PMC:7441788 / 6923-7429 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7441788","sourcedb":"PMC","sourceid":"7441788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7441788","text":" When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were \u003e100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18]. These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro. The conflicting results of these two studies may be related to different cell culture methods and experimental conditions. In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.\n\n4. ","divisions":[{"label":"label","span":{"begin":503,"end":505}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T24","span":{"begin":59,"end":64},"obj":"Body_part"},{"id":"T25","span":{"begin":364,"end":368},"obj":"Body_part"}],"attributes":[{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T59","span":{"begin":28,"end":36},"obj":"Disease"},{"id":"T60","span":{"begin":39,"end":48},"obj":"Disease"},{"id":"T61","span":{"begin":236,"end":244},"obj":"Disease"},{"id":"T62","span":{"begin":481,"end":489},"obj":"Disease"}],"attributes":[{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T67","span":{"begin":52,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T68","span":{"begin":176,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T69","span":{"begin":196,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T70","span":{"begin":247,"end":255},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T71","span":{"begin":364,"end":368},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T72","span":{"begin":492,"end":500},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T80","span":{"begin":82,"end":84},"obj":"Chemical"},{"id":"T81","span":{"begin":259,"end":261},"obj":"Chemical"},{"id":"T82","span":{"begin":457,"end":459},"obj":"Chemical"}],"attributes":[{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T3","span":{"begin":369,"end":376},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A3","pred":"meddra_id","subj":"T3","obj":"http://purl.bioontology.org/ontology/MEDDRA/10061447"},{"subj":"T3","pred":"source","obj":"LitCovid-sample-MedDRA"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T55","span":{"begin":82,"end":84},"obj":"Chemical"},{"id":"T56","span":{"begin":259,"end":261},"obj":"Chemical"},{"id":"T57","span":{"begin":457,"end":459},"obj":"Chemical"}],"attributes":[{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T55","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T56","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T57","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T64","span":{"begin":28,"end":38},"obj":"Species"},{"id":"T65","span":{"begin":236,"end":246},"obj":"Species"},{"id":"T66","span":{"begin":481,"end":491},"obj":"Species"}],"attributes":[{"id":"A64","pred":"ncbi_taxonomy_id","subj":"T64","obj":"NCBItxid:2697049"},{"id":"A65","pred":"ncbi_taxonomy_id","subj":"T65","obj":"NCBItxid:2697049"},{"id":"A66","pred":"ncbi_taxonomy_id","subj":"T66","obj":"NCBItxid:2697049"},{"subj":"T64","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T65","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T66","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T55","span":{"begin":201,"end":290},"obj":"Sentence"},{"id":"T56","span":{"begin":291,"end":413},"obj":"Sentence"},{"id":"T57","span":{"begin":414,"end":501},"obj":"Sentence"},{"id":"T58","span":{"begin":503,"end":505},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T55","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"282","span":{"begin":108,"end":110},"obj":"Gene"},{"id":"284","span":{"begin":457,"end":463},"obj":"Gene"},{"id":"285","span":{"begin":162,"end":164},"obj":"Gene"},{"id":"286","span":{"begin":150,"end":152},"obj":"Gene"},{"id":"287","span":{"begin":95,"end":97},"obj":"Gene"},{"id":"293","span":{"begin":236,"end":246},"obj":"Species"},{"id":"294","span":{"begin":481,"end":491},"obj":"Species"},{"id":"303","span":{"begin":259,"end":261},"obj":"Chemical"},{"id":"304","span":{"begin":277,"end":280},"obj":"Chemical"},{"id":"308","span":{"begin":28,"end":48},"obj":"Disease"},{"id":"311","span":{"begin":52,"end":58},"obj":"CellLine"}],"attributes":[{"id":"A287","pred":"pubann:denotes","subj":"287","obj":"Gene:56925"},{"id":"A294","pred":"pubann:denotes","subj":"294","obj":"Tax:2697049"},{"id":"A311","pred":"pubann:denotes","subj":"311","obj":"CVCL:0574"},{"id":"A304","pred":"pubann:denotes","subj":"304","obj":"MESH:D006886"},{"id":"A293","pred":"pubann:denotes","subj":"293","obj":"Tax:2697049"},{"id":"A285","pred":"pubann:denotes","subj":"285","obj":"Gene:56925"},{"id":"A282","pred":"pubann:denotes","subj":"282","obj":"Gene:56925"},{"id":"A286","pred":"pubann:denotes","subj":"286","obj":"Gene:56