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PMC:7441788 / 7549-9599 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T26 6-13 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 125-137 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T28 125-129 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T29 256-269 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T30 256-260 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 332-337 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 463-470 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 548-560 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T34 548-552 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 880-887 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 1275-1282 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 1321-1332 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T38 1500-1503 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T39 1577-1581 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 1632-1641 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T41 1681-1686 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T42 1693-1698 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 1862-1869 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 1878-1881 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T45 1886-1918 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T46 2002-2004 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T47 2006-2017 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T64 17-25 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 365-373 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 489-497 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 869-873 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T68 1143-1151 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 1739-1747 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T70 1749-1773 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T71 2026-2031 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T74 76-78 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T75 83-85 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T76 83-85 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T77 96-98 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T78 125-129 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T79 190-195 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T80 216-218 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T81 216-218 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T82 237-242 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T83 256-260 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T84 261-269 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T85 325-337 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T86 548-552 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T87 702-710 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T88 1349-1357 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T89 1436-1446 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T90 1569-1572 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T91 1575-1581 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T92 1591-1600 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T93 1665-1675 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T94 1679-1686 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T95 1691-1698 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T96 1852-1861 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T84 6-13 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 83-85 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T86 147-158 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T87 216-218 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T88 311-313 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T89 394-396 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T90 463-470 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 581-583 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T92 714-716 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T93 880-887 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 1004-1006 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T95 1068-1070 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T96 1101-1110 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T97 1275-1282 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98 1305-1316 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T99 1312-1316 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T100 1321-1332 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T101 1510-1512 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T102 1706-1717 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T103 1775-1777 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T104 1779-1790 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T105 1797-1815 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T106 1844-1851 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T107 1862-1869 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T108 1882-1884 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T109 1925-1927 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T110 1960-1974 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T111 1967-1970 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T113 1971-1974 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T116 1990-2000 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T117 2002-2004 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T4 147-176 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T5 280-293 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigation http://purl.bioontology.org/ontology/MEDDRA/10062026
T6 1706-1735 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T59 6-13 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T60 147-158 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T61 311-313 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T62 394-396 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T63 463-470 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T64 581-583 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T65 714-716 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T66 880-887 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T67 1004-1006 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T68 1068-1070 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T69 1275-1282 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 1305-1316 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T71 1321-1332 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T72 1706-1717 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T73 1775-1777 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T74 1779-1790 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T75 1797-1815 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T76 1862-1869 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 1960-1974 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T68 17-27 Species denotes SARS-CoV-2 NCBItxid:2697049
T69 365-375 Species denotes SARS-CoV-2 NCBItxid:2697049
T70 489-497 Species denotes SARS-CoV NCBItxid:694009
T71 869-873 Species denotes SARS NCBItxid:694009
T72 1143-1151 Species denotes COVID-19 NCBItxid:2697049
T73 1739-1747 Species denotes COVID-19 NCBItxid:2697049
T74 1749-1773 Species denotes coronavirus disease 2019 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T64 0-91 Sentence denotes The S protein of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19].
T65 92-275 Sentence denotes The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19].
T66 276-664 Sentence denotes The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective anti-SARS-CoV-2 concentrations of CQ had no significant effect on the synthesis and glycosylation of S protein on the surface of SARS-CoV, and although it had no significant effect on the cell surface expression of ACE2, CQ could destroy the glycosylation at the terminal glycosylation site of ACE2 [13].
T67 665-938 Sentence denotes Therefore, the mechanism of anti-CoV activity of CQ/HCQ may be at least partly related to the impairment of terminal glycosylation of ACE2, which may result in reduced binding affinities between ACE2 and SARS CoV S protein, thereby blocking receptor recognition (Figure 1).
T68 939-948 Sentence denotes Figure 1.
T69 949-1067 Sentence denotes Schematic representation of the possible mechanisms of CQ/HCQ against CoVs replication and modulating immune response.
T70 1068-1699 Sentence denotes CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells.
