7","span":{"begin":14,"end":18},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T8","span":{"begin":73,"end":78},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T9","span":{"begin":106,"end":111},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T9","span":{"begin":307,"end":314},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T5","span":{"begin":257,"end":270},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T5","span":{"begin":257,"end":270},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T26","span":{"begin":82,"end":92},"obj":"SP_7"},{"id":"T27","span":{"begin":146,"end":151},"obj":"SP_6;NCBITaxon:9606;PG_10"},{"id":"T28","span":{"begin":152,"end":156},"obj":"PG_10;PR:000003622"},{"id":"T29","span":{"begin":227,"end":231},"obj":"G_3;PG_10;PR:000003622"},{"id":"T30","span":{"begin":315,"end":321},"obj":"CHEBI:17089;CHEBI:17089"},{"id":"T31","span":{"begin":326,"end":332},"obj":"CHEBI:17089;CHEBI:17089"},{"id":"T32","span":{"begin":333,"end":339},"obj":"CHEBI:17089;CHEBI:17089"}],"text":"Highlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in protein-glycan and glycan-glycan interactions"}