PMC:7441788 / 8617-9248 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T36","span":{"begin":207,"end":214},"obj":"Body_part"},{"id":"T37","span":{"begin":253,"end":264},"obj":"Body_part"},{"id":"T38","span":{"begin":432,"end":435},"obj":"Body_part"},{"id":"T39","span":{"begin":509,"end":513},"obj":"Body_part"},{"id":"T40","span":{"begin":564,"end":573},"obj":"Body_part"},{"id":"T41","span":{"begin":613,"end":618},"obj":"Body_part"},{"id":"T42","span":{"begin":625,"end":630},"obj":"Body_part"}],"attributes":[{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T68","span":{"begin":75,"end":83},"obj":"Disease"}],"attributes":[{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T88","span":{"begin":281,"end":289},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T89","span":{"begin":368,"end":378},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T90","span":{"begin":501,"end":504},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T91","span":{"begin":507,"end":513},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T92","span":{"begin":523,"end":532},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T93","span":{"begin":597,"end":607},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T94","span":{"begin":611,"end":618},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T95","span":{"begin":623,"end":630},"obj":"http://purl.obolibrary.org/obo/CL_0000236"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T95","span":{"begin":0,"end":2},"obj":"Chemical"},{"id":"T96","span":{"begin":33,"end":42},"obj":"Chemical"},{"id":"T97","span":{"begin":207,"end":214},"obj":"Chemical"},{"id":"T98","span":{"begin":237,"end":248},"obj":"Chemical"},{"id":"T99","span":{"begin":244,"end":248},"obj":"Chemical"},{"id":"T100","span":{"begin":253,"end":264},"obj":"Chemical"},{"id":"T101","span":{"begin":442,"end":444},"obj":"Chemical"}],"attributes":[{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T68","span":{"begin":0,"end":2},"obj":"Chemical"},{"id":"T69","span":{"begin":207,"end":214},"obj":"Chemical"},{"id":"T70","span":{"begin":237,"end":248},"obj":"Chemical"},{"id":"T71","span":{"begin":253,"end":264},"obj":"Chemical"}],"attributes":[{"id":"A68","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T72","span":{"begin":75,"end":83},"obj":"Species"}],"attributes":[{"id":"A72","pred":"ncbi_taxonomy_id","subj":"T72","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T70","span":{"begin":0,"end":631},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"322","span":{"begin":196,"end":200},"obj":"Gene"},{"id":"323","span":{"begin":364,"end":367},"obj":"Gene"},{"id":"324","span":{"begin":477,"end":482},"obj":"Gene"},{"id":"325","span":{"begin":501,"end":504},"obj":"Gene"},{"id":"329","span":{"begin":75,"end":83},"obj":"Disease"}],"attributes":[{"id":"A322","pred":"pubann:denotes","subj":"322","obj":"Gene:59272"},{"id":"A323","pred":"pubann:denotes","subj":"323","obj":"Gene:1432"},{"id":"A324","pred":"pubann:denotes","subj":"324","obj":"Gene:959"},{"id":"A325","pred":"pubann:denotes","subj":"325","obj":"Gene:920"},{"id":"A329","pred":"pubann:denotes","subj":"329","obj":"MESH:C000657245"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

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"subj":"T205","obj":"https://www.uniprot.org/uniprot/P16003"},{"id":"A223","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/P06332"},{"id":"A224","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/P05542"},{"id":"A225","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/P05540"},{"id":"A226","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/P01730"},{"id":"A227","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/O77593"},{"id":"A228","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/O02805"},{"id":"A229","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/D3DUS5"},{"id":"A230","pred":"uniprot_id","subj":"T205","obj":"https://www.uniprot.org/uniprot/B2R737"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T70","span":{"begin":33,"end":42},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"},{"id":"T71","span":{"begin":393,"end":397},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T72","span":{"begin":509,"end":513},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T73","span":{"begin":550,"end":560},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T74","span":{"begin":613,"end":618},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T75","span":{"begin":625,"end":630},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T36","span":{"begin":207,"end":214},"obj":"Body_part"},{"id":"T37","span":{"begin":253,"end":264},"obj":"Body_part"},{"id":"T38","span":{"begin":432,"end":435},"obj":"Body_part"},{"id":"T39","span":{"begin":509,"end":513},"obj":"Body_part"},{"id":"T40","span":{"begin":564,"end":573},"obj":"Body_part"},{"id":"T41","span":{"begin":613,"end":618},"obj":"Body_part"},{"id":"T42","span":{"begin":625,"end":630},"obj":"Body_part"}],"attributes":[{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T11","span":{"begin":281,"end":296},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T12","span":{"begin":333,"end":346},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T13","span":{"begin":364,"end":367},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T14","span":{"begin":432,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0046776"},{"id":"T15","span":{"begin":523,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T61","span":{"begin":75,"end":83},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T11","span":{"begin":281,"end":296},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T12","span":{"begin":333,"end":346},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T13","span":{"begin":432,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0046776"},{"id":"T14","span":{"begin":523,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T11","span":{"begin":281,"end":296},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T12","span":{"begin":333,"end":346},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T13","span":{"begin":432,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0046776"},{"id":"T14","span":{"begin":523,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"322","span":{"begin":196,"end":200},"obj":"Gene"},{"id":"323","span":{"begin":364,"end":367},"obj":"Gene"},{"id":"324","span":{"begin":477,"end":482},"obj":"Gene"},{"id":"325","span":{"begin":501,"end":504},"obj":"Gene"},{"id":"329","span":{"begin":75,"end":83},"obj":"Disease"}],"attributes":[{"id":"A322","pred":"tao:has_database_id","subj":"322","obj":"Gene:59272"},{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"Gene:1432"},{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:959"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Gene:920"},{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}

{"project":"LitCovid-sentences","denotations":[{"id":"T70","span":{"begin":0,"end":631},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells."}