T71 1700-2050 Sentence denotes ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
322 1264-1268 Gene denotes ACE2 Gene:59272
323 1432-1435 Gene denotes p38 Gene:1432
324 1545-1550 Gene denotes CD154 Gene:959
325 1569-1572 Gene denotes CD4 Gene:920
326 1019-1023 Species denotes CoVs Tax:11118
327 1004-1006 Chemical denotes CQ MESH:D002738
328 1007-1010 Chemical denotes HCQ MESH:D006886
329 1143-1151 Disease denotes COVID-19 MESH:C000657245
350 147-178 Gene denotes angiotensin-converting enzyme 2 Gene:59272
351 180-184 Gene denotes ACE2 Gene:59272
352 317-321 Gene denotes ACE2 Gene:103231639
353 575-579 Gene denotes ACE2 Gene:59272
354 654-658 Gene denotes ACE2 Gene:59272
355 799-803 Gene denotes ACE2 Gene:59272
356 860-864 Gene denotes ACE2 Gene:59272
357 461-462 Gene denotes S Gene:43740568
358 4-5 Gene denotes S Gene:43740568
359 17-27 Species denotes SARS-CoV-2 Tax:2697049
360 489-497 Species denotes SARS-CoV Tax:694009
361 869-877 Species denotes SARS CoV Tax:694009
362 365-375 Species denotes SARS-CoV-2 Tax:2697049
363 698-701 Species denotes CoV Tax:11118
364 311-313 Chemical denotes CQ MESH:D002738
365 394-396 Chemical denotes CQ MESH:D002738
366 581-583 Chemical denotes CQ MESH:D002738
367 714-716 Chemical denotes CQ MESH:D002738
368 717-720 Chemical denotes HCQ MESH:D006886
369 325-331 CellLine denotes VeroE6 CVCL:0574

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1 4-13 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T34 147-178 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T49 180-184 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T50 317-321 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T51 461-470 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T84 575-579 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T85 654-658 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T86 799-803 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T87 860-864 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T88 878-887 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T121 1264-1268 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T122 1273-1282 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T155 1432-1435 Protein denotes p38 https://www.uniprot.org/uniprot/Q9Y4Y1|https://www.uniprot.org/uniprot/Q9Y2S7|https://www.uniprot.org/uniprot/Q9UFX6|https://www.uniprot.org/uniprot/Q9UFG0|https://www.uniprot.org/uniprot/Q9Q6X7|https://www.uniprot.org/uniprot/Q9PY95|https://www.uniprot.org/uniprot/Q9P060|https://www.uniprot.org/uniprot/Q9NV58|https://www.uniprot.org/uniprot/Q9H8M8|https://www.uniprot.org/uniprot/Q9H5H9|https://www.uniprot.org/uniprot/Q96JE4|https://www.uniprot.org/uniprot/Q96IL6|https://www.uniprot.org/uniprot/Q96HJ0|https://www.uniprot.org/uniprot/Q96GA9|https://www.uniprot.org/uniprot/Q7TD18|https://www.uniprot.org/uniprot/Q64010|https://www.uniprot.org/uniprot/Q63768|https://www.uniprot.org/uniprot/Q52LG1|https://www.uniprot.org/uniprot/Q04929|https://www.uniprot.org/uniprot/Q01552|https://www.uniprot.org/uniprot/P46108|https://www.uniprot.org/uniprot/P34717|https://www.uniprot.org/uniprot/P27586|https://www.uniprot.org/uniprot/P0C797|https://www.uniprot.org/uniprot/P0C796|https://www.uniprot.org/uniprot/P06663|https://www.uniprot.org/uniprot/P04383|https://www.uniprot.org/uniprot/O97628|https://www.uniprot.org/uniprot/O95433|https://www.uniprot.org/uniprot/D3DTH6|https://www.uniprot.org/uniprot/B4DUR9|https://www.uniprot.org/uniprot/B2R9L2|https://www.uniprot.org/uniprot/B2R846|https://www.uniprot.org/uniprot/B0LPE8|https://www.uniprot.org/uniprot/A8MWE8|https://www.uniprot.org/uniprot/A3KCU9
T191 1545-1550 Protein denotes CD154 https://www.uniprot.org/uniprot/Q9Z2V2|https://www.uniprot.org/uniprot/Q9R254|https://www.uniprot.org/uniprot/Q9BDN3|https://www.uniprot.org/uniprot/Q9BDM7|https://www.uniprot.org/uniprot/Q9BDM3|https://www.uniprot.org/uniprot/Q9BDC7|https://www.uniprot.org/uniprot/Q95MQ5|https://www.uniprot.org/uniprot/P63305|https://www.uniprot.org/uniprot/P63304|https://www.uniprot.org/uniprot/P51749|https://www.uniprot.org/uniprot/P29965|https://www.uniprot.org/uniprot/P27548|https://www.uniprot.org/uniprot/O97626|https://www.uniprot.org/uniprot/O97605
T205 1569-1572 Protein denotes CD4 https://www.uniprot.org/uniprot/Q9XS78|https://www.uniprot.org/uniprot/Q9UDE5|https://www.uniprot.org/uniprot/Q5U066|https://www.uniprot.org/uniprot/Q4ZGK2|https://www.uniprot.org/uniprot/Q29617|https://www.uniprot.org/uniprot/Q29037|https://www.uniprot.org/uniprot/Q28217|https://www.uniprot.org/uniprot/Q08340|https://www.uniprot.org/uniprot/Q08339|https://www.uniprot.org/uniprot/Q08338|https://www.uniprot.org/uniprot/Q08336|https://www.uniprot.org/uniprot/P79196|https://www.uniprot.org/uniprot/P79185|https://www.uniprot.org/uniprot/P79184|https://www.uniprot.org/uniprot/P46630|https://www.uniprot.org/uniprot/P33705|https://www.uniprot.org/uniprot/P16004|https://www.uniprot.org/uniprot/P16003|https://www.uniprot.org/uniprot/P06332|https://www.uniprot.org/uniprot/P05542|https://www.uniprot.org/uniprot/P05540|https://www.uniprot.org/uniprot/P01730|https://www.uniprot.org/uniprot/O77593|https://www.uniprot.org/uniprot/O02805|https://www.uniprot.org/uniprot/D3DUS5|https://www.uniprot.org/uniprot/B2R737