925"},{"id":"A308","pred":"pubann:denotes","subj":"308","obj":"MESH:C000657245"},{"id":"A303","pred":"pubann:denotes","subj":"303","obj":"MESH:D002738"},{"subj":"282","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"284","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"285","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"286","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"287","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"293","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"294","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"303","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"304","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"308","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"311","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T54","span":{"begin":39,"end":48},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T55","span":{"begin":59,"end":64},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T56","span":{"begin":364,"end":368},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T55","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T56","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T24","span":{"begin":59,"end":64},"obj":"Body_part"},{"id":"T25","span":{"begin":364,"end":368},"obj":"Body_part"}],"attributes":[{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T24","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T25","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T52","span":{"begin":28,"end":38},"obj":"Disease"},{"id":"T53","span":{"begin":39,"end":48},"obj":"Disease"},{"id":"T54","span":{"begin":236,"end":246},"obj":"Disease"},{"id":"T55","span":{"begin":481,"end":491},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T52","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"282","span":{"begin":108,"end":110},"obj":"Gene"},{"id":"284","span":{"begin":457,"end":463},"obj":"Gene"},{"id":"285","span":{"begin":162,"end":164},"obj":"Gene"},{"id":"286","span":{"begin":150,"end":152},"obj":"Gene"},{"id":"287","span":{"begin":95,"end":97},"obj":"Gene"},{"id":"293","span":{"begin":236,"end":246},"obj":"Species"},{"id":"294","span":{"begin":481,"end":491},"obj":"Species"},{"id":"303","span":{"begin":259,"end":261},"obj":"Chemical"},{"id":"304","span":{"begin":277,"end":280},"obj":"Chemical"},{"id":"308","span":{"begin":28,"end":48},"obj":"Disease"},{"id":"311","span":{"begin":52,"end":58},"obj":"CellLine"}],"attributes":[{"id":"A282","pred":"tao:has_database_id","subj":"282","obj":"Gene:56925"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Gene:56925"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"Gene:56925"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Gene:56925"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"Tax:2697049"},{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"Tax:2697049"},{"id":"A303","pred":"tao:has_database_id","subj":"303","obj":"MESH:D002738"},{"id":"A304","pred":"tao:has_database_id","subj":"304","obj":"MESH:D006886"},{"id":"A308","pred":"tao:has_database_id","subj":"308","obj":"MESH:C000657245"},{"id":"A311","pred":"tao:has_database_id","subj":"311","obj":"CVCL:0574"},{"subj":"282","pred":"source","obj":"LitCovid-PubTator"},{"subj":"284","pred":"source","obj":"LitCovid-PubTator"},{"subj":"285","pred":"source","obj":"LitCovid-PubTator"},{"subj":"286","pred":"source","obj":"LitCovid-PubTator"},{"subj":"287","pred":"source","obj":"LitCovid-PubTator"},{"subj":"293","pred":"source","obj":"LitCovid-PubTator"},{"subj":"294","pred":"source","obj":"LitCovid-PubTator"},{"subj":"303","pred":"source","obj":"LitCovid-PubTator"},{"subj":"304","pred":"source","obj":"LitCovid-PubTator"},{"subj":"308","pred":"source","obj":"LitCovid-PubTator"},{"subj":"311","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T55","span":{"begin":201,"end":290},"obj":"Sentence"},{"id":"T56","span":{"begin":291,"end":413},"obj":"Sentence"},{"id":"T57","span":{"begin":414,"end":501},"obj":"Sentence"},{"id":"T58","span":{"begin":503,"end":505},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d9ec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#e493ec"},{"id":"LitCovid-PD-CLO","color":"#93ecca"},{"id":"LitCovid-PD-CHEBI","color":"#ecb093"},{"id":"LitCovid-sample-MedDRA","color":"#9693ec"},{"id":"LitCovid-sample-CHEBI","color":"#a9ec93"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#ec93c3"},{"id":"LitCovid-sample-sentences","color":"#93ddec"},{"id":"LitCovid-sample-Pubtator","color":"#ece193"},{"id":"LitCovid-sample-PD-IDO","color":"#c793ec"},{"id":"LitCovid-sample-PD-FMA","color":"#93ecac"},{"id":"LitCovid-sample-PD-MONDO","color":"#ec9393"},{"id":"LitCovid-PubTator","color":"#93adec"},{"id":"LitCovid-sentences","color":"#c7ec93"}]}]}}