PMC:7441788 / 8498-9248
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T36 | 326-333 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T37 | 372-383 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T38 | 551-554 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T39 | 628-632 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T40 | 683-692 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T41 | 732-737 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T42 | 744-749 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T68 | 194-202 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T88 | 400-408 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T89 | 487-497 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T90 | 620-623 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T91 | 626-632 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T92 | 642-651 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T93 | 716-726 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T94 | 730-737 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T95 | 742-749 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T94 | 55-57 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T95 | 119-121 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T96 | 152-161 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T97 | 326-333 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T98 | 356-367 | Chemical | denotes | sialic acid | http://purl.obolibrary.org/obo/CHEBI_26667 |
| T99 | 363-367 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T100 | 372-383 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T101 | 561-563 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
LitCovid-sample-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T67 | 55-57 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T68 | 119-121 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T69 | 326-333 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T70 | 356-367 | Chemical | denotes | sialic acid | http://purl.obolibrary.org/obo/CHEBI_26667 |
| T71 | 372-383 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
LitCovid-sample-PD-NCBITaxon
| Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
|---|---|---|---|---|---|
| T72 | 194-202 | Species | denotes | COVID-19 | NCBItxid:2697049 |
LitCovid-sample-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T69 | 0-118 | Sentence | denotes | Schematic representation of the possible mechanisms of CQ/HCQ against CoVs replication and modulating immune response. |
| T70 | 119-750 | Sentence | denotes | CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells. |
LitCovid-sample-Pubtator
| Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
|---|---|---|---|---|---|
| 322 | 315-319 | Gene | denotes | ACE2 | Gene:59272 |
| 323 | 483-486 | Gene | denotes | p38 | Gene:1432 |
| 324 | 596-601 | Gene | denotes | CD154 | Gene:959 |
| 325 | 620-623 | Gene | denotes | CD4 | Gene:920 |
| 326 | 70-74 | Species | denotes | CoVs | Tax:11118 |
| 327 | 55-57 | Chemical | denotes | CQ | MESH:D002738 |
| 328 | 58-61 | Chemical | denotes | HCQ | MESH:D006886 |
| 329 | 194-202 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sample-UniProt
| Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
|---|---|---|---|---|---|
| T121 | 315-319 | Protein | denotes | ACE2 | https://www.uniprot.org/uniprot/Q9UFZ6 |
| T122 | 324-333 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
| T155 | 483-486 | Protein | denotes | p38 | https://www.uniprot.org/uniprot/Q9Y4Y1|https://www.uniprot.org/uniprot/Q9Y2S7|https://www.uniprot.org/uniprot/Q9UFX6|https://www.uniprot.org/uniprot/Q9UFG0|https://www.uniprot.org/uniprot/Q9Q6X7|https://www.uniprot.org/uniprot/Q9PY95|https://www.uniprot.org/uniprot/Q9P060|https://www.uniprot.org/uniprot/Q9NV58|https://www.uniprot.org/uniprot/Q9H8M8|https://www.uniprot.org/uniprot/Q9H5H9|https://www.uniprot.org/uniprot/Q96JE4|https://www.uniprot.org/uniprot/Q96IL6|https://www.uniprot.org/uniprot/Q96HJ0|https://www.uniprot.org/uniprot/Q96GA9|https://www.uniprot.org/uniprot/Q7TD18|https://www.uniprot.org/uniprot/Q64010|https://www.uniprot.org/uniprot/Q63768|https://www.uniprot.org/uniprot/Q52LG1|https://www.uniprot.org/uniprot/Q04929|https://www.uniprot.org/uniprot/Q01552|https://www.uniprot.org/uniprot/P46108|https://www.uniprot.org/uniprot/P34717|https://www.uniprot.org/uniprot/P27586|https://www.uniprot.org/uniprot/P0C797|https://www.uniprot.org/uniprot/P0C796|https://www.uniprot.org/uniprot/P06663|https://www.uniprot.org/uniprot/P04383|https://www.uniprot.org/uniprot/O97628|https://www.uniprot.org/uniprot/O95433|https://www.uniprot.org/uniprot/D3DTH6|https://www.uniprot.org/uniprot/B4DUR9|https://www.uniprot.org/uniprot/B2R9L2|https://www.uniprot.org/uniprot/B2R846|https://www.uniprot.org/uniprot/B0LPE8|https://www.uniprot.org/uniprot/A8MWE8|https://www.uniprot.org/uniprot/A3KCU9 |
