PMC:7443692 / 1134-1546 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7443692","sourcedb":"PMC","sourceid":"7443692","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7443692","text":"y neutralization and inform therapeutic strategies to inhibit viral infection.\n\nGraphical Abstract\n\nHighlights\n• Site-specific N-linked microheterogeneity is defined at 22 sites of SARS-CoV-2 Spike\n• Six sites of N-linked microheterogeneity of human ACE2 receptor are described\n• Molecular dynamics simulations of Spike and ACE2 show essential roles for glycosylation\n• We uncover roles for variants in prote","divisions":[{"label":"abstract","span":{"begin":80,"end":98}},{"label":"title","span":{"begin":80,"end":98}},{"label":"title","span":{"begin":100,"end":110}},{"label":"label","span":{"begin":111,"end":112}},{"label":"p","span":{"begin":114,"end":198}},{"label":"label","span":{"begin":199,"end":200}},{"label":"p","span":{"begin":202,"end":279}},{"label":"label","span":{"begin":280,"end":281}},{"label":"p","span":{"begin":283,"end":370}},{"label":"label","span":{"begin":371,"end":372}}],"tracks":[{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T6","span":{"begin":182,"end":192},"obj":"Species"},{"id":"T7","span":{"begin":246,"end":251},"obj":"Species"}],"attributes":[{"id":"A6","pred":"ncbi_taxonomy_id","subj":"T6","obj":"NCBItxid:2697049"},{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:9606"},{"subj":"T6","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T7","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T9","span":{"begin":80,"end":98},"obj":"Sentence"},{"id":"T10","span":{"begin":100,"end":110},"obj":"Sentence"},{"id":"T11","span":{"begin":111,"end":198},"obj":"Sentence"},{"id":"T12","span":{"begin":199,"end":279},"obj":"Sentence"},{"id":"T13","span":{"begin":280,"end":370},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T3","span":{"begin":62,"end":77},"obj":"Disease"},{"id":"T4","span":{"begin":182,"end":192},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T3","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T277","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T278","span":{"begin":327,"end":331},"obj":"Protein"}],"attributes":[{"id":"A277","pred":"uniprot_id","subj":"T277","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A278","pred":"uniprot_id","subj":"T278","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"subj":"T277","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T278","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T6","span":{"begin":68,"end":77},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T7","span":{"begin":114,"end":118},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T8","span":{"begin":173,"end":178},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T9","span":{"begin":206,"end":211},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T7","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T4","span":{"begin":62,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T5","span":{"begin":357,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T5","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T4","span":{"begin":62,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T5","span":{"begin":357,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T25","span":{"begin":62,"end":67},"obj":"NCBITaxon:10239"},{"id":"T26","span":{"begin":182,"end":192},"obj":"SP_7"},{"id":"T27","span":{"begin":246,"end":251},"obj":"SP_6;NCBITaxon:9606;PG_10"},{"id":"T28","span":{"begin":252,"end":256},"obj":"PG_10;PR:000003622"},{"id":"T29","span":{"begin":327,"end":331},"obj":"G_3;PG_10;PR:000003622"}],"attributes":[{"subj":"T25","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-PD-NCBITaxon","color":"#93ecb6","default":true},{"id":"LitCovid-sample-sentences","color":"#ec9c93"},{"id":"LitCovid-sample-PD-MONDO","color":"#93a4ec"},{"id":"LitCovid-sample-UniProt","color":"#beec93"},{"id":"LitCovid-sample-PD-IDO","color":"#ec93d8"},{"id":"LitCovid-sample-PD-GO-BP-0","color":"#93ece6"},{"id":"LitCovid-sample-GO-BP","color":"#eccc93"},{"id":"LitCovid-PMC-OGER-BB","color":"#b293ec"}]}]}}