T231 1700-1704 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T232 1706-1737 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T247 1954-1958 Protein denotes cGAS https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T259 1960-1983 Protein denotes cyclic GMP-AMP synthase https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T271 1990-2000 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T273 2026-2047 Protein denotes tumor necrosis factor https://www.uniprot.org/uniprot/Q9UIV3|https://www.uniprot.org/uniprot/Q9TTJ3|https://www.uniprot.org/uniprot/Q9P1Q2|https://www.uniprot.org/uniprot/Q9MYZ2|https://www.uniprot.org/uniprot/Q9JI27|https://www.uniprot.org/uniprot/Q9JI26|https://www.uniprot.org/uniprot/Q9BEA1|https://www.uniprot.org/uniprot/Q91VF3|https://www.uniprot.org/uniprot/Q8WNR1|https://www.uniprot.org/uniprot/Q8MKG8|https://www.uniprot.org/uniprot/Q8JFG3|https://www.uniprot.org/uniprot/Q8HZD9|https://www.uniprot.org/uniprot/Q8HZD6|https://www.uniprot.org/uniprot/Q8HYM0|https://www.uniprot.org/uniprot/Q75N23|https://www.uniprot.org/uniprot/Q6EE11|https://www.uniprot.org/uniprot/Q62326|https://www.uniprot.org/uniprot/Q5TM21|https://www.uniprot.org/uniprot/Q539C2|https://www.uniprot.org/uniprot/Q2MH05|https://www.uniprot.org/uniprot/P29553|https://www.uniprot.org/uniprot/P23563|https://www.uniprot.org/uniprot/P23383|https://www.uniprot.org/uniprot/P19101|https://www.uniprot.org/uniprot/P16599|https://www.uniprot.org/uniprot/P13296|https://www.uniprot.org/uniprot/P06804|https://www.uniprot.org/uniprot/P04924|https://www.uniprot.org/uniprot/P01375|https://www.uniprot.org/uniprot/O77764|https://www.uniprot.org/uniprot/O77510|https://www.uniprot.org/uniprot/O43647|https://www.uniprot.org/uniprot/O35853|https://www.uniprot.org/uniprot/O35734|https://www.uniprot.org/uniprot/O18779|https://www.uniprot.org/uniprot/A9QWR7|https://www.uniprot.org/uniprot/A5D9N8|https://www.uniprot.org/uniprot/A4IFT5|https://www.uniprot.org/uniprot/Q28339|https://www.uniprot.org/uniprot/Q28320|https://www.uniprot.org/uniprot/Q27978|https://www.uniprot.org/uniprot/Q1XHZ6|https://www.uniprot.org/uniprot/Q1WM27|https://www.uniprot.org/uniprot/Q1G1A2|https://www.uniprot.org/uniprot/Q19LH4|https://www.uniprot.org/uniprot/Q06599|https://www.uniprot.org/uniprot/Q006K5|https://www.uniprot.org/uniprot/P79374|https://www.uniprot.org/uniprot/P79337|https://www.uniprot.org/uniprot/P59695|https://www.uniprot.org/uniprot/P59694|https://www.uniprot.org/uniprot/P59693|https://www.uniprot.org/uniprot/P59684|https://www.uniprot.org/uniprot/P51743|https://www.uniprot.org/uniprot/P51742|https://www.uniprot.org/uniprot/P51435|https://www.uniprot.org/uniprot/P48094|https://www.uniprot.org/uniprot/P36939|https://www.uniprot.org/uniprot/P33620

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T58 42-46 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T59 120-124 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T60 125-129 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T61 190-195 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T62 237-242 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T63 251-255 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T64 256-260 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T65 332-337 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T66 548-552 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T67 646-650 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T68 1024-1035 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T69 1051-1066 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T70 1101-1110 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T71 1461-1465 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T72 1577-1581 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T73 1618-1628 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T74 1681-1686 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T75 1693-1698 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T76 1761-1768 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T26 6-13 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 125-137 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T28 125-129 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T29 256-269 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T30 256-260 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 332-337 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 463-470 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 548-560 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T34 548-552 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 880-887 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 1275-1282 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 1321-1332 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T38 1500-1503 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T39 1577-1581 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 1632-1641 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T41 1681-1686 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T42 1693-1698 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 1862-1869 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 1878-1881 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T45 1886-1918 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T46 2002-2004 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T47 2006-2017 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T3 430-439 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 444-457 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 602-615 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 623-645 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T7 632-645 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 773-795 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T9 782-795 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 1051-1066 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 1349-1364 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 1401-1414 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T13 1432-1435 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T14 1500-1503 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T15 1591-1600 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T16 1838-1842 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T17 1878-1881 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T18 1886-1918 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T19 2032-2040 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T20 2032-2040 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 2032-2040 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T22 