| T191 | 596-601 | Protein | denotes | CD154 | https://www.uniprot.org/uniprot/Q9Z2V2|https://www.uniprot.org/uniprot/Q9R254|https://www.uniprot.org/uniprot/Q9BDN3|https://www.uniprot.org/uniprot/Q9BDM7|https://www.uniprot.org/uniprot/Q9BDM3|https://www.uniprot.org/uniprot/Q9BDC7|https://www.uniprot.org/uniprot/Q95MQ5|https://www.uniprot.org/uniprot/P63305|https://www.uniprot.org/uniprot/P63304|https://www.uniprot.org/uniprot/P51749|https://www.uniprot.org/uniprot/P29965|https://www.uniprot.org/uniprot/P27548|https://www.uniprot.org/uniprot/O97626|https://www.uniprot.org/uniprot/O97605 |
| T205 | 620-623 | Protein | denotes | CD4 | https://www.uniprot.org/uniprot/Q9XS78|https://www.uniprot.org/uniprot/Q9UDE5|https://www.uniprot.org/uniprot/Q5U066|https://www.uniprot.org/uniprot/Q4ZGK2|https://www.uniprot.org/uniprot/Q29617|https://www.uniprot.org/uniprot/Q29037|https://www.uniprot.org/uniprot/Q28217|https://www.uniprot.org/uniprot/Q08340|https://www.uniprot.org/uniprot/Q08339|https://www.uniprot.org/uniprot/Q08338|https://www.uniprot.org/uniprot/Q08336|https://www.uniprot.org/uniprot/P79196|https://www.uniprot.org/uniprot/P79185|https://www.uniprot.org/uniprot/P79184|https://www.uniprot.org/uniprot/P46630|https://www.uniprot.org/uniprot/P33705|https://www.uniprot.org/uniprot/P16004|https://www.uniprot.org/uniprot/P16003|https://www.uniprot.org/uniprot/P06332|https://www.uniprot.org/uniprot/P05542|https://www.uniprot.org/uniprot/P05540|https://www.uniprot.org/uniprot/P01730|https://www.uniprot.org/uniprot/O77593|https://www.uniprot.org/uniprot/O02805|https://www.uniprot.org/uniprot/D3DUS5|https://www.uniprot.org/uniprot/B2R737 |
LitCovid-sample-PD-IDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T68 | 75-86 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
| T69 | 102-117 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T70 | 152-161 | http://purl.obolibrary.org/obo/IDO_0000559 | denotes | antiviral |
| T71 | 512-516 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
| T72 | 628-632 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
| T73 | 669-679 | http://purl.obolibrary.org/obo/IDO_0000607 | denotes | production |
| T74 | 732-737 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
| T75 | 744-749 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
LitCovid-sample-PD-FMA
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T36 | 326-333 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T37 | 372-383 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T38 | 551-554 | Body_part | denotes | MHC | http://purl.org/sig/ont/fma/fma84079 |
| T39 | 628-632 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T40 | 683-692 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T41 | 732-737 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T42 | 744-749 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-sample-PD-GO-BP-0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 102-117 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T11 | 400-415 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T12 | 452-465 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
| T13 | 483-486 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | p38 |
| T14 | 551-554 | http://purl.obolibrary.org/obo/GO_0046776 | denotes | MHC |
| T15 | 642-651 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sample-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T61 | 194-202 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-sample-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 102-117 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T11 | 400-415 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T12 | 452-465 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
| T13 | 551-554 | http://purl.obolibrary.org/obo/GO_0046776 | denotes | MHC |
| T14 | 642-651 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 102-117 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T11 | 400-415 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T12 | 452-465 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
| T13 | 551-554 | http://purl.obolibrary.org/obo/GO_0046776 | denotes | MHC |
| T14 | 642-651 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 322 | 315-319 | Gene | denotes | ACE2 | Gene:59272 |
| 323 | 483-486 | Gene | denotes | p38 | Gene:1432 |
| 324 | 596-601 | Gene | denotes | CD154 | Gene:959 |
| 325 | 620-623 | Gene | denotes | CD4 | Gene:920 |
| 326 | 70-74 | Species | denotes | CoVs | Tax:11118 |
| 327 | 55-57 | Chemical | denotes | CQ | MESH:D002738 |
| 328 | 58-61 | Chemical | denotes | HCQ | MESH:D006886 |
| 329 | 194-202 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T69 | 0-118 | Sentence | denotes | Schematic representation of the possible mechanisms of CQ/HCQ against CoVs replication and modulating immune response. |
| T70 | 119-750 | Sentence | denotes | CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells. |