PMC:7441788 / 7562-7912 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T27","span":{"begin":112,"end":124},"obj":"Body_part"},{"id":"T28","span":{"begin":112,"end":116},"obj":"Body_part"},{"id":"T29","span":{"begin":243,"end":256},"obj":"Body_part"},{"id":"T30","span":{"begin":243,"end":247},"obj":"Body_part"},{"id":"T31","span":{"begin":319,"end":324},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T64","span":{"begin":4,"end":12},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T74","span":{"begin":63,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T75","span":{"begin":70,"end":72},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T76","span":{"begin":70,"end":72},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T77","span":{"begin":83,"end":85},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T78","span":{"begin":112,"end":116},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T79","span":{"begin":177,"end":182},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T80","span":{"begin":203,"end":205},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T81","span":{"begin":203,"end":205},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T82","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T83","span":{"begin":243,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T84","span":{"begin":248,"end":256},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T85","span":{"begin":312,"end":324},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T85","span":{"begin":70,"end":72},"obj":"Chemical"},{"id":"T86","span":{"begin":134,"end":145},"obj":"Chemical"},{"id":"T87","span":{"begin":203,"end":205},"obj":"Chemical"},{"id":"T88","span":{"begin":298,"end":300},"obj":"Chemical"}],"attributes":[{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T4","span":{"begin":134,"end":163},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T5","span":{"begin":267,"end":280},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A4","pred":"meddra_id","subj":"T4","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A5","pred":"meddra_id","subj":"T5","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T60","span":{"begin":134,"end":145},"obj":"Chemical"},{"id":"T61","span":{"begin":298,"end":300},"obj":"Chemical"}],"attributes":[{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T68","span":{"begin":4,"end":14},"obj":"Species"}],"attributes":[{"id":"A68","pred":"ncbi_taxonomy_id","subj":"T68","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T65","span":{"begin":79,"end":262},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"350","span":{"begin":134,"end":165},"obj":"Gene"},{"id":"351","span":{"begin":167,"end":171},"obj":"Gene"},{"id":"352","span":{"begin":304,"end":308},"obj":"Gene"},{"id":"359","span":{"begin":4,"end":14},"obj":"Species"},{"id":"364","span":{"begin":298,"end":300},"obj":"Chemical"},{"id":"369","span":{"begin":312,"end":318},"obj":"CellLine"}],"attributes":[{"id":"A350","pred":"pubann:denotes","subj":"350","obj":"Gene:59272"},{"id":"A351","pred":"pubann:denotes","subj":"351","obj":"Gene:59272"},{"id":"A352","pred":"pubann:denotes","subj":"352","obj":"Gene:103231639"},{"id":"A359","pred":"pubann:denotes","subj":"359","obj":"Tax:2697049"},{"id":"A364","pred":"pubann:denotes","subj":"364","obj":"MESH:D002738"},{"id":"A369","pred":"pubann:denotes","subj":"369","obj":"CVCL:0574"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T34","span":{"begin":134,"end":165},"obj":"Protein"},{"id":"T49","span":{"begin":167,"end":171},"obj":"Protein"},{"id":"T50","span":{"begin":304,"end":308},"obj":"Protein"}],"attributes":[{"id":"A34","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A35","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q9NRA7"},{"id":"A36","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q9BYF1"},{"id":"A37","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q99N71"},{"id":"A38","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q99N70"},{"id":"A39","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q8R0I0"},{"id":"A40","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q86WT0"},{"id":"A41","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q6UWP0"},{"id":"A42","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q5RFN1"},{"id":"A43","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q5EGZ1"},{"id":"A44","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q58DD0"},{"id":"A45","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q56NL1"},{"id":"A46","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q56H28"},{"id":"A47","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/Q2PGE2"},{"id":"A48","pred":"uniprot_id","subj":"T34","obj":"https://www.uniprot.org/uniprot/C7ECU1"},{"id":"A49","pred":"uniprot_id","subj":"T49","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A50","pred":"uniprot_id","subj":"T50","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T58","span":{"begin":29,"end":33},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T59","span":{"begin":107,"end":111},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T60","span":{"begin":112,"end":116},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T61","span":{"begin":177,"end":182},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T62","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T63","span":{"begin":238,"end":242},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T64","span":{"begin":243,"end":247},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T65","span":{"begin":319,"end":324},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T27","span":{"begin":112,"end":124},"obj":"Body_part"},{"id":"T28","span":{"begin":112,"end":116},"obj":"Body_part"},{"id":"T29","span":{"begin":243,"end":256},"obj":"Body_part"},{"id":"T30","span":{"begin":243,"end":247},"obj":"Body_part"},{"id":"T31","span":{"begin":319,"end":324},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T57","span":{"begin":4,"end":14},"obj":"Disease"}],"attributes":[{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-PubTator","denotations":[{"id":"350","span":{"begin":134,"end":165},"obj":"Gene"},{"id":"351","span":{"begin":167,"end":171},"obj":"Gene"},{"id":"352","span":{"begin":304,"end":308},"obj":"Gene"},{"id":"359","span":{"begin":4,"end":14},"obj":"Species"},{"id":"364","span":{"begin":298,"end":300},"obj":"Chemical"},{"id":"369","span":{"begin":312,"end":318},"obj":"CellLine"}],"attributes":[{"id":"A350","pred":"tao:has_database_id","subj":"350","obj":"Gene:59272"},{"id":"A351","pred":"tao:has_database_id","subj":"351","obj":"Gene:59272"},{"id":"A352","pred":"tao:has_database_id","subj":"352","obj":"Gene:103231639"},{"id":"A359","pred":"tao:has_database_id","subj":"359","obj":"Tax:2697049"},{"id":"A364","pred":"tao:has_database_id","subj":"364","obj":"MESH:D002738"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"CVCL:0574"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"LitCovid-sentences","denotations":[{"id":"T65","span":{"begin":79,"end":262},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}

{"project":"2_test","denotations":[{"id":"32496926-24121034-132195666","span":{"begin":74,"end":76},"obj":"24121034"},{"id":"32496926-24121034-132195667","span":{"begin":258,"end":260},"obj":"24121034"}],"text":" of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19]. The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19]. The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective ant"}