2032-2040 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T57 17-27 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T58 365-375 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T59 489-497 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 869-873 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T61 1143-1151 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 1739-1747 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 1749-1773 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T64 2026-2031 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 2026-2031 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T3 430-439 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 444-457 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 602-615 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 623-645 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T7 632-645 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 773-795 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T9 782-795 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 1051-1066 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 1349-1364 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 1401-1414 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T13 1500-1503 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T14 1591-1600 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 1838-1842 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T16 1878-1881 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T17 1886-1918 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T18 2032-2040 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T19 2032-2040 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T20 2032-2040 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 2032-2040 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 430-439 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 444-457 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 602-615 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 623-645 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T7 632-645 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 773-795 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T9 782-795 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 1051-1066 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 1349-1364 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 1401-1414 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T13 1500-1503 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T14 1591-1600 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 1838-1842 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T16 1878-1881 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T17 1886-1918 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T18 2032-2040 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T19 2032-2040 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T20 2032-2040 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 2032-2040 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
322 1264-1268 Gene denotes ACE2 Gene:59272
323 1432-1435 Gene denotes p38 Gene:1432
324 1545-1550 Gene denotes CD154 Gene:959
325 1569-1572 Gene denotes CD4 Gene:920
326 1019-1023 Species denotes CoVs Tax:11118
327 1004-1006 Chemical denotes CQ MESH:D002738
328 1007-1010 Chemical denotes HCQ MESH:D006886
329 1143-1151 Disease denotes COVID-19 MESH:C000657245
350 147-178 Gene denotes angiotensin-converting enzyme 2 Gene:59272
351 180-184 Gene denotes ACE2 Gene:59272
352 317-321 Gene denotes ACE2 Gene:103231639
353 575-579 Gene denotes ACE2 Gene:59272
354 654-658 Gene denotes ACE2 Gene:59272
355 799-803 Gene denotes ACE2 Gene:59272
356 860-864 Gene denotes ACE2 Gene:59272
357 461-462 Gene denotes S Gene:43740568
358 4-5 Gene denotes S Gene:43740568
359 17-27 Species denotes SARS-CoV-2 Tax:2697049
360 489-497 Species denotes SARS-CoV Tax:694009
361 869-877 Species denotes SARS CoV Tax:694009
362 365-375 Species denotes SARS-CoV-2 Tax:2697049
363 698-701 Species denotes CoV Tax:11118
364 311-313 Chemical denotes CQ MESH:D002738
365 394-396 Chemical denotes CQ MESH:D002738
366 581-583 Chemical denotes CQ MESH:D002738
367 714-716 Chemical denotes CQ MESH:D002738
368 717-720 Chemical denotes HCQ MESH:D006886
369 325-331 CellLine denotes VeroE6 CVCL:0574

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T64 0-91 Sentence denotes The S protein of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19].
T65 92-275 Sentence denotes The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19].
T66 276-664 Sentence denotes The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective anti-SARS-CoV-2 concentrations of CQ had no significant effect on the synthesis and glycosylation of S protein on the surface of SARS-CoV, and although it had no significant effect on the cell surface expression of ACE2, CQ could destroy the glycosylation at the terminal glycosylation site of ACE2 [13].
T67 665-938 Sentence denotes Therefore, the mechanism of anti-CoV activity of CQ/HCQ may be at least partly related to the impairment of terminal glycosylation of ACE2, which may result in reduced binding affinities between ACE2 and SARS CoV S protein, thereby blocking receptor recognition (Figure 1).
T68 939-948 Sentence denotes Figure 1.
T69 949-1067 Sentence denotes Schematic representation of the possible mechanisms of CQ/HCQ against CoVs replication and modulating immune response.
T70 1068-1699 Sentence denotes CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells.
T71 1700-2050 Sentence denotes ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 2026-2031 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

2_test

Id Subject Object Predicate Lexical cue
32496926-24121034-132195666 87-89 24121034 denotes 19
32496926-24121034-132195667 271-273 24121034 denotes 19
32496926-16115318-132195668 660-662 16115318 denotes 13